1. This study assessed the effects of supine and semi-fowler positions on cerebral perfusion pressure (CPP) and other physiological parameters among 39 patients with acute traumatic brain injuries.
2. In the semi-fowler position, patients experienced a significant increase in CPP, oxygen levels, blood pressure, and decrease in carbon dioxide levels compared to supine. The semi-fowler position was found to positively impact blood gas values, blood pressure, respiration, and oxygen saturation.
3. The supine position was associated with a significant decrease in pulse rate but no other significant changes. The study recommends further research on additional positions like side-lying and prone to establish optimal positioning guidelines for traumatic brain injury patients
Postural Orthostatic Tachycardia Syndrome – Overview and Focus on Non-Pharmac...InsideScientific
During this webinar, sponsored by Finapres Medical Systems, Satish Raj, MD MSCI and Kate Bourne, BSc from the University of Calgary will briefly overview POTS, including diagnostic criteria, common symptoms and highlights from a large patient community survey. Following, they will then outline some of the non-pharmacological approaches to the management of the patient with POTS. Throughout this webinar there will be particular emphasis on recent data on the hemodynamic and symptomatic benefits of compression garments in the patients with POTS.
For more information, please visit: https://insidescientific.com/webinar/postural-orthostatic-tachycardia-syndrome-overview-and-focus-on-non-pharmacological-approaches/
Quantifying Cardiovascular and Behavioral Correlates of Fear in Mice: Implica...InsideScientific
To learn more and watch the webinar, go to:
https://insidescientific.com/webinar/quantifying-cardiovascular-and-behavioral-correlates-of-fear-in-mice-implications-for-ptsd-and-cardiovascular-disease-risk/
Post-traumatic stress disorder (PTSD) is a prevalent neuropsychological disorder that is in part characterized by exaggerated cardiovascular and autonomic arousal to trauma reminders, which over time may contribute to greater risk for cardiovascular disease (CVD) development (ie., stroke, hypertension). In both humans and rodents, cardiovascular and autonomic responses are strong measures of fear or threat assessment and therefore understanding how these systems go awry in anxiety disorders such as PTSD is critical for improving current PTSD therapies as well as reducing CVD risk in this population.
In this webinar, Dr. Paul Marvar and Benjamin Turley discuss research related to innovative methodology developed in rodent models for pairing real-time multi-modal assessment of behavioral (ie., freezing, startle) and cardiovascular (ie., blood pressure, heart rate) responses to cued fear learning and how these approaches may better inform underlying cardiovascular and autonomic impairments in fear-based disorders, such as PTSD.
Key Topics Include:
- To understand the physiological impact of PTSD on cardiovascular and autonomic homeostasis, CVD risk
- To understand how rodent models of conditioned fear learning can be used to assess real-time cardiovascular and autonomic fear or defensive emotional states in both home-cage and novel environments
- To further understand the benefits for using integrated behavioral and cardiovascular multi-modal methodologies and its translational implications for improved treatments for PTSD and CVD comorbidity
Pulse Wave Velocity: Theory, Applications, Methods, and Future DirectionsInsideScientific
Lee Stoner, PhD and Gabriel Zieff, MA present a complete, in-depth overview of their research involving Pulse Wave Velocity (PWV) in a variety of different applications and a deep dive into the methods they use to record high-quality, repeatable data.
Arguably, the “gold-standard” method for noninvasive assessment of cardiovascular disease risk is pulse wave velocity. The PWV is widely used in both epidemiological and physiological studies to assess arterial stiffness, a construct dependent on the functional and structural characteristics of a vessel. PWV is calculated by measuring the transit time of the arterial waveform between two points of a measured distance. The most widely studied path is between the carotid and femoral arteries, which represents the aorto-illiac pathway. Traditionally, these measurements are made using tonometers, which are highly sensitive pressure transducers. However, alternative approaches to tonometry are available, and pathways other than the aorta can be measured. These alternative approaches may be better suited for use with certain populations or study designs. The focus of the presentation is to assist the audience in identifying the correct research tool for their particular research paradigm. Specifically, these experts outline the theoretical principles underlying PWV, as well as the importance of this measure to both epidemiological and physiological studies. Subsequently, they highlight some of the different approaches for measuring PWV, including technical considerations. This is followed by discussion pertaining to the identification of the appropriate PWV measure for the specific study design and populations of interest. This includes consideration of internal and external validity. They end the session by providing some tips to facilitate high-quality PWV assessments.
Key Topics Include:
- Meaning and clinical importance of pulse wave velocity
- How to measure and interpret pulse wave velocity
- Considerations for internal- and external-validity
- Considerations for the measurement of pulse wave velocity of various study designs and populations
Postural Orthostatic Tachycardia Syndrome – Overview and Focus on Non-Pharmac...InsideScientific
During this webinar, sponsored by Finapres Medical Systems, Satish Raj, MD MSCI and Kate Bourne, BSc from the University of Calgary will briefly overview POTS, including diagnostic criteria, common symptoms and highlights from a large patient community survey. Following, they will then outline some of the non-pharmacological approaches to the management of the patient with POTS. Throughout this webinar there will be particular emphasis on recent data on the hemodynamic and symptomatic benefits of compression garments in the patients with POTS.
For more information, please visit: https://insidescientific.com/webinar/postural-orthostatic-tachycardia-syndrome-overview-and-focus-on-non-pharmacological-approaches/
Quantifying Cardiovascular and Behavioral Correlates of Fear in Mice: Implica...InsideScientific
To learn more and watch the webinar, go to:
https://insidescientific.com/webinar/quantifying-cardiovascular-and-behavioral-correlates-of-fear-in-mice-implications-for-ptsd-and-cardiovascular-disease-risk/
Post-traumatic stress disorder (PTSD) is a prevalent neuropsychological disorder that is in part characterized by exaggerated cardiovascular and autonomic arousal to trauma reminders, which over time may contribute to greater risk for cardiovascular disease (CVD) development (ie., stroke, hypertension). In both humans and rodents, cardiovascular and autonomic responses are strong measures of fear or threat assessment and therefore understanding how these systems go awry in anxiety disorders such as PTSD is critical for improving current PTSD therapies as well as reducing CVD risk in this population.
In this webinar, Dr. Paul Marvar and Benjamin Turley discuss research related to innovative methodology developed in rodent models for pairing real-time multi-modal assessment of behavioral (ie., freezing, startle) and cardiovascular (ie., blood pressure, heart rate) responses to cued fear learning and how these approaches may better inform underlying cardiovascular and autonomic impairments in fear-based disorders, such as PTSD.
Key Topics Include:
- To understand the physiological impact of PTSD on cardiovascular and autonomic homeostasis, CVD risk
- To understand how rodent models of conditioned fear learning can be used to assess real-time cardiovascular and autonomic fear or defensive emotional states in both home-cage and novel environments
- To further understand the benefits for using integrated behavioral and cardiovascular multi-modal methodologies and its translational implications for improved treatments for PTSD and CVD comorbidity
Pulse Wave Velocity: Theory, Applications, Methods, and Future DirectionsInsideScientific
Lee Stoner, PhD and Gabriel Zieff, MA present a complete, in-depth overview of their research involving Pulse Wave Velocity (PWV) in a variety of different applications and a deep dive into the methods they use to record high-quality, repeatable data.
