Cardiac Imp Of Perio Ds
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1. The document discusses the link between periodontal (gum) disease and cardiovascular disease, with earlier research in the 1980s and 1990s finding associations between periodontal bacteria/inflammation and heart attacks or strokes. 2. Periodontal disease may increase the risk of cardiovascular disease through the effects of bacteria and inflammatory mediators on blood vessels and platelets. Common risk factors and inflammatory responses are implicated in both conditions. 3. The document reviews potential periodontal treatment approaches involving antibiotics, antiseptics, and other drugs to help manage risks for both gum and heart health. A shift toward more medical-based periodontal therapy is discussed.
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Site do Instituto Superior Miguel Torga: www.ismt.pt
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The term periodontal medicine, as first suggested by Offenbacher, that defines a rapidly emerging branch of periodontology focusing on the wealth of new data establishing a strong relationship between periodontal health or disease and systemic health or disease.
This means a two-way relationship in which periodontal disease in an individual may be a powerful influence on an individual’s systemic health or disease as well as the more customarily understood role that systemic disease may have in influencing an individual’s periodontal health or disease.It would be new diagnostic and treatment strategies that recognize the relationship between periodontal disease and systemic disease.
William Hunter, attesting to the influence of oral sepsis on systemic health and disease.
Recently scientists and clinicians have begun to provide an increasing body of scientific evidence suggesting that moderate untreated periodontitis may affect an individual systemically, and may contribute to cardiovascular disease, diabetes and pre-term low birth weight.This is important new information indeed. It appears that not just teeth are at stake in maintaining good oral health.
Rather, oral health is an important component of general health, and individuals with periodontitis may be at risk for other diseases as well.
Evidence has also shed light on the converse side of the relationship between systemic health and oral health: the potential effects of inflammatory periodontal diseases on a wide range of organ systems.Pathogenesis of periodontitis has changed remarkably over last 30 years.
The non-specific accumulation of bacterial plaque was once thought to be the cause of periodontal destruction, but it is now recognized that periodontitis is an infectious disease associated with a small number of predominantly gram-negative microorganisms that exist in a subgingival biofilm.
Furthermore, the importance of the host in disease initiation and progression is clearly recognized.
Although pathogenic bacteria are necessary for periodontal disease, they are not sufficient alone to cause the disease.
A susceptible host is also imperative. In a host who has relatively low susceptibility to disease, bacterial pathogens may have no clinical effect.
This may be due to a particularly effective host immunoinflammatory response that eliminates pathogenic organisms while minimizing destruction of native tissues.
Conversely, in a host with relatively high disease susceptibility, marked destruction of periodontal tissues may result.Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection .Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection
Acc. To William Hunter in 1900,
Oral microorganism
The Global Strategy and Teamwork for Periodontal Health and Overall Health - ...
HOT TOPIC SESSION
The Global Strategy and Teamwork for Periodontal Health and Overall Health
Filippo Graziani
FDI World Dental Congress 2016 Poznań
Biomarkers in diabetes
This document discusses biomarkers in diabetes, including:
1. Biomarkers can help improve understanding of disease processes, predict disease severity and complications, and monitor treatment efficacy.
2. Liver enzymes like ALT and GGT, inflammatory markers like CRP and IL-6, and adipokines like adiponectin have been implicated in diabetes pathogenesis.
3. Simple risk scores combining basic measures like HbA1c and lipids can effectively predict diabetes, though more research is still needed on novel biomarkers.
Cv risk puzzle in ckd
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- Proteinuria is an important risk factor for cardiovascular disease, even at low levels. It is associated with endothelial dysfunction through mechanisms like increased inflammation, asymmetric dimethylarginine, and vascular cell adhesion molecules.
- Uremic toxins play a key role in cardiovascular risk through multiple pathways like oxidative stress, inflammation, epigen
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This document provides an overview of current approaches in periodontal care. It discusses initial cause-related therapy including scaling and root planing as well as adjunctive use of antimicrobials. It also covers corrective therapy such as surgical procedures and regenerative techniques. Supportive therapy including ongoing maintenance is also emphasized. Modification of the biofilm using approaches like antimicrobial peptides and probiotics as well as modification of the host response through diet are presented as potential novel therapies. The roles of lasers in non-surgical periodontal therapy are also summarized.
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Sophie-Davis-1262012.ppt
This document discusses the potential link between periodontal disease and cardiovascular disease. It reviews evidence that periodontal disease is associated with increased risk of cardiovascular events like heart attack and stroke. The evidence includes observational studies showing associations between worse periodontal disease measures and higher levels of inflammatory biomarkers linked to cardiovascular risk. Experimental criteria for causality are examined, including strength of association, consistency across studies, biological plausibility via inflammation pathways, and dose-response relationships between periodontal disease severity and cardiovascular outcomes. While the link between the two conditions requires more research, current evidence suggests periodontal disease may increase risk of cardiovascular disease through inflammation.
