Background: Chronic kidney disease is defined as the presence, for more than three months, of changes in the structure or function of the kidneys, secondary to a progressive decline in the number of nephrons, with a consequent deterioration in health resulting from the inability of the kidneys to perform their excretory functions, softener, and metabolism. Chronic kidney disease (CKD) is a clinical condition caused by the progressive and progressive loss of kidney function. Chronic kidney disease is not only implicated by the gradual deterioration of quality of life and life expectancy when it progresses to more advanced stages but also by the increase in cardiovascular morbidity and mortality, which is the leading cause of death in these patients. Aim: This paper aims to assess the outcomes of dyslipidemia in a dialysis patient. Patients and method: In this study, a descriptive cross-sectional study was applied to study the Assessment Outcomes of Dyslipidemia in Dialysis Patients in Iraq from 4th January 2021 to 7th August 2022. Data were collected for 150 patients in different hospitals in Iraq, where the patients were divided into two groups, the first group of patients, which included DIALYSIS PATIENTS, which included 80, and the second group, the control group, which included patients, which include 70 patients. Results and discussions: collected 150 cases distributed according to dialysis patients (80) and controls (70); the most frequent ages in this study ranged from 40-49 years old 34 (42.5%) patients group, 33 (47.14%) control group with a statistical difference of 0.0831. In this study was evaluated the Outcomes of dyslipidemia in a dialysis patient. Imbalances were found in levels of dyslipidemia which LDL 5.12±3.4 of the patients' group, as for the control group 2.1±3.3-HDL 2.43±2.4 of the patients' group, 1.4±1.5 for the control group, TRIGLYCERIDE 1.75±1.8 of patients group, 0.55±0.43 for the control group with A statistically significant relationship were found between dyslipidemia levels and outcomes in the group of patients at P value < 0.05.
Evaluate of the Physical Performance of Patients Undergoing HemodialysisAhmed Alkhaqani
Background: Chronic kidney disease (CKD) is a worldwide health burden with high costs to the health system. It is associated with increased morbidity and mortality as well as a reduced quality of life. With the increase in the number of maintenance hemodialysis patients, debilitating conditions of muscle wasting and atrophy have become one of the biggest concerns for patients with CKD.
Objectives: The present study aimed to measure the physical performance level of patients with end-stage kidney disease and undergoing regular hemodialysis through using a short physical performance battery (SPPB) scale.
Methods: A descriptive design study (cross-sectional) was conducted on participants selected from the Dialysis Kidney Unit at Al-Sadder Medical Hospital in Al-Najaf City in order to achieve the study aim. The period of study is from 20th December 2020 to 28th February 2021. A non-probability (purposive sample) technique was used consisted of (62) patients who are medically diagnosed with CKD and undergoing hemodialysis included in the present study. The data were collected using a questionnaire consisting of three parts, including socio-demographic, clinical data form, and short physical performance battery (SPPB) scale.
Results: Show that there is a significant difference between means throughout three periods of test-1 (6.10), test-2 (6.16), and test-3 (5.40) at P=0.024, that the levels of all of the physical performance are below the predicted levels at the baseline assessment and they still deteriorate even at the third assessment The results indicated that the poor physical performance of patients suffer from chronic kidney disease and undergoing hemodialysis treatment.
Conclusion: Patients with end-stage kidney disease and undergoing hemodialysis have a low level of physical performance. This result is related to the physical activity regarding the population on hemodialysis, not being related to the demographic and clinical data evaluated.
Chronic kidney disease (CKD) is a global public health problem
worldwide. The worldwide prevalence of CKD has increased in
various countries such as the U.S. (13.1%), Taiwan (9.8-11.9%),
Norway (10.2%), Japan (12.9-15.1%) China (3.2-11.3%), Korea (7.2- 13.7%), Thailand (8.45-16.3%), Singapore (3.2-18.6%), and Australia(11.2%)
Abstract— Non Alcoholic Fatty Liver Disease is also becoming public health impotance nowadays. So this study was aimed to determine the association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. This study includes a total of 222 subjects were enrolled as per the inclusion/exclusion criteria, out of which 110 cases who had NAFLD with hepatic steatosis on ultrasonography and 112 subjects who did not have NAFLD were considered control. These cases and controls were interrogated and investigated further. Observations were recorded and association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. Statistical methods used were unpaired student’s t-test for continuous variables, Fischer’s and chi-sq test for categorical variables using bivariate analysis by Graph Pad Instat Version 3.10. Risk was assessed in terms of Odd's Ratio. The patients with MS and NAFLD had a higher proportion of CVD compared with those who did not have NAFLD (29.1 vs 18.1 %). This study concludes that NAFLD is significantly associated with MS; most significant with WC, followed by TG and FBS and thus can be considered as hepatic component of MS. This needs more research with large multi-centric prospective studies to evaluate NAFLD as an independent risk factor for CVD.
Evaluate of the Physical Performance of Patients Undergoing HemodialysisAhmed Alkhaqani
Background: Chronic kidney disease (CKD) is a worldwide health burden with high costs to the health system. It is associated with increased morbidity and mortality as well as a reduced quality of life. With the increase in the number of maintenance hemodialysis patients, debilitating conditions of muscle wasting and atrophy have become one of the biggest concerns for patients with CKD.
Objectives: The present study aimed to measure the physical performance level of patients with end-stage kidney disease and undergoing regular hemodialysis through using a short physical performance battery (SPPB) scale.
Methods: A descriptive design study (cross-sectional) was conducted on participants selected from the Dialysis Kidney Unit at Al-Sadder Medical Hospital in Al-Najaf City in order to achieve the study aim. The period of study is from 20th December 2020 to 28th February 2021. A non-probability (purposive sample) technique was used consisted of (62) patients who are medically diagnosed with CKD and undergoing hemodialysis included in the present study. The data were collected using a questionnaire consisting of three parts, including socio-demographic, clinical data form, and short physical performance battery (SPPB) scale.
Results: Show that there is a significant difference between means throughout three periods of test-1 (6.10), test-2 (6.16), and test-3 (5.40) at P=0.024, that the levels of all of the physical performance are below the predicted levels at the baseline assessment and they still deteriorate even at the third assessment The results indicated that the poor physical performance of patients suffer from chronic kidney disease and undergoing hemodialysis treatment.
Conclusion: Patients with end-stage kidney disease and undergoing hemodialysis have a low level of physical performance. This result is related to the physical activity regarding the population on hemodialysis, not being related to the demographic and clinical data evaluated.