Arguably, the “gold-standard” method for noninvasive assessment of cardiovascular disease risk is pulse wave velocity. The PWV is widely used in both epidemiological and physiological studies to assess arterial stiffness, a construct dependent on the functional and structural characteristics of a vessel. PWV is calculated by measuring the transit time of the arterial waveform between two points of a measured distance. The most widely studied path is between the carotid and femoral arteries, which represents the aorto-illiac pathway. Traditionally, these measurements are made using tonometers, which are highly sensitive pressure transducers. However, alternative approaches to tonometry are available, and pathways other than the aorta can be measured. These alternative approaches may be better suited for use with certain populations or study designs. The focus of the presentation is to assist the audience in identifying the correct research tool for their particular research paradigm. Specifically, these experts outline the theoretical principles underlying PWV, as well as the importance of this measure to both epidemiological and physiological studies. Subsequently, they highlight some of the different approaches for measuring PWV, including technical considerations. This is followed by discussion pertaining to the identification of the appropriate PWV measure for the specific study design and populations of interest. This includes consideration of internal and external validity. They end the session by providing some tips to facilitate high-quality PWV assessments.
Key Topics Include:
- Meaning and clinical importance of pulse wave velocity
- How to measure and interpret pulse wave velocity
- Considerations for internal- and external-validity
- Considerations for the measurement of pulse wave velocity of various study designs and populations
Obstructive Sleep Apnoea (OSA) and Cerebrovascular Accidents (CVA) are common disorders in general population and share many common risk factors as age, gender, family history and obesity. However some of the strongest pathophysiological triggers for stroke are hypertension, atrial arrhythmias and atherosclerosis. Untreated OSA also contributes to these issues. Untreated sleep disorder breathing (SDB) such as OSA can lead to strokes, and strokes in the absence of prior history of OSA, might lead to SDB including Central Sleep Apnoea (CSA) and Obstructive Sleep Apnoea (OSA). Therefore it is of paramount importance to evaluate to the association between SDB and stroke and determine therapeutic approaches to treat SDB in such population.
Data Collection & Analysis in Human Autonomic Research: How to Guide to Succe...InsideScientific
In this American Physiological Society (APS) webinar produced in partnership with ADInstruments, Jackie Limberg, PhD discusses the basics of human autonomic research as well as some tips and tricks for successful human testing. Implementing key experimental controls and understanding nuances in data collection and analysis during human autonomic testing have important implications for the accuracy and reliability of your findings.
Dr. Limberg introduces the gold standards for measuring both basal and reflex autonomic responses in humans, what equipment is required, and how to minimize variability in your data. The focus of the webinar is on data collection, including recommendations for study design as well as data analysis and interpretation.
Key Topics Include:
- Identify tests appropriate for measuring basal versus reflex autonomic control
- Describe the pros and cons of tests used in human autonomic research
- Create a research setting that is conducive to reliable and accurate human autonomic data
- Select equipment appropriate for the research questions being addressed
- Anticipate and avoid areas that may increase data variability and reduce your ability to interpret results
Deborah Stein SMACC Chicago talk Trauma is Risky Business - delves into the risk patients and physicians undergo when treating or being treated for Trauma.
Stein’s speaks of the Risk Benefit Determination that physicians make daily and how this is used to best answer on going questions such as; can a patient have?, how do we care for this patient? and how do we best make all the these decisions?. Stein’s suggests a thorough Risk Benefit Determination will include:
Analysis of best available data
Use of best available judgement
Gathering of different opinions
An understanding that you won’t always make the right decision
To document the 'crap' out of it!
And to remember you’ll never know what you prevented from not occurring.
Stein’s also focuses on the risk to patients due to missed injuries and the processes physicians can take to help ensure that a patient injuries are not missed. Stating that 1.3-39% of injuries in trauma are missed (a majority of which present as orthopaedic cases).
Touching on the processes designed to prevent missed injuries such as;
Territory Trauma Survey
Roles of clinical decision rules
To scan the living ‘crap’ out of them - whole body CT scans (can decrease mortality but comes attached with its own risks).
Stein’s then delves into the risks trauma providers (physicians) face on a daily bases. Stating that in the USA trauma providers are one of the highest categories of physicians to be sued, have higher indemnity payment awarded against them and achieve a higher risk score in studies for being sued. While, lawsuits are more likely to increase the chance of physician burnout, career burnout, depression and are emotionally and physically exhausting. Steins sights recent studies that suggest the more open, honest and forthright a physician is with their error with their peers and their hospital the likelihood of being sued reduces.
Stein’s also notes that needle stick injuries in most departments have decreased in recent years due to universal precautions, yet have increased in trauma care due to the nature of the ER environment and proper precautions not being taken. Violence is of risk to attending ER nurses, physicians and paramedics, sighting an Australian study that 79% of triage nurses have experienced physical violence from patients. And, the emotional harm the trauma environment can have on trauma providers.
Steins suggests that trauma providers must be aware and learn how to manage risk better to ensure patient and provider safety.
A Study of Heart Rate Recovery Following Exercise in Healthy Young Adult MaleIOSR Journals
Abstract: Exercise has positive chronotropic effect on heart rate and on cessation heart rate returns to preexercise
level. A delay in heart rate recovery (HRR) (≤12beats in first minute) is considered abnormal and
reflects autonomic dysfunction.The present study was taken up to find out the presence of abnormal HRR in
normal subjects (Male) and to establish HRR as an independent autonomic marker. For the study 106 healthy
young adults (male) were subjected to exercise by Bicycle ergometer till targeted Heart Rate (85%Maximum
Heart Rate(MHR)) was achieved. HRR at the end of 1 minutefollowingcessation of exercise were tabulated. In
our study 23(21.7%) subjects showed Abnormal HRR indicating HRR could be an independent autonomic
marker. Keyword-HRR, MHR
An Integrated Understanding of Pressure and Flow – An Essential PartnershipInsideScientific
A tightly controlled relationship between blood pressure and organ blood flow is vital for matching an organ’s metabolic needs to the delivery of oxygen and nutrients. However, the nature of the pressure-flow relationship is complex and governed by multiple control systems, including local autoregulatory mechanisms at the level of the individual organ, as well as neural and hormonal modulation. To fully understand how pressure-flow relationships operate in health, and may be altered in pathological settings, it is essential to make direct, long-term assessments of blood pressure and blood flow under normal physiological conditions (ie in the conscious state).
In this presentation, Dr. McBryde shares insights from her studies of how the relationship between blood pressure and blood flow is altered in hypertension, to “consumer” organs such as the brain, and to “supply” circulations such as the mesenteric venous pool. She also discusses the variables that go into gathering accurate measurements of these two parameters in a lab setting.
Obstructive Sleep Apnoea (OSA) and Cerebrovascular Accidents (CVA) are common disorders in general population and share many common risk factors as age, gender, family history and obesity. However some of the strongest pathophysiological triggers for stroke are hypertension, atrial arrhythmias and atherosclerosis. Untreated OSA also contributes to these issues. Untreated sleep disorder breathing (SDB) such as OSA can lead to strokes, and strokes in the absence of prior history of OSA, might lead to SDB including Central Sleep Apnoea (CSA) and Obstructive Sleep Apnoea (OSA). Therefore it is of paramount importance to evaluate to the association between SDB and stroke and determine therapeutic approaches to treat SDB in such population.
Data Collection & Analysis in Human Autonomic Research: How to Guide to Succe...InsideScientific
In this American Physiological Society (APS) webinar produced in partnership with ADInstruments, Jackie Limberg, PhD discusses the basics of human autonomic research as well as some tips and tricks for successful human testing. Implementing key experimental controls and understanding nuances in data collection and analysis during human autonomic testing have important implications for the accuracy and reliability of your findings.
