Caco-2 cells are used for studying cell permeability of drug cadidates because: Select all that apply. 1.They absorb many drugs 2.They are similar to GI epithelial cells and are good for mimicking the human colon 3.They grow into a tight monolayer and hydrophilic drugs generally cannot pass through freely 4.They express membrane transporters for many small molecules Solution Caco2 cells are used for studying absorption of meny drugs. They are derived from colon cancer The cells have similarities with enterocytes lining the GI tract. The cells have to tight junctions. The cells cannot used as individual cells, but used as monolayer on filter. Hydrophilic drugs like metformin has poor pentration capacity. They have membrane transporters for small molecules. Hence all are correct answers..

1. Caco-2 cells are used for studying cell permeability of drug cadidates because:
Select all that apply.
1.They absorb many drugs
2.They are similar to GI epithelial cells and are good for mimicking the human colon
3.They grow into a tight monolayer and hydrophilic drugs generally cannot pass through freely
4.They express membrane transporters for many small molecules
Solution
Caco2 cells are used for studying absorption of meny drugs. They are derived from colon
cancer The cells have similarities with enterocytes lining the GI tract. The cells have to tight
junctions. The cells cannot used as individual cells, but used as monolayer on filter. Hydrophilic
drugs like metformin has poor pentration capacity. They have membrane transporters for small
molecules. Hence all are correct answers.