A Comparison of Different Strategies for Automated Semantic Document AnnotationAnsgar Scherp
We introduce a framework for automated semantic document annotation that is composed of four processes, namely concept extraction, concept activation, annotation selection, and evaluation. The framework is used to implement and compare different annotation strategies motivated by the literature. For concept extraction, we apply entity detection with semantic hierarchical knowledge bases, Tri-gram, RAKE, and LDA. For concept activation, we compare a set of statistical, hierarchy-based, and graph-based methods. For selecting annotations, we compare top-k as well as kNN. In total, we define 43 different strategies including novel combinations like using graph-based activation with kNN. We have evaluated the strategies using three different datasets of varying size from three scientific disciplines (economics, politics, and computer science) that contain 100, 000 manually labeled documents in total. We obtain the best results on all three datasets by our novel combination of entity detection with graph-based activation (e.g., HITS and Degree) and kNN. For the economic and political science datasets, the best F-measure is .39 and .28, respectively. For the computer science dataset, the maximum F-measure of .33 can be reached. The experiments are the by far largest on scholarly content annotation, which typically are up to a few hundred documents per dataset only.
Gregor Große-Bölting, Chifumi Nishioka, and Ansgar Scherp. 2015. A Comparison of Different Strategies for Automated Semantic Document Annotation. In Proceedings of the 8th International Conference on Knowledge Capture (K-CAP 2015). ACM, New York, NY, USA, , Article 8 , 8 pages. DOI=http://dx.doi.org/10.1145/2815833.2815838
Big Data Analysis: The curse of dimensionality in official statisticsDario Buono
Statistical authorities need to produce accurate data faster and in a cost effective way, to become more responsive to users´ demands, while at the same time continuing to provide high quality output. One way to fulfil this is to make use of all new accessible data sources, as for example administrative data and big data. As a result, statistical offices will have to deal more and more with a "huge" number" of time series, in particular for producing model based statistics.
Using high dimensional datasets will most likely urge statistical authorities to follow a different approach, in particular to be conscious that the measurement of socio-economic variables will follow more and more non-linear processes that could not be described by probability distributions that could be easily described by few parameters.
It will thus imply to adapt the way to observe the world through data taking into account at a greater extent uncertainty and complexity, which will in turn impact dissemination and communication activities of statistical authorities.
A Comparison of Different Strategies for Automated Semantic Document AnnotationAnsgar Scherp
We introduce a framework for automated semantic document annotation that is composed of four processes, namely concept extraction, concept activation, annotation selection, and evaluation. The framework is used to implement and compare different annotation strategies motivated by the literature. For concept extraction, we apply entity detection with semantic hierarchical knowledge bases, Tri-gram, RAKE, and LDA. For concept activation, we compare a set of statistical, hierarchy-based, and graph-based methods. For selecting annotations, we compare top-k as well as kNN. In total, we define 43 different strategies including novel combinations like using graph-based activation with kNN. We have evaluated the strategies using three different datasets of varying size from three scientific disciplines (economics, politics, and computer science) that contain 100, 000 manually labeled documents in total. We obtain the best results on all three datasets by our novel combination of entity detection with graph-based activation (e.g., HITS and Degree) and kNN. For the economic and political science datasets, the best F-measure is .39 and .28, respectively. For the computer science dataset, the maximum F-measure of .33 can be reached. The experiments are the by far largest on scholarly content annotation, which typically are up to a few hundred documents per dataset only.
Gregor Große-Bölting, Chifumi Nishioka, and Ansgar Scherp. 2015. A Comparison of Different Strategies for Automated Semantic Document Annotation. In Proceedings of the 8th International Conference on Knowledge Capture (K-CAP 2015). ACM, New York, NY, USA, , Article 8 , 8 pages. DOI=http://dx.doi.org/10.1145/2815833.2815838
Big Data Analysis: The curse of dimensionality in official statisticsDario Buono
Statistical authorities need to produce accurate data faster and in a cost effective way, to become more responsive to users´ demands, while at the same time continuing to provide high quality output. One way to fulfil this is to make use of all new accessible data sources, as for example administrative data and big data. As a result, statistical offices will have to deal more and more with a "huge" number" of time series, in particular for producing model based statistics.
Using high dimensional datasets will most likely urge statistical authorities to follow a different approach, in particular to be conscious that the measurement of socio-economic variables will follow more and more non-linear processes that could not be described by probability distributions that could be easily described by few parameters.
