The document summarizes 4 studies that investigated whether coffee consumption can help prevent Alzheimer's disease. Study 1 found that caffeine reduced amyloid plaques and improved cognition in mice. Study 2 observed lower dementia risk with moderate coffee drinking in humans. Study 3 reported that Alzheimer's patients consumed less coffee than non-patients. Study 4 found decreasing dementia risk with increasing coffee intake, though there may have been errors. The document discusses flaws in study designs and potential confounding factors like coffee type. It concludes that coffee may help prevent Alzheimer's disease when consumed in moderation.
Eat less, live longer cutting back on food can help repair the body by Dr.Ma...Healthcare consultant
Eating less can boost healthier ageing by protecting the body’s cells from harmful deterioration and the risk of cancer.
Scientists know an extreme diet does not appeal to many people but say their discovery could lead to ways of mimicking its effects and pave the way for an “anti-ageing pill.
Induced Pluripotent Stem Cell (iPSC) has opened up new approaches in disease modeling, personalized medicine, cell therapy, regenerative medicine and so on.
20+ good health reasons to drink coffee2abdunatfah
There are good reasons to drink coffee and there are a few reasons not to. This article is for those that are looking for reasons to keep drinking it.
After all, you may have a caffeine-hater in your life. You know the type – they’re always telling you what’s bad for your health.
20+ good health reasons to drink coffee2
Here’s a list of some good reasons to drink coffee. Memorize this list – so the next time you encounter your favorite coffee-hater you can pull out one of these babies
Idiopathic Scoliosis is a genetic disease (complex trait)Nelson Tang
Idiopathic Scoliosis (AIS) is caused by genetic factors in a complex trait model. It predicted the success of GWAS for AIS. On the other hand, genetic markers do not predict the progression of the curve for the majority of AIS patients.
Eat less, live longer cutting back on food can help repair the body by Dr.Ma...Healthcare consultant
Eating less can boost healthier ageing by protecting the body’s cells from harmful deterioration and the risk of cancer.
Scientists know an extreme diet does not appeal to many people but say their discovery could lead to ways of mimicking its effects and pave the way for an “anti-ageing pill.
Induced Pluripotent Stem Cell (iPSC) has opened up new approaches in disease modeling, personalized medicine, cell therapy, regenerative medicine and so on.
20+ good health reasons to drink coffee2abdunatfah
There are good reasons to drink coffee and there are a few reasons not to. This article is for those that are looking for reasons to keep drinking it.
After all, you may have a caffeine-hater in your life. You know the type – they’re always telling you what’s bad for your health.
20+ good health reasons to drink coffee2
Here’s a list of some good reasons to drink coffee. Memorize this list – so the next time you encounter your favorite coffee-hater you can pull out one of these babies
Idiopathic Scoliosis is a genetic disease (complex trait)Nelson Tang
Idiopathic Scoliosis (AIS) is caused by genetic factors in a complex trait model. It predicted the success of GWAS for AIS. On the other hand, genetic markers do not predict the progression of the curve for the majority of AIS patients.
A cross sectional study of the assessment of African swine fever virus status...ILRI
Poster prepared by Joyce Akol, Michel Dione, Denis Muhangi and Charles Masembe at the 4th Medical and Veterinary Virus Research (MVVR4) Symposium, Nairobi, 15-16 October 2015
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
Hacking for Healing at SXSW InteractiveDrBonnie360
Content and Visual Design by Tiffany Simms
Do you know why you should take steps to get healthy when you already think you are healthy?
DrBonnie360 brings together Linda Avey (We Are Curious Inc.), Poonacha Machaiah (JIYO), and Nicole Guthrie (HopeLab), to present you with your #HacktoHeal.
With Chronic Disease, especially autoimmune disease, slowly creeping up on us at an epidemic level, we can no longer ignore the importance of being healthy. The stage is set for personalized prevention. The science, research, data, digital health, and patients, are all ready for personalized prevention to become a reality.
