This document provides information about certification opportunities for histotechnicians (HTs) through the American Society for Clinical Pathology (ASCP). It discusses the benefits of ASCP certification, eligibility routes, the application process, exam format and content, and statistics. The exam uses a computer adaptive testing format and covers topics like fixation, processing, microtomy, and staining. Certification demonstrates competency and can lead to higher pay and more job opportunities in the histology field.
The document discusses trends in hematopoietic stem cell transplantation (HSCT) in Asia-Pacific countries over recent decades, including increasing numbers of both allogeneic and autologous HSCTs performed, as well as opportunities and challenges for improving access to and standards of HSCT in the region going forward. It also outlines strategies proposed by the Asia-Pacific Blood and Marrow Transplantation Group to address issues such as education and training, infrastructure development, and collaborative research.
Friday 1145 Di mario - how to set up a cto program in a cath labEuro CTO Club
Operator experience, sufficient patient volume, and dedicated centre equipment and staff are key components of a successful CTO program. A CTO operator should obtain experience as a fellow before operating independently, and seasoned operators should continue training through workshops and courses. Successful CTO programs require a minimum of two cath labs, adequate CTO caseload, multidisciplinary team support, and auditing of results.
The document summarizes a study examining outcomes of percutaneous coronary interventions (PCI) performed at facilities without on-site cardiac surgery compared to those with on-site surgery. The study analyzed data from over 308,000 PCI procedures reported to the National Cardiovascular Data Registry. Results showed procedural success and complication rates were similar between facility types, while in-hospital mortality was higher at off-site facilities for non-primary PCI but not for primary PCI patients. The data provide insights into the safety of PCI performed at centers without on-site cardiac surgery.
Carlo Di Mario - Recent Publications & Research in CTO: 2015-16Euro CTO Club
This document summarizes recent publications and research on chronic total occlusions (CTOs) from 2015-2016. It finds that the number of published manuscripts on CTOs has significantly increased in recent years. Several studies examined outcomes of patients undergoing percutaneous coronary intervention (PCI) on CTOs versus medical therapy or bypass surgery, finding lower mortality and adverse event rates with PCI. Other publications identified predictors of successful CTO recanalization and evaluated new techniques and scoring systems. Additional research investigated the physiological and anatomical changes in CTO arteries pre- and post-PCI using imaging modalities like intravascular ultrasound (IVUS) and computed tomography angiography (CTA).
Presentation of Dr. Philipp Hagen and Dr. Detlev Breyer on the Impact of Biomechanical Indices on Visual Outcome up to Five Years after Refractive Lenticule Extraction (ReLEx) SMILE. ESCRS, Vienna 2018.
This document discusses current and future innovation in the pharmaceutical industry from the perspective of Merck Research Laboratories. It outlines Merck's strategy to discover, develop, and bring innovative medicines to market by pursuing promising science, prioritizing key opportunities, and adapting to a changing landscape. Statistics are provided on Merck's 2018 clinical trial operations, and the relationships between product development teams, clinical sub-teams, and clinical trial teams. Considerations for clinical trial planning, site selection, and protocol design are examined. Pembrolizumab clinical development across many tumor types is reviewed, as are challenges developing a treatment for all genotypes of Hepatitis C.
11:20 Louvard - adjusting your level of competence to the difficulty of a CTOEuro CTO Club
1) Adjusting the difficulty level of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) cases to the skill level of the operator is important. This can be done through patient selection based on predictors of success and operator experience.
2) A team-based approach, use of new devices and techniques, individual case volumes, and proctoring can help improve CTO PCI success rates.
3) Scores like the J-CTO score and the new CL-SCORE can help predict procedural success and guide patient selection and referral. Maintaining a database is useful for monitoring outcomes and individual operator success.
Rapid review of endoscopy services - NHS ImprovementNHS Improvement
Rapid review of endoscopy services
NHS Improvement Jan 2012 shares emerging learning from front line services and identifies areas of good practice in addition to highlighting some key challenges that endoscopy departments are encountering today
The document discusses trends in hematopoietic stem cell transplantation (HSCT) in Asia-Pacific countries over recent decades, including increasing numbers of both allogeneic and autologous HSCTs performed, as well as opportunities and challenges for improving access to and standards of HSCT in the region going forward. It also outlines strategies proposed by the Asia-Pacific Blood and Marrow Transplantation Group to address issues such as education and training, infrastructure development, and collaborative research.
Friday 1145 Di mario - how to set up a cto program in a cath labEuro CTO Club
Operator experience, sufficient patient volume, and dedicated centre equipment and staff are key components of a successful CTO program. A CTO operator should obtain experience as a fellow before operating independently, and seasoned operators should continue training through workshops and courses. Successful CTO programs require a minimum of two cath labs, adequate CTO caseload, multidisciplinary team support, and auditing of results.
The document summarizes a study examining outcomes of percutaneous coronary interventions (PCI) performed at facilities without on-site cardiac surgery compared to those with on-site surgery. The study analyzed data from over 308,000 PCI procedures reported to the National Cardiovascular Data Registry. Results showed procedural success and complication rates were similar between facility types, while in-hospital mortality was higher at off-site facilities for non-primary PCI but not for primary PCI patients. The data provide insights into the safety of PCI performed at centers without on-site cardiac surgery.
Carlo Di Mario - Recent Publications & Research in CTO: 2015-16Euro CTO Club
This document summarizes recent publications and research on chronic total occlusions (CTOs) from 2015-2016. It finds that the number of published manuscripts on CTOs has significantly increased in recent years. Several studies examined outcomes of patients undergoing percutaneous coronary intervention (PCI) on CTOs versus medical therapy or bypass surgery, finding lower mortality and adverse event rates with PCI. Other publications identified predictors of successful CTO recanalization and evaluated new techniques and scoring systems. Additional research investigated the physiological and anatomical changes in CTO arteries pre- and post-PCI using imaging modalities like intravascular ultrasound (IVUS) and computed tomography angiography (CTA).
Presentation of Dr. Philipp Hagen and Dr. Detlev Breyer on the Impact of Biomechanical Indices on Visual Outcome up to Five Years after Refractive Lenticule Extraction (ReLEx) SMILE. ESCRS, Vienna 2018.
This document discusses current and future innovation in the pharmaceutical industry from the perspective of Merck Research Laboratories. It outlines Merck's strategy to discover, develop, and bring innovative medicines to market by pursuing promising science, prioritizing key opportunities, and adapting to a changing landscape. Statistics are provided on Merck's 2018 clinical trial operations, and the relationships between product development teams, clinical sub-teams, and clinical trial teams. Considerations for clinical trial planning, site selection, and protocol design are examined. Pembrolizumab clinical development across many tumor types is reviewed, as are challenges developing a treatment for all genotypes of Hepatitis C.
11:20 Louvard - adjusting your level of competence to the difficulty of a CTOEuro CTO Club
1) Adjusting the difficulty level of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) cases to the skill level of the operator is important. This can be done through patient selection based on predictors of success and operator experience.
2) A team-based approach, use of new devices and techniques, individual case volumes, and proctoring can help improve CTO PCI success rates.
3) Scores like the J-CTO score and the new CL-SCORE can help predict procedural success and guide patient selection and referral. Maintaining a database is useful for monitoring outcomes and individual operator success.
Rapid review of endoscopy services - NHS ImprovementNHS Improvement
Rapid review of endoscopy services
NHS Improvement Jan 2012 shares emerging learning from front line services and identifies areas of good practice in addition to highlighting some key challenges that endoscopy departments are encountering today
This document discusses Contract Research Organizations (CROs) and their role in supporting pharmaceutical clinical trials. It provides the following key points:
- CROs are service organizations that conduct clinical trials and other drug development work on behalf of pharmaceutical companies. This outsourcing has grown as drug development has become more complex.