It will thus imply to adapt the way to observe the world through data taking into account at a greater extent uncertainty and complexity, which will in turn impact dissemination and communication activities of statistical authorities.
Data Science - An emerging Stream of Science with its Spreading Reach & ImpactDr. Sunil Kr. Pandey
This is my presentation on the Topic "Data Science - An emerging Stream of Science with its Spreading Reach & Impact". I have compiled and collected different statistics and data from different sources. This may be useful for students and those who might be interested in this field of Study.
Data Science as a Service: Intersection of Cloud Computing and Data SciencePouria Amirian
Dr. Pouria Amirian explains data science, steps in a data science workflow and show some experiments in AzureML. He also mentions about big data issues in a data science project and solutions to them.
Data Science as a Service: Intersection of Cloud Computing and Data SciencePouria Amirian
Dr. Pouria Amirian from the University of Oxford explains Data Science and its relationship with Big Data and Cloud Computing. Then he illustrates using AzureML to perform a simple data science analytics.
From Lab to Factory: Or how to turn data into valuePeadar Coyle
We've all heard of 'big data' or data science, but how do we convert these trends into actual business value. I share case studies, and technology tips and talk about the challenges of the data science process. This is all based on two years of in-the-field research of deploying models, and going from prototypes to production.
These are slides from my talk at PyCon Ireland 2015
Slides for a talk given at "The Conference Formerly Known as Conversion Hotel" in November 2019. Covers what data science is, what data scientists do, and how you can start learning data science skills.
Architecting a Platform for Enterprise Use - Strata London 2018mark madsen
The goal in most organizations is to build multi-use data infrastructure that is not subject to past constraints. This session will discuss hidden design assumptions, review design principles to apply when building multi-use data infrastructure, and provide a reference architecture to use as you work to unify your analytics infrastructure.
The focus in our market has been on acquiring technology, and that ignores the more important part: the larger IT landscape within which this technology lives and the data architecture that lies at its core. If one expects longevity from a platform then it should be a designed rather than accidental architecture.
Architecture is more than just software. It starts from use and includes the data, technology, methods of building and maintaining, and organization of people. What are the design principles that lead to good design and a functional data architecture? What are the assumptions that limit older approaches? How can one integrate with, migrate from or modernize an existing data environment? How will this affect an organization's data management practices? This tutorial will help you answer these questions.
Topics covered:
* A brief history of data infrastructure and past design assumptions
* Categories of data and data use in organizations
* Analytic workload characteristics and constraints
* Data architecture
* Functional architecture
* Tradeoffs between different classes of technology
* Technology planning assumptions and guidance
#strataconf
Data Science in the Real World: Making a Difference Srinath Perera
We use the terms “Big Data” and “Data Science” for use of data processing to make sense of the world around us. Spanning many fields, Big Data brings together technologies like Distributed Systems, Machine Learning, Statistics, and Internet of Things together. It is a multi-billion-dollar industry including use cases like targeted advertising, fraud detection, product recommendations, and market surveys. With new technologies like Internet of Things (IoT), these use cases are expanding to scenarios like Smart Cities, Smart health, and Smart Agriculture.
These usecases use basic analytics, advanced statistical methods, and predictive technologies like Machine Learning. However, it is not just about crunching the data. Some usecases like Urban Planning can be slow, and there is enough time to process the data. However, with use cases like traffic, patient monitoring, surveillance the the value of results degrades much faster with time and needs results within milliseconds to seconds. Collecting data from many sources, cleaning them up, processing them using computation clusters, and doing all these fast is a major challenge.
This talk will discuss motivation behind big data and data science and how it can make a difference. Then it will discuss the challenges, systems, and methodologies for implementing and sustaining a data science pipeline.
Platform for Big Data Analytics and Visual Analytics: CSIRO use cases. Februa...Tomasz Bednarz
Presented at the ACEMS workshop at QUT in February 2015.
Credits: whole project team (names listed in the first slide).
Approved by CSIRO to be shared externally.
My keynote talk at San Diego Superdata conference, looking at history and current state of Analytics and Data Mining, and examining the effects of Big Data
Advances in Exploratory Data Analysis, Visualisation and Quality for Data Cen...Hima Patel
It is widely accepted that data preparation is one of the most time-consuming steps of the machine learning (ML) lifecycle. It is also one of the most important steps, as the quality of data directly influences the quality of a model. In this session, we will discuss the importance and the role of exploratory data analysis (EDA) and data visualisation techniques to find data quality issues and for data preparation, relevant to building ML pipelines. We will also discuss the latest advances in these fields and bring out areas that need innovation. Finally, we will discuss on the challenges posed by industry workloads and the gaps to be addressed to make data-centric AI real in industry settings.
