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Cellular Communication & Introduction to Drug Action  (MEDI 1203) Introduction to Pharmacology Musbah Tanira Department of Pharmacology and Clinical Pharmacy
Pharmacology Component ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Objectives ,[object Object],[object Object],[object Object],[object Object]
What is a drug? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Where the drugs come from? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is Pharmacology? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug discovery ,[object Object],[object Object],[object Object]
Drug  Development
Terminology in Pharmacology   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Terminology in Pharmacology   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Terminology in Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Discovery ,[object Object],[object Object],[object Object],[object Object]
Drug Names and Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Names and Classification ,[object Object],[object Object],[object Object],[object Object],[object Object]
How drugs are given? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ROUTES OF ADMINISTRATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cellular Communication & Introduction to Drug Action (MEDI 1203) How Do Drugs Get Absorbed Musbah Tanira Department of Pharmacology and Clinical Pharmacy
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Membrane properties ,[object Object],[object Object],[object Object],[object Object],non-polar tail phospholipid { polar head
Membrane properties Transmembrane protein Hydrophilic head Hydrophobic tail
Membrane properties ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Membrane properties
Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
pH effect ,[object Object],[object Object],[object Object],[object Object]
pH effect ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
pH effect
Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],Comparison Stomach Small intestine pH 1.5 - 4 6.7 - 8 Surface area (m 2 ) ~1 ~200 Blood flow (mL/min) 150 1000
Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bioavailability ,[object Object]

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