Brian Frenzel is the president and CEO of Tosk, Inc., which develops therapies to reduce or eliminate side effects from medications like chemotherapy-induced cardiotoxicity and cardiomyopathy. Cardiotoxicity is a common side effect of chemotherapy that can damage the heart muscle and lead to cardiomyopathy, limiting the heart's ability to pump blood. Symptoms of cardiomyopathy include fatigue, shortness of breath, and leg swelling. Brian Frenzel and Tosk are working to create drugs that prevent this serious side effect of chemotherapy treatments.

1. Brian Frenzel - Cardiotoxicity
and Cardiomyopathy

2. Brian Frenzel - Cardiotoxicity and
Cardiomyopathy
 With more than 30 years of experience in the pharmaceutical industry,
Brian Frenzel serves as president and chief executive officer of Tosk, Inc.
Under the leadership of Brian Frenzel, the firm creates therapies that reduce
or eliminate the side effects from other medications, such as
chemotherapy-induced cardiotoxicity.

3. Brian Frenzel - Cardiotoxicity and
Cardiomyopathy
 Cardiotoxicity is a common side effect of chemotherapy. The frequently
used chemotherapeutic doxorubicin causes this condition in cancer
patients. Cardiotoxicity can result in damage to the heart muscle known as
cardiomyopathy, which limits the ability of the heart to pump blood
through the body. Cardiotoxicity can also lead to arrhythmia.

4. Brian Frenzel - Cardiotoxicity and
Cardiomyopathy
 Individuals with cardiomyopathy might first recognize symptoms such as
fatigue, shortness of breath, and swelling of the legs. Doctors can identify it
by seeing an enlarged heart muscle image on an MRI or by hearing
abnormal heart/lung soundsmia.

5. Brian Frenzel - Cardiotoxicity and
Cardiomyopathy
 At Tosk, Brian Frenzel is working to develop drugs which limit or eliminate this
debilitating and potentially fatal result of chemotherapy.