This document discusses caffeine, including its history, sources, mechanism of action, metabolism, extraction processes, health benefits, negative side effects, and effects on heart disease. Some key points include:
- Caffeine acts as an antagonist of adenosine receptors in the brain, blocking the effects of adenosine and increasing neuronal activity.
- It is metabolized in the liver into compounds like paraxanthine and theobromine that also have physiological effects.
- Moderate caffeine intake from sources like coffee has potential health benefits but high intake is linked to increased risk of heart disease and other negative side effects.
- Decaffeination processes are used commercially to remove caffeine from coffee while retaining
Au-delà des nombreux bienfaits de la consommation à dose faible ou modérée, les conclusions de l'étude précisent que les effets indésirables pour les adultes (anxiété, agitation, insomnie, rythme cardiaque, etc.), qui n'ont pas de complexités de santé, pourraient intervenir à partir d'une consommation de 400 mg de caféine par jour. Cette dose étant réduite à 200 mg pour les femmes enceintes ou allaitantes.
L'étude n'aborde pas le sujet de l’acrylamide, substance chimique qui a poussé en 2018 l'Etat de Californie à adopter une législation stipulant que le café devait porter une étiquette d'avertissement sur le cancer.
EFFECT OF CAFFEINE IN CARDIOVASCULAR HEALTH- A DOUBLE.pptxDENirmanKanna
Caffeine (1,3,7-trimethylxanthine) is an alkaloid which act as a central nervous system (CNS) stimulant, that is naturally found in many different plants such as coffee beans, cocoa beans, tea leaves, guarana berries and the kola nut. It can also be artificially synthesized for use as a food additive, in dietary supplements, even medications in over the counter or pharmaceutical preparations where synthetic caffeine is identical to intrinsic or plant-derived caffeine. Many studies says that intake of caffeine in the safe dose range has been associated with a reduction in the risk of chronic diseases, especially cardiovascular disease. There is evidence that caffeine intake has both protective and negative effects on cardiovascular diseases, so we named caffeine as a double edge sword. In this review, we had explained about safe dose range of caffeine, positive and negative effects of caffeine in cardiovascular health.
Au-delà des nombreux bienfaits de la consommation à dose faible ou modérée, les conclusions de l'étude précisent que les effets indésirables pour les adultes (anxiété, agitation, insomnie, rythme cardiaque, etc.), qui n'ont pas de complexités de santé, pourraient intervenir à partir d'une consommation de 400 mg de caféine par jour. Cette dose étant réduite à 200 mg pour les femmes enceintes ou allaitantes.
L'étude n'aborde pas le sujet de l’acrylamide, substance chimique qui a poussé en 2018 l'Etat de Californie à adopter une législation stipulant que le café devait porter une étiquette d'avertissement sur le cancer.
EFFECT OF CAFFEINE IN CARDIOVASCULAR HEALTH- A DOUBLE.pptxDENirmanKanna
Caffeine (1,3,7-trimethylxanthine) is an alkaloid which act as a central nervous system (CNS) stimulant, that is naturally found in many different plants such as coffee beans, cocoa beans, tea leaves, guarana berries and the kola nut. It can also be artificially synthesized for use as a food additive, in dietary supplements, even medications in over the counter or pharmaceutical preparations where synthetic caffeine is identical to intrinsic or plant-derived caffeine. Many studies says that intake of caffeine in the safe dose range has been associated with a reduction in the risk of chronic diseases, especially cardiovascular disease. There is evidence that caffeine intake has both protective and negative effects on cardiovascular diseases, so we named caffeine as a double edge sword. In this review, we had explained about safe dose range of caffeine, positive and negative effects of caffeine in cardiovascular health.
EFFECT OF CAFFEINE IN CARDIOVASCULAR HEALTH- A DOUBLE.pptxDENirmanKanna
Caffeine (1,3,7-trimethylxanthine) is an alkaloid which act as a central nervous system (CNS) stimulant, that is naturally found in many different plants such as coffee beans, cocoa beans, tea leaves, guarana berries and the kola nut. It can also be artificially synthesized for use as a food additive, in dietary supplements, even medications in over the counter or pharmaceutical preparations where synthetic caffeine is identical to intrinsic or plant-derived caffeine. Many studies says that intake of caffeine in the safe dose range has been associated with a reduction in the risk of chronic diseases, especially cardiovascular disease. There is evidence that caffeine intake has both protective and negative effects on cardiovascular diseases, so we named caffeine as a double edge sword. In this review, we had explained about safe dose range of caffeine, positive and negative effects of caffeine in cardiovascular health.
