Pathophysiology1.

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What is pathophysiology

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Pathophysiology1.

  1. 1. Pathophysiology
  2. 2. What is pathophysiology?  A subject to explore the rule of origin and evolution of disease processes and the fundamental mechanisms.
  3. 3. Difference from Physiology Also named:  Physiopathology  Physiology of Disease  Physiology of Disordered Function
  4. 4. Difference from Pathology  Pathology emphasizes the structural changes  Pathophysiology focuses on the functional and metabolic alterations and the mechanisms
  5. 5. The Methodologies Used in Pathophysiology  Traditionally, limited in systemic or organic levels.  Now, more methods
  6. 6. Why is Pathophysiology Important? As a bridge not between the basic science and diseases but various basic sciences .  Enabling the students, clinicians and other practitioners to understand why and how diseases develop and various clinical manifestations appear, and what are the fundamental mechanisms. 
  7. 7. How the Teaching of Pathophysiology is Arranged?  Introduction  Fundamental pathological processes  Organic pathophysiology  Cellular and molecular pathophysiology
  8. 8. Major Points in Learning Pathophysiology  The general concepts  The etiology and pathogenesis  The alterations in metabolism and functions  The principles for the prevention and therapies
  9. 9. How to Learn Pathophysiology?  Grasp the major points  Use dialectical thinking and methods  Selectively review related knowledge learned previously  Pay attention to experimental courses  Pay attention to clinical practices
  10. 10. Conspectus of Disease
  11. 11. Concept of Disease Disease is referred as aberrant manifestation of deregulated homeostasis caused by harmful agents.  The development of a disease is definitely a pathologic process with a characteristic set of signs and symptoms involved in the whole body or any of its parts. 
  12. 12. Concept of Health  Health is the state of the organism when it functions optimally without evidence of disease.  The definition of health from WHO: Health indicates not only without any evidence of disease, but also a state of complete well-being physically, psychologically and socially.
  13. 13. Etiology of disease  Etiology is used to study the causative agents including microorganisms, environmental, social factors and personal habits as contributing factors that causes disease.  Answer the question why disease happens.
  14. 14. Etiological factors Extrinsic Factors  Biological agents  Chemical agents  Physical agents  Nutritional imbalance
  15. 15. Etiological factors Intrinsic Factors  Genetic factors  Congenital factors  Immunological factors  Psychological factors
  16. 16. Predisposing factors  Genetic constitution  Physiological diathesis  Psychological characteristics
  17. 17. Precipitating Factors  Natural conditions  Physical condition  Social condition
  18. 18. Pathogenesis of disease  Disruption of homeostasis  Process of damage and anti-damage  Reversal role of cause and result  Correlation between systemic and local regulations
  19. 19. Outcome of disease  Complete recovery  Incomplete  Death recovery
  20. 20. Brain Death (WHO criteria )  Cessation of spontaneous respiration  Irreversible coma  Absence of cephalic reflexes and dilated pupils  Absence of any electrical activity of the brain  Absence of brain blood flow
  21. 21. Thanks

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