- When deciding whether and how to use a CRO, companies consider tactical, maximal, or strategic outsourcing based on their internal resources. Selecting the right CRO requires evaluating their capabilities, compatibility with the sponsor's needs, and costs.
- Managing the sponsor-CRO relationship is critical to ensure success. This involves clearly defining roles and responsibilities, establishing performance metrics,
This document discusses Medtronic's strategy to address global healthcare needs by developing new therapies and technologies, expanding access through globalization, and optimizing costs and efficiencies. Medtronic aims to become a healthcare solutions provider by improving clinical outcomes, expanding access to care, and translating the clinical value of its products into economic benefits. The document provides examples of Medtronic technologies like its Integrity and Resolute Integrity drug-eluting stents and the Symplicity renal denervation system. It also outlines Medtronic's portfolio and programs to facilitate adoption of transradial access procedures.
This document provides information on ongoing research projects within the Biostatistics, Epidemiology and Scientific Computing department at King Faisal Specialist Hospital & Research Centre. It describes two ongoing registry projects - the Thromboembolic Disorders Registry established in 2001 to study thromboembolic episodes and bleeding disorders during anticoagulation therapy, and the Cleft Lip and Palate Registry established in 1999 to determine the type and prevalence of cleft lip and palate in the hospital's patient population and contribute to reporting. The document gives background and objectives for each registry.
ClinActis Pte Ltd is a full service CRO providing clinical trial services to the pharmaceutical, medical device, medical nutrition and biotech companies in Asia Pacific. Established in 2009, ClinActis Pte Ltd is headquartered in Singapore.
ClinActis Experience
• 45 years experience in clinical research in pharmaceutical and biotechnology companies as well as CROs
• 28 years experience in Asia Pacific, including Australia/New Zealand, China, Malaysia, Hong Kong, India, Indonesia, The Philippines, Singapore, South Korea, Taiwan, Thailand and Japan
• Extensive knowledge of regulatory frameworks, best KOLs and sites across the region
• Vast therapeutic experience including Cardiovascular, CNS, Endocrinology, Infectious diseases, Oncology, and Respiratory
Stroke unit development and evaluation Jacek Staszewski 2015Jacek Staszewski
This document discusses strategies to improve stroke care and treatment. It outlines the benefits of stroke unit care compared to general medical wards, including reduced mortality, dependency, and length of stay. It also discusses various quality indicators that stroke units and centers should monitor, such as thrombolysis rates and door-to-needle times. The document advocates for a tiered system of stroke care with certified acute stroke units and centers that can provide more advanced treatments and meet quality standards. It also discusses strategies to optimize pre-hospital management and in-hospital workflows to increase thrombolysis treatment rates and reduce treatment delays.
Troy Stockman is a healthcare leader seeking a new leadership role. He has over 25 years of experience in healthcare administration, including managing physician practices, designing new hospitals, and leading regional service lines. His resume summarizes his roles as CEO of a spine hospital and director of neuroscience and diagnostic services. He demonstrates expertise in areas like population health, EHR implementation, and quality programs.
Quality, Risk & Compliance: Risk Management for Sponsors, Site, and CROsMedpace
This document discusses risk management in clinical trials from multiple perspectives. It provides statistics on the high costs and time required to bring new drugs to market. It defines quality as an absence of errors that matter and compliance as adherence to regulatory and GCP requirements. Key aspects of risk management are identified, including risk identification, evaluation, control, and review. Process mapping and risk assessment tools are presented. Quality by design and continual improvement concepts are also covered.
Case presentation (lab analytical quality assurance problem )Rania Elsharkawy
This case presentation describes a 64-year-old female patient who visited the laboratory for requested tests and encountered discrepant results between two laboratories for her intact parathyroid hormone (iPTH) level. The receptionist failed to record the patient's drug history, including her use of biotin supplements. After initial testing found low iPTH, total calcium, and alkaline phosphatase levels consistent with adynamic bone disease, a second laboratory found a significantly higher iPTH level. The laboratory investigated potential pre-analytical, analytical, and post-analytical errors and determined biotin interference affected the iPTH assay, providing a falsely low result. The case highlights the importance of thorough history taking including medication
This 60-minute webcast discusses appropriate cardiac testing techniques and treatment of coronary artery disease (CAD) to help primary care clinicians. The target audience is primary healthcare professionals. It will address gaps in CAD risk assessment, testing, and outcomes. Specific learning objectives include comparing CAD risk assessment tools, cardiac stress test types, and imaging modalities. It will also identify gender differences in CAD presentation and testing. The activity is supported by an educational grant and aims to help primary care integrate the latest CAD research into practice.
Critical Care Research: Connection to PracticeAllina Health
1) The document discusses a critical care research program at Abbott Northwestern Hospital with the goals of conducting studies to improve patient outcomes, enhance quality of care, and reduce costs.
2) The program involves intensivists, hospitalists, and other clinical specialties conducting studies and presenting findings to improve practice.
3) Several ongoing studies are summarized that examine issues like postoperative monitoring, pulmonary ultrasound scoring, infection risks, and outcomes after procedures.
This document summarizes a presentation about post-CCT surgical fellowships. It discusses how the apprenticeship model of surgical training is changing, with more trainees pursuing subspecialty fellowship training after completing their CCT. It provides an overview of the Royal College of Surgeons of England's Senior Clinical Fellowship scheme, which establishes standards for fellowship programs. It also shares the presenter's experience completing an RCSE-accredited robotic urology fellowship, highlighting the structured training, improved surgical outcomes, and career benefits it provided.
NeoGenomics provides cancer genetic testing services to oncologists, pathologists, and hospitals. It has experienced strong and consistent growth in revenue and tests performed annually through expanding its test menu, increasing sales force productivity, and gaining market share. The company aims to continue its growth by launching new tests, pursuing partnerships and acquisitions, and capitalizing on the large and growing market for cancer genetic testing fueled by an aging population and advancements in targeted therapies.
- NeoGenomics is a pure-play cancer genetics testing company that has experienced fast revenue and test volume growth through expanding its test menu and increasing sales force productivity. Its "tech-only" business model focuses on partnerships with oncologists and hospitals to provide genetic testing services.
- The company has consistently grown its annual revenue and tests performed historically through new test innovations, a growing sales force, and greater productivity. It is targeting further market share gains and operating leverage to accelerate cash flow and earnings growth.
Specialized oncology reference laboratory providing the latest testing technologies, global/tech-only options, and interactive education to the pathology community
Offer the complete spectrum of diagnostic services through nationwide network of laboratories
Dedicated to providing superior service, faster turn-around times, and complete attention to the needs of our clients and their patients
This presentation provides an overview of NeoGenomics, a cancer genetics testing company. Key points include:
- NeoGenomics has experienced strong and consistent growth in revenue and test volume historically through strategic partnerships and an expanding test menu.
- The company focuses on fast turnaround times and exceptional client service to drive continued growth.
- Management aims to increase market share and profitability through expanding sales coverage, new test offerings like next generation sequencing, and potential M&A opportunities.
- NeoGenomics seeks to capitalize on favorable industry trends like an aging population, rise of personalized medicine, and consolidation in the cancer diagnostics field.
Cancer Diagnostics Reference Laboratory / NeoGenomics April 2014 investors company overview presentation. This presentation highlights the following:
--Fast growing cancer genetics lab servicing Oncologists, Pathologists and Hostpitals
--Strategic client partnerships created by "Tech-Only" model
--Dynamic, rapidly-growing and consolidating industry
Industry-leading revenue & test volume growth
--Strong productivity and operating leverage leading to accelerating cash flow and net income
--Strong Management Team with large cap lab experience
The presentation provides an overview of NeoGenomics, a cancer genetic testing company. It highlights the company's consistent historical growth in tests performed and revenue. The management team has significant experience in large cap clinical laboratories. The company aims to continue expanding its test menu and market share through new product development and partnerships within the fast-growing cancer genetic testing industry.
