Blood pressure is the force exerted by blood on the walls of arteries. It is measured as systolic over diastolic pressure in mmHg. Systolic pressure occurs when the heart contracts and diastolic when it relaxes. Blood pressure is regulated by the cardiovascular center in the brain through neural mechanisms like baroreceptor and chemoreceptor reflexes and hormonal factors like renin-angiotensin-aldosterone system and epinephrine. Local auto-regulation and factors like age, exercise and stress also affect blood pressure.
Blood Pressure Basics
Measured by Force of Blood on Artery Walls
Measured in Millimeters of Mercury (mmHg)
Factors Affecting Blood Pressure:
Volume of Water in Body
Salt Content of Body
Condition of Kidneys, Nervous System and Blood Vessels (Arteries and Veins)
Levels of Various Hormones in Body (adrenal hormones eg.aldosterone)
Definition of Blood pressure:
The Bp is the pressure of the blood within the arteries.
OR
Blood pressure is the pressure of circulating blood against the walls of blood vessels.
OR
Blood pressure (BP) is the pressure exerted by blood on the walls of a blood vessel that helps to push blood through the body.
Arteries take blood away from the heart.
Arterial Pressure is the force exerted by the blood upon the walls of the arteries.
Veins bring blood to the heart.
Venous Pressure is the force exerted by the blood upon the wall of the veins.
Systole over Diastole
Blood Pressure = Systolic Pressure over Diastolic Pressure
120/80 mmHg (Healthy Measurement)
Blood Pressure is Highest(120) During Systole (Ventricles Contract and send blood out)
Blood Pressure is Lowest (80) pressure During Diastole( Ventricles Relax and Refill )
Systolic blood pressure measures the amount of pressure that blood exerts on vessels while the heart is beating(systole).
The optimal systolic blood pressure is 120 mmHg.
Diastolic blood pressure measures the pressure in the vessels between heartbeats(diastole). The optimal diastolic blood pressure is 80 mmHg.
FACTORS AFFECTING BP
Age, race, family history, overweight, alcoholism.high intake of sodium. Less potassium, chronic diseases, stress etc.
REGULATION OF BLOOD PRESSURE
SHORT-TERM NEURAL CONTROL
Neural or nervous system regulating of blood pressure is achieved through the role of cardiovascular centers and baroreceptor stimulation.
Autonomic nervous system: the part of the nervous system that regulates the involuntary activity of the heart, blood pressure modulation.
Sympathetic nervous system: under stress raises blood pressure and heart rate, constricts blood vessels.
Parasympathetic: inhibits or opposes the effects of the sympathetic nervous system.
Baroreceptor: a nerve ending that is sensitive to changes in blood pressure in the blood vessels .
Norepinephrine: Epinephrine increases arterial pressure.
SHORT-TERM CHEMICAL CONTROL
Blood pressure is controlled chemically through dilation or constriction of the blood vessels by vasodilators and vasoconstrictors.
Constriction or dilation of blood vessels alters resistance, increasing or decreasing blood pressure respectively.
vasodilation: The dilation (widening) of a blood vessel. Ex:Nitroglycerin,hydralazine
vasoconstriction: The constriction (narrowing) of a blood vessel.epinephrine ,dopamine.
The Classical RAS Pathway Works
The important members of the classical RAS pathway are:
Renin
Angiotensin I
Angiotensin II
Angiotensin converting enzyme 1 (ACE1)
Aldosterone
This presentation gives you a brief, understandable, captivating and presentable idea on the physiology of blood pressure regulation both on hypertension and hypotension cases.
Cardiovascular system (blood pressure, hypertension) Pharmacy Universe
The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
The circulatory system includes the lymphatic system, which circulates lymph.[1] The passage of lymph for example takes much longer than that of blood.[2] Blood is a fluid consisting of plasma, red blood cells, white blood cells, and platelets that is circulated by the heart through the vertebrate vascular system, carrying oxygen and nutrients to and waste materials away from all body tissues. Lymph is essentially recycled excess blood plasma after it has been filtered from the interstitial fluid (between cells) and returned to the lymphatic system. The cardiovascular (from Latin words meaning "heart" and "vessel") system comprises the blood, heart, and blood vessels.[3] The lymph, lymph nodes, and lymph vessels form the lymphatic system, which returns filtered blood plasma from the interstitial fluid (between cells) as lymph.
