Nutraceutical product development has numerous benefits but still faces many challenges in India, and the food research lab intends to address these issues. More info: https://www.foodresearchlab.com/blog/nutraceutical-product/challenges-in-indian-nutraceutical-product-development/

1. CHALLENGESI
N
INDIAN
NUTRACEUTI
CAL
PRODUCT
DEVELOPMENT
An Academic presentation by
Dr. Nancy Agnes, Head, Technical Operations,
FoodResearchLab Group: www.foodresearchlab.com
Email: info@foodresearchlab.com

2. TOPI
C DI
SCUSSI
ON
Introduction
Nutraceutical Product
Development Challenges
Solutions

3. Introduction
Nutraceuticalproductdevelopmenthasnumerousbenefitsbut
still faces many challenges in India, and the food research lab
intendsto addressthese issues.
Nutraceutical formulations arethought to provide physiological
benefitsor immunityagainst subsequent diseasessuch asstress,
cardiovascular disorders, diabetes, cancer
, Parkinson's and
Alzheimer's, neurological, pulmonary and respiratory disorders,
and mayact asimmunomodulators.
Contd...

4. Although it may be simple for a nutraceutical product
development contract R&D to create pharmaceutical tablets,
powders, capsules,suppositories and soon incorporating bioactive
food, obtaining sufficient bioavailability for such nutraceuticals is
extremelydifficult.
Nutraceutical product development and functional mealswith
different characteristicshave the potential to provide unique
goodsto the globe at large.
Contd...

6. Nutraceutical formulations experience many problems that limit
their efficacy.
Better-characterized and research-proven goods made by
nutraceutical contract manufacturing will assist in boosting
customer confidence in nutraceutical and functional food items
worldwide.

7. NutraceuticalProduct Development Challenges
Nutraceuticals appear to be distinguishable from functional foods
in a variety of ways that challenge the regulatory ideas of food and
pharmaceuticals.
There are two obvious concerns to the nutraceutical formulation
industry: regulatory uncertainty and the trustworthiness of
labelling claims. Regulatory ambiguity arises both nationally,
providing the regulatory quagmire in which the nutraceutical
contract manufacturing are now surviving, and in export markets
due to a lack of international agreement on how to label
nutraceuticals.
Contd...

8. Several plants have varying degrees of the same medicinal activity.
For example, more than 100 plants have been found to have anti-
diabetic or hypoglycemia effects in India.
Nutraceutical contract manufacturing companies delays in
identifying such compounds due to lack of communication and
indigenous knowledge.
The limited solubility, stability, and permeability of the bioactive
component in the gastrointestinal tract frequently jeopardise
bioavailability
Contd...

9. Curcumin, for example, has low oral bioavailability due to shallow
blood levels, restricted tissue distribution, apparent quick
metabolism,and a short circulation half-life.
Another example is probioticsencapsulationtechnology(PET),
which has recently been developed as a mechanism for probiotic
delivery. Biomaterial selection, solvent type, and toxicity are all
factors that contribute to cell survival.
The selection of appropriate technology is critical in the
formulation of probiotics.
Contd...

10. Drug delivery refers to the process of efficiently and safely
introducing an active medicinal component into the body.
The introduction of innovative delivery systems into the
nutraceutical sector has been delayed due to their complexity,
high cost, and time consumption.
As a result, conventional forms have been utilised for many years,
yet, as previously stated, they have several flaws. Nutraceutical
contract manufacturing and nutraceutical product development
dwells under this issues.
Contd...

11. Traditional herbaldosageformulaehave been created for many years. Permeation enhancers,
surface modifiers,prodrugs,colloidal lipid carriers,and othernewcarriers,for example,havebeen
created.
The inherent powderiness of free phytosterolsdue to their crystalline formisanother problem for
food ingredientmanufacturers.The particle sizeof solid componentshasasignificant impacton
organoleptic characteristics of mealssuch astaste and feel.
Insoluble particlesmaycontribute grittiness and coarseness,which contribute to the overall
mouth-feel of meals.
Contd...

12. One difficultythat hasbeen overlookedisraisingpublic awarenessabout the need of making
healthy eating choices.
Individualchoosing isthe single mostimportantdriving elementin the food souk'sexpansion.Itis
now possible to assumethat individual customerseat whatthey choose.

13. Solutions
The worldwide approach to nutraceutical
regulationand marketingisverydiversified.
Thisismostlydue to the difficultiesin
classifying such items,the lackof an
adequate regulatoryclassforthese hybrid
products,and varyingperspectiveson whatis
regarded to be sufficient scientific proof to
conclude theirfunctionality
.
Contd...

14. The unified approach to breaking thisbarriercan help create auniversally acceptable definition.
India recently put its definition on the FSSAI site, and the FDA and EU have bought in their
regulatorychanges.
When the ethnobotanical method isused for drug development, informationavailablefrom
traditionalknowledge holdersisshared.
Respecting the intellectual property rights of a certain cultural group, tribe, or local people in a
place whereplants areharvested based on their ethnomedicalexpertise isvital.Thiscan help lead
to understanding more and extracting the right and newsources.
Contd...

15. The introduction of nanotechnology for pharmaceutical useshas
created a new route for improving the stability, solubility, or
permeabilityof problematic nutraceuticals.
The purpose isto promotehealth and wellnessaspeople'saverage
agesincrease.
The addition of genericsinto the marketmayreduce the price of a
few nutraceuticals, but people's relianceon such goods and their
expanding reach indicate that marketgrowthwillremainconstant.

16. Conclusion
The global use of nutraceuticalsisquickly
increasing,owing to their stated safetyand
efficacy.
The use of sophisticated nanosized drug
deliverysystemsasaplatformfor
nutraceutical compositionhasrecently
gained popularity
.
Contd...

17. Thisisinspired bythe encouraging findings for the nutraceuticalsevaluated in bioavailability,
safety,targeting,and stability.
As aresult,numerous drug deliverymethods, such asnanoparticles, liposomes,dendrimers,
phytosomes,nanoemulsions,and others,were developed.
However
,there areseveralobstacles associated withnutraceutical formulationregarding efficacy,
safety,and regulatorycompliance.
Concerned institutionshavenot identified aworldwidedefinition.Globally, regulatoryagencies
havenot been establishedto control and regulate nutraceuticals.

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