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Why Does Coffee Improve Memory?
http://buyorganiccoffee.org/1779/why-does-coffee-improve-memory/
Everyone knows that coffee help us wake up in the morning and keeping during a long day. What is also the case is that coffee can help your memory. The easy part is that if you are more awake you will pay attention better and are more likely to remember things. But, does coffee help long term memory? Medical News Today comments on coffee and women’s risk of dementia.
Researchers have long suggested that caffeine - a mild stimulant present in coffee, tea, and cola - has cognitive benefits.
A study published in the journal Nature Neuroscience in 2014, for example, identified a link between coffee intake and improved long-term memory.
The new findings - recently published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences - offer further evidence of caffeine's brain benefits, after finding the stimulant may help to stave off cognitive decline in later life.
Here is the older study first of all. The quoted article is from Nature Neuroscience, 17, 201-203 (2014) and is titled Post-study caffeine administration enhances memory consolidation in humans.
It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.
So, there is measurable proof that long term memory is improved with coffee. What the later study reported in MNT shows is that long term coffee consumption is associated with a reduced risk of dementia.
Drinking Coffee Does Not Damage Your Heart
http://buyorganiccoffee.org/1589/drinking-coffee-does-not-damage-your-heart/
There are cardiovascular benefits to drinking coffee so drink up according to an article published in the New York Post.
Researchers from the University of California San Francisco looked at 1,388 people who were taking part in a larger heart study, specifically 60 percent of group who said drinking caffeinated drinks - coffee, tea and chocolate - were part of their daily routine.
The researchers looked for heart irregularities - premature ventricular and atrial contractions - in the participants over a year, but found that there were no differences among the participants, average age 72, regardless of their caffeine intake.
Their findings go against the conventional clinical knowledge in the medical world that caffeine causes palpitations, which can lead to more chronic problems including heart failure or arrhythmias.
In fact, they discovered that “habitual coffee drinkers” actually have less of a chance of developing coronary artery disease.
This is another addition to the list of benefits of coffee, especially organic coffee.
Steps to Literature Review:
1. Define a topic
2. Choose the type of review you wish to write
3. Search and Research the literature
4. Take notes while reading
5. Start writing
Data collection methods to improve reproducibilityDigital Science
"Reproducibility, data collection, and laboratory management technologies" - Louis Culot, CEO of Biodata
Slides from Shaking It Up: Challenges and Solutions in Scholarly Information Management, San Francisco, April 22, 2015
A cross sectional study of the assessment of African swine fever virus status...ILRI
Poster prepared by Joyce Akol, Michel Dione, Denis Muhangi and Charles Masembe at the 4th Medical and Veterinary Virus Research (MVVR4) Symposium, Nairobi, 15-16 October 2015
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
Hacking for Healing at SXSW InteractiveDrBonnie360
Content and Visual Design by Tiffany Simms
Do you know why you should take steps to get healthy when you already think you are healthy?
DrBonnie360 brings together Linda Avey (We Are Curious Inc.), Poonacha Machaiah (JIYO), and Nicole Guthrie (HopeLab), to present you with your #HacktoHeal.
With Chronic Disease, especially autoimmune disease, slowly creeping up on us at an epidemic level, we can no longer ignore the importance of being healthy. The stage is set for personalized prevention. The science, research, data, digital health, and patients, are all ready for personalized prevention to become a reality.
We Are Curious, JIYO, and Hopelab bring SXSW the steps to finding and maintaining their optimal health.
The key to all this is finding the right feedback loops for each of you and maintaining balance.
Medicinal plants and alzimer A series of LecturesByMr. Allah Dad Khan for...Mr.Allah Dad Khan
A series of LecturesByMr. Allah Dad Khan former Director General Agriculture Extension Khyber Pakhtunkhwa Province and Visiting Professor the University of Agriculture Peshawar Pakistan allahdad52@gmail.com
Why Does Coffee Improve Memory?
http://buyorganiccoffee.org/1779/why-does-coffee-improve-memory/
Everyone knows that coffee help us wake up in the morning and keeping during a long day. What is also the case is that coffee can help your memory. The easy part is that if you are more awake you will pay attention better and are more likely to remember things. But, does coffee help long term memory? Medical News Today comments on coffee and women’s risk of dementia.