This presentation provides an overview of NeoGenomics, a cancer genetic testing company. Key points include:
- NeoGenomics has experienced consistent historical growth in the number of cancer tests performed and annual revenue.
- The company focuses on fast-growing cancer genetics testing and has strategic partnerships with oncologists and hospitals.
- Management aims to continue expanding the test menu and achieving operating leverage to accelerate cash flow and earnings.
Tests of Knowledge: How Can They Contribute to Maintenance of Certification ...IAMRAreval2015
Tests of knowledge can contribute to maintenance of certification (MoC) and revalidation in two ways: assessment of learning and assessment for learning. Assessment of learning uses high-stakes knowledge tests summatively to identify doctors with performance problems, while assessment for learning takes a longitudinal approach through frequent, low-stakes tests to provide feedback and assist doctors in keeping knowledge up to date. There are challenges to the use of knowledge tests, such as determining relevant content and preventing tests from being seen as irrelevant facts, that different assessment approaches aim to address.
This document discusses quality control in histopathology. It defines key terms like quality control, quality assurance, and total quality management. It outlines the pre-analytical, analytical and post-analytical phases of quality control and highlights variables that can affect quality in each phase like personnel training, equipment, and interpretation of results. It provides recommendations for achieving quality control through standardized procedures, monitoring turnaround times, participation in proficiency testing, and review of reports. The goal is to generate accurate histopathology reports and enable easy retrieval if needed.
ICPI Pathology Recruitment Powerpoint - October 2014James Douglas
This document provides an overview of career opportunities in pathology. It discusses the various practice settings pathologists can work in, including community practice, academic practice, and industry. It also summarizes compensation levels, benefits, lifestyle factors, and job market trends for pathologists. There is currently a shortage of pathologists projected to increase over the next two decades. The job market for pathologists is described as excellent with opportunities for employment upon completing residency or fellowship training.
This presentation provides an overview of the company, which provides cancer genetic testing services. It highlights the company's fast growth, experienced management team, expanding product and service offerings including next generation sequencing and liquid biopsy tests. The company has achieved significant reductions in costs per test through economies of scale and innovation. Financial metrics show accelerating revenue, earnings, and cash flow in recent years through both organic growth and acquisition.
This document discusses Contract Research Organizations (CROs) and their role in supporting pharmaceutical clinical trials. It provides the following key points:
- CROs are service organizations that conduct clinical trials and other drug development work on behalf of pharmaceutical companies. This outsourcing has grown as drug development has become more complex.
- When deciding whether and how to use a CRO, companies consider tactical, maximal, or strategic outsourcing based on their internal resources. Selecting the right CRO requires evaluating their capabilities, compatibility with the sponsor's needs, and costs.
- Managing the sponsor-CRO relationship is critical to ensure success. This involves clearly defining roles and responsibilities, establishing performance metrics,
This document discusses Medtronic's strategy to address global healthcare needs by developing new therapies and technologies, expanding access through globalization, and optimizing costs and efficiencies. Medtronic aims to become a healthcare solutions provider by improving clinical outcomes, expanding access to care, and translating the clinical value of its products into economic benefits. The document provides examples of Medtronic technologies like its Integrity and Resolute Integrity drug-eluting stents and the Symplicity renal denervation system. It also outlines Medtronic's portfolio and programs to facilitate adoption of transradial access procedures.
This document provides information on ongoing research projects within the Biostatistics, Epidemiology and Scientific Computing department at King Faisal Specialist Hospital & Research Centre. It describes two ongoing registry projects - the Thromboembolic Disorders Registry established in 2001 to study thromboembolic episodes and bleeding disorders during anticoagulation therapy, and the Cleft Lip and Palate Registry established in 1999 to determine the type and prevalence of cleft lip and palate in the hospital's patient population and contribute to reporting. The document gives background and objectives for each registry.
ClinActis Pte Ltd is a full service CRO providing clinical trial services to the pharmaceutical, medical device, medical nutrition and biotech companies in Asia Pacific. Established in 2009, ClinActis Pte Ltd is headquartered in Singapore.
ClinActis Experience
• 45 years experience in clinical research in pharmaceutical and biotechnology companies as well as CROs
• 28 years experience in Asia Pacific, including Australia/New Zealand, China, Malaysia, Hong Kong, India, Indonesia, The Philippines, Singapore, South Korea, Taiwan, Thailand and Japan
• Extensive knowledge of regulatory frameworks, best KOLs and sites across the region
• Vast therapeutic experience including Cardiovascular, CNS, Endocrinology, Infectious diseases, Oncology, and Respiratory
Stroke unit development and evaluation Jacek Staszewski 2015Jacek Staszewski
This document discusses strategies to improve stroke care and treatment. It outlines the benefits of stroke unit care compared to general medical wards, including reduced mortality, dependency, and length of stay. It also discusses various quality indicators that stroke units and centers should monitor, such as thrombolysis rates and door-to-needle times. The document advocates for a tiered system of stroke care with certified acute stroke units and centers that can provide more advanced treatments and meet quality standards. It also discusses strategies to optimize pre-hospital management and in-hospital workflows to increase thrombolysis treatment rates and reduce treatment delays.
Troy Stockman is a healthcare leader seeking a new leadership role. He has over 25 years of experience in healthcare administration, including managing physician practices, designing new hospitals, and leading regional service lines. His resume summarizes his roles as CEO of a spine hospital and director of neuroscience and diagnostic services. He demonstrates expertise in areas like population health, EHR implementation, and quality programs.
Quality, Risk & Compliance: Risk Management for Sponsors, Site, and CROsMedpace
This document discusses risk management in clinical trials from multiple perspectives. It provides statistics on the high costs and time required to bring new drugs to market. It defines quality as an absence of errors that matter and compliance as adherence to regulatory and GCP requirements. Key aspects of risk management are identified, including risk identification, evaluation, control, and review. Process mapping and risk assessment tools are presented. Quality by design and continual improvement concepts are also covered.
Case presentation (lab analytical quality assurance problem )Rania Elsharkawy
This case presentation describes a 64-year-old female patient who visited the laboratory for requested tests and encountered discrepant results between two laboratories for her intact parathyroid hormone (iPTH) level. The receptionist failed to record the patient's drug history, including her use of biotin supplements. After initial testing found low iPTH, total calcium, and alkaline phosphatase levels consistent with adynamic bone disease, a second laboratory found a significantly higher iPTH level. The laboratory investigated potential pre-analytical, analytical, and post-analytical errors and determined biotin interference affected the iPTH assay, providing a falsely low result. The case highlights the importance of thorough history taking including medication
This 60-minute webcast discusses appropriate cardiac testing techniques and treatment of coronary artery disease (CAD) to help primary care clinicians. The target audience is primary healthcare professionals. It will address gaps in CAD risk assessment, testing, and outcomes. Specific learning objectives include comparing CAD risk assessment tools, cardiac stress test types, and imaging modalities. It will also identify gender differences in CAD presentation and testing. The activity is supported by an educational grant and aims to help primary care integrate the latest CAD research into practice.
Critical Care Research: Connection to PracticeAllina Health
1) The document discusses a critical care research program at Abbott Northwestern Hospital with the goals of conducting studies to improve patient outcomes, enhance quality of care, and reduce costs.
2) The program involves intensivists, hospitalists, and other clinical specialties conducting studies and presenting findings to improve practice.
3) Several ongoing studies are summarized that examine issues like postoperative monitoring, pulmonary ultrasound scoring, infection risks, and outcomes after procedures.
