Server-side scripting involves using programming languages and frameworks to generate dynamic web content on the server before delivering it to users' browsers. Unlike client-side scripting, which runs in users' browsers, server-side scripting allows code execution on the server, enabling personalized content generation. Popular server-side scripting languages include PHP, Python, Node.js, Perl, and Ruby, while common client-side languages are JavaScript, HTML, and CSS. The document discusses introducing server-side scripting and dynamic functionality to websites to engage users and require them to return for continually updating information.