Simpson edited version
This document discusses the relationship between obesity, cholesterol, triglycerides, and metabolic syndrome. It notes that adipose tissue plays a key role in inflammation and the development of cardiometabolic risk factors. Accumulation of macrophages in adipose tissue promotes inflammation linked to conditions like insulin resistance, dyslipidemia, and atherosclerosis. While removing abdominal fat does not improve risks, reducing visceral fat does help glucose and insulin sensitivity. The document also outlines assessments, lifestyle interventions, nutraceuticals, exercise, and pharmaceutical treatments for metabolic syndrome.
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Biblical Revelation On Nutrition
The document discusses biblical revelations about nutrition and health based on passages from the Bible. It states that sickness and disease plague mankind due to a lack of knowledge, and that God's words in the Bible contain the truth about health and disease prevention. It provides examples from the Bible of the types of meat, fat, and plants that are healthy to eat according to biblical teachings.
6. cvs
This document discusses the potential linkages between periodontal disease and systemic diseases like coronary heart disease and stroke. It suggests that periodontal disease may influence these conditions through three main mechanisms: shared risk factors, the periodontium acting as a reservoir for bacteria and inflammatory mediators, and transient bacteremias from periodontal infections potentially causing endothelial dysfunction. The document reviews evidence on specific inflammatory markers and pathogens that may provide biological pathways for this periodontal-systemic connection. It proposes models to explain potential direct and indirect impacts of periodontal infection on atheroma formation and thrombus development that can lead to heart disease and stroke.
Queneau
This document summarizes key points about iatrogenesis and drug-related risks in the elderly. It discusses age-related changes that increase risks, such as changes in body composition and drug distribution. Examples of high-risk drug classes are provided, like anticoagulants, psychotropic drugs, and antineoplastic agents. Specific situations that increase risks, such as polypharmacy and malnutrition, are also described.
Neuroendocrine Tumors in 2019
1. Neuroendocrine tumors (NETs) are increasing in incidence and are often metastatic at diagnosis. They originate from neuroendocrine cells and secrete hormones.
2. Somatostatin analogues are first-line treatment for symptomatic control in NETs but resistance can develop. Chemotherapy has limited efficacy except in high-grade tumors.
3. Emerging biomarkers and molecular targeted therapies such as inhibitors of angiogenesis are improving outcomes beyond traditional approaches.
Autoimmunity&Food
This document discusses the relationship between various autoimmune diseases and nutrition/food. It begins by introducing common autoimmune diseases that affect different organ systems. It then discusses evidence that vitamin D deficiency is associated with increased risk of inflammatory bowel disease and rheumatoid arthritis. Food restriction is also found to lower risk of systemic lupus erythematosus. The document focuses on links between vitamin D and multiple sclerosis, finding that low vitamin D levels correlate with higher MS risk and severity. Vitamin D is thought to have immunomodulatory effects that may help prevent and treat MS. Cow's milk consumption is also discussed in relation to increased type 1 diabetes risk through potential molecular mimicry.
Diabetes and Periodontal Disease The Relation
Dr Kaumudi Joshipura explains the relation between Diabetes and Periodontal Disease.Dr Kaumudi presently works at a Dental School at Puerto Rico and is a MPH graduate Harvard School of Public Health.
Perio And Cvd
Periodontal disease is associated with increased risk of cardiovascular disease through several mechanisms. Periodontal bacteria and their byproducts can directly infect and damage blood vessel walls or trigger body-wide inflammation. Studies have found these bacteria present in atherosclerotic plaques and higher levels in those with periodontal disease. Patients with periodontal disease have higher blood markers of inflammation like C-reactive protein which are linked to cardiovascular events. Epidemiological studies associate periodontal disease with increased risk of heart attack and stroke. However, a causal link has not been definitively proven due to other shared risk factors.
Periodontal Medicine: Impact of periodontal disease on systemic health
Periodontal medicine is an emerging branch of periodontology that focuses on relationship of periodontal health/ disease and systemic health/ disease.
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The Global Strategy and Teamwork for Periodontal Health and Overall Health - ...
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
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These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
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Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
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Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
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June 14, 2024Know the difference between Endodontics and Orthodontics.
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Cardiac Imp Of Perio Ds
- 1. CARDIAC IMPLICATIONS OF PERIODONTAL DISEASE LCDR Kurt J. Brockman, DC, USN
- 10. BECK’S CASCADE Perio Pathogen LPS Endotoxin MØ+ PGE & IL Vasodilation Vasopermeability Connective Tissue Degradation Vasculature Platelets Endothelial Deposition Smooth Muscle Deposition
Editor's Notes
- I t has long been theorized that there is a relationship between periodontal disease and cardiovascular disease. Only in the last decade, however, has science made progress in identifying what dentists have long observed; that there are cardiac implications in periodontal disease patients. As science discovers new ways to identify the specific disease process, and pathogens, the dental profession discovers new ways to manage the disease from a medical approach. The dental practitioner will be challenged with a new paradigm in the next decade and well into the new millennium. Therefore, this report is submitted to update the provider on the subject.