This document discusses how program management offices (PMOs) can be at the heart of change programs in the NHS. It provides three case studies of PMOs: 1) planning strategic programs for clinical commissioning groups, 2) delivering local health programs, and 3) delivering cost improvement programs at an NHS foundation trust. The PMOs established governance processes, regular reporting cycles, and project/program management tools to provide oversight and ensure programs were on track to achieve outcomes and savings targets. Lessons included understanding stakeholder needs, having project owners responsible for data, establishing regular reporting rhythms, and taking a holistic approach to people, processes, and technology.