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Patients with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) who received drug-eluting stents were compared in terms of outcomes. Patients with IDDM had higher rates of major adverse cardiac events compared to those with NIDDM one year after receiving drug-eluting stents. Rates of death, myocardial infarction, and target vessel revascularization were higher in patients with IDDM versus NIDDM. Careful follow-up is needed for patients with IDDM who receive drug-eluting stents.
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![http://www.nexusmedica.com/web/articulos/r663/a16955/g-18-4-002.pdf<br />Comparison of outcomes in patients with insulin-dependent versus non-insulin dependent diabetes mellitus receiving drug-eluting stents (from the first phase of the prospective multicenter German DES.DE registry).<br />Akin I, Bufe A, Eckardt L, Reinecke H, Senges J, Richardt G, Kuck KH, Schneider S, Nienaber CA; DES.DE Study Group.<br />Am J Cardiol. 2010 Nov 1;106(9):1201-7. Epub 2010 Sep 9.PMID: 21029813 [PubMed - indexed for MEDLINE]Related citations<br />http://www.fundaciondiabetes.org/documentos/alimentacion_ancianos/box_alimentacion_ancianos.htm<br />](https://image.slidesharecdn.com/bibliografiaarticulos-110212020105-phpapp01/85/Bibliografiaarticulos-1-320.jpg)
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Race Affects Attitudes
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Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Race Affects Attitudes
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Bibliografiaarticulos
- 1. http://www.nexusmedica.com/web/articulos/r663/a16955/g-18-4-002.pdf<br />Comparison of outcomes in patients with insulin-dependent versus non-insulin dependent diabetes mellitus receiving drug-eluting stents (from the first phase of the prospective multicenter German DES.DE registry).<br />Akin I, Bufe A, Eckardt L, Reinecke H, Senges J, Richardt G, Kuck KH, Schneider S, Nienaber CA; DES.DE Study Group.<br />Am J Cardiol. 2010 Nov 1;106(9):1201-7. Epub 2010 Sep 9.PMID: 21029813 [PubMed - indexed for MEDLINE]Related citations<br />http://www.fundaciondiabetes.org/documentos/alimentacion_ancianos/box_alimentacion_ancianos.htm<br />