This document summarizes a presentation about post-CCT surgical fellowships. It discusses how the apprenticeship model of surgical training is changing, with more trainees pursuing subspecialty fellowship training after completing their CCT. It provides an overview of the Royal College of Surgeons of England's Senior Clinical Fellowship scheme, which establishes standards for fellowship programs. It also shares the presenter's experience completing an RCSE-accredited robotic urology fellowship, highlighting the structured training, improved surgical outcomes, and career benefits it provided.
NeoGenomics provides cancer genetic testing services to oncologists, pathologists, and hospitals. It has experienced strong and consistent growth in revenue and tests performed annually through expanding its test menu, increasing sales force productivity, and gaining market share. The company aims to continue its growth by launching new tests, pursuing partnerships and acquisitions, and capitalizing on the large and growing market for cancer genetic testing fueled by an aging population and advancements in targeted therapies.
- NeoGenomics is a pure-play cancer genetics testing company that has experienced fast revenue and test volume growth through expanding its test menu and increasing sales force productivity. Its "tech-only" business model focuses on partnerships with oncologists and hospitals to provide genetic testing services.
- The company has consistently grown its annual revenue and tests performed historically through new test innovations, a growing sales force, and greater productivity. It is targeting further market share gains and operating leverage to accelerate cash flow and earnings growth.
Specialized oncology reference laboratory providing the latest testing technologies, global/tech-only options, and interactive education to the pathology community
Offer the complete spectrum of diagnostic services through nationwide network of laboratories
Dedicated to providing superior service, faster turn-around times, and complete attention to the needs of our clients and their patients
This presentation provides an overview of NeoGenomics, a cancer genetics testing company. Key points include:
- NeoGenomics has experienced strong and consistent growth in revenue and test volume historically through strategic partnerships and an expanding test menu.
- The company focuses on fast turnaround times and exceptional client service to drive continued growth.
- Management aims to increase market share and profitability through expanding sales coverage, new test offerings like next generation sequencing, and potential M&A opportunities.
- NeoGenomics seeks to capitalize on favorable industry trends like an aging population, rise of personalized medicine, and consolidation in the cancer diagnostics field.
Cancer Diagnostics Reference Laboratory / NeoGenomics April 2014 investors company overview presentation. This presentation highlights the following:
--Fast growing cancer genetics lab servicing Oncologists, Pathologists and Hostpitals
--Strategic client partnerships created by "Tech-Only" model
--Dynamic, rapidly-growing and consolidating industry
Industry-leading revenue & test volume growth
--Strong productivity and operating leverage leading to accelerating cash flow and net income
--Strong Management Team with large cap lab experience
The presentation provides an overview of NeoGenomics, a cancer genetic testing company. It highlights the company's consistent historical growth in tests performed and revenue. The management team has significant experience in large cap clinical laboratories. The company aims to continue expanding its test menu and market share through new product development and partnerships within the fast-growing cancer genetic testing industry.
This presentation provides an overview of NeoGenomics, a cancer genetic testing company. Key points include:
- NeoGenomics has experienced consistent historical growth in the number of cancer tests performed and annual revenue.
- The company focuses on fast-growing cancer genetics testing and has strategic partnerships with oncologists and hospitals.
- Management aims to continue expanding the test menu and achieving operating leverage to accelerate cash flow and earnings.
Tests of Knowledge: How Can They Contribute to Maintenance of Certification ...IAMRAreval2015
Tests of knowledge can contribute to maintenance of certification (MoC) and revalidation in two ways: assessment of learning and assessment for learning. Assessment of learning uses high-stakes knowledge tests summatively to identify doctors with performance problems, while assessment for learning takes a longitudinal approach through frequent, low-stakes tests to provide feedback and assist doctors in keeping knowledge up to date. There are challenges to the use of knowledge tests, such as determining relevant content and preventing tests from being seen as irrelevant facts, that different assessment approaches aim to address.
This document discusses quality control in histopathology. It defines key terms like quality control, quality assurance, and total quality management. It outlines the pre-analytical, analytical and post-analytical phases of quality control and highlights variables that can affect quality in each phase like personnel training, equipment, and interpretation of results. It provides recommendations for achieving quality control through standardized procedures, monitoring turnaround times, participation in proficiency testing, and review of reports. The goal is to generate accurate histopathology reports and enable easy retrieval if needed.
ICPI Pathology Recruitment Powerpoint - October 2014James Douglas
This document provides an overview of career opportunities in pathology. It discusses the various practice settings pathologists can work in, including community practice, academic practice, and industry. It also summarizes compensation levels, benefits, lifestyle factors, and job market trends for pathologists. There is currently a shortage of pathologists projected to increase over the next two decades. The job market for pathologists is described as excellent with opportunities for employment upon completing residency or fellowship training.
This presentation provides an overview of the company, which provides cancer genetic testing services. It highlights the company's fast growth, experienced management team, expanding product and service offerings including next generation sequencing and liquid biopsy tests. The company has achieved significant reductions in costs per test through economies of scale and innovation. Financial metrics show accelerating revenue, earnings, and cash flow in recent years through both organic growth and acquisition.
This company presentation provides an overview of a cancer genetic testing services company. Key points include:
- The company has experienced strong and consistent growth in revenue and test volume over the past 10 years through both organic growth and acquisitions.
- It provides a broad menu of genetic and molecular testing services including next generation sequencing and is developing liquid biopsy tests.
- The company has an experienced management team with experience in large reference laboratories. It is focused on innovation, cost management, and expanding its commercial footprint.
- Financial results show increasing margins, productivity, and adjusted EBITDA despite lower average prices per test, demonstrating strong operating leverage as the business scales.
6_State of the Department_ OB-Gyn 2013Julian Thach
The document provides an overview and summary of the Department of Obstetrics and Gynecology at UC Irvine for 2012/13. It discusses the department's mission, vision, clinical divisions, faculty composition and roles, clinical practice metrics like charges, collections and work RVUs, quality metrics, resident and medical student education programs, and accreditation status. Overall revenues and productivity increased over the past 5 years while quality metrics like c-section and episiotomy rates decreased. Student evaluations of the clerkship and residency programs were positive.
ECMO CPR
ECMO in Cardiac arrest has increased exponentially in the past 10 years, on the back of, up until very recently, non-randomised, predominantly retrospective studies.
What is the efficacy?
Appropriate patient selection?
Cost effectiveness and model of delivery of ECPR?
Finally is ECMO really the intervention or just optimising the chain of survival?
Dr.Avinash Phadke lecture at TMH.Whether to be a generalist or a specialist i...Ajay Phadke
Whether to be a generalist or a specialist in pathology in todays scenario. Adresses the future of pathology and the options which lie with today's younger generation.
This company presentation provides an overview of NeoGenomics and their cancer genetic testing services. Some key points:
- NeoGenomics is a fast-growing cancer genetics lab that services oncologists, pathologists, and hospitals through strategic partnerships and a tech-only model.
- They have an experienced management team with experience at large cap labs and offer the most comprehensive cancer testing menu in the industry.
- NeoGenomics has demonstrated a proven track record of consistent growth over the last 10 years with 65% CAGR in revenue and test volume.
- Their focus for 2015 includes expanding next generation sequencing, developing a prostate cancer liquid biopsy test, launching new products, and growing their clinical trials business
The Business of Genomic Testing by James CrawfordKnome_Inc
This document summarizes the key findings from a survey of 13 early adopter institutions that have implemented next-generation genomic sequencing (NGS) technologies. The survey identified common drivers for adoption including demands from clinical colleagues, anticipated efficiency gains, and acquiring institutional expertise. It also explored barriers such as lack of informatics expertise and high costs. Respondents provided lessons learned such as NGS being more complicated than expected and the importance of multidisciplinary teams. Common measures of successful outcomes included growth in test volumes and expansion of testing menus. The document concludes with recommendations for professional organizations like the College of American Pathologists, including providing educational programs and testing standards.
