Antidiabetic spices

1. Antidiabetic
Spices

2. What are spices?
In the culinary arts, the word spice refers to any dried part of a
plant, other than the leaves, used for seasoning and flavoring
a recipe, but not used as the main ingredient.

5. Cinnamon
• glucose
• insulin and insulin
sensitivity
• lipids, or fats, in the
blood
• antioxidant status
• blood pressure
• lean body mass
• digestion

6. nt J Food Sci. 2019; 2019: 4138534.
Published online 2019 Mar 4. doi: 10.1155/2019/4138534
PMCID: PMC6425402
PMID: 30949494
The Effect of Different Amounts of Cinnamon Consumption on Blood Glucose in
Healthy Adult Individuals
Nildem Kizilaslan
1 and Nihal Zekiye Erdem 2
Author information Article notes Copyright and License information Disclaimer
Conclusions
In particular a 3–6 g of cinnamon consumption was found to affect certain blood parameters of
individuals positively. Therefore, it is considered to be beneficial to raise awareness of
individuals to be conscious to regularly consume cinnamon.

7. Fenugreek Seeds
• reduce intestinal glucose
absorption
• delay gastric emptying
• improve insulin sensitivity
and action
• reduce concentrations of
lipid-binding protein
• Reduce Inflammation
• Reduce the risk of heart and
blood pressure conditions

8. Ayu. 2017 Jan-Jun; 38(1-2): 24–27.
doi: 10.4103/ayu.AYU_209_15
PMCID: PMC5954247
PMID: 29861588
A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A
parallel group, randomized single-blind trial
Manjiri Ranade and Nikhil Mudgalkar1
Conclusion:
A simple complementary addition of fenugreek seeds can have a synergistic effect along with
diet control and exercise on fasting blood glucose and HbA1c but is of delayed occurrence.

9. Cumin seeds
• stimulates the insulin production
• trigger insulin secretion right
from the pancreas and insulin
sensitivity in the skeletal muscles.
• This makes the liver cells to get
enhanced, and the muscular
tissues to uptake the glucose.
• It contains phytonutrients like
thymoquinone, crystalline
nigellone, and beta-sitosterol; all
of which are wonderful glucose-
lowering components
• Vitamin B and other health
benefitting minerals like iron,
zinc, calcium, and copper.

10. Antidiabetic influence of dietary cumin seeds (Cuminum cyminum) in streptozotocin induced
diabetic
Abstract
Cumin seed (), a commonly consumed spice was examined for a
possible anti-diabetic influence in streptozotocin induced
diabetic. An eight week dietary regimen containing cumin
powder (1.25%) was found to be remarkably beneficial, as
indicated by reduction in hyperglycaemia and glucosuria. This
was also accompanied by improvement in body weights of
diabetic animals on the cumin diet. Dietary cumin also countered
other metabolic alterations as revealed by lowered blood urea
level and reduced excretions of urea and creatinine by diabetic.

11. Turmeric
• Managing glucose
• Reversing prediabetes
• diabetic nephropathy,
also called diabetic
kidney disease
• pain resulting from
inflammatory
conditions
• such as rheumatoid
arthritis

12. Conclusion
Recent research has provided the scientific basis for “traditional” curcumin and confirmed the important
role of curcumin in the prevention and treatment of diabetes and its associated disorders. Curcumin could
favorably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycemia,
hyperlipidemia, and islet apoptosis and necrosis (Figure 2). In addition, curcumin could prevent the
deleterious complications of diabetes. Despite the potential tremendous benefits of this multifaceted nature
product, results from clinical trials of curcumin are only available in using curcumin to treat diabetic
nephropathy, microangiopathy and retinopathy so far. Studies are badly needed to be done in humans to
confirm the potential of curcumin in limitation of diabetes and other associated disorders. Further, multiple
approaches are also needed to overcome limited solubility and poor bioavailability of curcumin.
Evid Based Complement Alternat Med. 2013; 2013: 636053.
Published online 2013 Nov 24. doi: 10.1155/2013/636053
PMCID: PMC3857752
PMID: 24348712
Curcumin and Diabetes: A Systematic Review
Dong-wei Zhang, 1 ,* Min Fu, 2 Si-Hua Gao, 1 and Jun-Li Liu 2 ,*
Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.