Researchers have long suggested that caffeine - a mild stimulant present in coffee, tea, and cola - has cognitive benefits.
A study published in the journal Nature Neuroscience in 2014, for example, identified a link between coffee intake and improved long-term memory.
The new findings - recently published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences - offer further evidence of caffeine's brain benefits, after finding the stimulant may help to stave off cognitive decline in later life.
Here is the older study first of all. The quoted article is from Nature Neuroscience, 17, 201-203 (2014) and is titled Post-study caffeine administration enhances memory consolidation in humans.
It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.
So, there is measurable proof that long term memory is improved with coffee. What the later study reported in MNT shows is that long term coffee consumption is associated with a reduced risk of dementia.
Drinking Coffee Does Not Damage Your Heart
http://buyorganiccoffee.org/1589/drinking-coffee-does-not-damage-your-heart/
There are cardiovascular benefits to drinking coffee so drink up according to an article published in the New York Post.
Researchers from the University of California San Francisco looked at 1,388 people who were taking part in a larger heart study, specifically 60 percent of group who said drinking caffeinated drinks - coffee, tea and chocolate - were part of their daily routine.
The researchers looked for heart irregularities - premature ventricular and atrial contractions - in the participants over a year, but found that there were no differences among the participants, average age 72, regardless of their caffeine intake.
Their findings go against the conventional clinical knowledge in the medical world that caffeine causes palpitations, which can lead to more chronic problems including heart failure or arrhythmias.
In fact, they discovered that “habitual coffee drinkers” actually have less of a chance of developing coronary artery disease.
This is another addition to the list of benefits of coffee, especially organic coffee.
Steps to Literature Review:
1. Define a topic
2. Choose the type of review you wish to write
3. Search and Research the literature
4. Take notes while reading
5. Start writing
Data collection methods to improve reproducibilityDigital Science
"Reproducibility, data collection, and laboratory management technologies" - Louis Culot, CEO of Biodata
Slides from Shaking It Up: Challenges and Solutions in Scholarly Information Management, San Francisco, April 22, 2015
Wagner College Forum for Undergraduate Research, Vol. 18 No. 1Wagner College
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Monitor common gases, weather parameters, particulates.
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Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
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of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
1. Can Coffee help prevent
Alzheimer’s Disease?
Suthapat Sathityatiwat
5380055
2. Method of Research
• Search Engines:
– Scopus
– Google Scholar
– Science Direct
• Key Words:
– Alzheimer’s
– Coffee
– Mice
– Human
3. Overview
What is Alzheimer’s Disease?
4 Study Cases: Important Results
Discussion
Flaws
Confounders
Conclusion
4. What causes Alzheimer’s disease?
Plague of ß-amyloid proteins
• Increase in level of ß-Amyloid in the brain.
1. Alzheimer’s Association. (n.d.). Brain Plaques and Tangles. Alzheimer's Association. Retrieved March 17, 2014, from http://www.alz.org/braintour/
2. Arendash, G. W., Schleif, W., Rezai-Zadeh, K., Jackson, E. K., Zacharia, L., Cracchiolo, J. R., et al. (2006). Caffeine protects alzheimer's mice against
sognitive impairment and reduces brain ß-Amyloid production. Neuroscience, 142, 941-952.
3. Alzheimer’s Association. (n.d.). What is Alzheimer's?. Alzheimer's Association. Retrieved March 15, 2014, from http://www.alz.org alzheimers
What is Alzheimer’s Disease?
• Alzheimer’s disease:
– The most common form of dementia
• Dementia
– memory loss and decline in other intellectual
abilities.
5. Paper #1 Paper #2 Paper #3 Paper #4
Point-of-View For For For Against
Subject mice human human human
N (Male:Female) 57 1409 (534:875) 54 pairs (26: 28) 3494 (all male)
Background - Eastern Finland Caucasians Japanese American
mean age (yrs.) initial: 4 months
Final: 9½ months
Mid-life: 50.4
Late-life: 71.3
70.8±7.75 Mid-life: 55
Late-life: 82
Duration (yrs.) 5½ months 21 20 27
Comparison
Group
Control : NT and Tg
Case: Tg+caff
L (0-2 cup/day)
M (3-5 cup/day)
H (>5 cup/day)
AD vs. non-AD
patients
0 (oz./day)
4-8 (oz./day)
12-16 (oz./day)
≥20 (oz./day)
Measurement 9 behavioral tests Questionnaire Interviews Interviews
e.g.