Evidence-Based Clinical Practice Guidelines for OBSTETRICS AND GYNECOLOGY
Certification Presentation Ro
1.
2. Opportunities and Routes for HT
Certification and QIHC Qualification
Joelle Weaver MAOM, HTL
(ASCP), QIHC
J. Weaver MAOM, HTL (ASCP), QIHC 2012 2
3. Introduction
• In this presentation I hope to clarify the
professional advantages to pursuing ASCP
certification as well as talk about the process
and the registry exam itself.
• I hope that this will provide some helpful
information for anyone contemplating
certification but who is not sure what is
involved or where to begin.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 3
4. Learning Objectives
At the conclusion of this presentation participants will be able to:
1. Identify the mission of the BOC in providing certification.
2. Discuss the benefits of certification.
3. Differentiate between licensure and certification.
4. Identify vacancy and wage factors affecting employment opportunities in
histology.
5. Identify the routes and the requirements for eligibility for the HT
certification exam and the QIHC qualification.
6. Identify the HT exam content, format, and scope.
7. Discuss the CMP requirements for histology certifications.
8. Identify opportunities and resources for education and training in
histotechnology.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 4
5. BOC Mission
• The Board of certification mission is to
“provide excellence in certification for
laboratory professionals”.
• The largest and oldest pathology and
laboratory medicine society and is the “gold
standard” in certification for laboratory
professionals.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 5
6. History and structure of the BOC
Founded in 1928 by the ASCP. To date over 460,000 individuals
have been certified. The ASCP is accredited by the American
National Standards Institute (ANSI). The board of Governors of
the ASCP BOC consists of 25 members:
• 5 pathologists nominated by ASCP
• 5 laboratory professionals nominated by ASCP
• 4 representatives from the American Society for Clinical
Laboratory Sciences (ASCLS).
• 2 representatives from the Association of Genetic
Technologists (AGT).
• 1 other representative from a laboratory society
• 1 public mentor
J. Weaver MAOM, HTL (ASCP), QIHC 2012 6
7. What is certification?
• Certification is the process by which a non-governmental
agency grants recognition of competence to an individual
who has met certain predetermined qualifications as
specified by the granting agency. Having certification is
typically offered within an industry to uphold certain
standards.
• Licensure is mandated through regulatory or government
agencies which define title and scope of practice.
• Certification is generally voluntary, but can be required or
part of the licensure process. Licensure is generally a
required process necessary to practice within a defined
jurisdiction.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 7
8. Why become certified?
• Certification demonstrates your commitment to
the profession.
• Employers prefer and often require certifications.
• Demonstrating competency via certification can
provide you a competitive advantage for more
job opportunities, higher pay, and increased job
security.
• ASCP Survey results show that 69.4% of staff and
91.6% of supervisors in histology departments
are certified (2011 ASCP Vacancy Survey of
Clinical Laboratories).
J. Weaver MAOM, HTL (ASCP), QIHC 2012 8
9. Factors & barriers affecting
certification
• ASCP policy and elimination of OJT route.
• Education and training availability.
• Lack of public awareness of histotechnology field.
• Lack of knowledge of the certification
process, requirements and steps involved.
• Lack of knowledge of benefits to individuals for
becoming certified.
• I hope to address most of these topics within this
presentation.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 9
10. ASCP policy to support recognition has
inadvertently created barriers to entry
• In 2005 the ASCP eliminated the high school and OJT and
route for HT certification in an effort to increase the
professional perception of the field, and attract high quality
applicants to the struggling Histotechnology profession.
• While the intention was to raise the status of the
profession, this has made some increased obstacles for new
candidates for ASCP certification in histology.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 10
11. Histology is a great profession
DEMAND IS AN OPPORTUNITY
J. Weaver MAOM, HTL (ASCP), QIHC 2012 11
12. Lab Careers- Opportunity Overview
• The Bureau of Labor Statistics projects clinical laboratory technician
employment growth of 14.7 percent between 2010 and 2020, adding
23,800 more professionals to the 161,200 jobs currently in this field.
• One of the most appealing aspects of this profession is the relatively easy
attainability of the education and training requirements as compared to
many other medical professions.
• Most laboratory technicians possess an associate's degree from a
community college or junior college program accredited by the National
Accrediting Agency for Clinical Laboratory Sciences (NAACLS). More
complex procedures are reserved for clinical laboratory technologists, who
must possess a bachelor's degree.
• Those that successfully complete training and certification are in huge
demand, and often get placed into jobs very rapidly.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 12
13. Overview of HT Demand
• Nationally, the majority of laboratories filled most positions within six months of
posting an opening, however a statistically significant number of openings take
longer than one year to fill .
• Across the nation, vacancy rates were highest for blood banking (11.6%), histology
(9.81%), and chemistry (8.62%) departments. The lowest vacancy rates occurred in
the departments of cytology (5.14%) and immunology (5.56%).
• There were an estimated 28,400 working histologists as of 2008. However ½ of
those 28,400 will reach retirement age in the next 4 years.
• Consider that an estimated 31,200 new histotechs will be needed by 2015 to
replace retirees and anticipated need by 2015. Since only 477 new HT were
certified as of 2009, then potential there will be a potential deficit of over 29,000
certified HT staff by 2015.
• According the an ASCP report, laboratory managers appear to choose certified
rather than non-certified staff .
• Obtaining certification will ensure that you are competitive in the current job
market and prepared to meet the demand of new testing methods, accreditation
and in many states licensure requirements.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 13
14. “Big Picture” Statistics
Overall % of Histology % of Histology % of Histology
Histology staff certified vacancies staff expected
vacancy rate taking more to retire
than 1 year to within 5 years
fill
9.81% 69.4% 13.7% 15.3%
Data: ASCP 2011 Vacancy Survey of US Laboratories. Lab Medicine. Vol.42. No. 4. pp. 193-256
J. Weaver MAOM, HTL (ASCP), QIHC 2012 14
15. General Correlation of Education & Job Skills to
Earnings
J. Weaver MAOM, HTL (ASCP), QIHC 2012 15
16. How much do Histologists earn?
SALARY INFORMATION
J. Weaver MAOM, HTL (ASCP), QIHC 2012 16
17. Wage by Occupational Title in the
Laboratory
J. Weaver MAOM, HTL (ASCP), QIHC 2012 17
18. Breakdown of national wage level averages
for HT and HTL’s
• Staff level HTs earn an average of $22.68 (SD =
$5.28) per hour.
• Certified staff HTs earns 14.7% more than non-
certified HT staff.
• The average hourly wage for staff HTLs is
$26.00 (SD = $5.83).
• * 2010 ASCP Wage Survey of Clinical
Laboratories
J. Weaver MAOM, HTL (ASCP), QIHC 2012 18
19. Regional salary variations-2005 data
Regions Cost of living Median Annual Median average salary/position
unit (unit=100) Income ( unit=1000) (unit=$5/hour)
Mean Mean HT HTL
Northeast 141.7 51.4 19.35 23.73
East north 105.5 46.2 18.51 21.15
central
South central 100.6 42.1 18.00 20.82
Atlantic
West south 95.5 38.5 18.72 19.44
central
West north 98.5 43.6 17.08 21.32
central
Far west 117.4 48.3 18.24 22.54
National totals 109.9 45.0 18.47 21.63
J. Weaver MAOM, HTL (ASCP), QIHC 2012 19
20. How do I begin the steps to get certified?
PROCESS TO CERTIFICATION
J. Weaver MAOM, HTL (ASCP), QIHC 2012 20
21. Routes to HT ASCP certification
To be eligible for the HT examination category, an applicant must satisfy the requirements
of at least one of the following routes:
Route 1:
Successful completion of a NAACLS accredited Histotechnician program within the
last 5 years prior to the date of application for examination; OR
Route 2:
At least 60 semester hours (90 quarter hours) of academic credit from a regionally
accredited college/university, with a combination of 12 semester hours (18 qtrs) of biology
and chemistry (must include credit hours in both), or an associate degree from a regionally
accredited college/university, with a combination of 12 semester hours (18 quarter
hours)of biology and chemistry (must include credit hours in both), AND one year full time
acceptable experience in a histopathology (clinical, veterinary, industry or research)
laboratory in the U.S., Canada or an accredited laboratory* within the last ten years.