Chronic kidney disease (CKD) is a global public health problem
worldwide. The worldwide prevalence of CKD has increased in
various countries such as the U.S. (13.1%), Taiwan (9.8-11.9%),
Norway (10.2%), Japan (12.9-15.1%) China (3.2-11.3%), Korea (7.2- 13.7%), Thailand (8.45-16.3%), Singapore (3.2-18.6%), and Australia(11.2%)
Abstract— Non Alcoholic Fatty Liver Disease is also becoming public health impotance nowadays. So this study was aimed to determine the association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. This study includes a total of 222 subjects were enrolled as per the inclusion/exclusion criteria, out of which 110 cases who had NAFLD with hepatic steatosis on ultrasonography and 112 subjects who did not have NAFLD were considered control. These cases and controls were interrogated and investigated further. Observations were recorded and association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. Statistical methods used were unpaired student’s t-test for continuous variables, Fischer’s and chi-sq test for categorical variables using bivariate analysis by Graph Pad Instat Version 3.10. Risk was assessed in terms of Odd's Ratio. The patients with MS and NAFLD had a higher proportion of CVD compared with those who did not have NAFLD (29.1 vs 18.1 %). This study concludes that NAFLD is significantly associated with MS; most significant with WC, followed by TG and FBS and thus can be considered as hepatic component of MS. This needs more research with large multi-centric prospective studies to evaluate NAFLD as an independent risk factor for CVD.
Anaemia in Chronic Renal Failure Patients Undergoing Haemodialysis: A across ...Neeleshkumar Maurya
ABSTRACT Chronic renal failure disease is frequently associated with anaemia and the level of anaemia correlates with the stage of chronic kidney disease (CKD). A cross-sectional study was conducted in 44 chronic kidney disease patients in the department of medicine, M.L.B. Medical College, Jhansi during the period January to June, 2018. The study was evaluating the profile of anaemia and to find the association between the severity of anaemia and ckd-5 patients time period of taking on haemodialysis. Haemoglobin, blood urea, serum albumin, serum creatinine levels were examined using standard techniques. There was a significant difference in the haemoglobin of CKD patients taking 30 days regular interval 3 times values (P <0.05). All 44 patients (100%) were anaemic there was no significant correlation between the severity of anaemia and serum creatinine levels (P > 0.82) the most frequent anaemia in chronic kidney disease patients was a malnourished type of a moderate degree anaemic (7 10mg/dl). A significant correlation was not found between the severity of anomie and serum creatinine levels 30 day interval of CKD of patients on haemodialysis. Keywords: - haemodialysis, anomie, serum creatinine, haemoglobin, malnutrition.
Comparative Study of Hscrp in Chronic Kidney Diseaseiosrphr_editor
Chronic kidney disease (CKD) is a global threat to health mainly in developing countries because therapy is expensive and lifelong. over 1 million people worldwide are on dialysis or with a functioning graft. Early detection of Chronic kidney disease (CKD) and its consequent complications can prevent its grave complications . It causes not only significant morbidity but also it causes high mortality. Because of increase in incidence of Diabetes mellitus, hypertension, obesity and an aging population there is increase in progression of chronic kidney disease to end stage renal disease (ESRD). . Cardiovascular disease (CVD) is the major cause of mortality in haemodialysis patients and so it has become imperative to have a screening programme at all levels to detect CKD at an early stage and to initiate specific therapy to reduce the progression of renal disease and also the burden of ESRD (1). High sensitive C-Reactive protein (Hs CRP) assay is useful for sensitive detection of inflammatory state (2,3). This study aims at estimating Hs CRP as a marker of inflammation in CKD patients...
Impact of Hemodialysis on lipid profile among chronic renal failure patients ...Neeleshkumar Maurya
Chronic Renal Failure (CRF) patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. Many a time CRF patients live on hemodialysis on regular basis. Chronic renal failure (CRF) is complicated by characteristic dyslipidemias. We sought to evaluate the pattern of lipid profile in CRF patients with and without hemodialysis. Study were divided into 2 groups, Group-I: CRF patients who never undergone hemodialysis (24) and Group-II: CRF patients on hemodialysis (24). We obtained serum samples from patients in the morning after an overnight fast and were analyzed for total cholesterol (TC), triglycerides (TGs), HDL, LDL and VLDL. Significant change (p<0.05) was found in Total cholesterol (TC), HDL-C, VLDL-C, HDL-C(level) between first and second group.
Keywords: Chronic renal failure, cardiovascular disease, Haemodialysis, CKD stage – 5
Study of Endothelial Dysfunction in Type 2 Diabetes Mellitusiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
ABSTRACT- In today’s modern lifestyle high blood cholesterol is one of the most dreaded causes of heart diseases among the global population. Fast lifestyle, lack of exercise, obesity and improper food intake all sum up to deranged lipid profile as well as diabetes. Diabetes and high blood cholesterol goes hand in hand which leads to an increased incidence of coronary artery and cardiovascular disorders which still remains as one of the leading causes of mortality overall. In the present study there has been an effort put to draw a correlation between glycosylated hemoglobin which is a marker for level of blood glucose in diabetic patients as well as deranged lipid profile. Blood samples collected in sterile vials were first centrifuged and then put into analyzer for the computation of the lipid profile and the glycosylated hemoglobin. Results computed were made a note of and then prepared for statistical analysis. Results thus obtained showed that females showed significantly higher levels of total serum cholesterol and Non-HDL compared to males other than that their lipid parameters were a little higher than males in general. Diabetic female patients showed a significantly higher level of glycosylated hemoglobin. There was a significant difference in the HDL values of patients in pre diabetic state and worst control of glycemic hemoglobin. There were also significant differences observed in the TGL, TGL/HDL and VLDL values between Diabetic and control patients. In general there were increased correlation of HbA1c with TSC and LDL and the respective ratios as HbA1c increases while LDL/HDL showed a significant increase with HbA1c.
Key-words- Cholesterol, Diabetes mellitus, Lipid profile, HDL, LDL, Lipid ratios
Study of Clinical Evaluation of Autonomic Dysfunction in Type 2 DMiosrjce
Diabetic autonomic neuropathy (DAN) is usually less recognizable than diabetic sensory motor
peripheral neuropathy early in the course of Type 2 diabetes mellitus. Subclinical autonomic nerve damage
occurs more widely in patients with diabetes mellitus than was hitherto suspected and is assuming greater
importance because of the implications for morbidity and mortality. By the time symptoms have developed,
autonomic damage in majority of the organs is irreversible and carries a poor prognosis. There is a need to
detect autonomic neuropathy at an early stage.
In view of this we studied on 100 patients of Type 2 diabetes mellitus who attended Diabetic Clinic (Every
Friday) in Government General Hospital, Vijayawada. With the simple non invasive tests of cardiovascular
reflex function, objective assessment of autonomic neuropathy was made. Ewing, et al introduced a test battery
for studying autonomic damage in diabetic patients. This battery has been widely accepted as a means to
classify autonomic neuropathy in terms of its severity. Detecting autonomic dysfunction using cardiovascular
autonomic function tests might help to improve the quality of life and expectancy of affected patient.
Fatty liver index correlates with non-alcoholic fatty liver disease, but not ...Enrique Moreno Gonzalez
Fatty liver index (FLI) was recently established to predict non-alcoholic fatty liver disease (NAFLD) in general population, which is known to be associated with coronary artery atherosclerotic disease (CAD).