The dramatic rise in the use of Social Media (SM) platforms such as Facebook and Twitter provide access to an unprecedented amount of user data. Users may post reviews on products and services they bought, write about their interests, share ideas or give their opinions and views on political issues. There is a growing interest in the analysis of SM data from organisations for detecting new trends, obtaining user opinions on their products and services or finding out about their online reputations. A recent research trend in SM analysis is making predictions based on sentiment analysis of SM. Often indicators of historic SM data are represented as time series and correlated with a variety of real world phenomena like the outcome of elections, the development of financial indicators, box office revenue and disease outbreaks.
System Dynamics, Analytics & Big Data (16th Conference of the UK Chapter of t...Michael Mortenson
This talk investigates the relationship between system dynamics, analytics and big data. Drawing on both a historical analysis and text analytics, similarities and differences are identified, and some suggestions on how future research may provide value for the System Dynamics community.
Tips and Tricks to be an Effective Data ScientistLisa Cohen
Data Science is an evolving field, that requires a diverse skill set. From Analytical Techniques to Career Advice, this talk is full of practical tips that you can apply immediately to your job.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Data Science - An emerging Stream of Science with its Spreading Reach & ImpactDr. Sunil Kr. Pandey
This is my presentation on the Topic "Data Science - An emerging Stream of Science with its Spreading Reach & Impact". I have compiled and collected different statistics and data from different sources. This may be useful for students and those who might be interested in this field of Study.
Data Science as a Service: Intersection of Cloud Computing and Data SciencePouria Amirian
Dr. Pouria Amirian explains data science, steps in a data science workflow and show some experiments in AzureML. He also mentions about big data issues in a data science project and solutions to them.
Data Science as a Service: Intersection of Cloud Computing and Data SciencePouria Amirian
Dr. Pouria Amirian from the University of Oxford explains Data Science and its relationship with Big Data and Cloud Computing. Then he illustrates using AzureML to perform a simple data science analytics.
From Lab to Factory: Or how to turn data into valuePeadar Coyle
We've all heard of 'big data' or data science, but how do we convert these trends into actual business value. I share case studies, and technology tips and talk about the challenges of the data science process. This is all based on two years of in-the-field research of deploying models, and going from prototypes to production.
These are slides from my talk at PyCon Ireland 2015
Slides for a talk given at "The Conference Formerly Known as Conversion Hotel" in November 2019. Covers what data science is, what data scientists do, and how you can start learning data science skills.
Architecting a Platform for Enterprise Use - Strata London 2018mark madsen
The goal in most organizations is to build multi-use data infrastructure that is not subject to past constraints. This session will discuss hidden design assumptions, review design principles to apply when building multi-use data infrastructure, and provide a reference architecture to use as you work to unify your analytics infrastructure.
The focus in our market has been on acquiring technology, and that ignores the more important part: the larger IT landscape within which this technology lives and the data architecture that lies at its core. If one expects longevity from a platform then it should be a designed rather than accidental architecture.
Architecture is more than just software. It starts from use and includes the data, technology, methods of building and maintaining, and organization of people. What are the design principles that lead to good design and a functional data architecture? What are the assumptions that limit older approaches? How can one integrate with, migrate from or modernize an existing data environment? How will this affect an organization's data management practices? This tutorial will help you answer these questions.
Topics covered:
* A brief history of data infrastructure and past design assumptions
* Categories of data and data use in organizations
* Analytic workload characteristics and constraints
* Data architecture
* Functional architecture
* Tradeoffs between different classes of technology
* Technology planning assumptions and guidance
#strataconf
Data Science in the Real World: Making a Difference Srinath Perera
We use the terms “Big Data” and “Data Science” for use of data processing to make sense of the world around us. Spanning many fields, Big Data brings together technologies like Distributed Systems, Machine Learning, Statistics, and Internet of Things together. It is a multi-billion-dollar industry including use cases like targeted advertising, fraud detection, product recommendations, and market surveys. With new technologies like Internet of Things (IoT), these use cases are expanding to scenarios like Smart Cities, Smart health, and Smart Agriculture.