* laboratory accredited by a CMS approved accreditation organization (i.e.,
AABB, CAP, COLA, DNV, The Joint Commission, etc.).
J. Weaver MAOM, HTL (ASCP), QIHC 2012 21
22. Experience Requirements
• To fulfill the experience requirement for the Histotechnician examination, you
must have experience, within the last ten years, in the following areas:
• Fixation
• Microtomy
• Processing
• Staining
• Full-time experience is defined as a minimum of thirty-five (35) hours per week.
Individuals who have part-time experience may be permitted to utilize prorated
part-time experience.
• To document your clinical laboratory experience (if required):
• Use experience documentation forms (for the appropriate certification category
and route number) must be downloaded and printed from the ASCP website at
www.ascp.org/certification .
J. Weaver MAOM, HTL (ASCP), QIHC 2012 22
23. Establishing eligibility
Eligibility to take a certification examination is established by:
1. Meeting the stated minimum requirements for the particular category of
certification
2. Submission of the appropriate application form
3. Payment of the appropriate application fee
4. Submission of all appropriate documentation including official transcripts
indicating the appropriate degree
Before your examination eligibility can be determined, you must submit the
appropriate documents verifying that you meet the current ASCP Board of
Certification requirements before you are eligible to sit for the registry exam.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 23
24. Verification of Academic Education
• If college credits are required for the examination
category, you must
submit an official transcript or transcript evaluation.
• Continuing Education courses are not acceptable in fulfilling
the academic requirements.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 24
25. Verification of Training
Route 1. NAACLS or CAAHEP Accredited Programs
• If you are currently enrolled in or have completed a NAACLS or CAAHEP accredited
training program within the last five years, the printed application form must
include the program director’s name and the school code number must be
indicated. The education received from a NAACLS or CAAHEP accredited program
is acceptable for a period of five (5) years from the date of completion of that
program.
Route 2:
• You must download the appropriate training documentation form from the ASCP
web site at: www.ascp.org/certification .
• If you are unable to download the form, go to www.aspc.org or fax us at 312-541-
4845 to request printed copies. The training documentation form must be
completed by your program director and attached to a letter, on letterhead, signed
by the program director verifying the accuracy of the information.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 25
26. Application Process
• The steps in the application process are
outlined within the handout with links to
important forms and contact information.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 26
27. What can I expect when I sit for the HT registry exam?
ASCP HT EXAMINATION
J. Weaver MAOM, HTL (ASCP), QIHC 2012 27
29. CAT Testing format
Computer Adaptive Testing (CAT) -
1. An examinee’s score on the exam is not influenced by the scores of other examinees
who take the exam.
2. When you answer correctly, the next test question has a slightly higher level of
difficulty.
The difficulty level of the questions presented to the examinee continues to increase
until a question is answered incorrectly. Then a slightly easier question is presented. In
this way the test is tailored to the individual’s ability level.
3. Each question, in the test bank is calibrated for level of difficulty, the weight (value)
given to each question is determined by the level of difficulty.
4. The examinee must answer enough difficult questions to achieve a score above the
pass point.
5. To pass the certification examination, the examinee’s scores must exceed the minimum
pass score.
6. You will have to check in at the testing center with your admission letter, identification
and no calculators allowed.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 29
30. Question taxonomy- levels of question
difficulty
• Taxonomy I (level 1) RECALL
- ability to recognize knowledge from specific facts to
theory.
• Taxonomy II ( level 2) INTERPRETATION
-ability to utilize recalled knowledge to interpret or
apply data.
• Taxonomy III ( level 3) PROBLEM SOLVING
-ability to utilize recalled information and the application
of distinct criteria to resolve problems or make
appropriate decisions.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 30
31. Question format
• All questions are multiple choice and will
appear on the screen one at a time.
• You must answer one at a time ( can’t skip).
• Color photos, diagrams, charts and other
images may be incorporated and appear on
the screen with the question.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 31
32. ASCP Exam Statistics for January – December 2011
Exam 1st year Mean # Taking Pass rate 1st Total
Type certified exam attempt certified
pass for (ever)
program
grads
HT 1948 458 772 519 test takers - 327-74% 22,416
67%
HTL 1980 443 283 183 test takers- 100-35% 3,141
65%
J. Weaver MAOM, HTL (ASCP), QIHC 2012 32
33. How do I prepare for the exam?
SUGGESTIONS FOR STUDY AND
PREPARATION
J. Weaver MAOM, HTL (ASCP), QIHC 2012 33
34. Study Resources-Foundation Text
• Histotechnology: A Self-Instructional Text
(3rd Edition) ISBN: 9780891895817
• Authors: Freida L. Carson and
Christa Hladik
List Price: $150.00, Member Price: $115.00
• Combo Price!
(Order both the Histotechnology text and the
HistoDeck Flash Cards)
List Price: $195.00
Member Price: $170.00
• Histotechnology: Complete Study Package,
Order # HTPK3, Get the complete
Histotechnology Study package -- textbook,
workbook, and HistoDeck flash cards.
• Available @ ASCP
http://www.ascp.org/ASCPStore/Store/Books
/5817.aspx
J. Weaver MAOM, HTL (ASCP), QIHC 2012 34
35. Study Guide
• Board of Registry Study Guide:
Histotechnology Examinations (2nd
edition), Order # 473X | ISBN: 089189473X
• Authors: Freida Carson, PhD
Laura Culver Edgar, MT(ASCP)
Donna Surges Tatum, PhD
• The guide includes:
• Guidelines for taking the test
• Information about the
development, content, structure and scoring of
the test
• Practice questions and answers
• Image-based questions
• List Price: $65.00
• Member Price: $50.00
• http://www.ascp.org/Store/Books/Board-
Registry-Study-Guide-Histotechnology-
J. Weaver MAOM,Examinations-2nd-edition.html#StoreList
HTL (ASCP), QIHC 2012 35
36. From the ASCP website
• Reading lists http://www.ascp.org/PDF/BOC-
PDFs/Bibliography/ReadingListHTL.aspx
• Exam content guidelines http://www.ascp.org/PDF/BOC-
PDFs/Guidelines/ExaminationContentGuidelineHT.aspx
• Online practice tests includes a 90-day online access to the practice
tests, comprehensive diagnostic scores, and discussion boards. If you are an
institutional purchaser that would like to pay by check or purchase order
(minimum of 20 tests to use a check or purchase order), download Order Form
(PDF). http://www.ascp.org/Board-of-Certification/Exam-Preparation/Online-
practice-tests
• BOR Study guide ( shown previously) http://www.ascp.org/Store/Books/Board-
Registry-Study-Guide-Histotechnology-Examinations-2nd-edition.html#StoreList
J. Weaver MAOM, HTL (ASCP), QIHC 2012 36
37. NSH Study Materials
• The NSH provides many study resources
including texts, self assessments, flash
cards, an on line learning center, and other
study aids offered through the NSH
marketplace.
• Certification study aids page located at :
http://www.nsh.org/content/certification-
exam-study-aids
J. Weaver MAOM, HTL (ASCP), QIHC 2012 37
38. Study strategy for success
• There is NO substitute for knowing the material.