Blood Pressure Basics
Measured by Force of Blood on Artery Walls
Measured in Millimeters of Mercury (mmHg)
Factors Affecting Blood Pressure:
Volume of Water in Body
Salt Content of Body
Condition of Kidneys, Nervous System and Blood Vessels (Arteries and Veins)
Levels of Various Hormones in Body (adrenal hormones eg.aldosterone)
Definition of Blood pressure:
The Bp is the pressure of the blood within the arteries.
OR
Blood pressure is the pressure of circulating blood against the walls of blood vessels.
OR
Blood pressure (BP) is the pressure exerted by blood on the walls of a blood vessel that helps to push blood through the body.
Arteries take blood away from the heart.
Arterial Pressure is the force exerted by the blood upon the walls of the arteries.
Veins bring blood to the heart.
Venous Pressure is the force exerted by the blood upon the wall of the veins.
Systole over Diastole
Blood Pressure = Systolic Pressure over Diastolic Pressure
120/80 mmHg (Healthy Measurement)
Blood Pressure is Highest(120) During Systole (Ventricles Contract and send blood out)
Blood Pressure is Lowest (80) pressure During Diastole( Ventricles Relax and Refill )
Systolic blood pressure measures the amount of pressure that blood exerts on vessels while the heart is beating(systole).
The optimal systolic blood pressure is 120 mmHg.
Diastolic blood pressure measures the pressure in the vessels between heartbeats(diastole). The optimal diastolic blood pressure is 80 mmHg.
FACTORS AFFECTING BP
Age, race, family history, overweight, alcoholism.high intake of sodium. Less potassium, chronic diseases, stress etc.
REGULATION OF BLOOD PRESSURE
SHORT-TERM NEURAL CONTROL
Neural or nervous system regulating of blood pressure is achieved through the role of cardiovascular centers and baroreceptor stimulation.
Autonomic nervous system: the part of the nervous system that regulates the involuntary activity of the heart, blood pressure modulation.
Sympathetic nervous system: under stress raises blood pressure and heart rate, constricts blood vessels.
Parasympathetic: inhibits or opposes the effects of the sympathetic nervous system.
Baroreceptor: a nerve ending that is sensitive to changes in blood pressure in the blood vessels .
Norepinephrine: Epinephrine increases arterial pressure.
SHORT-TERM CHEMICAL CONTROL
Blood pressure is controlled chemically through dilation or constriction of the blood vessels by vasodilators and vasoconstrictors.
Constriction or dilation of blood vessels alters resistance, increasing or decreasing blood pressure respectively.
vasodilation: The dilation (widening) of a blood vessel. Ex:Nitroglycerin,hydralazine
vasoconstriction: The constriction (narrowing) of a blood vessel.epinephrine ,dopamine.
The Classical RAS Pathway Works
The important members of the classical RAS pathway are:
Renin
Angiotensin I
Angiotensin II
Angiotensin converting enzyme 1 (ACE1)
Aldosterone
This presentation gives you a brief, understandable, captivating and presentable idea on the physiology of blood pressure regulation both on hypertension and hypotension cases.
Cardiovascular system (blood pressure, hypertension) Pharmacy Universe
The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
The circulatory system includes the lymphatic system, which circulates lymph.[1] The passage of lymph for example takes much longer than that of blood.[2] Blood is a fluid consisting of plasma, red blood cells, white blood cells, and platelets that is circulated by the heart through the vertebrate vascular system, carrying oxygen and nutrients to and waste materials away from all body tissues. Lymph is essentially recycled excess blood plasma after it has been filtered from the interstitial fluid (between cells) and returned to the lymphatic system. The cardiovascular (from Latin words meaning "heart" and "vessel") system comprises the blood, heart, and blood vessels.[3] The lymph, lymph nodes, and lymph vessels form the lymphatic system, which returns filtered blood plasma from the interstitial fluid (between cells) as lymph.
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
Heart rate is the number of heartbeats per unit of time, usually per minute.
The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart).
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
Heart rate is the number of heartbeats per unit of time, usually per minute.
The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart).