These usecases use basic analytics, advanced statistical methods, and predictive technologies like Machine Learning. However, it is not just about crunching the data. Some usecases like Urban Planning can be slow, and there is enough time to process the data. However, with use cases like traffic, patient monitoring, surveillance the the value of results degrades much faster with time and needs results within milliseconds to seconds. Collecting data from many sources, cleaning them up, processing them using computation clusters, and doing all these fast is a major challenge.
This talk will discuss motivation behind big data and data science and how it can make a difference. Then it will discuss the challenges, systems, and methodologies for implementing and sustaining a data science pipeline.
Platform for Big Data Analytics and Visual Analytics: CSIRO use cases. Februa...Tomasz Bednarz
Presented at the ACEMS workshop at QUT in February 2015.
Credits: whole project team (names listed in the first slide).
Approved by CSIRO to be shared externally.
My keynote talk at San Diego Superdata conference, looking at history and current state of Analytics and Data Mining, and examining the effects of Big Data
Advances in Exploratory Data Analysis, Visualisation and Quality for Data Cen...Hima Patel
It is widely accepted that data preparation is one of the most time-consuming steps of the machine learning (ML) lifecycle. It is also one of the most important steps, as the quality of data directly influences the quality of a model. In this session, we will discuss the importance and the role of exploratory data analysis (EDA) and data visualisation techniques to find data quality issues and for data preparation, relevant to building ML pipelines. We will also discuss the latest advances in these fields and bring out areas that need innovation. Finally, we will discuss on the challenges posed by industry workloads and the gaps to be addressed to make data-centric AI real in industry settings.
The dramatic rise in the use of Social Media (SM) platforms such as Facebook and Twitter provide access to an unprecedented amount of user data. Users may post reviews on products and services they bought, write about their interests, share ideas or give their opinions and views on political issues. There is a growing interest in the analysis of SM data from organisations for detecting new trends, obtaining user opinions on their products and services or finding out about their online reputations. A recent research trend in SM analysis is making predictions based on sentiment analysis of SM. Often indicators of historic SM data are represented as time series and correlated with a variety of real world phenomena like the outcome of elections, the development of financial indicators, box office revenue and disease outbreaks.
System Dynamics, Analytics & Big Data (16th Conference of the UK Chapter of t...Michael Mortenson
This talk investigates the relationship between system dynamics, analytics and big data. Drawing on both a historical analysis and text analytics, similarities and differences are identified, and some suggestions on how future research may provide value for the System Dynamics community.
Tips and Tricks to be an Effective Data ScientistLisa Cohen
Data Science is an evolving field, that requires a diverse skill set. From Analytical Techniques to Career Advice, this talk is full of practical tips that you can apply immediately to your job.
Similar to Bring survey sampling techniques into big data (20)
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
4. Summary
I. What is a data science team? How can a (survey) statistician fit into
it?
II. Examples of awesome ‘big data’ challenges that could use
statisticians
6. I. Data science and data scientists
Data scientists = combination of computer science, statistics, applied
mathematics and domain expertise
Type A data scientist = Focused on analyses, decision science
Type B data scientist = Focused on production data application
(typically ML, recommendations, etc.)
7. What does our type B data science team do?
Machine Learning in games! Example: Recommendations (from Netflix:
Basilico, 2015)
8. What does our type B data science team do?
Send data
Send content
Compute
ML
models
9. What does our type B data science team do?
At core: programming team
- Production code:
- Distributed computation
- Optimized algorithms
- Code history and reviews
Tech stack:
10. Modern data science teams
The (in)famous data science Venn diagram (Conway, 2013)
11. Modern data science teams
Some truths:
- Blur the line between all jobs (opportunities, not requirements)
- Unicorns are rare but they do exist
- Let them have fun!
- Pay them accordingly!
More generally: Create opportunities for everyone to learn from every
domain
12. Modern data science teams
What can statisticians get from CS culture
- Quality control for statisticians (hint: it’s the same!):
- Distributed computation
- Optimized algorithms
- Code history and reviews
R community has a very positive influence in introducing CS quality
processes for statistics and data science (for example see Wickham,
2015 on git).
13. II. Examples of ‘big data’ challenges that
could use statisticians
14. II. Examples of challenges
1. A/B testing
2. Sampled events (understanding data sources)
3. Improving ML algorithms (quality)
4. Improving ML algorithms (speed)
5. Understanding user feedback
15. II. Examples of challenges
1. A/B testing
A/B testing = ‘big data’ term for Randomized Controlled Trial (RCT)
Very useful for:
- Product shipping
- Business decisions
For example Microsoft has a dedicated team doing extensive work on
A/B testing (see Deng, 2018).