• You will be able to do well by thorough preparation, and by
use of practice questions to learn how to take this type of test
well.
• Go in knowing the exam format, question types and topics.
• Use a process of elimination for “stumpers” as with all MC
tests .
• Don’t be overly critical of yourself, there has never been a
perfect registry exam score- simply do your best. ( note the
score range is 400-999).
• Make sure you are well rested on exam day!
J. Weaver MAOM, HTL (ASCP), QIHC 2012 38
39. Using content guidelines
• This is NOT simply a recall examination, so you must strive to learn the
underlying theory and principles and be able to apply them to presented
situations and problems. This replicates actual practical use of knowledge in lab
situations.
• The exam covers ALL of histology practice, so techniques, stains and methods
you may not perform in your job will be topics for questions. The exam
committee designs the test to cover as broad a “scope of practice” as possible.
• I encourage you NOT just to attempt memorization. Not only will this only be
stored in short term memory and quickly forgotten. You will likely do poorly on
application and taxonomy II & III questions if you only memorize.
• I recommend using the content guidelines with the resource texts to fill in and
expand the information on the outline. But flash cards or other study methods
may work well for you.
• Once you have worked through the outline, use practice questions and tests to
determine your weak areas to go back over and devote more study time.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 39
40. Content Category
• Content area= Staining – know
tissues, procedures, instrumentation, reagents/dyes, & mounting procedures (
following content guideline).
• Subtopic = Histochemical stains
• Stain Group =Carbohydrates = aldehyde or ketone derivatives of alcohols.
Occur as polymerized sugar chains, often combined with proteins or lipids.
CHO categories:
Polysaccharides and Mucopolysaccharides( mucosubstances) including
neutral, acid, sulfated, non-sulfated
(carboxylated), mucoproteins, glycoproteins, Mucolipids .
Some CHO special stain examples:
PAS, PAS-D, Best’s Carmine, Alcian Blue ( pH 1.0, 2.5), Colloidal Iron
J. Weaver MAOM, HTL (ASCP), QIHC 2012 40
41. Grouping Carbohydrates
• Glycogen- only polysaccharide found in higher
animals as a polymer of glucose.
• Mucopolysaccharides are highly polymerized
disaccharide units divided into acid and
neutral.
• Acid mucopolysaccharides ( mucosubstances)
often called “mucin”.
• Complexes of mucopolysaccharides with
lipids, proteins also.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 41
42. CHO Category Table & Stains
CHO type Tissue element Histochemical stain
Polysaccharide-glycogen Hepatocytes, muscle PAS-D, Best’s Carmine, AB -,
Coll. Fe-
Neutral Mucosubstances GI epithelium, thyroid colloid, Mucicarmine ( GI
Goblet cells epithelium), PAS +
Acid mucosubstances Many tissues, sublingual AB +
glands, non –sulfated in
synovial membranes
Sulfated mucosubstances Goblet cells(weak sulfated), AB +, Mucicarmine +
duodenal and colonic
Mucoproteins Basement membranes, Weak AB, PAS +, Coll. Fe -
mucoid cells pituitary
Glycoproteins Collagen, reticulin, CT Trichrome, PAS +, Faint AB,
Coll. Fe -
Mucolipids Cerebrosides, nerve tissue PAS +, AB -, Coll. Fe-
J. Weaver MAOM, HTL (ASCP), QIHC 2012 42
43. Dissecting a special stain
• Technique- Periodic Acid Schiff Reaction
• Application: most often used to demonstrate basement membranes, glycogen and
fungus, and PAS + mucosubstances secreted by epithelium of GI, lung, cervix. Used
to differentiate between secreting adenocarcinomas vs. undifferentiated
squamous cell carcinoma ( PAS-).
• Principle: Tissue is first oxidized by periodic acid. The oxidation results in the
formation of aldehyde groups where CHO are present in tissue elements. The
aldehydes are detected by the application of Schiff’s ( Leucofushin). Sulfurous
rinses follow to remove excess and to prevent false + oxidation by air exposure.
Warm water rinses intensify color.
• Results- PAS + tissue elements are rose to rose- red, counterstain depends on
method. Hematoxylin, light green common; light green typically used with fungus.
• + Control depends on technique used; liver, kidney, fungus containing, cervix.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 43
44. Example organization for study
• PAS – Periodic Acid Schiff Reaction
• General stain category : Histochemical, CHO stain.
• Used with/for:
• Glycogen- PAS with/without diastase, fungus
• Neutral Mucin-PAS-H
• PAS for fungus
• PAS –basement membranes
• Considered rather non-specific CHO stain, gains specificity for glycogen
with diastase. Mucins are PAS + but also stain with Mucicarmine, which is
much better stain for mucins from epithelium sources. Glycogen may have
diagnostic significance in tumors such as carcinomas, mesotheliomas, and
rhabdomyosarcoma.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 44
45. PAS Reaction Flow chart
Staining mechanism
↓
Oxidation ( periodic acid)
↓
Chemical reaction ( Schiff’s reagent with aldehydes( CHO)
↓
Recolorization ( water- followed by sulfurous rinse)
↓
Counterstain ( Hematoxylin, light green)
Note controls needed for technique, and that parallel control sections used with PAS- Diastase
for Glycogen.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 45
46. Sample Questions
1. The most commonly used stain procedure for demonstration of glycogen is?
A. PAS reaction with and without diastase
B. Alcian Blue-PAS
C. Mucicarmine
D. Aldehyde Fuschin
2. An enzyme employed to increase specificity and identification for glycogen with
PAS staining is?
A. Hyaluronidase
B. Sialidase
C. Diastase
D. Ribonuclease
J. Weaver MAOM, HTL (ASCP), QIHC 2012 46
47. Sample Questions
3. Glycogen is a carbohydrate that is normally classified as a/an:
A. Acid mucosubstance
B. Mucoprotein
C. Glycoprotein
D. Polysaccharide
4. Parallel sections are stained with PAS, ( with/without). In evaluating the
stain results, the stained section should:
A. Demonstrate acid mucosubstances
B. Show sites of non-staining where glycogen was removed
C. Show sites of non-specific PAS + staining
D. Demonstrate that the procedure is non-specific for Glycogen
J. Weaver MAOM, HTL (ASCP), QIHC 2012 47
49. Certification Maintenance Program
(CMP)
• After passing the examination, you will receive a packet of
• information welcoming you as part of the ASCP certified laboratory
• team, including:
• Certificate of Certification suitable for framing, valid for three years
• Certification Maintenance Program (CMP) packet
• This information will be mailed to you approximately 3 – 5 weeks after the
examination scores are mailed. The initials “CM” in superscript must be
used after your certification initials immediately upon receipt of your
certification [i.e., MLS(ASCP)CM].
• In order to maintain your certification, you must complete the
Certification Maintenance
• Program (CMP), as described below, every three years.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 49
50. CMP credits needed
• HT, HTL, beginning in year 2004 – 36 CMP
points required to include:
• 1 point laboratory or patient safety( i.e.
quality control, quality assurance)
• Remaining points in area(s) of
specialty, management, education or other
related
• laboratory areas of interest
• 1 CMP point= 1 contact hour=1 CMLE credit.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 50
51. CEU Sources
• Formal continuing education courses—continuing education credits
awarded by AACME accredited programs, ASCP CMLE approved
programs, AACC ACCENT approved programs, ASCLS PACE approved
programs, CE programs sponsored by other professional societies and
courses taken at regionally accredited colleges/universities.
• Employer offered courses (in-service, instrument training, vendor
sponsored)
• Competence assessment from employer (documentation of continued
competency in specific laboratory areas).
• Subscription or online self-instructional courses for which CMLE, ACCENT
or PACE credits are awarded.