Presentation during the Bureau of Agricultural Research (BAR) Seminar Series on January 26, 2017 at RDMIC Bldg., cor. Visayas Ave., Elliptical Rd., Diliman, Quezon City
So during quarantine, it is very important to stay in shape and stay fit. This doesn’t just cover from your workout but also a very healthy diet. Therefore, Green tea is actually SCIENTIFICALLY PROVEN to have great health effects! It doesn’t just help you burn fat, but also keeps your mind fresh! As you know, Staying mentally fit is AS important as staying physically fit.
20+ good health reasons to drink coffee2abdunatfah
There are good reasons to drink coffee and there are a few reasons not to. This article is for those that are looking for reasons to keep drinking it.
After all, you may have a caffeine-hater in your life. You know the type – they’re always telling you what’s bad for your health.
20+ good health reasons to drink coffee2
Here’s a list of some good reasons to drink coffee. Memorize this list – so the next time you encounter your favorite coffee-hater you can pull out one of these babies
Caffeine-Pharmacology and other info by DrugsInfoAkash Agnihotri
It's is all you need to know about caffeine. All the information available in this ppt, made by authenticated sources. That is following evidence-based medicine process.
Follow @drugs_info_ on Instagram
@drugsinfo01 on facebook and
youtube/DrugsInfo
While low to moderate doses are generally safe, caffeine is addictive and users can become dependent on it and find it difficult to quit or even cut back.Caffeine dependence was even named as a new mental disorder this year. Anyone who's ever quit cold turkey knows it can trigger pounding headaches, mental fuzziness and fatigue for a couple of days until the body adjusts.
EFFECT OF CAFFEINE IN CARDIOVASCULAR HEALTH- A DOUBLE.pptxDENirmanKanna
Caffeine (1,3,7-trimethylxanthine) is an alkaloid which act as a central nervous system (CNS) stimulant, that is naturally found in many different plants such as coffee beans, cocoa beans, tea leaves, guarana berries and the kola nut. It can also be artificially synthesized for use as a food additive, in dietary supplements, even medications in over the counter or pharmaceutical preparations where synthetic caffeine is identical to intrinsic or plant-derived caffeine. Many studies says that intake of caffeine in the safe dose range has been associated with a reduction in the risk of chronic diseases, especially cardiovascular disease. There is evidence that caffeine intake has both protective and negative effects on cardiovascular diseases, so we named caffeine as a double edge sword. In this review, we had explained about safe dose range of caffeine, positive and negative effects of caffeine in cardiovascular health.
Presentation during the Bureau of Agricultural Research (BAR) Seminar Series on January 26, 2017 at RDMIC Bldg., cor. Visayas Ave., Elliptical Rd., Diliman, Quezon City
So during quarantine, it is very important to stay in shape and stay fit. This doesn’t just cover from your workout but also a very healthy diet. Therefore, Green tea is actually SCIENTIFICALLY PROVEN to have great health effects! It doesn’t just help you burn fat, but also keeps your mind fresh! As you know, Staying mentally fit is AS important as staying physically fit.
20+ good health reasons to drink coffee2abdunatfah
There are good reasons to drink coffee and there are a few reasons not to. This article is for those that are looking for reasons to keep drinking it.
After all, you may have a caffeine-hater in your life. You know the type – they’re always telling you what’s bad for your health.
20+ good health reasons to drink coffee2
Here’s a list of some good reasons to drink coffee. Memorize this list – so the next time you encounter your favorite coffee-hater you can pull out one of these babies
Caffeine-Pharmacology and other info by DrugsInfoAkash Agnihotri
It's is all you need to know about caffeine. All the information available in this ppt, made by authenticated sources. That is following evidence-based medicine process.
Follow @drugs_info_ on Instagram
@drugsinfo01 on facebook and
youtube/DrugsInfo
While low to moderate doses are generally safe, caffeine is addictive and users can become dependent on it and find it difficult to quit or even cut back.Caffeine dependence was even named as a new mental disorder this year. Anyone who's ever quit cold turkey knows it can trigger pounding headaches, mental fuzziness and fatigue for a couple of days until the body adjusts.
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1. Caffeine :
Good & bad effects on human
Food Engineering and Technology Department
Tezpur University, Tezpur, Assam, 784028
Presenting by
Jayanta Pal (FPL 13015)
Yesmin Ara Begum (FPL 13004)
2. INTRODUCTION
Caffeine (1,3,7-trimethylxanthine) is a purine alkaloid that
occurs naturally in coffee beans
Some physiological effects associated with caffeine
administration include central nervous system stimulation,
acute elevation of blood pressure, increased metabolic rate,
and diuresis.
Caffeine is rapidly and almost completely absorbed in the
stomach and small intestine and distributed to all tissues,
including the brain.
It is found in varying quantities in the seeds, leaves
fruits of some plants, where it act as a natural
pesticide.
Beverage containing coffee such as coffee, tea
soft drinks, & energy drinks.
3. HISTORY
1st use of caffeine as early as 600,000 BCE .