Dr. Limberg introduces the gold standards for measuring both basal and reflex autonomic responses in humans, what equipment is required, and how to minimize variability in your data. The focus of the webinar is on data collection, including recommendations for study design as well as data analysis and interpretation.
Key Topics Include:
- Identify tests appropriate for measuring basal versus reflex autonomic control
- Describe the pros and cons of tests used in human autonomic research
- Create a research setting that is conducive to reliable and accurate human autonomic data
- Select equipment appropriate for the research questions being addressed
- Anticipate and avoid areas that may increase data variability and reduce your ability to interpret results
Deborah Stein SMACC Chicago talk Trauma is Risky Business - delves into the risk patients and physicians undergo when treating or being treated for Trauma.
Stein’s speaks of the Risk Benefit Determination that physicians make daily and how this is used to best answer on going questions such as; can a patient have?, how do we care for this patient? and how do we best make all the these decisions?. Stein’s suggests a thorough Risk Benefit Determination will include:
Analysis of best available data
Use of best available judgement
Gathering of different opinions
An understanding that you won’t always make the right decision
To document the 'crap' out of it!
And to remember you’ll never know what you prevented from not occurring.
Stein’s also focuses on the risk to patients due to missed injuries and the processes physicians can take to help ensure that a patient injuries are not missed. Stating that 1.3-39% of injuries in trauma are missed (a majority of which present as orthopaedic cases).
Touching on the processes designed to prevent missed injuries such as;
Territory Trauma Survey
Roles of clinical decision rules
To scan the living ‘crap’ out of them - whole body CT scans (can decrease mortality but comes attached with its own risks).
Stein’s then delves into the risks trauma providers (physicians) face on a daily bases. Stating that in the USA trauma providers are one of the highest categories of physicians to be sued, have higher indemnity payment awarded against them and achieve a higher risk score in studies for being sued. While, lawsuits are more likely to increase the chance of physician burnout, career burnout, depression and are emotionally and physically exhausting. Steins sights recent studies that suggest the more open, honest and forthright a physician is with their error with their peers and their hospital the likelihood of being sued reduces.
Stein’s also notes that needle stick injuries in most departments have decreased in recent years due to universal precautions, yet have increased in trauma care due to the nature of the ER environment and proper precautions not being taken. Violence is of risk to attending ER nurses, physicians and paramedics, sighting an Australian study that 79% of triage nurses have experienced physical violence from patients. And, the emotional harm the trauma environment can have on trauma providers.
Steins suggests that trauma providers must be aware and learn how to manage risk better to ensure patient and provider safety.
A Study of Heart Rate Recovery Following Exercise in Healthy Young Adult MaleIOSR Journals
Abstract: Exercise has positive chronotropic effect on heart rate and on cessation heart rate returns to preexercise
level. A delay in heart rate recovery (HRR) (≤12beats in first minute) is considered abnormal and
reflects autonomic dysfunction.The present study was taken up to find out the presence of abnormal HRR in
normal subjects (Male) and to establish HRR as an independent autonomic marker. For the study 106 healthy
young adults (male) were subjected to exercise by Bicycle ergometer till targeted Heart Rate (85%Maximum
Heart Rate(MHR)) was achieved. HRR at the end of 1 minutefollowingcessation of exercise were tabulated. In
our study 23(21.7%) subjects showed Abnormal HRR indicating HRR could be an independent autonomic
marker. Keyword-HRR, MHR
An Integrated Understanding of Pressure and Flow – An Essential PartnershipInsideScientific
A tightly controlled relationship between blood pressure and organ blood flow is vital for matching an organ’s metabolic needs to the delivery of oxygen and nutrients. However, the nature of the pressure-flow relationship is complex and governed by multiple control systems, including local autoregulatory mechanisms at the level of the individual organ, as well as neural and hormonal modulation. To fully understand how pressure-flow relationships operate in health, and may be altered in pathological settings, it is essential to make direct, long-term assessments of blood pressure and blood flow under normal physiological conditions (ie in the conscious state).
In this presentation, Dr. McBryde shares insights from her studies of how the relationship between blood pressure and blood flow is altered in hypertension, to “consumer” organs such as the brain, and to “supply” circulations such as the mesenteric venous pool. She also discusses the variables that go into gathering accurate measurements of these two parameters in a lab setting.
Manuscript editing service | Primary and secondary data | Neurogenic ShockPubrica
Pubrica writers have worked with numerous journals in medical and scientific subjects. We work with scientists and researchers across the globe to write novel manuscripts that explain finding in a clear and cohesive structure. We provide prepublication services, including editing, proofreading, rewriting, and translation services for your manuscript.
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This presentation provides a general introduction to neuroanatomy after cerebral hemispherectomy, a procedure where half the brain is removed to stop intractable epilepsy that originates from one side of the brain. Topics include potential of the remaining hemisphere, cortical plasticity, clinical presentation of hemiparesis due to innervation by only the ipsilateral corticospinal tract, life span impairments. Various case studies discussed.
Presented at the Combined Section Meeting of the American Physical Therapy Association
February 2014
By: Dr. Stella de Bode, Ph.D. Chief Science Officer, The Brain Recovery Project
Nisha Pagan, PT, DPT, NCS, PCS, Owner Wholehearted Pediatric Physical Therapy
Nursing Case Study of a Patient with Severe Traumatic Brain Injuryrubielis
This details the critical care nurse's role in caring for a patient with severe traumatic brain injury, managing ICP and brain oxygenation. Ties in closely with Orem's self-care deficit theory for nursing.
Cardiovascular Pathophysiology In the Setting of Spinal Cord InjuryInsideScientific
Dr. Christopher West shares his research that investigates the cardiovascular and autonomic changes that occur following spinal cord injury as well as the efficacy of neuro-therapeutic interventions.
Dr. West’s group uses small and large in vivo animal models to understand how the circuitry that controls the cardiovascular system changes following injury and what the downstream impact of these changes are for heart and blood vessel function. They also use these models to test the efficacy of novel therapies in the both the acute and chronic setting following injury. In the clinical and athletic spinal cord injury population, his group has conducted a number of mechanistic and applied studies to, 1) improve the understanding of how best to hemodynamically manage acutely injured patients, and 2) enhance the capacity of the cardiovascular system to enable an improved exercise response.
This webinar introduces the major cardiovascular changes that have been characterized following spinal cord injury in animal models and the clinical population. Chris shares some exciting results from recent studies in which his group has tested the efficacy of novel therapies to improve cardiovascular function. Finally, he provides his outlook for the future of the field.
OPEN ACCESS: Prognostic implications of conversion from non-shockable to shoc...Emergency Live
The prognostic significance of conversion from non-shockable to shockable rhythms in patients with initial non-shockable rhythms who experience out-of-hospital cardiac arrest (OHCA) remains unclear. We hypothesized that the neurological outcomes in those patients would improve with subsequent shock delivery following conversion to shockable rhythms, and that the time from initiation of cardiopulmonary resuscitation by emergency medical services personnel to the first defibrillation (shock delivery time) would influence those outcomes. READ MORE HERE: http://ccforum.com/content/18/5/528/abstract#
La transidentité, un sujet qui fractionne les FrançaisIpsos France
Ipsos, l’une des principales sociétés mondiales d’études de marché dévoile les résultats de son étude Ipsos Global Advisor “Pride 2024”. De ses débuts aux Etats-Unis et désormais dans de très nombreux pays, le mois de juin est traditionnellement consacré aux « Marches des Fiertés » et à des événements festifs autour du concept de Pride. A cette occasion, Ipsos a réalisé une enquête dans vingt-six pays dressant plusieurs constats. Les clivages des opinions entre générations s’accentuent tandis que le soutien à des mesures sociétales et d’inclusion en faveur des LGBT+ notamment transgenres continue de s’effriter.
