Atherosclerosis

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7. Arteriosclerosis is the most common disease of the
arteries; the term means “hardening of the arteries”.
DEFINITION
 It is the diffuse process whereby the muscle
fibers and the endothelial lining of the walls
of small arteries and arterioles become
thickened.

8. CAUSES
Modifiable risk factors
 Nicotine use (i.e., Tobacco smoking, chewing)
 Diet (contributing to hyperlipidimia)
 Hypertension
 Diabetes
 Stress
 Sedentary life style.
Non modifiable risk factors
 Age
 Gender
 Family history

9. CLINICAL MANIFESTATION
 The clinical signs and symptoms resulting from atherosclerosis
depend on the organ or tissue affected. The consequences of
atherosclerosis are:
Myocardial infarction
Ischemic heart disease(IHD)
Cardiovascular accident ( Transient ischemic attack or
stroke).
Subarachnoid hemorrhage may result.
Peripheral arterial diseases.
Aneurysms.

10. 1. Blood test: Lipid profile
2. ECG.
3. Chest X-ray.
4. Echocardiogram.
5. Ankle/brachial Index.
6. Angiography.
7. Stress testing.
DIAGNOSIS
0

11.  Anti-cholesterol medications: Example: Statins. (Atorvastatin,
fluvastatin, Lovastatin).Tab Atorvastatin10mg PO OD.
 Anti-platelet medications:Tab. Aspirin 75mg PO OD., Tab.
Clopidogrel 75mg PO OD.
 Thrombolytic therapy: Inj. Streptokinase .
 Beta blockers: E.g. Metaprolol, Atenolol, propanolol.
Tab. Metaprolol 12.5 mg PO OD.
 Angiotensin-converting enzyme (ACE) inhibitors: E.g. enalapril.
Tab. Enalapril 2.5mg or 5mg. depending on the blood pressure.
 Calcium channel blockers: E.g. Tab. Amlodipine 2.5mg, 5mg or 10
mg dose can be adjusted according to the blood pressure.
 Diuretics:E.g. Tab. Frusemide 20mg
MEDICAL MANAGEMENT

12. • Get regular medical checkups.
• Control blood pressure.
• Check cholesterol.
• Don’t smoke.
• Exercise regularly.
• Maintain a healthy weight.
• Eat a heart-healthy diet.
• Manage stress.
PREVENTION

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