16. II. Examples of challenges
1. A/B testing
Need for carefully crafted sampling designs (Image from Miller).
17. II. Examples of challenges
2. Sampled tracking events
Event = single information sent to server when something happens
Some events are sampled to reduce load (CPU, network, storage)
18. II. Examples of challenges
2. Sampled tracking events
Example: analysis of balancing in a fighting game
An event is sent by a sample of players when they use a new weapon.
Question: is sword A better than sword B?
-> Analysis of matches where these weapons are used
…
19. II. Examples of challenges
2. Sampled tracking events
… This is an indirect sampling design (Lavallée, 2009)
(Unequal probabilities because of players preferences, game rules, etc.)
Our ‘quick-and-dirty’ solution: calibration and R package Icarus
(Rebecq, 2016)
20. II. Examples of challenges
3. Better probabilities for ML algorithms using sampling calibration
Using sampling calibration (Deville, 1992) to craft better probabilities
from ML algorithms
1. Example with balancing of sample data:
http://nc233.com/2018/07/weighting-tricks-for-machine-learning-
with-icarus-part-1/
21. II. Examples of challenges
3. Better probabilities for ML algorithms using sampling calibration
22. II. Examples of challenges
3. Better probabilities for ML algorithms using sampling calibration
2. Directly calibrate output probabilities (WIP)
- Better simulations
- Better recommendations
23. II. Examples of challenges
4. Speed up big data tasks
Example: Sampling to speed up network analyses (Leskovec, 2016 and Rebecq,
2017)
24. II. Examples of challenges
5. Understand user feedback
Sentiment analysis (Pang, 2002)
Direct feedback from community
Vs.
Sampling and carefully crafted questionnaire
25. Conclusion
- A lot of interesting topics in survey sampling literature can be super
useful for ‘big data’ problems (research and practice)
- Hire a statistician for your type A data science team!
- Hire a statistician for your type B data science team!
- If you’re a statistician, look into ‘big data’ jobs for interesting
challenges!
27. References (1)
[Basilico, 2015] BASILICO, Justin. Recommendations for building Machine Learning systems
https://www.slideshare.net/SessionsEvents/justin-basilico-research-engineering-manager-at-netflix-at-mlconf-
sf-111315
[Conway, 2013] CONWAY, Drew. The data science Venn diagram http://drewconway.com/zia/2013/3/26/the-
data-science-venn-diagram
[Deville, 1992] DEVILLE, Jean-Claude and SÄRNDAL, Carl-Erik. Calibration estimators in survey sampling. Journal
of the American statistical Association, 1992, vol. 87, no 418, p. 376-382.
[Deng, 2018] DENG, Alex, KNOBLICH, Ulf, and LU, Jiannan. Applying the Delta method in metric analytics: A
practical guide with novel ideas. arXiv preprint arXiv:1803.06336, 2018.
[Lavallée, 2009] LAVALLÉE, Pierre. Indirect sampling. Springer Science & Business Media, 2009.
28. References (2)
[Leskovec, 2016] LESKOVEC, Jure and SOSIČ, Rok. Snap: A general-purpose network analysis and graph-mining
library. ACM Transactions on Intelligent Systems and Technology (TIST), 2016, vol. 8, no 1, p. 1.
[Miller] MILLER, Evan. Evan Miller’s sample size calculator https://www.evanmiller.org/ab-testing/sample-
size.html
[Pang, 2002] PANG, Bo, LEE, Lillian, and VAITHYANATHAN, Shivakumar. Thumbs up?: sentiment classification
using machine learning techniques. In : Proceedings of the ACL-02 conference on Empirical methods in natural
language processing-Volume 10. Association for Computational Linguistics, 2002. p. 79-86.
[Rebecq, 2017] REBECQ, Antoine. Sampling graphs https://nc233.com/2017/03/sampling-graphs-mad-stat-
seminar-at-toulouse-school-of-economics/
29. References (3)
[Rebecq, 2016] REBECQ, Antoine. Icarus: un package R pour le calage sur marges et ses variantes. In : 9e
colloque francophone sur les sondages, Gatineau (Canada). 2016.
[Wickham, 2015] WICKHAM, Hadley. R packages: organize, test, document, and share your code. " O'Reilly
Media, Inc.", 2015 (page on git available at http://r-pkgs.had.co.nz/git.html)