This study aims to investigate whether FLI correlates with NAFLD and with newly diagnosed CAD in a special Chinese population who underwent coronary angiography.
Disparity of Interstitial Glucose for Capillary Glucose in Dialysis Diabetic ...semualkaira
The prevalence of chronic kidney disease (CKD) has steadily increased and diabetes is now considered the leading cause of endstage kidney disease (ESRD). Glycemic control in chronic renal
patients on dialysis presents additional difficulties because both
uremia and dialysis can affect insulin secretion and tissue insulin
sensitivity
Running head MEDICAL CARE PLANNING FOR PATIENTS WITH CHRONIC KIDN.docxjeanettehully
Running head: MEDICAL CARE PLANNING FOR PATIENTS WITH CHRONIC KIDNEY DISEASE
Medical care planning for patients with Chronic Kidney DiseaseNorys GilSouth University
Medical care planning for patients with Chronic Kidney Disease
Introduction
Chronic Kidney is a disorder that disturbs the correct working of the kidney, which is increasingly becoming a challenge to the health care sector. Just like any other chronic disease, CKD comes with the responsibility of ensuring that a patient gets maximum medical treatment facilities and attention as much as possible. “The definition and classification of chronic kidney disease (CKD) have evolved, but current international guidelines define this condition as decreased kidney function as shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m2 or markers of kidney damage, or both, of at least three months duration, regardless of the underlying cause”, Morton & Masson, 2017.
Morbidity and comorbidity of chronic Kidney disease
Weak/low results are closely associated with CKD; this is because of the burdens that are so high when it comes to comorbidity. Many pieces of research have indicated that CKD relates to diabetes and hypertension conditions. Intense conditions of chronic kidney disease also lead to heart complications. There is little information on the mental difficulties that come with CKD.
“Chronic kidney disease (CKD) can be associated with adverse clinical outcomes, poor quality of life, and high health-care costs; clinicians need to understand that these observations result from a high burden of comorbidity among CKD patients”, (Manns &Hemmelgarn 2010). Key morbidities of CKD, therefore, include pulmonary complications, diabetes, hypertension, and atrial fibrillation. CKD, to a very high degree, leads to characteristics such as myocardial infarction, dementia, hypothyroidism, depression, and stroke. All comorbidities remain classified as concordant others that closely relate with CKD but ranked as discordant include; asthma, constipation, lymphoma dementia, etc.
Impacts of chronic kidney disease
Various medical reports by the health care agencies and organizations, including the World Health Organization show that CKD is a growing complication that has become a big concern of the public health care sector not just in the United States but around the globe. An estimation of over 26 million people is affected by CKD in the country. Annual reports have shown that this number is likely to increase if serious investments are in the health care sector. Hypertension and diabetes are proven, leading causes of kidney complications. To an individual, CKD can lead to other primary complications such as nephropathy, lupus, and continuity of kidney failure. The country invests billions of money annually, something that is becoming hard to sustain because of the annual increase in population and the number of those affected by CKD.
As of 2006, over $23 billion was spent on C ...
Study of Hyponatremia and its Outcome in Cirrhosis of Liversemualkaira
1.1. Background: Hyponatremia in cirrhosis is currently defined
as a serum sodium level of less than 130 meq/L. Recent studies
have reported that lower serum sodium levels are associated with
increased complications and mortality leading to incorporation of
sodium in the Model For End Stage Liver Disease. Therefore, we
undertook this study in our tertiary hospital to study serum sodium
levels in patients admitted with cirrhosis of liver and its outcome.
Type 2 Diabetes Mellitus: The Concerned Complications and Target OrgansApollo Hospitals
Diabetes has been considered as the most dreaded non-communicable disease consuming the mankind rapidly. WHO has predicted the number of diabetics to be approximately 366 millions by 2030. The disease is characterized by hyperglycemia and the basic symptoms are polyphagia, polydipsia and polyuria. The autoimmune type 1 diabetes represent almost 1% of the total diabetic population, the rest being that of type 2 diabetes (T2D). Type 2 diabetes has been linked to a variety of factors such as heredity, environmental factors, unhealthy eating habits, sedentary lifestyle, stress etc. The uncontrolled hyperglycemia has profound deleterious effects on almost all the organs and results in various cardiovascular disorders, retinopathy, neuropathy, and nephropathy. Recent studies have revealed an array of pulmonary dysfunctions related with T2D ranging from respiratory defects to tuberculosis. Diabetes also predisposes the person to hepatic dysfunctions like NAFLD and HCC and a range of infections at various sites which are difficult to manage. Post-surgical infections are of special interest for subjects with uncontrolled hyperglycemia prior to surgery. Scientists all over the world are revealing different pathways and associated therapies for type 2 diabetes in order to control the pathological effects covering almost whole body physiology.
The Statutory Interpretation of Renewable Energy Based on Syllogism of Britis...AI Publications
The current production for energy consumption generates harmful impacts of carbon dioxide to the environment causing instability to sustainable development goals. The constitutional reforms of British Government serve to be an important means of resolving any encountered incompatibilities to political environment. This study aims to evaluate green economy using developed equation for renewable energy towards political polarization of corporate governance. The Kano Model Assessment is used to measure the equivalency of 1970 Patents Act to UK Intellectual Property tabulating the criteria for the fulfillment of sustainable development goals in respect to the environment, artificial intelligence, and dynamic dichotomy of administrative agencies and presidential restriction, as statutory interpretation development to renewable energy. The constitutional forms of British government satisfy the sustainable development goals needed to fight climate change, advocate healthy ecosystem, promote leadership of magnates, and delegate responsibilities towards green economy. The presidential partisanship must be observed to delineate parties of concerns and execute the government prescriptions in equivalence to the dichotomous relationship of technology and the environment in fulfilling the rights and privileges of all citizens. Hence, the political elites can execute corporate governance towards sustainable development of renewable energy promoting environmental parks and zero emission target of carbon dioxide discharges. The economic theory developed in statutory interpretation for renewable energy serves as a tool to reduce detrimental impacts of carbon dioxide to the environment, mitigate climate change, and produce artefacts of bioenergy and artificial intelligence promoting sustainable development. It is suggested to explore other vulnerabilities of artificial intelligence to prosper economic success.
Enhancement of Aqueous Solubility of Piroxicam Using Solvent Deposition SystemAI Publications
Piroxicam is a non-steroidal anti-inflammatory drug that is characterized by low solubility-high permeability. The present study was designed to improve the dissolution rate of piroxicam at the physiological pH's through its increased solubility by using solvent deposition system.
