Node.js is a JavaScript runtime environment that allows building fast, scalable network applications using event-driven, asynchronous I/O. It uses Google's V8 JavaScript engine and can run on Windows, Mac OS, and Linux. Node.js is commonly used for building servers, APIs, real-time apps, streaming data, and bots. Typical Node.js apps use NPM to install packages for tasks like databases, web frameworks, testing, and more. Node.js handles non-blocking I/O through callbacks to avoid blocking and optimize performance. A basic HTTP server in Node.js creates a server, handles requests, and sends responses.