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Question 1:
    Can we identify an individual marker of brain maturity
    using whole-brain gray matter volume?




                                                             Franke et al, 2012
R Toro




Spin into potential hemispheric specific maturation
Testing Feasibility
Question 2
What are the volumetric subcortical relationships with age
(amygdala, thalamus caudate, hyppocampus)

…..to be continued
Question 3a:
What is the trajectory and
   nature of abnormal
  neurodevelopment in
          ASD?


     Question 3b:
 And what are the most
  sensitive metrics for
      measuring
  neurodevelopment?
Question 4:
Will group differences between a young cohort A and
an older cohort B be “the same” as differences seen
between two other randomly selected, age-matched
cohorts C and D?

* Outcomes of interest: 1. overall brain volume
                        2. volume of subcortical structures

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Brain hack-ABIDEworkgroup

  • 1.
  • 2. Question 1: Can we identify an individual marker of brain maturity using whole-brain gray matter volume? Franke et al, 2012 R Toro Spin into potential hemispheric specific maturation
  • 4. Question 2 What are the volumetric subcortical relationships with age (amygdala, thalamus caudate, hyppocampus) …..to be continued
  • 5. Question 3a: What is the trajectory and nature of abnormal neurodevelopment in ASD? Question 3b: And what are the most sensitive metrics for measuring neurodevelopment?
  • 6. Question 4: Will group differences between a young cohort A and an older cohort B be “the same” as differences seen between two other randomly selected, age-matched cohorts C and D? * Outcomes of interest: 1. overall brain volume 2. volume of subcortical structures

Editor's Notes

  1. Method: Relevant vector regression (robust to sites differences)