Johnny Depp Long Hair: A Signature Look Through the Yearsgreendigital
Johnny Depp, synonymous with eclectic roles and unparalleled acting prowess. has also been a significant figure in fashion and style. Johnny Depp long hair is a distinctive trademark among the various elements that define his unique persona. This article delves into the evolution, impact. and cultural significance of Johnny Depp long hair. exploring how it has contributed to his iconic status.
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Introduction
Johnny Depp is an actor known for his chameleon-like ability to transform into a wide range of characters. from the eccentric Captain Jack Sparrow in "Pirates of the Caribbean" to the introspective Edward Scissorhands. His long hair is one constant throughout his evolving roles and public appearances. Johnny Depp long hair is not a style choice but a significant aspect of his identity. contributing to his allure and mystique. This article explores the journey and significance of Johnny Depp long hair. highlighting how it has become integral to his brand.
The Early Years: A Budding Star with Signature Locks
1980s: The Rise of a Young Heartthrob
Johnny Depp's journey in Hollywood began in the 1980s. with his breakout role in the television series "21 Jump Street." During this time, his hair was short, but it was already clear that Depp had a penchant for unique and edgy styles. By the decade's end, Depp started experimenting with longer hair. setting the stage for a lifelong signature.
1990s: From Heartthrob to Icon
The 1990s were transformative for Johnny Depp his career and personal style. Films like "Edward Scissorhands" (1990) and "Benny & Joon" (1993) saw Depp sporting various hair lengths and styles. But, his long, unkempt hair in "What's Eating Gilbert Grape" (1993) began to draw significant attention. This period marked the beginning of Johnny Depp long hair. which became a defining feature of his image.
The Iconic Roles: Hair as a Character Element
Edward Scissorhands (1990)
In "Edward Scissorhands," Johnny Depp's character had a wild and mane that complemented his ethereal and misunderstood persona. This role showcased how long hair Johnny Depp could enhance a character's depth and mystery.
Captain Jack Sparrow: The Pirate with Flowing Locks
One of Johnny Depp's iconic roles is Captain Jack Sparrow from the "Pirates of the Caribbean" series. Sparrow's long, dreadlocked hair symbolised his rebellious and unpredictable nature. The character's look, complete with beads and trinkets woven into his hair. was a collaboration between Depp and the film's costume designers. This style became iconic and influenced fashion trends and Halloween costumes worldwide.
Other Memorable Characters
Depp's long hair has also been featured in other roles, such as Ichabod Crane in "Sleepy Hollow" (1999). and Roux in "Chocolat" (2000). In these films, his hair added a layer of authenticity and depth to his characters. proving that Johnny Depp with long hair is more than a style—it's a storytelling tool.
Off-Screen Influenc
Have you ever wondered about the lost city of Atlantis and its profound connection to our modern world? Ruth Elisabeth Hancock’s podcast, “Visions of Atlantis,” delves deep into this intriguing topic in a captivating conversation with Michael Le Flem, author of the enlightening book titled “Visions of Atlantis.” This podcast episode offers a thought-provoking blend of historical inquiry, esoteric wisdom, and contemporary reflections. Let’s embark on a journey of discovery as we unpack the mysteries of ancient civilizations and their relevance to our present existence.
Care Instructions for Activewear & Swim Suits.pdfsundazesurf80
SunDaze Surf offers top swimwear tips: choose high-quality, UV-protective fabrics to shield your skin. Opt for secure fits that withstand waves and active movement. Bright colors enhance visibility, while adjustable straps ensure comfort. Prioritize styles with good support, like racerbacks or underwire tops, for active beach days. Always rinse swimwear after use to maintain fabric integrity.
MRS PUNE 2024 - WINNER AMRUTHAA UTTAM JAGDHANEDK PAGEANT
Amruthaa Uttam Jagdhane, a stunning woman from Pune, has won the esteemed title of Mrs. India 2024, which is given out by the Dk Exhibition. Her journey to this prestigious accomplishment is a confirmation of her faithful assurance, extraordinary gifts, and profound commitment to enabling women.
Is your favorite ring slipping and sliding on your finger? You're not alone. Must Read this Guide on What To Do If Your Ring Is Too Big as shared by the experts of Andrews Jewelers.
From Stress to Success How Oakland's Corporate Wellness Programs are Cultivat...Kitchen on Fire
Discover how Oakland's innovative corporate wellness initiatives are transforming workplace culture, nurturing the well-being of employees, and fostering a thriving environment. From comprehensive mental health support to flexible work arrangements and holistic wellness workshops, these programs are empowering individuals to navigate stress effectively, leading to increased productivity, satisfaction, and overall success.
Gujarat Details in Hindi for children's for presentation in school
Cerebral perfusion pressure among acute traumatic brain injury patients at supine versus semi fowler positions (2)
1. Advances in Life Science and Technology
ISSN 2224-7181 (Paper) ISSN 2225-062X (Online)
Vol.12, 2013
www.iiste.org
Cerebral Perfusion Pressure among Acute Traumatic Brain
Injury Patients at Supine versus Semi-Fowler Positions
1
Tahsien Mohamed Okasha, 2Khaled Samir Anbar & 3*Yousria Abd El Salam Seloma
1 Clinical instructor- Critical Care and Emergency Nursing- Cairo University
2Prof. of Neurosurgery - Faculty of Medicine- Cairo University
3
Lecturer of Critical Care and Emergency Nursing- Cairo University
* E-mail of the corresponding author: yousriaseloma@yahoo.com
Abstract
Background: Positioning is one of the most frequently performed nursing activities in the intensive care units.
However literature review documented lack of knowledge about the relationship of cerebral dynamics and
different body positions among acute traumatic brain injury patients. Aim: the aim of this study is to assess the
effect of supine and semi-fowler position on cerebral perfusion pressure among patients with acute traumatic
brain injuries at Cairo University Hospital as indicated by: Glasgow coma score (GCS), arterial blood gases
values (ABG), oxygen saturation and vital signs (pulse, blood pressure and respiratory rate). Research
questions: What is the effect of supine position on cerebral perfusion pressure among patients with acute
traumatic brain injuries? And what is the effect of semi fowler position on cerebral perfusion pressure among
patients with acute traumatic brain injuries? Sample: Convenience sample of 39 patients admitted with acute
traumatic brain injury. Design: Descriptive exploratory repeated measures study. Setting: University Hospital in
Cairo. Tools: Initial acute traumatic brain injury patient’s assessment sheet, and cerebral oxygenation and
physiological parameters assessment sheet for acute traumatic brain injury patients. Result: The mean age was
28.5 ±7.9 years. (74.4%) have normal body weight, (25.6%) were having cerebral contusion. Significant increase
of CPP, Pao2, SaO2, SPO2, mean arterial pressure and systolic blood pressure, in 15 min post semi-fowler
position assessment with a significant decrease of PaCo2. Significant decrease of pulse rate in supine position
was evident. With no significant changes in diastolic blood pressure and GCS. Conclusion: Semi-fowler
position was found to affect the ABG values, mean arterial pressure, respiratory rate, SpO2 and CPP positively.
Recommendation: Studying the effect of side lying and prone position to establish data base about the optimal
body position for acute traumatic head injury patients is highly recommended with replication of this study on
larger probability sample.
Key words: supine position, semi-fowler position, physiological parameters, cerebral perfusion pressure, acute
traumatic brain injury.
1.