1820 - Caffeine was first isolated from coffee by German chemist Friedlieb
Ferdinand Runge,.
1821 - . Pelletier coined the term "caffeine" from the French word for coffee
(café), and this term became the English word "caffeine".
1821 - Pure caffeine extracted from coffee.
1880 - Caffeinated soft drinks appear.
1903 - Researchers remove caffeine from beans ‘without destroying the flavor’.
1923 - Decaffeinated coffee is introduced to the United States.
1940 - The US imports 70 percent of the world coffee crop.
1962 - American per-capita coffee consumption peaks at more than three cups
a day.
1995 - Coffee becomes the worlds most popular beverage (overtaking tea ) .
5. Which Foods and Beverages Contain Caffeine
Table 1. Caffeine source and amount of caffeine content
6. Mechanism of Action
Caffeine's primary mechanism of
action is as an
antagonist of adenosine receptors
in the brain.
Adenosine in the Brain
In the brain neurons are transmitting
electrical energy.
When activity is too high adenosine
molecules stop the neuron cells
from firing.
Caffeine blocks adenosine
receptors with its own
molecule preventing the
adenosine molecule from
binding.
Brain activity remains at its
excited state and can even
increase in activity because
adenosine is unable to slow
it down.
7. The binding of Adenosine
to an adenosine receptor
causes the receptor to
undergo a shape change
which triggers a
biochemical cascade. The
end result is the opening of
ion channels and the
slowing of activity.
The binding of caffeine to
a adenosine receptor
causes a shape change
that does not initiate a
biochemical cascade.
Instead, neuronal activity
remains the same or
increase.
Adenosine Caffeine
Adenosine
Receptor
Adenosine
Receptor
8. Caffeine Metabolism
Caffeine is metabolized in liver results into three
metabolic dimethylxanthines, each of which has its
own effects on the body:
Paraxanthine : Increases lipolysis, leading to
elevated glycerol and free fatty acid levels in
the blood plasma.
Theobromine : Dilates blood vessels and
increases urine volume.
Theophylline : Relaxes smooth muscles of the
bronchi, and is used to treat asthma.
11. Health Benefits of Caffeine
Caffeine helps ward off Alzheimer’s.
In Japan researchers have shown that caffeine
increases memory.
Caffeine detoxes the liver and cleanses the colon
when taken as a caffeine enema.
Caffeine can stimulate hair growth on balding men
and women.
Caffeine relieves post work-out muscle pain by up
to 48%.
Caffeine can ease depression by increasing
dopamine in the brain.
12. Caffeine increases stamina during exercise.
Caffeine protects against eyelid spasm.
Caffeine may protect against Cataracts.
Caffeine may prevent skin cancer. A new study
out of Rutgers University found that caffeine
prevented skin cancer in hairless mice.
People who consume caffeine have a lower risk
of suicide.
Caffeine may reduce fatty liver in those with
non-alcohol related fatty liver disease. This study
comes out of Duke University.
13. Caffeine For Treatment of Alzheimer Disease (AD)
Epidemiologic studies have increasingly
suggested that caffeine could be an effective
therapeutic against Alzheimer’s disease (AD).
An in vivo experiments was conducted on a
transgenic mouse model for AD to determine if
caffeine have beneficial actions to protect
against or reverse AD-like cognitive impairment
and AD pathology.
14. AD transgenic (Tg) mice of age between
4 and 9 months were given (300 mg/L)
caffeine in their drinking water from young
adulthood into older age.
The resultant amount of caffeine intake
for each mouse (approximately 1.5
mg/day) was the human equivalent of
500 mg or 5 cups of coffee per day
showed protection against memory
impairment and lower brain levels of the
abnormal protein (amyloid-β; Aβ).
15. Fig. 3. Result of effect of caffeine on Alzheimer Disease
16. The effect of acute administration of
caffeinated and decaffeinated
coffee on transgenic was also
studied .
At 3 hours following treatment,
plasma Aβ1−40 levels in 3-month old
Tg mice were substantially reduced
by 41%.
By contrast, decaffeinated coffee
and saline treatments had no effect
on plasma Aβ1−40 levels.
17. Fig. 4 . Ability of (caffeinated) coffee to acutely suppress plasma Aβ levels,
but not de-caffeinated coffee or saline control
18. A similar finding was found in a
clinical extension of this study in AD
mice.
This initial clinical studies reported
that acute oral caffeine
administration (400 mg) to aged
humans induces an immediate
decrease in blood Aβ levels.
19. Negative Side Effects of Caffeine
Effects on Heart Rate and Blood
Pressure
Osteoporosis
Diabetes
Loss of sleep
Fertility and miscarriage
Hormonal Effects
21. Bad Effect of Caffeine on Coronary Heart
Diseases
Several studies have examined the relationship between
coffee consumption and coronary heart disease (CHD)
risk. In general, case-control studies have found high
coffein intakes to be associated with significantly
increased risk of CHD or myocardial infarction (MI).
