Basic overview of what happens when stars die. This presentation covers white dwarfs, electron degeneracy pressure, neutron stars, neutron degeneracy pressure, black holes, event horizons and singularities
A presentation I gave to the Brighton Astronomy Society in Jan 2016 - http://brightonastro.com/ , https://www.facebook.com/brightonastro/
Annoyingly that's removed the videos from the slides, so here are links to those:
https://www.youtube.com/watch?v=e-P5IFTqB98&t=18s
(This Youtube channel "In a nutshell" is absolutely fantastic by the way and I highly recommend a look through their other videos!)
https://www.youtube.com/watch?v=duoHtJpo4GY
https://vimeo.com/8723702
I've also made my notes from preparing the slides available here as well:
https://docs.google.com/document/d/1gqgsAbvoCB_7-_gPToqOuSixc02YnU-ajf-uT60R1vc/edit?usp=sharing
-- there are LOTS of further links to interesting videos in there as well, that I didn't use on the night so worth a scan through.
Any further questions, feel free to ask in comments on here
search on NASA site also go through the latest news related to black holes before presenting your seminar.
many queries are asked related to black holes.
present the astronomical data's for Good delivery of seminar.In the 18th century John Michell and Pierre-Simon Laplace first mentioned about the objects with a huge gravitation, from which even light cannot escape.
In 1915 Albert Einstein developed the theory of general relativity.
Karl Schwarzschild finds black holes as a solution to Einstein’s equations (1916)
Robert Oppenheimer and Hartland Snyder predict that massive stars can collapse into black holes (1939)
A black hole is a region of space that has so much mass concentrated in it that there is no way for a nearby object to escape its gravitational pull.”
Black holes are exotic structures whose gravitational fields are so powerful that they trap everything, even light. They were first postulated by Albert Einstein's theory of general relativity.”
This can happen when a star is dying.
Though they are black they are invisible to us.
The density of a black hole is so great it would be like taking the whole Earth and crushing into a volume smaller than a 1” marble!.
Stellar-mass: 3 to 20 times the mass of our Sun
Supermassive: Black holes with millions to billions of times the mass of our Sun
Mid-mass: In between stellar-mass and supermassive.
A presentation I gave to the Brighton Astronomy Society in Jan 2016 - http://brightonastro.com/ , https://www.facebook.com/brightonastro/
Annoyingly that's removed the videos from the slides, so here are links to those:
https://www.youtube.com/watch?v=e-P5IFTqB98&t=18s
(This Youtube channel "In a nutshell" is absolutely fantastic by the way and I highly recommend a look through their other videos!)
https://www.youtube.com/watch?v=duoHtJpo4GY
https://vimeo.com/8723702
I've also made my notes from preparing the slides available here as well:
https://docs.google.com/document/d/1gqgsAbvoCB_7-_gPToqOuSixc02YnU-ajf-uT60R1vc/edit?usp=sharing
-- there are LOTS of further links to interesting videos in there as well, that I didn't use on the night so worth a scan through.
Any further questions, feel free to ask in comments on here
search on NASA site also go through the latest news related to black holes before presenting your seminar.
many queries are asked related to black holes.
present the astronomical data's for Good delivery of seminar.In the 18th century John Michell and Pierre-Simon Laplace first mentioned about the objects with a huge gravitation, from which even light cannot escape.
In 1915 Albert Einstein developed the theory of general relativity.
Karl Schwarzschild finds black holes as a solution to Einstein’s equations (1916)
Robert Oppenheimer and Hartland Snyder predict that massive stars can collapse into black holes (1939)
A black hole is a region of space that has so much mass concentrated in it that there is no way for a nearby object to escape its gravitational pull.”
Black holes are exotic structures whose gravitational fields are so powerful that they trap everything, even light. They were first postulated by Albert Einstein's theory of general relativity.”
This can happen when a star is dying.
Though they are black they are invisible to us.
The density of a black hole is so great it would be like taking the whole Earth and crushing into a volume smaller than a 1” marble!.
Stellar-mass: 3 to 20 times the mass of our Sun
Supermassive: Black holes with millions to billions of times the mass of our Sun
Mid-mass: In between stellar-mass and supermassive.
Detail about Black holes. It's definition, components and then history of black hole and General theory of relativity.
Life cycle of a star and formation of black hole in space.