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2. • Blood pressure is the force or pressure of
the blood against the walls of the blood
vessels.
• Arterial blood pressure is a measure of the
pressure exerted by the blood as it flows
through the arteries. It is the result of the
ejection of blood from the left ventricle into
the aorta.
3. • Blood pressure is mentioned in terms of
systolic blood pressure over diastolic blood
pressure.
• Systolic blood pressure is the highest
pressure attained in arteries during systole
and diastolic blood pressure is the lowest
arterial pressure during diastole
4.
5. • The systolic pressure is the pressure as a
result of contraction of the ventricles. When
the left ventricle contracts and pushes blood
into the aorta the pressure produced within
the arterial system is called the systolic
blood pressure.
• In adults it is about 120 mmHg.
6. • The diastolic pressure is the pressure when
the ventricles are at rest.
• When complete cardiac relaxation occurs
and the heart is resting after the ejection of
blood, the pressure within the arteries is
called diastolic blood pressure.
• In an adult it is about 80 mmHg.
7. • Arterial blood pressure is
measured with a sphygmomanometer.
• Blood pressure is recorded as a fraction:
systolic pressure over the diastolic pressure,
and expressed in millimeters of mercury
(mm Hg).
• A typical blood pressure for a healthy adult is
120/80 mmHg.
8. Pulse pressure
• The difference between systolic and diastolic
blood pressures is the pulse pressure.
• A normal pulse pressure is about 40 mmHg.
9. Factors Affecting Blood Pressure
• Age: The pressure rises with age, reaching a peak at
the onset of puberty, and then tends to decline.
• Exercise: Physical activity increases the cardiac
output and hence the blood pressure.
• Stress: Stimulation of the sympathetic nervous
system increases cardiac output and
vasoconstriction of the arterioles, thus increasing
the blood pressure.
• Race: African Americans tend to have higher blood
pressures than European Americans. The exact
reasons are unclear.
10. • Sex: Females have lower blood pressures than
males due to hormonal variations. After
menopause, women have higher blood
pressures.
• Medications: Many medications, including
caffeine, may increase or decrease the blood
pressure.
• Obesity: Predispose to hypertension.
• Positions: Sitting, standing or lying down
position cause slight variation in BP.
• Diurnal variations (time of day): Pressure is
lowest early in the morning, when the
metabolic rate is lowest, then rises throughout
the day and peaks in the late afternoon or
evening.
11. • Medical conditions: Any condition affecting
the cardiac output, blood volume, blood
viscosity, and/or compliance of the arteries has
a direct effect on the blood pressure.
• Temperature: Because of increased metabolic
rate, fever can increase blood pressure.
However, external heat causes vasodilation and
decreased blood pressure. Cold causes
vasoconstriction and elevates blood pressure.
12. Regulation of blood pressure
1. Regulation by cardio vascular center
2. Neural regulation
3. Hormonal regulation
4. Auto regulation
13. 1. Regulation by cardiovascular center
The cardiovascular (CV) center in the medulla
oblongata controls neural, hormonal, and local negative
feedback systems that regulate blood pressure.
Groups of neurons within the CV center regulate
heart rate, contractility (force of contraction) of the
ventricles, and blood vessel diameter. Some neurons
stimulate the heart (cardiostimulatory center); others
inhibit the heart (cardioinhibitory center).
Some neurons control blood vessel diameter by
causing constriction (vasoconstrictor center) or dilation
(vasodilator center) which is referred as the vasomotor
center. All group of neurons in the CV center neurons
communicate one another and function together.
14.
15. • The cardiovascular center receives input
both from higher brain regions and from
sensory receptors (proprioceptors,
baroreceptors, and chemoreceptors).
• Output from the cardiovascular center flows
along sympathetic and parasympathetic
neurons of the ANS.
Sympath
etic
impulse
via cardiac
accelerator
nerves
Reach
heart
Sympatheti
c
stimulation
Increases
heart
rate and
contractil
ity
Increases
BP
16. • The cardiovascular center also sends
impulses to smooth muscle in blood vessel
walls via vasomotor nerves. This produce
sympathetic stimulation and results in
vasoconstriction. Thus increases BP.