• Other educational activities—such as research and preparation for
presenting a workshop or course, authoring journal articles, presenting
posters, etc.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 51
52. Industry trends in lab careers and
education
• General consensus:
• Not enough programs with new grads to meet
demands
• Lack of awareness of profession
J. Weaver MAOM, HTL (ASCP), QIHC 2012 52
53. Histology Awareness
• 2007 survey conducted by the Coordinating Council on the Clinical Laboratory Workforce
(CCCLW) found that the sources which led survey respondents to first become interested
in the field ( listed in order of importance) were:
1. A relative or friend
2. A college catalog or college visit
3. A high school science teacher
4. A tour of a medical laboratory
5. Personal research
6. Career fairs
• 76% of these respondents reported that they first became aware of laboratory career
options only after leaving high school. Those of us working in the field need to spread the
word!
• See handout for more detailed data on the state of histology programs nationally.
• See handout for list of NAACLS accredited Histotechnology programs. Link to NSH
Histotechnology program affiliate page with contacts
http://www.nsh.org/content/schools
J. Weaver MAOM, HTL (ASCP), QIHC 2012 53
54. Where can I find out about Histotechnology Education
& Training Opportunities?
• The best, most concise places to see listings of available training programs
and schools is the NSH or NAACLS listings at.
• NSH program list : http://www.nsh.org/content/schools
• NAACLS approved program search page:
http://www.naacls.org/search/programs.asp
• Both websites list programs by location, instructional delivery
methods, and contacts.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 54
55. Scholarships
• Example: Siemens and ASCP Award Over 100
Scholarships to Medical Laboratory Students
in 2012
http://finance.boston.com/boston/news/read
?GUID=20884103
• I have a list of other scholarships and awards
available in the handout.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 55
56. ASCP qualification opportunities
• Qualification in Cytometry, QCYM
• Qualification in Immunohistochemistry, QIHC
• Qualification in Laboratory Informatics, QLI
• Qualification in Laboratory Safety, QLS
For each qualification category, you’ll find a choice of routes that
you can take to verify your eligibility for the qualification,
depending on the education and training you’ve completed.
http://www.ascp.org/Board-of-Certification/Qualification#tabs-1
J. Weaver MAOM, HTL (ASCP), QIHC 2012 56
57. What are the advantages of completing a
Qualification?
• Visible recognition of specific skills in a technical area with the Qualification initials
after the ASCP credentials
• Recognition by state licensure—the state of Florida recognizes those individuals
certified and qualified as HT(ASCP)QIHC toward meeting the specialist licensure
requirements for histology
• More job possibilities—career mobility throughout the country
• Professional growth—keeping up with state of the art technology
• Each qualification is a three-year credential that may be renewed by providing
documentation of continuing education activities in the appropriate discipline.
• Qualification will not, in itself, entitle the individual to membership in ASCP.
Individuals must be ASCP certified as a technician, technologist or specialist to be
eligible for ASCP membership.
• Eligibility, routes and experience requirements are listed in the handout.
J. Weaver MAOM, HTL (ASCP), QIHC 2012 57
58. Thanks!
• Thank you for allowing me to present this
information to you today!
• I hope that I have been able to supply some
useful information, and we can take some
time now to see if anyone has any questions
or comments.
• Note I have included a references page of
resources if you need more information in the
handout
J. Weaver MAOM, HTL (ASCP), QIHC 2012 58
Editor's Notes
The ASCP generally supports state licensure.As of November 2009, 11 states have licensure for at least some laboratory professions. Other states do not license, but require more stringent education/training requirements than are stipulated in the Clinical Laboratory Improvement Amendments of 1988 ( CLIA). The following states have licensure for at least some laboratory personnel:California (1937), Florida(19760,Nevada(1967),Tennessee (1967), Hawaii(1974), North Dakota(1990), West Virginia(1991), Rhode Island(1992), Louisiana(1992), Montana(1993), New York(2004), Puerto Rico (1939).These following state have legislature active attempting to obtain state licensure or regulations:Minnesota, Texas, Illinois, Massachusetts, Michigan, Vermont, Washington, New Jersey, Iowa, Utah, Ohio, South Carolina, Wyoming, Pennsylvania, Virginia, South Dakota, Delaware, Missouri, Georgia, Alaska.
A contributing factor that has influenced the reduced number of histology graduates are the increased education and certification requirements for an entry level position. This began in 2005 when credit issued toward certification from OJT training and work experience was eliminated. Attainment of college course completion in math, anatomy and chemistry and formal training is now required. The ASCP made this decision based on demands for higher quality, more productivity, and accuracy in laboratory practice- all considerations that have been correlated with increased education and training. The goal of course, has been to encourage those currently working and those entering the field to become better trained and more knowledgeable. In the long term, this is a good goal, but the short-term effects add to the present “not enough” situation by making the initial entry into the field more demanding and time consuming.
Source: Lab Medicine Official Publication of the American Society for Clinical Pathology, ASCP 2009. vol. 40, no. 3. pp.133-141. Hiring DifficultiesAt the staff level, vacancies in the histology and microbiology departments took longest to fill . At the supervisor level, histology and blood banking/transfusion medicine supervisory positions were the hardest to fill, at 24.0% and 23.0%. Overall 13.7 % of histology vacancies took longer than one year to fill.
Hourly wages by job category demonstrate a relationship between compensation and both educational level and experience
Histology salaries are driven by: 1. local supply and demand, 2. negotiationLocal demands, different pay scales, and individual factors have resulted in a chaotic salary situation. South central Atlantic includes Alabama, Delaware, District of Columbia, Florida, Kentucky, Georgia, Maryland, Mississippi, N/S Carolinas, Tennessee, Virginia and West Virginia. Buesa, R. Better Pay for Histotechs. How Negotiation Can help Fatten Your Paycheck. Advance Magazine, Jan. 26, 2008. Vol. 20. No.2.
The pass rates have remained relatively stable over time. Here are the 2011 certification exam statistics as an example of the level of certification exam difficulty. There is some increase in the number of test takers, but the pass rates are approximately 65% in general. The burden of improving pass rates is primarily on the directors and faculty of training programs to improve curriculum and instructional methods.
Histotechnology Flash CardsOrder # 5930 | ISBN: 9780891895930 Authors:Freida L. Carson Christa Hladik Description:Designed for quick and easy self-study for the ASCP HTL certifying examination, HistoDeck flash cards include questions structured like those on the exam. The cards cover content based on the new third edition of Freida Carson’s classic Histotechnology volume and include additional images not included in the book. If you use flash cards for exam prep, this is the study tool for you.Contents:Fixation (38 questions, 13 images)Immunohistochemistry (30 questions, 6 images)Instrumentation (20 questions, 15 images)Processing (19 questions, 10 images)Routine staining (33 questions, 17 images)Safety (32 questions, 5 images)Special staining (74 questions, 39 images)Miscellaneous (34 questions, 6 images)Combo Price!(Order both the Histotechnology text and the HistoDeck Flash Cards)List Price: $195.00Member Price: $170.00
Example simple recall question AExample recall question 2- The correct answer is C. An enzyme used to identify glycogen is diastase. Glycogen is removed from a tissue section by diastase digestion. Identification is done by comparing the results for PAS staining of the digested slide versus the undigested tissue sections.
D- the correct answer is D. Carbohydrates can be divided into 2 major groups, polysaccharides, glycogen being the major polysaccharide found in animals, and a larger group called mucosubstances, that includes mucopolysaccharides, mucoproteins, and mucolipids. Example tax II – question 4- The correct answer is B. Diastase should remove glycogen from a tissue section making it possible to determine sites of positivity on the undigested slide that result from PAS + staining of glycogen. This provides a level of histochemical specificity for glycogen.