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Bioavailability studies lecture7

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Bioavailability Adapted by: Sereta Campbell-Elliott B. Pharm; M Pharm. Sc Prepared By: Marcia Williams
What is a drugs’ bioavailability? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Assessment of Bioavailability ,[object Object],[object Object]
Important parameters in bioavailability studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Important parameters in bioavailability studies (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Illustration of bioavailability variables
Representation of Bioavailability Data ,[object Object],[object Object],[object Object]
Representation of Bioavailability Data(cont’d) ,[object Object],[object Object]
AUC Measurement ,[object Object],[object Object],[object Object],[object Object],[object Object]
Illustration of Trapezoid Method from graph
AUC Measurement 4.10 5 6.77 4 11.1 3 18.4 2 30.3 1 38.9 0.5 Plasma Conc (  g/ml) Time (hr)
Absolute and Relative Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Urinary Drug Excretion Data ,[object Object],[object Object],[object Object],[object Object],[object Object]
Urinary Drug Excretion Data (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Urine Data
Urine Data ,[object Object],[object Object],[object Object],[object Object]
The following tetracycline plasma and urinary data are obtained following intravenous administration of 250 mg tetracycline to a 70 kg subject: 62.0 73     8.0 13 0.90 12 10.0 11 1.05 10 12.0 9 1.2 8 13.0 7 1.50 6 16.6 5 1.71 4 29.4 3 2.40 1.5 X,urine (mg) t(h) C,plasma (ug/ml) t(h)

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Bioavailability studies lecture7