The document discusses the evolution and current landscape of home health tracking devices, emphasizing the importance of user perception, actionable data, profitability, and regulatory safety. It highlights advancements in urine testing technology and the potential future of smart toilets while critiquing existing products for shortcomings and false negatives. Various upcoming innovations and a range of biomarker tests are mentioned, indicating a promising direction for home health diagnostics.

1. FestiHealth 2020
Contact daniel@bisu.bio for details
Home health is in the bathroom
The present and future of personal health tracking
The key to knowing you

2. What you’ll learn
What devices are available for home health tracking today?
What factors make or break a health tracking device?
What can we learn about our bodies from our urine?
Where are home urine testing and smart toilets today?
What other little-known devices are coming soon?
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5

3. Home health tracking has come a long way
Blood glucose meter CGMBlood draws

4. Epigenetic testing
Home health tracking has come a long way
Early gene sequencers Consumer genetic testing

5. Home health tracking has come a long way
Body comp analyzerBIA scaleBodyfat calipers

6. In 13 years we’ve come from this…
First FitBit prototype

7. …to this
DNAActivity Blood sugar Brain activity Food allergies
Sleep Body fat MicrobiomePain relief Digestion

8. Successful devices must pass four tests
Does it pass the user value perception test?
Is the data at least actionable?
Can it be manufactured profitably?
Is it safe for regulatory purposes?
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9. Does it pass the user value perception test?
Perceived value Perceived benefit (Pain + Time + Cost)= -
1

10. Perceived value Perceived benefit (Pain + Time + Cost)= -
* IF YOU’RE DIABETIC, ON KETO AND/OR A BIOHACKER
HIGH MED MEDHIGH*
Does it pass the user value perception test?1

11. Perceived value Perceived benefit (Pain + Time + Cost)= -
LOW-MED* ZERO MED-HIGHZERO
* A MIX OF REASONABLE DATA AND HIGH FASHION VALUE
Does it pass the user value perception test?1

12. Perceived value Perceived benefit (Pain + Time + Cost)= -
MED HIGHHIGHHIGH*
* GUT HEALTH IS HOT AND CURIOSITY DRIVES THE FIRST PURCHASE, BUT IS IT A REPEAT?
Does it pass the user value perception test?1

13. Purpose Biomarker Gold standard
Know my blood
sugar right now
Spot glucose Gold standard
CGM glucose Actionable
A1C Useless
Is the data at least actionable?2

14. Purpose Biomarker Gold standard
Know my blood
sugar over the
last 24 hours
Spot glucose Actionable
CGM glucose Gold standard
A1C Useless
Is the data at least actionable?2

15. Purpose Biomarker Gold standard
Know my average
blood sugar over
last 3 months
Spot glucose Useless
CGM glucose Actionable
A1C Gold standard
Is the data at least actionable?2

16. Can it be manufactured profitably?
A prototype is not a product!
3

17. *Cor is actually not dead, they just went underground, but the point
is - don’t pre-sell until you’re sure you can ship at the right price!
Can it be manufactured profitably?
Beware of death by crowdfunding
3

18. Passing the first test is key, but not enough!
Does it pass the user value perception test?
Is the data at least actionable?
Can it be manufactured profitably?
Is it safe for regulatory purposes?
1
2
3
4
YES!
SOMETIMES…
PROBABLY NOT…
HELL NO!

19. We have a rich range of great devices
DNAActivity Blood sugar Brain activity Food allergies
Sleep Body fat MicrobiomePain relief Digestion

20. …but we’re still throwing away
huge amounts of data every day

21. Isn’t blood the gold standard? It depends.
Biomarker Gold standard
Glucose Blood
Sodium Blood
Magnesium Urine
Zinc Faeces
Cortisol Saliva
Hydration None

22. Urine test strips are old -
they were invented in 1956!
Glucose
Albumin (kidney disease)
Urobilinogen (liver disease)
Bilirubin (liver disease)
Leukocytes & nitrite (infections)
RBCs (infections)
AcAc ketones
pH (dietary acid load)
Specific gravity
Creatinine

23. Urine test strips
have a high
false negative risk
Biomarker Meaning Issues
Glucose Sign of high blood sugar
Renal threshold varies
and goes up with age
Albumin
protein
Sign of kidney damage
GFR can be declining even
where no protein in urine
Leukocytes
& nitrite
Sign of urinary tract infection
Not all UTIs produce
leukocytes or nitrite
Bilirubin &
urobilinogen
Sign of liver condition
Liver enzymes can be
abnormal without urine data

24. Very little evolution since then…
Phone-read test stripClinical strip analyzer

25. …until now
Phone-read test strip Microfluidic analyzerClinical strip analyzer

26. Bisu test experience

27. Bisu test experience

28. Bisu test experience

29. Bisu test experience

30. Bisu test experience

31. Bisu test experience

32. Bisu app experience

33. New urine data
BHB ketones
Sodium
Potassium
Magnesium
Calcium
Urea nitrogen (protein intake)
Uric acid
Cotinine (tobacco use)
EtG (alcohol use)
New saliva data
pH (cavity & erosion risk)
Blood (gum disease)
Calcium (cavity & erosion risk)
Phosphate (cavity & erosion risk)
Glucose (correlates in diabetics)
Bisu data
Conventional urine biomarkers
Glucose
Albumin (kidney disease)
Urobilinogen (liver disease)
Bilirubin (liver disease)
Leukocytes & nitrite (infections)
RBCs (infections)
AcAc ketones
pH (dietary acid load)
Specific gravity
Creatinine

34. One device, with a range of tests
for each need

35. Test stick roll-out plan
20232021 2022
Pre-FDA
Dietary health
Post-FDA
Pet health
Baby diaper
Oral health check (saliva)
Post-FDA
Fertility
Cortisol
Washlet

36. The old standard
Poor user experience
Low-sensitivity measurement method
One measurement taken at fixed point in time
Limited range of biomarkers
False negative risk
Risk of cross-contamination between test pads
Risk of contamination to environment

37. The gold standard
Simple, pleasant user experience
Superior measurement accuracy
20-100 data points per biomarker per test
Much wider range of biomarkers
Avoids false negative risk
No risk of cross-contamination
Low risk of environmental contamination

38. Where are the health toilets?
2001
• Panasonic creates the concept
• Measures glucose in urine
• …but never releases it

39. 4
2008
• TOTO releases Intelligence Toilet II
• Also measures glucose in urine
• Released but shut down 2 years later
Where are the health toilets?

40. 2020
• A mix of prototypes, vapor and failure
• Most still using old test strip tech
• 3-5 years until product on sale
• Biomesense is one to watch
Where are the health toilets?
Toilet sensor Toilet seat Full toilet
Urine
analysis
-
Faeces
analysis
- -
Visual
analysis
-

41. Prototype or product?
20 years in the making
100 patents filed
…coming soon?

42. The inventor’s dilemma
What I want
to make
What the
customer wants
What will
make a profit

43. What will
make a profit
The health tracking device inventor’s dilemma
What I want
to make
What is actually
backed by science
What the FDA
is cool with
What the
customer wants

44. (Other) ones to watch
World’s first home multi-
biomarker blood lab
World’s first multi-
biomarker CGM
World’s first toilet-based
microbiome analyzer

45. Thank you!
Beta from Q4 2020, on sale in 2021!
Email me at daniel@bisu.bio
Join our wait list at www.bisu.bio