More Related Content
Similar to Assessment Outcomes Dyslipidaemia in Dialysis Patient
Anaemia in Chronic Renal Failure Patients Undergoing Haemodialysis: A across ...Neeleshkumar Maurya
ABSTRACT Chronic renal failure disease is frequently associated with anaemia and the level of anaemia correlates with the stage of chronic kidney disease (CKD). A cross-sectional study was conducted in 44 chronic kidney disease patients in the department of medicine, M.L.B. Medical College, Jhansi during the period January to June, 2018. The study was evaluating the profile of anaemia and to find the association between the severity of anaemia and ckd-5 patients time period of taking on haemodialysis. Haemoglobin, blood urea, serum albumin, serum creatinine levels were examined using standard techniques. There was a significant difference in the haemoglobin of CKD patients taking 30 days regular interval 3 times values (P <0.05). All 44 patients (100%) were anaemic there was no significant correlation between the severity of anaemia and serum creatinine levels (P > 0.82) the most frequent anaemia in chronic kidney disease patients was a malnourished type of a moderate degree anaemic (7 10mg/dl). A significant correlation was not found between the severity of anomie and serum creatinine levels 30 day interval of CKD of patients on haemodialysis. Keywords: - haemodialysis, anomie, serum creatinine, haemoglobin, malnutrition.
Comparative Study of Hscrp in Chronic Kidney Diseaseiosrphr_editor
Chronic kidney disease (CKD) is a global threat to health mainly in developing countries because therapy is expensive and lifelong. over 1 million people worldwide are on dialysis or with a functioning graft. Early detection of Chronic kidney disease (CKD) and its consequent complications can prevent its grave complications . It causes not only significant morbidity but also it causes high mortality. Because of increase in incidence of Diabetes mellitus, hypertension, obesity and an aging population there is increase in progression of chronic kidney disease to end stage renal disease (ESRD). . Cardiovascular disease (CVD) is the major cause of mortality in haemodialysis patients and so it has become imperative to have a screening programme at all levels to detect CKD at an early stage and to initiate specific therapy to reduce the progression of renal disease and also the burden of ESRD (1). High sensitive C-Reactive protein (Hs CRP) assay is useful for sensitive detection of inflammatory state (2,3). This study aims at estimating Hs CRP as a marker of inflammation in CKD patients...
Impact of Hemodialysis on lipid profile among chronic renal failure patients ...Neeleshkumar Maurya
Chronic Renal Failure (CRF) patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. Many a time CRF patients live on hemodialysis on regular basis. Chronic renal failure (CRF) is complicated by characteristic dyslipidemias. We sought to evaluate the pattern of lipid profile in CRF patients with and without hemodialysis. Study were divided into 2 groups, Group-I: CRF patients who never undergone hemodialysis (24) and Group-II: CRF patients on hemodialysis (24). We obtained serum samples from patients in the morning after an overnight fast and were analyzed for total cholesterol (TC), triglycerides (TGs), HDL, LDL and VLDL. Significant change (p<0.05) was found in Total cholesterol (TC), HDL-C, VLDL-C, HDL-C(level) between first and second group.
Keywords: Chronic renal failure, cardiovascular disease, Haemodialysis, CKD stage – 5
Study of Endothelial Dysfunction in Type 2 Diabetes Mellitusiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
ABSTRACT- In today’s modern lifestyle high blood cholesterol is one of the most dreaded causes of heart diseases among the global population. Fast lifestyle, lack of exercise, obesity and improper food intake all sum up to deranged lipid profile as well as diabetes. Diabetes and high blood cholesterol goes hand in hand which leads to an increased incidence of coronary artery and cardiovascular disorders which still remains as one of the leading causes of mortality overall. In the present study there has been an effort put to draw a correlation between glycosylated hemoglobin which is a marker for level of blood glucose in diabetic patients as well as deranged lipid profile. Blood samples collected in sterile vials were first centrifuged and then put into analyzer for the computation of the lipid profile and the glycosylated hemoglobin. Results computed were made a note of and then prepared for statistical analysis. Results thus obtained showed that females showed significantly higher levels of total serum cholesterol and Non-HDL compared to males other than that their lipid parameters were a little higher than males in general. Diabetic female patients showed a significantly higher level of glycosylated hemoglobin. There was a significant difference in the HDL values of patients in pre diabetic state and worst control of glycemic hemoglobin. There were also significant differences observed in the TGL, TGL/HDL and VLDL values between Diabetic and control patients. In general there were increased correlation of HbA1c with TSC and LDL and the respective ratios as HbA1c increases while LDL/HDL showed a significant increase with HbA1c.
Key-words- Cholesterol, Diabetes mellitus, Lipid profile, HDL, LDL, Lipid ratios
Study of Clinical Evaluation of Autonomic Dysfunction in Type 2 DMiosrjce
Diabetic autonomic neuropathy (DAN) is usually less recognizable than diabetic sensory motor
peripheral neuropathy early in the course of Type 2 diabetes mellitus. Subclinical autonomic nerve damage
occurs more widely in patients with diabetes mellitus than was hitherto suspected and is assuming greater
importance because of the implications for morbidity and mortality. By the time symptoms have developed,
autonomic damage in majority of the organs is irreversible and carries a poor prognosis. There is a need to
detect autonomic neuropathy at an early stage.
In view of this we studied on 100 patients of Type 2 diabetes mellitus who attended Diabetic Clinic (Every
Friday) in Government General Hospital, Vijayawada. With the simple non invasive tests of cardiovascular
reflex function, objective assessment of autonomic neuropathy was made. Ewing, et al introduced a test battery
for studying autonomic damage in diabetic patients. This battery has been widely accepted as a means to
classify autonomic neuropathy in terms of its severity. Detecting autonomic dysfunction using cardiovascular
autonomic function tests might help to improve the quality of life and expectancy of affected patient.
Fatty liver index correlates with non-alcoholic fatty liver disease, but not ...Enrique Moreno Gonzalez
Fatty liver index (FLI) was recently established to predict non-alcoholic fatty liver disease (NAFLD) in general population, which is known to be associated with coronary artery atherosclerotic disease (CAD).
This study aims to investigate whether FLI correlates with NAFLD and with newly diagnosed CAD in a special Chinese population who underwent coronary angiography.
Disparity of Interstitial Glucose for Capillary Glucose in Dialysis Diabetic ...semualkaira
The prevalence of chronic kidney disease (CKD) has steadily increased and diabetes is now considered the leading cause of endstage kidney disease (ESRD). Glycemic control in chronic renal
patients on dialysis presents additional difficulties because both
uremia and dialysis can affect insulin secretion and tissue insulin
sensitivity
Running head MEDICAL CARE PLANNING FOR PATIENTS WITH CHRONIC KIDN.docxjeanettehully
Running head: MEDICAL CARE PLANNING FOR PATIENTS WITH CHRONIC KIDNEY DISEASE
Medical care planning for patients with Chronic Kidney DiseaseNorys GilSouth University
Medical care planning for patients with Chronic Kidney Disease
Introduction
Chronic Kidney is a disorder that disturbs the correct working of the kidney, which is increasingly becoming a challenge to the health care sector. Just like any other chronic disease, CKD comes with the responsibility of ensuring that a patient gets maximum medical treatment facilities and attention as much as possible. “The definition and classification of chronic kidney disease (CKD) have evolved, but current international guidelines define this condition as decreased kidney function as shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m2 or markers of kidney damage, or both, of at least three months duration, regardless of the underlying cause”, Morton & Masson, 2017.