Introduction:
Traumatic brain injury (TBI) is a leading cause of death worldwide, particularly in those younger than 40 years.
Head injury and TBI are two distinct entities that are often, but not necessarily, related. A head injury is best
defined as an injury that is clinically evident upon physical examination and is recognized by the presence of
ecchymoses, lacerations, deformities, or the presence of rhinorrhea or otorrhea. Traumatic brain injury refers to
an injury to the brain itself and can occur without external signs of trauma (Macias, et al. 2009).
Traumatic brain injury is a major source of disability, death and cost (emotional and financial) to society. It is
important to recognize that the neurological damage that occurs often develops after the initial impact damage
and it is the control of this secondary brain injury that is imperative. With the control of secondary brain injury,
the patient’s prognosis improves; this has been demonstrated by progressive and significant reductions in
mortality from 50 to 35 to 25% (and lower) over the last 30 years (Lu et al. 2005). This has largely occurred
because of a change in focus on patient management with the emphasis on promotion of adequate cerebral
perfusion. To enable this, protocols that focus on maintenance of neuronal perfusion have been developed and
introduced into practice (Sarah. McGloin, Anne & McLeod, 2010).
Cerebral perfusion pressure (CPP) is the difference between the arterial pressure in the feeding arteries as they
enter the subarachnoid space and the pressure in the draining veins before they enter the dural sinuses. As both
of these pressures are difficult to measure, CPP is seen to be the difference between mean arterial pressure
(MAP) and ICP or CVP (as an estimate of tissue pressure). The cerebral blood vessels will constrict or dilate to
33
2. Advances in Life Science and Technology
ISSN 2224-7181 (Paper) ISSN 2225-062X (Online)
Vol.12, 2013
www.iiste.org
maintain a stable CPP: this ability to auto regulate blood flow through the cerebral vasculature is a key to
ensuring that perfusion is constant. The diameter of the cerebral vessels change inversely with changes in
pressure: as the CPP rises, the vessels constrict and if CPP reduces, the vessels dilate. CPP is a surrogate for
CBF that is commonly utilized at the bedside in the Neuroscience ICU, CPP between 60 and 80 mmHg is
commonly targeted (Bhardwaj & Mirski, 2011).
While the exact effects of body position, a critical component of basic nursing care in the intensive care units
(ICU), on intracranial physiology after traumatic brain injury are not well defined, the current practice in most
neurocritical care units is to elevate the head of the bed in an effort to reduce intracranial pressure by facilitating
venous outflow without compromising cerebral perfusion pressure (CPP) and cardiac output (Brain Trauma
Foundation, 2007). On the contrast, it has been suggested that the horizontal position (supine) reduces the risk
for systemic hypotension. Furthermore, some authors argue that a horizontal body position increases cerebral
perfusion pressure improving cerebral blood flow (Winkelman, 2012). However the American Association of
Neurological Surgeons has not referred to head position in their most recent guidelines, Brain Trauma
Foundation (2010) does not include specific recommendations for optimal patient positioning practices after
severe brain injury, and Similarly, guidelines on care of subarachnoid haemorrhage (SAH) patients are unclear
about optimal patient position (Blissitt, Mitchell & Newell, 2011).
Turning and repositioning also may be associated with transient increases in ICP and subsequent changes in
cerebral and cardiovascular variables (Price, Collins, & Gallagher, 2003). In a literature review on positioning
for diverse patient populations, Sullivan (2000) suggests that caution should be used with side-lying positions
and HOB elevation no greater than 45[degrees] should be used for TBI patients. Varying degrees of head
elevation have been associated with changes in jugular venous outflow, intracranial pressure, cerebral perfusion
pressure, and cerebral tissue oxygenation. Head elevation is generally presumed to be associated with enhanced
jugular venous outflow and decreased intracranial pressure. However, the relationship between head elevation
and cerebral perfusion pressure and cerebral tissue oxygenation is less clearly understood (Fan. 2004 &
Marklew. 2006).
Nursing care of the head-injured patient can present many challenges for the critical care nurse and, as a
consequence, a thorough knowledge of the hemodynamics and neuro-dynamics sequence of traumatic brain
injury is required. To answer the question of the optimal body position for traumatic brain injury patients in these
times of evidence-based practice there is clearly a need for many researches to be undertaken in many areas in
the care of the head-injured patient (Bratton et al., 2007). Therefore, the aim of this study is to assess the effect
of different body positions (supine and semi-fowler position) on cerebral oxygenations and physiological
parameters among patients with acute traumatic brain injuries at Cairo University Hospital as indicated by:
Glasgow coma score (GCS), Arterial blood gases values (ABG), Oxygen saturation by pulse oximeter and Vital
signs (pulse, blood pressure and respiratory rate).
2.
Significance of the study:
Until now, the question of optimal body position for brain-injured patients has not been addressed in systematic
studies and It has been observed from clinical experience that patient's position changes are always done as a
routine, choosing the appropriate body position for performing the nursing activities, in addition frequently
performed nursing activities in the critical care units for all the patients to prevent integumentary complication
with less consideration to patients’ hemodynamics. However there is lack of knowledge about the relation of
cerebral dynamics and different body positions (Fan. 2004 & Marklew. 2006), since cerebral oxygenation and
physiological parameters play a crucial role in hemodynamic stability of traumatic brain injured (TBI) patients.
Thus the present study conducted in an attempts to establish data base information about hemodynamic and
oxygenation parameters in different body positions (supine & semi-fowler position) this might generate
knowledge to help nursing professionals in planning care for such a group of patients as well the other health
professionals, in addition it could have a positive effect upon health status of the similar group of patients.
3.
Aim of the study:
The aim of this study is to assess the effect of different body positions (supine and semi-fowler position) on
cerebral oxygenations and physiological parameters among patients with acute traumatic brain injuries at Cairo
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University Hospital as indicated by: Glasgow coma score (GCS), Arterial blood gases values (ABG), Oxygen
saturation by pulse oximeter and Vital signs (pulse, blood pressure and respiratory rate).
4.
Research questions:
To fulfill the aim of this study the following research questions were formulated:
Q1: What is the effect of supine position on cerebral oxygenations and physiological parameters among
patients with acute traumatic brain injuries?
Q2: What is the effect of semi fowler position on cerebral oxygenations and physiological parameters among
patients with acute traumatic brain injuries?
5.
Subjects and Methods:
5.1 Research Design
Descriptive exploratory design was adopted in the current study; single center repeated measures used to
describe the effect of supine and semi-fowler positions on physiological parameters and cerebral oxygenations
among acute traumatic brain injury patients.
5.2 Setting
The study was carried out at Emergency Department at one University Hospital, in Cairo Governorate. It is one
of the largest educational university hospitals in Egypt in this field, and it receives patients from all governorates
of Egypt and other countries. The neurosurgery ICU unit consists of (12 beds), and intermediate unite consists of
(10 beds). The number of occupied bed in ICU is 12 beds. The unit receives patients with Varity of diagnosis
such as traumatic brain injury (TBI), spinal cord injury, brain tumor, and spontaneous cerebral hemorrhage for
preoperative, postoperative and conservative management.
5.3 Subjects
Convenience sample of 39 adult male and female patients who are diagnosed as having brain injury with GCS
between 3 & 14, were recruited to fulfill the aim of this study within the first 48 hours of hospital admission.
With the following exclusion criteria Spinal cord injury, diabetic, hypertensive’s, chronic obstructive pulmonary
disease patients (COPD) , body mass index of more than 30 kg/m2, Shocked, feverish (temperature of more than
38 degree), and those with respiratory acidosis.
