study of disease by scientific methods Pathogenesis Environmental and Genetic Factors

1. study of disease by scientific methods

5. an abnormal variation in structure
or function of any part of the body
DISEASE
Pathology gives explanations of a disease by studying the
following four aspects of the disease:
1. Etiology,
2. Pathogenesis,
3. Morphologic changes and
4. Functional derangements and clinical significance.

6. cause of the disease
PRIMARY ETIOLOGY
cause of a disease is known
IDIOPATHIC
cause of the disease is unknown

10. MORPHOLOGIC CHANGES
structural alterations in cells or tissues that occur
following the pathogenetic mechanisms
GROSS MORPHOLOGIC CHANGES
changes that can be seen with the naked eye
MICROSCOPIC CHANGES
seen under the microscope are called
microscopic changes

11. FUNCTIONAL DERANGEMENTS
and CLINICAL SIGNIFICANCE
The morphologic changes in the organ
influence the normal function of the organ.
By doing so, they determine the clinical
features (symptoms and signs), course, and
prognosis of the disease.

12. Etiology Pathogenesis
Morphologic Changes
Clinical Features & Prognosis

16. A.ENVIRONMENTAL FACTORS
1. Physical agents
2. Chemicals
3. Nutritional deficiencies &
excesses
4. Infections & infestations
5. Immunological factors
6. Psychogenic factors

17. B. Genetic Factors

18. COURSE OF DISEASE
Exposure Biological onset
Clinical onset
Permanent damage Death