Para
sympathe
tic
impulse
Via
vagus
nerve
Reach
heart
Inhibitory
action
Decrease
heart
rate
Decrease
BP
17. 2. Neural regulation
• The nervous system regulation of BP is a negative
feed back mechanism via baroreceptor reflexes and
chemoreceptor reflexes.
i. Baroreceptor reflexes
Baroreceptors are pressure-sensitive sensory
receptors, located in the aorta, internal carotid arteries
and other large arteries in the neck and chest. They
send impulses to the cardiovascular center to help
regulate blood pressure.
The two most important baroreceptor reflexes
are the carotid sinus reflex and the aortic reflex.
18. • Baroreceptors in the wall of the carotid
sinuses initiate the carotid sinus reflex
helps to regulate blood pressure in the
brain. Nerve impulses from the carotid sinus
reach the cardiovascular center via
glossopharyngeal nerves.
• Baroreceptors in the wall of the aorta
initiate the aortic reflex, which regulates
systemic blood pressure. Nerve impulses
from aortic baroreceptors reach the
cardiovascular center via vagus (X) nerves.
19. Decrease BP
impulses from baroreceptors to CV center
parasympathetic stimulation
sympathetic stimulation
secretion of epinephrine and norepinephrine
by the adrenal medulla
Increased heart rate vasoconstriction
Increased CO systemic vascular resistance
Increase BP negative feed back
20. ii. Chemoreceptor Reflexes
Chemoreceptors are sensory receptors that
monitor the chemical composition of blood
located close to the baroreceptors of the carotid
sinus and arch of the aorta. Chemoreceptors
detect changes in blood level of O2, CO2, and H+.
Hypoxia (lowered O2 availability), acidosis
(an increase in H+ concentration) or hypercapnia
(excess CO2) stimulates the chemoreceptors to
send impulses to the cardiovascular center.
In response, the CV center increases
sympathetic stimulation to arterioles and veins,
producing vasoconstriction and increases blood
pressure.
21. 3. Hormonal regulation
Hormonal regulation of BP is done by
i. Renin–angiotensin–aldosterone system
ii. Epinephrine and norepinephrine
iii. Antidiuretic hormone (ADH)
iv. Atrial natriuretic peptide
22. i. Renin–angiotensin–aldosterone system
Renal blood flow
Blood volume
Blood pressure
Secretion of renin by kidneys
Angiotensinogen Angiotensin 1
by ACE
Angiotensin 2
Secretion of aldosterone Vasoconstriction
Increases blood pressure
23. When renal blood flow is reduced or
blood volume decreases or BP drops the
enzyme renin is secreted by kidney cells.
Renin converts the plasma protein
angiotensinogen, produced by the liver, to
angiotensin 1. Angiotensin converting enzyme
(ACE) converts angiotensin 1 to angiotensin 2.
Angiotensin 2 causes vasoconstriction and
increases blood pressure. Also angiotensin 2
stimulates secretion of aldosterone which
causes vasoconstriction and increases blood
pressure.
24. ii. Epinephrine and norepinephrine
In response to sympathetic stimulation, the
adrenal medulla releases epinephrine and
norepinephrine. These hormones increase
cardiac output by increasing the rate and force of
heart contractions. Thus increases BP.
Sympathetic stimulation
Release of epinephrine and norepinephrine
Increase heart rate and contractions
Increase CO
Increase BP
25. iii. Antidiuretic hormone (ADH)
Decreased blood volume
ADH released from the posterior pituitary
Vasoconstriction ADH promotes movement of
water from kidney tubules into
bloodstream
blood volume and urine
output
Increases CO
Increases blood pressure
26. iv. Atrial natriuretic peptide
Atrial natriuretic peptide (ANP) is
released by cells in the atria of the heart. ANP
lowers blood pressure by causing vasodilation
and by promoting the loss of salt and water in
the urine, which reduces blood volume.
27. 4. Auto regulation
• The ability of a tissue to automatically adjust
its blood flow to match its metabolic demands
is called autoregulation.
• In heart autoregulation is an important
contributor to increased blood flow through
the tissue.
• Stimuli that cause autoregulatory changes in
blood flow are;
– Physical changes: Warming promotes vasodilation,
and cooling causes vasoconstriction.
– Vasodilating and vasoconstricting chemicals