5.4 Tools
Two tools were formulated to collect data pertinent to this study. These tools were constructed by the researcher
and revised by a panel of 5 medical and critical care nursing experts then piloted on 5 patients to ensure clarity,
objectivity, relevance, and feasibility of the study tools and to establish the Content and face validity of these
tools. These tools are:
1- Initial acute traumatic brain injury patient’s assessment sheet: This sheet covering 3 main parts: Part (1):
covers the socio-demographic data such as (age, gender and admission date). Part (2): is related to general
medical data: this part contain data related to patient diagnosis, past medical history, oxygen devices used,
prescribed medications, Glasgow coma scale and body mass index. Part (3): devoted to the initial vital signs
assessment; containing assessment of pulse, systole, diastole and mean blood pressure, respiratory rate and
central venous pressure.
2- Cerebral oxygenation and Physiological parameters assessment sheet for acute traumatic brain injury
patients. This sheet contains items covering 3 main parts: Part (1): Includes assessment of physiological
parameters: such as (pulse rate, systolic blood pressure, diastolic blood pressure, mean blood pressure and
respiratory rate). Part (2): deals with assessment of consciousness using Glasgow coma scale. Part (3):
provide data related to assessment of cerebral oxygenation: through arterial blood gases values (SaO2, PaO2
and PaCo2), oxygen saturation level by pulse oximeter.
5.4.1 Tools validity
Content validity was done to identify the degree to which the used tools measure what was supposed to be
measured. Tools developed by the investigator were examined by a panel of five medical and critical care
nursing experts to determine whether the included items are clear and suitable to achieve the aim of the current
study.
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Ethical consideration
An official permission to conduct the study was obtained from directors of the Critical Care department at the
University Hospital. Written consents were obtained from head nurses; in addition, patients' agreements to be
included in the study were obtained after explanation of the nature and purpose of the study. Each patient was
free to either participate or not in this study and had the right to withdraw from the study at any time without any
rationale; also, patients were informed that data will not be included in any further researches without another
new consent if they do not mind. Confidentiality and anonymity of each subject were assured through coding of
all data.
5.6 Techniques for data collections
Structured interview, reviewing medical /nursing records and direct patients observation were utilized to fill out
the study tools.
5.7 Procedure
The current study was carried out on two phases, designation and implementation phases which are:
5.7.1
Designation phase:
It was concerned with the construction and preparation of the different data collection tools, in addition to
obtaining managerial arrangement to carry out the study.
5.7.2
Implementation phase:
The investigator visited the ICU of neurosurgery on daily bases, during morning and afternoon shifts reviewing
the medical and nursing records to identify the patients who matched the inclusion criteria. Then formal consent
was taken to be included in the study after explaining the purpose and the nature of the study. The patients were
assessed during the first 48 hours of the patients’ admission. Body mass index was calculated for all adult acute
traumatic brain injury patients who were fulfilling the inclusion criteria; those with BMI of less than 30kg/m2
were included in the study. Then the Socio demographic and medical related data were obtained and recorded
from the patients’ files (tool 1), initial patient assessment of base line vital signs, GCS, oxygen saturation, ABG
values, oxygen device used, and the medication used were done and result documented.
Cerebral oxygenation and Physiological parameters assessment sheet for acute traumatic brain injury patients
(Tool 2), were fulfilled by the researcher through direct observation before changing position and 15 minutes
after changing position in the two selected position (supine & semi-fowler position) this was checked three times
on different intervals for each patient in each position to obtain the mean value for each position.
5.8 Statistical analysis data
Upon completion of the data collection, data were tabulated and analyzed using SPSS program; relevant
statistical analysis was used to test the obtained data. Descriptive statistics were applied (eg. mean, standard
deviation, frequency, percentage). Also t-test and one way repeated measure ANOVA test were applied using the
significant level p≤ 0.05.
6.
Results
Statistical finding of the current study are presented in three main sections; section one is related to the sociodemographic and medical data of the studied subjects. Section two is devoted to the answers of the two stated
research questions and section three is delineated to the additional correlational findings.
Section one: Socio-demographic and medical data of the studied subjects: Figures (1-5) are related.
Figure (1) shows that more than half of the stuided sample (56.4 %) their age ranged from 25 to 30 years old
with a mean age of 28.5±7.9.
Figure (2) shows that the majority of the studied subjects (92.3%) were males.
Figure (3) shows that the majority of the studied sample (74.40%) their body mass index ranged between 20 &
25 Kg/m2 (normal weight).
Figure (4) shows that (25.6%) of the studied sample were diagnosed as having cerebral contusion, followed by
(23.1%) with intracerebral hemorrhage, (17.9%) with extradural hematoma, (15.4%) with subdural hematoma,
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(7.7%) with skull fracture and equal percentages (5.1%) were having cerebral hematoma and subarachnoid
hemorrhage.
Figure (5) shows that the highest percentage of the studied sample (33.3%) were connected with t-tube for
oxygen therapy, (28.2%) were connected to oxygen mask, (23.1%) were on room air, and (15.4%) were
mechanically ventilated.
Section two: This section is devoted to the answers of the two stated research questions. Tables (1- 3) are related
to the answer of these research questions.
Table (1); denotes that there a significant increase in cerebral perfusion pressure(CPP), systolic blood pressure,
mean arterial pressure, SpO2 with significant decrease of respiratory rate in 15 min post semi-fowler position.
Significant increase of pulse rate in supine position. With no significant changes in diastolic blood pressure and
GCS.
Table (2); denotes that there is a highly significant increase of PaO2, SaO2 and decrease of PaCo2 in the 15 min
post semi-fowler position.
Table (3) Table (3): illustrates no significant changes of initial GCS with pre and post supine and semi-fowler
GCS scores.
7. Discussion:
Discussion of the results obtained from the current study are presented in two main sections; section one
specified to describe the studied group as regards to their socio-demographic characteristics and medical data.
The second section is concerned with answering the research questions.
Section 1: socio-demographic characteristics and medical data:
The current study revealed that more than half of studied subjects age ranged from 25 -30 years old, male
subjects represent the great majority, three quarter of them have BMI ranged between 20-25 kg/m2, quarter of
the studied subject were diagnosed as brain contusion, and more than quarter of the studied subject were
connected with t-tube for oxygen therapy.
The rational for these findings may be due to the male in this age group are more likely to engage in activities
that make them more vulnerable for head trauma (like driving, sports, and fights). The body mass index for the
studied subject was classified as normal weight this may be due to increased activity in this age and life style.
The main cause is road traffic accidents, cars crashes which are more associated with cerebral contusion as a
result of mechanism of injury.
The current study revealed that more than half of the stuided subjects their age ranged from 25 to 30 years old.
These findings are in concordance with (Styrke, 2007) who reviewed Traumatic brain injuries in a well-defined
population: epidemiological aspects and severity, indicated that Median age of traumatic brain injury patients
was 23 years. Also (Fitzharris, Dandona, Kumar, & Dandona, 2009) who studied Crash characteristics and
patterns of injury among hospitalized motorized two-wheeled vehicle users in urban India stated that median
age was 31 years and the great majority were male.
Male patients represent the great majority of the studied subjects in the current study. This finding is in
concordance with (BMJ, 2008) who studied Predicting outcome after traumatic brain injury: practical
prognostic models based on large cohort of international patients mentioned that the majority (81%) of the
patients were male.
The current study revealed that three quarter of the studied subjects their body mass index was ranged between
20 to 25. In this regards (Brown, et al, 2006) studied obesity and traumatic brain injury, found that the great
majority was lean patients have normal weight (BMI = 24 +/- 4 kg/m2).
