Ikai Lan gave a talk about building cloud applications using Google App Engine. They demonstrated TweetEngine, an open source Twitter application built on App Engine, to explain key concepts. These included OAuth for secure authentication, internationalization (i18n) for localized versions, AppStats for application profiling, and Task Queues for background processing. The talk aimed to show how App Engine handles infrastructure concerns so developers can focus on code, and whet the audience's appetite for building cloud applications.