Morris Water Maze
Health check Computerized axial
tomography or MRI
Computed
tomography or MRI
Soluble/insoluble
ß-Amyloid levels
Cognitive test Cognitive test Cognitive test
- Coffee
consumption
Coffee
consumption
Coffee
consumption
4 Study Cases
6. Paper #1
Point-of-View For
Subject mice
N (Male:Female) 57
Background -
mean age (yrs.) initial: 4 months
Final: 9½ months
Duration (yrs.) 5½ months
Comparison
Group
Control :
Nontransgenic and
Transgenic
Case:
Transgenic+caffeine
Measurement 19 behavioral tests
e.g. Morris Water Maze
Soluble/insoluble ß-Amyloid levels
Paper #1
“Caffeine Protects Alzheimer’s Mice
Against Cognitive Impairment and Reduces
Brain ß-Amyloid Production”
Neuroscience (2006)
Author: Gary W. Arendash*1,2, W. Schleif, K. Rezai-
Zadeh, E.K. Jackson, L. C. Zacharia, J. R. Cracchiolo, D.
Shippy and J. Tan
*1 The Florida Alzheimer’s Disease Research Center,
Tampa, FL, USA
*2 Department of Cell Biology, Microbiology, and
Molecular Biology, University of South Florida, Tampa,
FL, USA
1.5 mg/day = human’s 5 cups/day
4 Study Cases
7. Soluble/insoluble Amyloid-ß levels
1. Arendash, G. W., & Cao, C. (2010). Caffeine and Coffee as Therapeutics Against Alzheimer's Disease. Journal of Alzheimer's Disease, 20, S117-S126.
8. Paper #1
Point-of-View For
Subject mice
N
(Male:Female)
57
Background -
mean age (yrs.) initial: 4 months
Final: 9½ months
Duration (yrs.) 5½ months
Comparison
Group
Control :
Nontransgenic and
Transgenic
Case:
Transgenic+caffeine
Measurement 19 behavioral tests
e.g. Morris Water Maze
Soluble/insoluble ß-Amyloid levels
4 Study Cases
1. Arendash, G. W., Schleif, W., Rezai-Zadeh, K., Jackson, E. K., Zacharia, L.,
Cracchiolo, J. R., et al. (2006). Caffeine protects alzheimer's mice against cognitive impairment
and reduces brain ß-Amyloid production. Neuroscience, 142, 941-952.
Results
37%32%
9. Paper #2
Point-of-View For
Subject human
N (Male:Female) 1409 (534:875)
Background Eastern Finland
mean age (yrs.) Mid-life: 50.4
Late-life: 71.3
Duration (yrs.) 21
Comparison Group L (0-2 cup/day)
M (3-5 cup/day)
H (>5 cup/day)
Measurement Questionnaire
Health check
Cognitive test
Coffee consumption
Paper #2:
“Midlife Coffee and Tea Drinking and the
Risk of Late-Life Dementia:
A Population-Based CAIDE Study”
Author:
Marjo H. Eskelinen*, Tiia Ngandu, Jaakko Tuomilehto,
Hilkka Soininen, and Miia Kivipelto
*Department of Neurology, University of Duopio, P.O.
Kuopio, Finland
4 Study Cases
Result
Hypothesis:
Drinking coffee decreases
the chance of getting
Alzheimer’s Disease (DA)
62%-64%
10. Paper #3
Point-of-View For
Subject human
N (Male:Female) 54 pairs (26: 28)
Background Caucasians
mean age (yrs.) 70.8±7.75
Duration (yrs.) 20
Comparison
Group
Control: non-AD
Case: AD
Measurement Interviews
Computerized axial
tomography or MRI
Cognitive test
Coffee consumption
Paper #3:
“Does Caffeine Intake Protect from Alzheimer’s
Disease?”