Different types of choice after star's life end.
Different types of Black hole on basis on mass of Parent star. and classification of black holes on basis of charge and rotational motion of black holes. Quantum theory of physics.
Study of Black holes using Quantum mechanics by Steaphen Hawking.
Current research on black holes.
Neutron star ,an interesting part of astronomy. sobur hossain
A small work about neutron star which will make you interest in astrophysics ,a fascinating things on this earth.Moreover you will learn some facts about astronomy.
Astronomy - State of the Art - GalaxiesChris Impey
Astronomy - State of the Art is a course covering the hottest topics in astronomy. In this section, the properties of galaxies are discussed, including supermassive black holes and dark matter.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
More Related Content
Similar to Astronomy - White Dwarfs_Neutron Stars_Black Holes.pptx
Detail about Black holes. It's definition, components and then history of black hole and General theory of relativity.
Life cycle of a star and formation of black hole in space.
Different types of choice after star's life end.
Different types of Black hole on basis on mass of Parent star. and classification of black holes on basis of charge and rotational motion of black holes. Quantum theory of physics.
Study of Black holes using Quantum mechanics by Steaphen Hawking.
Current research on black holes.
Neutron star ,an interesting part of astronomy. sobur hossain
A small work about neutron star which will make you interest in astrophysics ,a fascinating things on this earth.Moreover you will learn some facts about astronomy.
Astronomy - State of the Art - GalaxiesChris Impey
Astronomy - State of the Art is a course covering the hottest topics in astronomy. In this section, the properties of galaxies are discussed, including supermassive black holes and dark matter.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
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Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
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Astronomy - White Dwarfs_Neutron Stars_Black Holes.pptx
1. BLACK HOLES
AIM: USE STELLAR EVOLUTION TO DESCRIBE HOW
BLACK HOLES ARE FORMED
DEFINE THE EVENT HORIZON AND A SINGULARITY
2.
3. THE SUN WILL BECOME A
WHITE DWARF
• In a white dwarf the atoms are getting pressed together
• Gravity compacts the matter inward
• The electrons in the atoms cannot be squeezed any more
4.
5. ELECTRON DEGENERACY PRESSURE
• When all the atoms are filled with
electrons – we call it a “degenerate” gas
• The white dwarf is stable due to a
balance between inward gravitational
pressure and out electron degeneracy
pressure
6. CHANDRASEKAR LIMIT
• There is a limit to how massive a white
dwarf can be
• If too much mass is introduced, then gravity
will be stronger than electron degeneracy
pressure
• The result is the electrons are “ejected” from
the star
7. CHANDRASEKAR LIMIT
• The Chandrasekhar Limit of 1.4 solar masses, is the
theoretical maximum mass a white dwarf star can have
and still remain a white dwarf
8. HOW CAN WHITE DWARF STARS GAIN MASS?
WHERE DOES THE EXTRA MASS COME FROM?
BINARY STAR SYSTEMS
WHITE DWARFS CAN
STEAL MASS FROM
THEIR COMPANION
STAR
9.
10. TYPE 1A SUPERNOVA
• When a white dwarf exceeds 1.4 solar
masses it explodes
• This type of supernova have a known
luminosity
• Used to calculate distances in space
11. WHITE DWARF STARS ARE VERY DENSE.
WHAT IS DENSER THAN A WHITE DWARF?
•Neutron stars!!!!
•And black holes!!!
12. NEUTRON STARS
• Like white dwarfs, they are held together by
neutron degeneracy pressure
13. NEUTRON STARS LIMIT
• Neutron stars also have limits
of how massive they can be
• About 3 Solar masses
16. BLACK HOLES
• Black holes are the most massive and
most dense objects in the universe.
• It has two major characteristics
• An event horizon
• A singularity
17. BLACK HOLES – EVENT HORIZON
• Event Horizon - the spherical outer
boundary of a black hole loosely considered
to be its "surface."
• It is the point that the gravitational
influence of the black hole becomes so
great that not even light is fast enough to
escape it
20. BLACK HOLE - SINGULARITY
• The singularity at the center of a
black hole is the ultimate no
man's land: a place where
matter is compressed down to
an infinitely tiny point, and all
conceptions of time and space
completely break down.
Editor's Notes
By R.N. Bailey - Own work, CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=59672008