A group of motor impairment syndromes resulting from disorders of early brain development and often associated with epilepsy and abnormalities of speech, vision and intellect
A group of motor impairment syndromes resulting from disorders of early brain development and often associated with epilepsy and abnormalities of speech, vision and intellect
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Definition
• Cerebral Palsy is a group of permanent, disorders of movement and/or
posture and of motor function, which are due to a non-progressive
interference, lesion, or abnormality of the developing/immature brain.
3.
4. Causes
Prenatal
• Prematurity (Gestational age less than 36 weeks)
• Low Birth Weight (less than 2500 g), which could be due to poor
nutritional status of the mother
• Maternal epilepsy
• Hyperthyroidism
Infections (TORCH = Toxoplasmosis, Other (Syphilis, Varicella-Zoster,
Parvovirus B19,) Rubella, Cytomegalovirus (CMV), Herpes Simplex Virus)
• Eclampsia
• Drug Abuse
• Trauma
• Multiple Pregnancies
• Placental Insufficiency
5. Perinatal
•Premature Rupture of Membranes
•Prolonged and Difficult Labour
•Vaginal Bleeding at the time of admission for labour
•Bradycardia
Postnatal(0-2 years)
•Central Nervous System infection (encephalitis, meningitis)
•Hypoxia
•Seizures
•Coagulopathies
•Neonatal Hyperbilirubinemia
•Head Trauma
6. Anatomical Classifications
• Unilateral: One side of the body is affected
• Bilateral: Both sides of the body are affected
• Quadriplegia, diplegia/Paraplegia and hemiplegia, monoplegia
• Dyskinetic Cerebral Palsy and Ataxic Cerebral Palsy: always involve the whole
body (bilateral).
7.
8. Hemiplegia (Unilateral)
• With hemiplegia, one side of the body is involved with the upper
extremity generally more affected than the lower.
• Seizure disorders, visual field deficits, tactile agnosia, and
proprioceptive loss are likely.
• Twenty percent of children with spastic Cerebral Palsy have hemiplegia.
A focal traumatic, vascular, or infectious lesion is the cause in many
cases.
• A unilateral brain infarct with post-hemorrhagic porencephaly (cysts or
cavities within the cerebral hemisphere) can be seen on Magnetic
Resonance Imaging (MRI).
9. Diplegia (Bilateral)
• With diplegia, the lower extremities are severely involved and the arms are
mildly involved.
• Intelligence usually is normal, and epilepsy is less common.
• Fifty per cent of children with Spastic Cerebral Palsy have diplegia. A history of
prematurity is usual.
• Diplegia is becoming more common as more low- birth-weight babies
survive.
• MRI reveals mild Periventricular Leukomalacia (PVL).
10. Quadriplegia (Bilateral)
• With quadriplegia, all four limbs, the trunk and muscles that control
the mouth, tongue and pharynx are involved.
• Thirty percent of children with Spastic Cerebral Palsy have quadriplegia.
More serious involvement of lower extremities is common in
premature babies.
• Some have perinatal hypoxic ischemic encephalopathy. MRI reveals
Periventricular Leukomalacia (PVL).
11. Classification on the basis of Brain area
involved
1. Spastic Cerebral Palsy - is the most common form of Cerebral Palsy.
Approximately 80% to 90% of children with Cerebral Palsy have Spastic
Cerebral Palsy.
• Spastic Cerebral Palsy is characterized by at least two of the following
symptoms, which may be unilateral (hemiplegia) or bilateral:
• An abnormal pattern of posture and/or movement
• Increased tone (not necessarily constantly)
• Pathological reflexes (hyperreflexia or pyramidal signs e.g. Babinski
response)
12. Dyskinetic CP
• Abnormal movements that occur when the child initiates movement are named
Dyskinesias.
• Dysarthria,Dysphagia and drooling accompany the movement problem.
Intellectual development is generally normal, however severe dysarthria makes
communication difficult and leads the outsider to think that the child has
intellectual impairment.
• DyskineticCerebral Palsy accounts for approximately 10% to 15 % of all cases of
Cerebral Palsy.
• Hyperbilirubinemia or severe anoxia causes basal ganglia dysfunction and
results in DyskineticCerebral Palsy.
• DyskineticCerebral Palsy is characterised by the following Symptoms:
• Abnormal pattern of posture and/or movement, and
• Involuntary, uncontrolled, recurring, occasionally stereotyped movements of
affected body parts
13. Ataxic CP
• Ataxia is loss of balance, coordination and fine motor control.
• Ataxic children cannot coordinate their movements. They are hypotonic during the
first 2 years of life.
• Muscle tone becomes normal and ataxiabecomes apparent toward the age of 2 to 3
years.
• Children who can walk have a wide-based gait and a mild intention tremor
(Dysmetria).
• Dexterity and fine motor control is poor.
• Ataxia is associated with cerebellar lesions. Ataxia is often combined with spastic
diplegia.
• Ataxic Cerebral Palsy is characterized by the following symptoms:
• Abnormal pattern of posture and/or movement
• Lost of orderly muscular coordination, so that movements are performed with
abnormal force, rhythm, and accuracy
14.
15. Mixed CP
• Children with a mixed type of Cerebral Palsy commonly have mild
spasticity, dystonia and/or athetoid movements.
• Ataxia may be a component of the motor dysfunction in children in this
group.
• Ataxia and spasticity often occur together.
• Spastic Ataxic Diplegia is a common mixed type that often is associated
with hydrocephalus.
16. Associated Problems
• Epilepsy
• Visual Problems
• Hearing Loss
• Speech and Communication
• Feeding Difficulty & Failure to Thrive
• Respiratory Problems
• Incontinence
• Intellectual Impairment