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Learning Objectives To know about the structure of cell membrane. To know about diffusion and diffusion through cell membrane.
Lipid Barrier of the Cell Membrane and Cell Membrane Transport Proteins
Diffusion Random molecular movement of substances molecule by molecule, either through intermolecular spaces in the membrane or in combination with a carrier protein.
Active transport Movement of ions or other substances across the membrane in combination with a carrier protein in such a way that the carrier protein causes the substance to move against an energy gradient.
Diffusion Two types of diffusion takes place across cell membrane:- 1-Simple diffusion 2-Facilitated diffusion
Simple diffusion It means the kinetic movement of molecules or ions that occurs through a membrane opening or through intermolecular spaces without any interaction with carrier proteins in the membrane.
Pathways of simple diffusion ,[object Object]
Through watery channels that penetrate all the way through some large transport proteins. ,[object Object]
Velocity of kinetic motion
Number of opening in membrane
Size of the openings,[object Object]
Diffusion of Lipid soluble substances ,[object Object]
High lipid soluble substances:-
Oxygen
Nitrogen
CO2
Alcohol,[object Object]
Diffusion through Protein channels It has two imp. characteristics:- ,[object Object]
Gating of proteins channels,[object Object]
Shape
Nature of electrical charge
Chemical bonds on inside surface,[object Object]
Inner surface  are strongly negatively charged.
These –ive charges pull small dehydrated Na ions into channel.
Once inside the channel , go in either direction.,[object Object]
K channels Selective for K ions. 0.3 by 0.3 nm in diameter. Not negatively charged. Chemical bonds are different.

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Cell Part 1

  • 1. THIS SLIDE IS PRESENTED TO YOU BY HAMZA RASHEED & MUHAMMED HAFEEZ (ADMIN OF HELP IN STUDIES ON FACEBOOK) http://www.facebook.com/group.php?v=wall&gid=319795502526 PLEASE STOP PIRACY & STEALING PEOPLE WORK, AND GET a LIFE. PEACE THANKS
  • 2.
  • 3. Learning Objectives To know about the structure of cell membrane. To know about diffusion and diffusion through cell membrane.
  • 4.
  • 5.
  • 6. Lipid Barrier of the Cell Membrane and Cell Membrane Transport Proteins
  • 7.
  • 8. Diffusion Random molecular movement of substances molecule by molecule, either through intermolecular spaces in the membrane or in combination with a carrier protein.
  • 9. Active transport Movement of ions or other substances across the membrane in combination with a carrier protein in such a way that the carrier protein causes the substance to move against an energy gradient.
  • 10. Diffusion Two types of diffusion takes place across cell membrane:- 1-Simple diffusion 2-Facilitated diffusion
  • 11.
  • 12. Simple diffusion It means the kinetic movement of molecules or ions that occurs through a membrane opening or through intermolecular spaces without any interaction with carrier proteins in the membrane.
  • 13.
  • 14.
  • 16. Number of opening in membrane
  • 17.
  • 18.
  • 19. High lipid soluble substances:-
  • 22. CO2
  • 23.
  • 24.
  • 25.
  • 26. Shape
  • 28.
  • 29. Inner surface are strongly negatively charged.
  • 30. These –ive charges pull small dehydrated Na ions into channel.
  • 31.
  • 32. K channels Selective for K ions. 0.3 by 0.3 nm in diameter. Not negatively charged. Chemical bonds are different.
  • 33.
  • 34.
  • 36.
  • 37. Voltage Gating When there is strong negative charge inside of cell membrane, it causes Na gates to remain tightly closed. When inside negativity is lost, these gates would open suddenly and Na pores inward.
  • 38.
  • 39. K gates are on intracellular ends of K channels and open when inside of CM becomes positively charged. Their opening is partly responsible for terminating action potential.
  • 40. Chemical Gating Some protein channel gates open by binding of chemical substances with the protein. It causes conformational change that opens or closes the gates. This is chemical or ligand gating.
  • 41. Example is the role of Ach in acetylcholine channels. Ach opens the channel and provide -ivity inside that allows uncharged molecules or positive ions to pass through.
  • 42. Important for transmission of nerve signal from one nerve cell to another or from nerve cell to muscle cell.