The biological approach to explaining smoking behavior focuses on the stages of addiction - initiation, maintenance, and relapse. Genetic factors and neurochemistry, particularly the dopamine reward system and endogenous opioid system, are implicated in the addiction process and the development of physical dependency and tolerance. Research evidence from twin and gene studies provides support for genetic influences, while animal studies further validate the dopamine reward model of addiction. However, the biological model has relative weaknesses in explaining smoking initiation compared to behavioral and cognitive approaches.