Two separate meta-analyses that combined the results
of eight case-control studies found that CHD risk was 40–
60% higher in those who consumed 5 or more cups of
coffee daily compared to those who did not drink
coffee.
22. The effect of coffee or caffeine consumption on people
with established CHD has not been well studied. One
case-control study found that heavy coffee
consumption, defined as more than 10 cups daily, was
associated with a significant increase in the risk of
sudden cardiac arrest in patients with established
coronary artery disease.
However, a multi center prospective study of 1935
patients who survived a MI found no association
between coffee consumption and survival over the next
4 years, even in the heaviest coffee consumers.
It should be noted that few patients reported consuming
more than 5-10 cups of coffee daily in all study.
23. Decaffeination
Decaffeination is a commercial process used to remove caffeine
from coffee.
There are four major commercial processes used to remove
caffeine from coffee.
a) Conventional decaffeination uses the chemical Methylene
Chloride.
b) "Natural" decaffeination uses the chemical Ethyl Acetate.
c) Water decaffeination uses water.
d) Carbon Dioxide decaffeination uses CO2 (SCFE).
24. Benefits of Decaffeination
Decaffeination markedly reduces the
amount of caffeine in a product without
affecting the flavor,
Making a Choice
The choice of caffeinated versus
decaffeinated comes down to personal
preference, states Fit Day. Caffeine is safe
when consumed regularly in moderate
amounts.
27. Conclusion
The good and bad of caffeine
Caffeine is part of modern life. Regular coffee
drinkers include the majority of adults and a growing
number of children. The recommendation for most
people is to enjoy one or two cups of coffee a day,
which will allow you to capitalize on its health benefits
without incurring health drawbacks. Extensive recent
research has put forth that coffee is far more healthful
than it is harmful. Very little bad and a lot of good
come from drinking it.
28. References
Carrillo, J.A., and Benitez, J. 2000. Clinically significant pharmacokinetic interactions
between dietary caffeine and medications. Clin. Pharmacokinet, 39:127–153.
de Vreede-Swagemakers, J.J., Gorgels, A.P., Weijenberg, M.P. et al. 1999. Risk indicators
for out-of-hospital cardiac arrest in patients with coronary artery disease. J. Clin
Epidemiol., 52:601–607.
Gary W. Arendasha,b,∗ and Chuanhai Caob,c. 2010. “Caffeine and Coffee as
Therapeutics Against Alzheimer’s Disease” Journal of Alzheimer’s Disease 20 S117–S126
Greenland, S. 1993. A meta-analysis of coffee, myocardial infarction, and coronary death.
Epidemiology., 4:366–374.
Hammar, N., Andersson, T., Alfredsson, L. et al. 2003. Association of boiled and filtered
coffee with incidence of first nonfatal myocardial infarction: the SHEEP and the VHEEP
study. J. Intern. Med., 253:653–659.
Haskó G, Linden J, Cronstein B, Pacher P (September 2008). "Adenosine receptors:
therapeutic aspects for inflammatory and immune diseases". Nat Rev Drug Discov 7 (9):
759–70. doi:10.1038/nrd2638. PMC 2568887. PMID 18758473.
29. Higdon, Jane V., And Frei, Balz., 2006. ” Coffee and Health: A Reviewof Recent
Human Research”. Critical Reviews in Food Science and Nutrition, 46:101–123
http://www.energyfiend.com/top-10-caffeine-health-benefits
James, J.E. 2004. Critical review of dietary caffeine and blood pressure:A relationship
that should be taken more seriously. Psychosom. Med.,66:63–71.
Kawachi, I., Colditz, G. A., and Stone, C. B. 1994. Does coffee drinking increase the
risk of coronary heart disease? Results from a meta-analysis. Br. Heart J., 72:269–275.
Kuffler SW, Edwards C (November 1958). "Mechanism of gamma aminobutyric acid
(GABA) action and its relation to synaptic inhibition". J. Neurophysiol. 21 (6): 589–610.
PMID 13599049.
Mukamal, K.J., Maclure, M., and Muller, J.E., 2004. Caffeinated coffee consumption
and mortality after acute myocardial infarction. Am. Heart J., 147:999–1004.
Spiller, M.A. 1998. The Chemical Components of Coffee. In: Caffeine.pp. 97–161.
Spiller, G. A., Ed., CRC Press, Boca Raton.
Tavani, A., Bertuzzi, M., Negri, E. et al. 2001. Alcohol, smoking, coffee and risk of non-
fatal acute myocardial infarction in Italy. Eur. J. Epidemiol., 17:1131–1137
30. Food Engineering and Technology Department
Tezpur University, Tezpur, Assam, 784028