Author: Gary W. Arendash*1,2 and Chuanhai Cao
*1 The Florida Alzheimer’s Disease Research Center, Tampa, FL,
USA
*2 Department of Cell Biology, Microbiology, and Molecular
Biology, University of South Florida, Tampa, FL, USA
0-99 mg/day
100-200 “
201-300 “
301-400 “
401-500 “
501-600 “
4 Study Cases
Result
Hypothesis:
AD patient drank less coffee
compared to non-AD
11. Paper #4
Point-of-View Against
Subject human
N (Male:Female) 3494 (all male)
Background Japanese American
mean age (yrs.) Mid-life: 55
Late-life: 82
Duration (yrs.) 27
Comparison
Group
0 (oz./day)
4-8 (oz./day)
12-16 (oz./day)
≥20 (oz./day)
Measurement Interviews
Computed tomography or MRI
Cognitive test
Coffee consumption
Paper #4:
“Coffee Intake in Midlife and Risk of Dementia
and its Neuropathologic Correlates”
Author:
Rebecca P. Gerlber*, Helen Petrovitch, Kamal H. Masaki, G.
Webster Ross, and Lon R. White
* Honolulu-Asia Aging Study at Kuakini Medical Center, the VA
Pacific Islands Healthcare System, Department of Medicine,
University of Hawaii, John A. Burns School of Medicine,
Homolulu, HI, USA
4 Study Cases
Result
(25/588)*100%= 4.25% 3.63% 3.50% 3.02% 1.80%
Possible error in data
analysis???
12. Discussion
• Flaws in Research Design
– Paper #1: Mice vs. Human
– Paper #2: measurement method might not give
accurate enough result.
– Paper #3: only 54 pairs
– Paper #4: possible error in data analysis?
13. Confounders
Types of coffee Method of Preparation
– Robusta
– Arabica
Green coffee beans
Green coffee beans
Roasted
Roasted
Filtered or non-filtered?
Filtered or non-filtered?
14. Arabica vs. Robusta
x 3
Green
Coffee
Beans
Roasted
Coffee
Beans
1. Alves, R. C., Casal, S., Alves, M. R., & Oliveira, M. B. (2009). Discrimination between arabica and robusta coffee species on the basis of their tocopherol
profiles. Food Chemistry, 114, 295-299.
15. Conclusion
What is Alzheimer’s Disease?
4 Study Cases: Important Results
Discussion
Flaws
Confounders
Conclusion
Coffee can help prevent Alzheimer’s disease.
Drink coffee, but in moderation.
16. Reference
Alves, R. C., Casal, S., Alves, M. R., & Oliveira, M. B. (2009). Discrimination between arabica and robusta
coffee species on the basis of their tocopherol profiles. Food Chemistry, 114, 295-299.
Alzheimer’s Association. (n.d.). Brain Plaques and Tangles. Alzheimer's Association. Retrieved March 17, 2014,
from http://www.alz.org/braintour/plaques_tangles.aspAlzheimer’s Association. (n.d.). What is
Alzheimer's?.
Alzheimer's Association. Retrieved March 15, 2014, from
http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp
Arendash, G. W., Schleif, W., Rezai-Zadeh, K., Jackson, E. K., Zacharia, L., Cracchiolo, J. R., et al. (2006).
Caffeine protects alzheimer's mice against cognitive impairment and reduces brain ß-Amyloid production.
Neuroscience, 142, 941-952.
Arendash, G. W., & Cao, C. (2010). Caffeine and Coffee as Therapeutics Against Alzheimer's Disease. Journal
of Alzheimer's Disease, 20, S117-S126.
Eskelinen, M. J., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009). Midlife coffee and tea
drinking and the risk of late-life dementia: A population-based CAIDE study. Journal of Alzheimer's
Disease, 16, 85-91.
John, S. (2010, November 25). Morris Water Maze. Wikipedia. Retrieved March 17, 2014, from
http://en.wikipedia.org/wiki/File:MorrisWaterMaze.svg
Maia, L., & Mendonca, A. d. (2002). Does caffeine intake protect from Alzheimer's disease?. European Journal
of Neurology, 9, 377-382.