Morbidity and comorbidity of chronic Kidney disease
Weak/low results are closely associated with CKD; this is because of the burdens that are so high when it comes to comorbidity. Many pieces of research have indicated that CKD relates to diabetes and hypertension conditions. Intense conditions of chronic kidney disease also lead to heart complications. There is little information on the mental difficulties that come with CKD.
“Chronic kidney disease (CKD) can be associated with adverse clinical outcomes, poor quality of life, and high health-care costs; clinicians need to understand that these observations result from a high burden of comorbidity among CKD patients”, (Manns &Hemmelgarn 2010). Key morbidities of CKD, therefore, include pulmonary complications, diabetes, hypertension, and atrial fibrillation. CKD, to a very high degree, leads to characteristics such as myocardial infarction, dementia, hypothyroidism, depression, and stroke. All comorbidities remain classified as concordant others that closely relate with CKD but ranked as discordant include; asthma, constipation, lymphoma dementia, etc.
Impacts of chronic kidney disease
Various medical reports by the health care agencies and organizations, including the World Health Organization show that CKD is a growing complication that has become a big concern of the public health care sector not just in the United States but around the globe. An estimation of over 26 million people is affected by CKD in the country. Annual reports have shown that this number is likely to increase if serious investments are in the health care sector. Hypertension and diabetes are proven, leading causes of kidney complications. To an individual, CKD can lead to other primary complications such as nephropathy, lupus, and continuity of kidney failure. The country invests billions of money annually, something that is becoming hard to sustain because of the annual increase in population and the number of those affected by CKD.
As of 2006, over $23 billion was spent on C ...
Study of Hyponatremia and its Outcome in Cirrhosis of Liversemualkaira
1.1. Background: Hyponatremia in cirrhosis is currently defined
as a serum sodium level of less than 130 meq/L. Recent studies
have reported that lower serum sodium levels are associated with
increased complications and mortality leading to incorporation of
sodium in the Model For End Stage Liver Disease. Therefore, we
undertook this study in our tertiary hospital to study serum sodium
levels in patients admitted with cirrhosis of liver and its outcome.
Type 2 Diabetes Mellitus: The Concerned Complications and Target OrgansApollo Hospitals
Diabetes has been considered as the most dreaded non-communicable disease consuming the mankind rapidly. WHO has predicted the number of diabetics to be approximately 366 millions by 2030. The disease is characterized by hyperglycemia and the basic symptoms are polyphagia, polydipsia and polyuria. The autoimmune type 1 diabetes represent almost 1% of the total diabetic population, the rest being that of type 2 diabetes (T2D). Type 2 diabetes has been linked to a variety of factors such as heredity, environmental factors, unhealthy eating habits, sedentary lifestyle, stress etc. The uncontrolled hyperglycemia has profound deleterious effects on almost all the organs and results in various cardiovascular disorders, retinopathy, neuropathy, and nephropathy. Recent studies have revealed an array of pulmonary dysfunctions related with T2D ranging from respiratory defects to tuberculosis. Diabetes also predisposes the person to hepatic dysfunctions like NAFLD and HCC and a range of infections at various sites which are difficult to manage. Post-surgical infections are of special interest for subjects with uncontrolled hyperglycemia prior to surgery. Scientists all over the world are revealing different pathways and associated therapies for type 2 diabetes in order to control the pathological effects covering almost whole body physiology.
Similar to Assessment Outcomes Dyslipidaemia in Dialysis Patient (20)
The Statutory Interpretation of Renewable Energy Based on Syllogism of Britis...AI Publications
The current production for energy consumption generates harmful impacts of carbon dioxide to the environment causing instability to sustainable development goals. The constitutional reforms of British Government serve to be an important means of resolving any encountered incompatibilities to political environment. This study aims to evaluate green economy using developed equation for renewable energy towards political polarization of corporate governance. The Kano Model Assessment is used to measure the equivalency of 1970 Patents Act to UK Intellectual Property tabulating the criteria for the fulfillment of sustainable development goals in respect to the environment, artificial intelligence, and dynamic dichotomy of administrative agencies and presidential restriction, as statutory interpretation development to renewable energy. The constitutional forms of British government satisfy the sustainable development goals needed to fight climate change, advocate healthy ecosystem, promote leadership of magnates, and delegate responsibilities towards green economy. The presidential partisanship must be observed to delineate parties of concerns and execute the government prescriptions in equivalence to the dichotomous relationship of technology and the environment in fulfilling the rights and privileges of all citizens. Hence, the political elites can execute corporate governance towards sustainable development of renewable energy promoting environmental parks and zero emission target of carbon dioxide discharges. The economic theory developed in statutory interpretation for renewable energy serves as a tool to reduce detrimental impacts of carbon dioxide to the environment, mitigate climate change, and produce artefacts of bioenergy and artificial intelligence promoting sustainable development. It is suggested to explore other vulnerabilities of artificial intelligence to prosper economic success.
Enhancement of Aqueous Solubility of Piroxicam Using Solvent Deposition SystemAI Publications
Piroxicam is a non-steroidal anti-inflammatory drug that is characterized by low solubility-high permeability. The present study was designed to improve the dissolution rate of piroxicam at the physiological pH's through its increased solubility by using solvent deposition system.
Analysis of Value Chain of Cow Milk: The Case of Itang Special Woreda, Gambel...AI Publications
Ethiopia has a long and rich history of dairy farming, which was mostly carried out by small and marginal farmers who raised cattle, camels, goats, and sheep, among other species, for milk. Finding the Itang Special Woreda cow milk value chain is the study's main goal. In order to gather primary data, 204 smallholder dairy farmer households were randomly selected, and the market concentration ratio was calculated using 20 traders. Descriptive statistics, econometric models, and rank analysis were used to achieve the above specified goals. Out of all the participants in the milk value chain, producers, cafés, hotels, and dairy cooperatives had the largest gross marketing margins, accounting for 100% of the consumer price in channels I and II, 55% in channels III and V, and 25.5% in channels V. The number of children under five, the number of milking cows owned, the amount of money from non-dairy sources, the frequency of extension service contacts, the amount of milk produced each day, and the availability of market information were found to have an impact on smallholders' involvement in the milk market. Numerous obstacles also limited the amount of milk produced and marketed. The poll claims that general health issues, sickness, predators, and a lack of veterinary care are plaguing farmers. In order to address the issue of milk perishability, the researchers recommended the host community and organization to construct an agro milk processor, renovate the dairy cooperative in the study region, and restructure the current conventional marketing to lower the transaction and cost of milk marketing.