The current study revealed that more than one quarter of the study subjects were diagnosed as having brain
contusion in this regards (Narotam, Morrison, & Nathoo, 2009) who studied brain tissue oxygen monitoring in
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traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy, found that
The majority of injuries were sustained in motor vehicle crashes, and diffuse brain injury was the most common
abnormality.
The current study revealed that more than half of the studied subjects was connected with t-tube for oxygen
therapy in this regards (Elm, Schoettker, Henzi, Osterwalder, & Walder, 2009) studied pre-hospital tracheal
intubation in patients with traumatic brain injury: systematic review of current evidence: a systematic literature
search reported that the available evidence did not support any benefit from pre-hospital intubation and
mechanical ventilation after traumatic brain injury (TBI). Additional arguments need to be taken into account,
including medical and procedural aspects.
Section two: This section is concerned with answering the research questions:
The current study revealed statistical significant increase of systolic blood pressure, mean blood pressure,
cerebral perfusion pressure (CPP), SpO2 and significant decrease of respiratory rate in semi-fowler position.
Significant increase of pulse rate in supine position, and no significant changes of GCS in different position.
There was highly significant statistical increase of PaO2, SaO2 and decrease of PaCo2 in the 15 min post semifowler position.
The underlying rational for this result may be due to the role of semi-fowler position in decreasing ICP and as a
result of this improvement of CPP. Increased oxygenation and decreased PaCo2 may be due to in the semifowler position tidal volume increased due to lowering of diaphragm and increase alveolar expansion. The
semi-fowler position maximizes lung volumes, flow rate and capacities increases spontaneous tidal volumes,
and decreases the pressure on the diaphragm exerted by abdominal contents, increase in respiratory system
compliance so oxygenation increased and PaCo2 decreased.
The current study revealed statistical significant increase of systolic blood pressure, mean blood pressure, SpO2
and significant decrease of respiratory rate in semi-fowler position. Significant increase of pulse rate in supine
position. In contrast with these finding (Ledwith et-al, 2010) who studied effect of body position on cerebral
oxygenation and physiologic parameters in patients with acute neurological conditions, found that.
Hemodynamic parameters were similar in the various positions. Also (Palazón, Asensi, López, Bautista &
Candel, 2008) who studied effect of head elevation on intracranial pressure, cerebral perfusion pressure, and
cerebral blood flow in patients with cerebral hemorrhage, stated that ICP were significantly higher in horizontal
position and all the physiological parameters were not significantly affected by the change in head elevation.
Also (Wojner, Alexander, Garami, Chernyshev, & Alexandrov, 2005) who studied Heads down Flat positioning
improves blood flow velocity in acute ischemic stroke stated that middle cerebral artery (MCA) mean flow
velocity (MFV) increased in all patients with lowering head position to 0 degree , Mean arterial pressure and
heart rate were unchanged throughout the intervention, Immediate neurologic improvement occurred in three
patients (15%) after lowering head position, and concluded that acute ischemic stroke patients may benefit from
lower head-of-the-bed positions to promote residual blood flow to ischemic brain tissue.
Also (Eser, Khorshid, Gunes, & Demir, 2007) stated that the blood pressure tended to drop in the standing
position compared with the sitting, supine and supine with crossed legs. Systolic and diastolic blood pressure
was the highest in supine position when compared with the other positions. There was a difference between
systolic blood pressures and this was statistically significant, but the difference between diastolic blood
pressure was not statistically significant. All changes in systolic blood pressure were statistically significant
except those from supine to supine position with crossed legs.
Also (Emerson & Banasik, 2006) studied effect of position on selected hemodynamic parameters in
postoperative cardiac surgery patients (supine, 45 degrees right lateral, and 45 degrees left lateral) stated that
Statistically significant differences were found in response to position in systolic and diastolic blood pressure,
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central venous pressure, and heart rate. Certain positions produced greater changes in selected variables, both in
the total group and within specific subgroups.
The current study revealed significant increase of the cerebral perfusion pressure (CPP) in semi-fowler
positions this finding in concordance with (Winkelman. 2012) who studied Effect of backrest position on
intracranial and cerebral perfusion pressures in traumatically brain-injured adults found that Use of backrest
elevation of 30 degrees resulted in significant improvements in CPP.
Meyer, Teasell, Megyesi, & Bayona (2012) in evidence-based review of moderate to severe acquired brain
injury stated that there is level 2 evidence based on one randomized control trial (RCT) that 30 degrees of head
elevation reduces intracranial pressure with concomitant increments in cerebral perfusion pressure. Elevating
the head by 30 degrees improves intracranial and cerebral perfusion pressures. Also (Meixensberger, Baunach,
Amschler, Dings, & Roosen 1997) who studied Influence of body position on tissue-pO2, cerebral perfusion
pressure and intracranial pressure in patients with acute brain injury stated that Compared with the 30 degree
head position ICP was significantly higher and CPP significantly lower at the 0 degrees head position. Brain
tissue oxygenation (ti-pO2) and mean arterial blood pressure were unaffected by head position.
The current study revealed that there is no statistical significant change of diastolic blood pressure and GCS in
the initial, supine and semi-fowler position this finding in concordance with (Ledwith, Bloom, Wilensk, Coyle,
Polomano & Roux, 2010) who studied the effect of body position on cerebral oxygenation and physiological
parameters among patients with acute neurological conditions found that no significant changes of
physiological parameters recorded with changes in head elevation.
The current study revealed a highly significant statistical increase of PaO2, SaO2 and decrease of PaCo2 in the
15 min post semi-fowler position these finding in concordance with (Shah, 2012) studied the comparison of
effect of semi fowler’s vs. side lying position on tidal volume & pulse oxymetry in ICU patients found that
PaO2 significantly increased and PaCo2 significantly decreased in semi-fowler position.
In contrast (Tyson & Nightingale, 2004) in studying the effects of position on oxygen saturation in acute stroke:
a systematic review stated that there was strong evidence that body position did not affect oxygen saturation in
acute stroke patients without relevant (respiratory) co-morbidities. There was limited evidence that sitting in a
chair had a beneficial effect and lying positions had a deleterious effect on oxygen saturation in acute stroke
patients with respiratory co-morbidities, and concluded that acute stroke patients without respiratory comorbidities can adopt anybody position, people with respiratory co-morbidities should be positioned as upright
as possible.
Also (Safari, Ansari, & Mohsen, 2002) who studied the effect of body position on arterial oxygen saturation in
acute stroke stated that mean arterial oxygen saturation values for all patients were >90% for the hour spent in
each test position for all patients. There were no changes in arterial oxygen saturation across the hour spent in
the test positions (repeated-measures analysis of variance). No differences in arterial oxygen saturation were
identified among positions (analysis of covariance).
The current study revealed that the pulse rate significantly increased in the supine position in contrast to these
finding (Palazón, Asensi, López, Bautista & Candel, 2008) who studied Effect of head elevation on intracranial
pressure, cerebral perfusion pressure, and cerebral blood flow in head-injured patients found that physiological
parameters were not affected by changes in head elevation.
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The current study revealed highly significant decrease of respiratory rate in the 15 min post semi-fowler
position in contrast to these finding (Naylor, 2006) who studied a modified postural drainage position produces
less cardiovascular stress than a head-down position in patients with severe heart disease: a quasi-experimental
study, found there were no significant respiratory responses to either postural drainage manoeuvre.