13. Red Chili
• Improve Post
prandial
glucose
• helps lower the
heart rate

14. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism
August 2006
American Journal of Clinical Nutrition 84(1):63-9
DOI:10.1093/ajcn/84.1.63
Source
PubMed
Authors:
Abstract
Conversely, the C-peptide/insulin quotient (an indicator of hepatic insulin clearance) was
highest after the CAC meal (P = 0.002). Regular consumption of chili may attenuate
postprandial hyperinsulinemia.

15. Clove
• anti-inflammatory
• analgesic and
digestive health
benefits for diabetes.
• Cloves also help
keep your blood
sugar levels in check
and are known to
promote insulin
production

16. Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK
Abstract
Clove (Syzygium aromaticum flower buds) EtOH extract significantly suppressed an increase in
blood glucose level in type 2 diabetic KK-A(y) mice. In-vitro evaluation showed the extract had
human peroxisome proliferator-activated receptor (PPAR)-γ ligand-binding activity in a GAL4-
PPAR-γ chimera assay. Bioassay-guided fractionation of the EtOH extract resulted in the isolation
of eight compounds, of which dehydrodieugenol (2) and dehydrodieugenol B (3) had potent
PPAR-γ ligand-binding activities, whereas oleanolic acid (4), a major constituent in the EtOH
extract, had moderate activity. Furthermore, 2 and 3 were shown to stimulate 3T3-L1
preadipocyte differentiation through PPAR-γ activation. These results indicate that clove has
potential as a functional food ingredient for the prevention of type 2 diabetes and that 2-4
mainly contribute to its hypoglycemic effects via PPAR-γ activation.

17. Ginger
• Glycaemic
control
• Improves Blood
sugar levels

18. Iran J Pharm Res. 2015 Winter; 14(1): 131–140.
PMCID: PMC4277626
PMID: 25561919
The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, Apolipoprotein B,
Apolipoprotein A-I and Malondialdehyde in Type 2 Diabetic Patients
Nafiseh Khandouzi,a Farzad Shidfar,b,* Asadollah Rajab,c Tayebeh Rahideh,d Payam
Hosseini,e and Mohsen Mir Taherif
Author information Article notes Copyright and License information Disclaimer
Abstract
Diabetes mellitus is the most common endocrine disorder, causes many complications such as
micro- and macro-vascular diseases. Anti-diabetic, hypolipidemic and anti-oxidative properties
of ginger have been noticed in several researches.It seems that oral administration of ginger
powder supplement can improves fasting blood sugar, hemoglobin A1c, apolipoprotein B,
apolipoprotein A-I, apolipoprotein B/apolipoprotein A-I and malondialdehyde in type 2 diabetic
patients. So it may have a role in alleviating the risk of some chronic complications of diabetes.

19. GARLIC
• Improve blood
glucose control
• Improves
cholesterol level

20. Effect of garlic supplement in the management of type
2 diabetes mellitus (T2DM): a meta-analysis of
randomized controlled trials
Juan Wang, Xiuming Zhang, Haili Lan, and Weijia Wang
Author information Article notes Copyright and License
information Disclaimer
Conclusion
The present study confirms that additional garlic contributes to
improved blood glucose control in 1–2 weeks as well as in 24 weeks in
T2DM, and plays positive roles in total cholesterol and high/low density
lipoprotein regulation in 12 weeks. The potential sustained effects
involving insulin resistance relief seems promising, however further
studies are warranted to support the finding.

21. Jeshthamadh/
Yashtimadhu/ Mulethi
• Anti-inflammatory
• Improves blood sugar level

22. Anti-Diabetic Activity of Glycyrrhiza glabra - An In vitro Study
P.S.Karthikeson, Lakshmi.T* Department of Pharmacology, Saveetha dental college &Hospitals,
Chennai, India. *Corresponding author’s E-mail: lakshmi@saveetha.com Received: 20-02-2017;
Revised: 18-03-2017; Accepted: 25-04-2017
CONCLUSION
Inhibition of α-glucosidase and α-amylase enzyme activity leads to a reduction in disaccharide
hydrolysis which has beneficial effects on glycemic index control in diabetic patients and can
reduce the incidence of post prandial hyperglycemia. As the plant extract was reported for
having anti-diabetic activity in vivo, its activity was evaluated in vitro. In conclusion, the present
study indicates that Glcyrrhiza glabraethanolic root extract shows prominent antioxidant and
anti-diabetic activity.

23. How to Use Spices