Minds and Machines: Impact of Emotional Intelligence on Investment Decisions ...AI Publications
In the evolving landscape of financial decision-making, this study delves into the intricate relationships among Emotional Intelligence (EI), Artificial Intelligence (AI), and Investment Decisions (ID). By scrutinizing the direct influence of human emotional intelligence on investment choices and elucidating the mediating role of AI in this process, our research seeks to unravel the complex interplay between minds and machines. Through empirical analysis, we reveal that EI not only directly impacts ID but also exerts its influence indirectly through AI-mediated pathways. The findings underscore the pivotal role of emotional awareness in investor decision-making, augmented by the technological capabilities of AI. It suggests that most investors are influenced by the identified emotional intelligence when making investment decisions. Furthermore, AI substantially impacts investors' decision-making process when it comes to investing; nevertheless, AI partially mediates the relationship between emotional intelligence and investment decisions. This nuanced understanding provides valuable insights for financial practitioners, policymakers, and researchers, emphasizing the need for holistic strategies that integrate emotional and technological dimensions in navigating the intricacies of modern investment landscapes. As the synergy between human intuition and artificial intelligence becomes increasingly integral to financial decision-making, this study contributes to the ongoing discourse on the symbiotic relationship between minds and machines in investments.0
Bronchopulmonary cancers are common cancers with a poor prognosis. It is the leading cause of death by cancer in Algeria and in the world. Behind this unfavorable prognosis hides numerous disparities according to age, sex, and exposure to risk factors, ranking 4th among incident cancers and developing countries including Algeria, all sexes combined. It ranks 2nd cancers in men and 3rd among women. Whatever the age observed, the incidence of this cancer is higher in men than in women, however the gap is narrowing to the detriment of the latter. The results of scientific research agree to relate trends in incidence and mortality rates to tobacco consumption, including passive smoking. Furthermore, other risk factors are mentioned such as exposure to asbestos in the workplace or to radon for the general population, or even genetic predisposition. However, the weight of these etiological and/or predisposing factors is in no way comparable to that of tobacco in the genesis of lung cancer and the resulting mortality. We provide a literature review in our article on the descriptive and analytical epidemiology of lung cancer.
Further analysis on Organic agriculture and organic farming in case of Thaila...AI Publications
The objective of this paper is to present Further analysis on Organic agriculture and organic farming in case of Thailand agriculture and enhancing farmer productivity. In view of the demand for organic fertilizers, efforts should also be made to enhance and to develop more effective of compost, bio-fertilizer, and bio-pesticides currently used by farmers. Likewise, emphasis should also be laid on the cultivation of legumes and other crops that can enhance the fertility of the soil, as practiced by farmers in many developing countries to fertilize their lands. On the other hand, most of the farmers who practice this farm system found that they are adopting a number of SLMs and interested in joining the meeting or training to gain more and more knowledge.
Current Changes in the Role of Agriculture and Agri-Farming Structures in Tha...AI Publications
The objective os this study is to present Current Changes in the Role of Agriculture and Agri-Farming Structures in Thailand and Vietnam with SLM practices. Farmer’s adoption and investment in SLM is a key for controlling land degradation, enhancing the well-being of society, and ensuring the optimal use of land resources for the benefit of present and future generations (World Bank, 2006; FAO, 2018). And agriculture remains an essential element of lives of many farmers in term of the strong cultural and symbolic values that attach current working generation to do and to spend time for it but not intern of income generating.
Growth, Yield and Economic Advantage of Onion (Allium cepa L.) Varieties in R...AI Publications
Haphazard and low soil fertility, low yielding verities and poor agronomic practices are among the major factors constraining onion production in the central rift valley of Ethiopia. Therefore, a field experiment was conducted in East Showa Zone of Adami Tulu Jido Combolcha district in central rift valley areas at ziway from October 2021 to April 2022 to identify appropriate rate of NPSB fertilizer and planting pattern of onion varieties. The experiment was laid out in split plot design of factorial arrangement in three replications. The main effect of NPSB blended fertilizer rates and varieties (red coach and red king) significantly (p<0.01) influenced plant height, leaf length, leaf diameter, leaf number and fresh leaf weight, shoot dry matter per plant, and harvest index. Total dry biomass, bulb diameter, neck diameter, average fresh bulb weight, bulb dry matter, marketable bulb yield, and total bulb yield were significantly (p<0.01) influenced only by the main effect of NPSB blended fertilizer rates. In addition, unmarketable bulb yield was statistically significantly affected (p≥0.05) by the blended fertilizer rates and planting pattern. Moreover, days to 90% maturity of onion was affected by the main factor of NPSB fertilizer rate, variety and planting pattern. The non-fertilized plants in the control treatment were inferior in all parameters except unmarketable bulb yield and harvest index. Significantly higher marketable bulb yield (41 t ha-1) and total bulb yield (41.33 t ha-1) was recorded from 300 kg ha-1 NPSB blended fertilizer rate applied. Double row planting method and hybrid red coach onion variety had also gave higher growth and yields. The study revealed that the highest net benefit of Birr, 878,894 with lest cost of Birr 148,006 by the combinations of 150 kg blended NPSB ha-1 with double row planting method (40cm*20cm*7cm) and red coach variety which can be recommendable for higher marketable bulb yield and economic return of hybrid onion for small scale farmers in the study area. Also, for resource full producers (investors), highest net benefit of Birr 1,205,372 with higher cost (159,628 Birr) by application of 300 kg NPSB ha-1 is recommended as a second option. However, the research should be replicated both in season and areas to more verify the recommendations.
Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canariu...AI Publications
The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.
The goal of neuroprotection is to shield neurons against damage, whether that damage is caused by environmental factors, pathogens, or neurodegenerative illnesses. Inhibiting protein-based deposit buildup, oxidative stress, and neuroinflammation, as well as rectifying abnormalities of neurotransmitters like dopamine and acetylcholine, are some of the ways in which medicinal herbs have neuroprotective effects [1-3]. This review will focus on the ways in which medicinal herbs may protect neurons.
A phytochemical and pharmacological review on canarium solomonenseAI Publications
The genus Canarium L. consists of 75 species of aromatic trees which are found in the rainforests of tropical Asia, Africa and the Pacific. The medicinal uses, botany, chemical constituents and pharmacological activities are now reviewed. Various compounds are tabulated according to their classes their structures are given. Traditionally canarium solomonense have been used to treat a broad array of illnesses. Pharmacological actions for canarium solomonense as discussed in this review include antibacterial, antimicrobial, antioxidant, anti-inflammatory, hepatoprotective and antitumor activity.
Influences of Digital Marketing in the Buying Decisions of College Students i...AI Publications
This research investigates the influence of digital marketing channels on purchasing decisions among college students in Ramanathapuram District. The study highlights that social media marketing, online advertising, and mobile marketing exhibit substantial positive effects on purchase decisions. However, email marketing's impact appears to be more complex. Moreover, the study explores how demographic variables like gender and academic level shape these effects. Notably, freshman students display varying susceptibility to specific digital marketing messages compared to their junior, senior, or graduate counterparts. These findings offer crucial insights for marketers aiming to tailor their strategies effectively to the preferences and behaviors of college students. By understanding the differential impacts of various digital marketing channels and considering demographic nuances, marketers can refine their approaches, optimize engagement, and ultimately enhance the effectiveness of their campaigns in targeting this demographic.
