This document discusses how ZigBee wireless technology can help address various challenges in healthcare through real-time location systems (RTLS). It provides an overview of Awarepoint's RTLS architecture that uses a ZigBee network to track assets and optimize workflows across a large healthcare campus with multiple buildings. The system provides accurate in-room location tracking to drive clinical workflows without requiring additional technologies. It also discusses key considerations for adequate RTLS coverage and how Awarepoint has deployed their ZigBee-based solution across hospitals.