Elizabeth & Winslow, (2012) stated that the right position made breathing easier, since respiratory rate was
significantly lower in the right position compared with the high Fowler's position, while tidal volume was
significantly higher in the right position compared with the high Fowler's. Respiratory rate was also
significantly lower in the 45[degrees] position compared with the 90 degrees position, and mean heart rate was
significantly higher in high Fowler's than in the flat position. Most patients preferred the right or 45 degrees
positions.
The current study revealed that the systolic, and mean arterial pressure were significantly increased in the
semi-fowler position and this disagree with (Meixensberger, Baunach, Amschler, Dings, & Roosen 1997) who
studied the influence of body position on tissue-pO2, cerebral perfusion pressure and intracranial pressure in
patients with acute brain injury who found that the blood pressure were unaffected by head position.
Also (Shahdadi, Mazloum, Badakhsh, & EsmatBandani, 2010) studied Comparison of blood pressure in the
supine and semi-Fowler's position during hemodialysis, reported that There was no statistical significant
difference between two positions in terms of hypotension . The mean systolic blood pressure in supine and
Fowler's position were 117.7 and 113.11 mm/Hg, respectively. The mean diastolic blood pressure in supine and
Fowler's position were 66 and 65.5 mm/Hg, respectively and there was no statistical significant difference
between two positions in terms of diastolic blood pressure.
The current study revealed a highly significant increase of SpO2 in the 15 min post semi-fowler position. In
contrast to this finding (Shah, 2012) studied the comparison of effect of semi fowler’s vs. side lying position
on tidal volume & pulse oxymetry in ICU patients found that SpO2 not affected by positions. Also (Smith,
Harten, Jack, Carter, & Kinsella, 2010) who studied pre-oxygenation in healthy volunteers: a comparison of the
supine and 45° seated positions stated that there was no difference in the increase in tissue oxygenation when
comparing the supine and seated positions, and conclude that there is no evidence that pre-oxygenation in the
45° seated position improves tissue oxygenation in young healthy volunteers compared with the supine
position.
Also (Safari, Ansari, & Mohsen, 2002) studied: study of semi-fowlers position and its duration effect on the
arterial blood gases results in patients under mechanical ventilation hospitalized in general ICU the findings
showed that semi-fowler's position did not have any positive effects on oxygenation and gas exchange. Also,
the findings indicated that the effect of lying duration (15, 30, 45, 60 minutes) in semi-fowler's position on
oxygenation and gas exchange wasn't significant.
8.
Conclusion:
Based on the result of the current study, it can be concluded that the semi-fowler position has positive effect on
cerebral dynamics as it helps in improving the cerebral perfusion pressure (CPP), hemodynamic parameters as
mean and systolic blood pressure, respiratory rate, and oxygenation parameters in the form of oxygen saturation
(SpO2), and arterial blood gases values (PaO2, SaO2, and PaCo2).
9.
Recommendations:
1.
2.
Replication of the study on a larger probability sample selected from different geographical areas in
Egypt is recommended to obtain more generalizable data.
Further studies should be carried out in order to assess the effect of other body positions.
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Acknowledgment
We are heartily thankful to, Professor Warda Youssef Mohammed- dean of the faculty of nursing –Cairo
University, whose encouragement, guidance and support from the initial to the final level enabled us to finish
this research.
Last but not least we offer our regards and blessings to all patients who were the sample of this research
paper.
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Figure (1): Percentage distribution of the studied sample as regards to their age groups (n =39).
Age Distribution
20.40%
(18 - 24 yrs)
23.20%
(25 - 30 yrs)
(31 - 50 yrs)
56.40%
X±SD= 28.5 ± 7.9
42
11. Advances in Life Science and Technology
ISSN 2224-7181 (Paper) ISSN 2225-062X (Online)
Vol.12, 2013
www.iiste.org
Figure (2) Percentage Distribution of the Studied Sample as regards to Their Gender (n =39).
Gender Distribution
7.7 %
Females
Males
92.3 %
Figure (3) Percentage distribution of the studied sample as regards to their body mass index (bmi) (n =39).
Body Mass Index distribution
(normal weight)
from 20-25kg/m2
25.6
(overweight)
from26-30kg/m2
74.4
Figure (4) Percentage distribution of the studied group as regards to their brain injury pathology (n =39)
Distribution of head injury pathology
25.60%
23.10%
17.90%
15.40%
5.10%
43
7.70%
5.10%
12. Advances in Life Science and Technology
ISSN 2224-7181 (Paper) ISSN 2225-062X (Online)
Vol.12, 2013
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Figure (5): Percentage distribution of the studied sample as regards to their oxygen therapy device used (n
=39)
Oxygen therapy device used
33.3%
28.2%
23.1%
15.4%
Table (1); One way ANOVA for vital signs, SpO2 and GCS during the five assessments for the studied
subjects (n = 39).
Variable
Initial
assessment
̅
Supine position
Pre
15 minutes
Post
̅
Semi-fowler
̅
Pre
̅
position
F /P
15 minutes
Post
̅
Pulse rate
91 ± 19.8
100 ± 9.8
95± 21.2
98 ± 20.3
97 ± 23
3.272/.022*
Respiratory rate
24 ± 3.3
21 ± 4.4
21 ± 5.2
22 ± 5.5
21 ± 5.2
3.670/.013*
Systole BP
124 ± 13.5
128 ± 4.5
128 ± 15
130 ± 15
128 ± 4.7
2.743/.044*
Diastole BP
79 ± 11.5
77 ± 11
77 ± 11.3
78 ± 11.1
78 ± 9.5
2.046/.109
Mean BP
95 ± 12.8
94 ± 12.2
94 ± 12.5
97 ± 13.3
96 ± 12.7
4.366/.006**
SpO2
94 ± 6.4
97 ± 5.1
98 ± 1.6
98 ± 1.9
99 ± 1.8
5.791/.001**
GCS
8 ± 3.5
8 ± 3.7
8 ± 3.7
8 ± 3.7
8 ± 3.7
.061/.806
CPP (n=30)
86 ± 12.5
86 ± 12
86 ± 12.6
GCS
Glasgow coma scale.
CPP
Cerebral perfusion pressure. (CPP = MAP - CVP).
CVP
Central venous pressure.
BP
Blood Pressure
̅
8
44
1.7 .
89 ± 13
88 ± 12
4.36/.006**
13. Advances in Life Science and Technology
ISSN 2224-7181 (Paper) ISSN 2225-062X (Online)
Vol.12, 2013
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Table (2) ; One way ANOVA for arterial blood gases value during initial assessment, 15 min post supine
position and 15 min post semi-fowler position for the studied subjects (n = 39).
Variable
Initial assessment
̅
15 min post supine
position
̅
15 min post semi-fowler
position
̅
F /P
Pao2
87 ± 22.3
117 ± 64.6
119 ± 59.5
6. 98/.003*
Paco2
40 ± 7.6
37 ± 9.0
36 ± 7.3
13.66/.000**
Sao2
88 ± 6.8
94 ± 6.4
94 ± 6.3
12.41/.000**
Table (3): Differences in glasgow coma scale of the studied subjects during the five assessments (n= 39)
Variable
X+ SD
Initial GCS
8.4 ± 3.77
Initial GCS
8.4 ± 3.77
Initial GCS
8.4 ± 3.77
.806
.248
.806
.248
.806
.248
.806
8.3 ± 3.58
GCS pre semi-fowler position
.248
8.3 ± 3.58
GCS 15 minutes post supine position
p value
8.3 ± 3.58
GCS pre supine position
t value
Initial GCS
8.3 ± 3.58
GCS 15 minutes post semi-fowler position
8.4 ± 3.77
GCS: Glasgow coma scale
45