A Study on Performance of the Karnataka State Cooperative Agriculture & Rural...AI Publications
The Karnataka State Co-operative Agriculture and Rural Development Bank Limited is the apex bank of all the primary co-operative agriculture and rural development banks in the state. All the PCARD Banks in the state are affiliated to it. The KSCARD Bank provides financial accommodation to the PCARD Banks for their lending operations. In order to quick sanction and disbursement of loans and supervision over the PCARD Banks the KSCARD Bank has opened district level branches. Bank has established Women Development Cell to promote entrepreneurship among women in 2005. The Bank is identifying women borrowers in the rural areas by assigning suitable projects to motivate their self-confidence to lead independent life. Progress made in financing women entrepreneurs women.
Breast hamartoma is a rare, well-circumscribed, benign lesion made up of a variable quantity of glandular, adipose and fibrous tissue. This is a lesion that can affect women at any age from puberty. With the increasingly frequent use of imaging methods such as mammography and ultrasound as well as breast biopsy, cases of hamartoma diagnosed are increasing. The diagnosis of these lesions is made by mammography. The histological and radiological aspects are variable and depend on its adipose tissue content. The identification of these lesions is important in order to avoid surgical excisions. We report radio-clinical and pathological records of breast hamartoma.
A retrospective study on ovarian cancer with a median follow-up of 36 months ...AI Publications
Ovarian cancer is relatively common but serious and has a poor prognosis. The aim of this study is to highlight the epidemiological, diagnostic, therapeutic and evolutionary aspects of this malignant pathology managed at the Bejaia university hospital center. This is a retrospective and descriptive study over a period of 3 years (2019 - 2022) carried out on 20 patients who developed ovarian cancer. The average age of the patients was 50 years old, 53.23% of whom were over 45 years old. The CA-125 blood test was positive in 18 out of 20 patients. The tumors were discovered on ultrasound in 87.10% of cases and at laparotomy in 12.90%. Total hysterectomy with bilateral adnexectomy was the most performed procedure (64.52%). The early postoperative course was simple. 15 patients underwent second look surgery (16.13%) for locoregional recurrences. Epithelial tumors were the most frequent histological type (93.55%), including 79% in the advanced stage ( IIIc -IV) and 21% in the early stage (Ia- Ib ). Adjuvant chemotherapy was administered in 80% of patients. With a median follow-up of 36 months, 2 patients were lost to follow-up. The evolution was favorable in 27.42% and in 25.81% deaths occurred late postoperatively. Ovarian cancer is not common but serious given the advanced stages and the high rate of late postoperative deaths which were largely observed in patients deprived of adequate neoadjuvant or adjuvant chemotherapy.
More analysis on environment protection and sustainable agriculture - A case ...AI Publications
This study presents a case of tea and coffee crops , esp. environment protection and sustainable agriculture in Son La and Thai Nguyen of Vietnam. Research results show us that The process of having an agricultural product goes through many steps such as planting, planning, harvesting, packing, transporting, storing and distributing. - The State adopts policies to encourage innovation of agricultural production models and methods towards sustainability, adapting to climate change, saving water, and limiting the use of inorganic fertilizers and pesticides. chemicals and products for environmental treatment in agriculture; develop environmentally friendly agricultural models. Our research limitation is that we can expand for other crops, industries and markets as well.
Assessment of Growth and Yield Performance of Twelve Different Rice Varieties...AI Publications
The present investigation entitled “Assessment of growth and yield performance of twelve different rice varieties under north Konkan coastal zone of Maharashtra” was carried out during the kharif season of the year 2021 and 2022 on the field of ASPEE, Agricultural Research and Development Foundation, Tansa Farm, At Nare, Taluka Wada, District Palghar, Maharashtra, India. The experiment was laid out in Randomized Block Design (RBD). The twelve varieties namely Zini, Jaya, Dandi, Rahghudya, Govindbhog, Dangi, Gurjari, VNR-7, VNR-8, VNR-9, Karjat-3, and Karjat-5 were replicated thrice. The plant height (cm), number of tillers per plant, number of panicles per plant, number of panicles (m²), and length of panicle (cm) were noted to the maximum with cv. “VNR-7”. The highest number of seeds per panicle, test weight (gm), grain yield (q/ha), and straw yield (q/ha) were recorded with the cv. “VNR-7”. While the lowest number of days to 50% flowering was also recorded with cv. “VNR-7” during the year 2021 and 2022.
Cultivating Proactive Cybersecurity Culture among IT Professional to Combat E...AI Publications
In the current digital landscape, cybercriminals continually evolve their techniques to execute successful attacks on businesses, thus posing a great challenge to information technology (IT) professionals. While traditional cybersecurity approaches like layered defense and reactive security have helped IT professionals cope with traditional threats, they are ineffective in dealing with evolving cyberattacks. This paper focuses on the need for a proactive cybersecurity culture among IT professionals to enable them combat evolving threats. The paper emphasis that building a proactive security approach and culture can help among IT professionals anticipate, identify, and mitigate latent threats prior to them exploiting existing vulnerabilities. This paper also points out that as IT professionals use reactive security when dealing with traditional attacks, they can use it collaboratively with proactive security to effectively protect their networks, data, and systems and avoid heavy costs of dealing with cyberattack’s aftermaths and business recovery.
