1. Coronary artery disease (CAD) occurs when there is an imbalance between the oxygen supply and demand of the heart muscle, usually due to atherosclerosis of the coronary arteries. 2. CAD is the leading cause of death worldwide for those over age 20 and prevalence increases with age. 3. Risk factors for CAD include hypertension, diabetes, dyslipidemia, smoking, obesity, and sedentary lifestyle. 4. Treatment involves medication, percutaneous interventions such as stents, and coronary artery bypass grafting depending on the severity and location of blockages.