The Impacts of Viral Hepatitis on Liver Enzymes and BilrubinAI Publications
Viral hepatitis is an infection that causes liver inflammation and damage. Several different viruses cause hepatitis, including hepatitis A, B, C, D, and E. The hepatitis A and E viruses typically cause acute infections. The hepatitis B, C, and D viruses can cause acute and chronic infections. Hepatitis A causes only acute infection and typically gets better without treatment after a few weeks. The hepatitis A virus spreads through contact with an infected person’s stool. Protection by getting the hepatitis A vaccine. Hepatitis E is typically an acute infection that gets better without treatment after several weeks. Some types of hepatitis E virus are spread by drinking water contaminated by an infected person’s stool. Other types are spread by eating undercooked pork or wild game. Hepatitis B can cause acute or chronic infection. Recommendation for screening for hepatitis B in pregnant women or in those with a high chance of being infected. Protection from hepatitis B by getting the hepatitis B vaccine. Hepatitis C can cause acute or chronic infection. Doctors usually recommend one-time screening of all adults ages 18 to 79 for hepatitis C. Early diagnosis and treatment can prevent liver damage. The hepatitis D virus is unusual because it can only infect those who have a hepatitis B virus infection. A coinfection occurs when both hepatitis D and hepatitis B infections at the same time. A superinfection occurs already have chronic hepatitis B and then become infected with hepatitis D. The aim of this study is to find the effect of each type of viral hepatitis on the bilirubin (TB , DSB) , and liver enzymes; AST, ALT, ALP,GGT among viral hepatitis patients. 200 patients were selected from the viral hepatitis units in the central public health laboratory in Baghdad city, all the chosen cases were confirmed as a positive samples , they are classified into four equal group each with fifty individual and with a single serological viral hepatitis type either; anti-HAV( IgM ) , HBs Ag , anti-HCV ,or anti-HEV(IgM ). All patients were tested for; serum bilirubin ( TB ,D.SB ) , AST , ALT , ALP , GGT. Another fifty quite healthy and normal person was selected as a control group for comparison. . Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBVAST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver cell damage than AST, It is relatively specific for hepatocyte necrosis with a marked elevations in viral hepatitis. Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBV.AST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver
Determinants of Women Empowerment in Bishoftu Town; Oromia Regional State of ...AI Publications
The purpose of this study was to determine the status of women's empowerment and its determinants using women's asset endowment and decision-making potential as indicators. To determine representative sample size, this study used a two-stage sampling technique, and 122 sample respondents were selected at random. To analyze the data in this study, descriptive statistics and a probit model were used. The average women's empowerment index was 0.41, indicating a relatively lower status of women's empowerment in the study area. According to the study's findings, only 40.9% of women were empowered, while the remaining 59.1% were not. The probit model results show that women's access to the media, women's income, and their husbands' education status have a significant and positive impact on the status of women's empowerment, while the family size of households has a negative impact. As a result, it is important to enhance women's access to the media and income, promote family planning and contraception, and improve men's educational status in order to improve the status of women's empowerment.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
2. Alhelu et al./ Assessment Outcomes Dyslipidaemia in Dialysis Patient
Int. J. Med. Phar. Drug Re., 7(1), 2023
Online Available at: https://www.aipublications.com/ijmpd/ 20
and progressive loss of kidney function. Chronic
kidney disease is not only implicated by the gradual
deterioration of quality of life and life expectancy
when it progresses to more advanced stages but also
by the increase in cardiovascular morbidity and
mortality, which is the leading cause of death in these
patients [2]. The death rate for end-stage CKD is 30
times higher than that of the general population and
may be up to 1,000 times higher when it affects lower-
risk populations, such as children and adolescents,
where its prevalence is increasing due to the higher life
expectancy of the general population. [3,4]. Moreover,
the prevalence of chronic kidney disease in Spain,
according to the data of the EPIRCE study, is close to
10% when jointly assessing eGFR and albuminuria,
with 21.4% of subjects over 64 years of age reporting
only an eGFR < 60 mL/min / 1.73 sq. m. Age is the
risk factor that has been associated primarily with
CKD, with loss of function marked onset from the
third decade of life, with significant loss of renal
function from 60 years of age [5]. Based on German
studies, CKD is an independent risk factor for
cardiovascular disease, even in children and
adolescents whose exposure to other cardiovascular
risk factors is lower than in adults [6]. As a result,
atherosclerosis in patients with chronic kidney disease,
both pre-existing and new, presents an accelerated
progression, increasing the incidence of premature
cardiovascular events (in men <55 years or women <65
years). This effect may be related to a diffuse
inflammatory pattern that persists, although some
triggering factors can be corrected, such as renal artery
revascularization in cases of renal artery stenosis [7,8].
For all these reasons, chronic kidney disease should be
considered as a high and even very high
cardiovascular risk condition, which requires early
diagnosis and treatment and treatment of potentially
modifiable risk factors identified during the disease
[9]. Based on studies in the US, it is estimated that 6%
of the US population is in stages 1 and 2, while 4.5% is
focused on stages 3 and 4 of the same. 1 In Venezuela
for 2008, the figures for deaths from this disease were
dealt with for 1923, which accounted for 1.44% of all
deaths. As for the Spanish study, it indicates that
abnormalities of lipid metabolism similar to those
implicated in atherosclerosis (increased triglycerides,
total cholesterol, LDL, lipoprotein B, and decreased
non-HDL cholesterol) may also contribute to the
development of kidney injury, in particular, if
associated with proteinuria or high blood pressure
[11]. Plasma triglycerides begin to rise in the early
stages of CKD and are the result of elevated
production of lipoproteins rich in triglycerides,
increased synthesis of VLDL, and decreased rate of
partial catabolism due to decreased activity of
endothelial lipase (lipoprotein lipase (LPL) and liver
lipase). As a result, CKD patients had reduced plasma
HDL-cholesterol concentrations compared to non-
uremic individuals. Due to the lower apo A1 level and
lower LCAT activity, the reduced capacity of HDL
cholesterol particles may impair the reverse transport
of cholesterol from peripheral cells to the liver, thus
burdening the vascular system and promoting
atherosclerosis [12]. To follow up, the decrease in
lipoprotein lipase (LPL) activity and the consequent
decrease in VLDL catabolism play an important role,
leading to increased triglycerides and lower HDL
cholesterol. On the other hand, coexisting
hypoalbuminemia, by increasing levels of free lecithin,
can reduce lecithin- cholesterol acyltransferase (LCAT)
activity [13]. Cerebrovascular disease (CVD) begins
and Progresses during renal disease, years before
developing renal failure. On initiation of dialysis
treatment, 18% of patients had an acute myocardial
infarction (AMI), 22% had angina, 37% had episodes of
congestive heart failure, and approximately 80% had
left ventricular low ejection fraction (LVEF) <40% or
left ventricular hypertrophy or both [14]. Therefore,
they constitute the number one cause of mortality in
chronic kidney disease, and atherogenic lipoproteins
play an essential role in its development. Patients
deficient in this enzyme develop renal fatty deposits,
and progressive renal failure as chronic
hyperlipidemia (CKD) is associated with the
thickening of the carotid intima and media [15]. In the
early stages, there are also prebiotic changes: nocturnal
hypertension, insulin resistance, increased serum
lipoprotein, C-reactive protein, fibrinogen, and
parathyroid hormone changes that contribute to
cardiovascular (CV) damage. This paper aims to assess
the outcomes of dyslipidemia in a dialysis patient. [16]
II. MATERIAL AND METHOD
In this study, a descriptive cross-sectional study was
applied to study the Assessment Outcomes of
3. Alhelu et al./ Assessment Outcomes Dyslipidaemia in Dialysis Patient
Int. J. Med. Phar. Drug Re., 7(1), 2023
Online Available at: https://www.aipublications.com/ijmpd/ 21
Dyslipidemia in Dialysis Patients in Iraq from 4th
January 2021 to 7th August 2022. Data were collected
for 150 patients from different hospitals in Iraq, where
the patients were divided into two groups, the first
group of patients, which included DIALYSIS
PATIENTS for 80 cases, and the second group, which
was the control group which include 70 patients.
A statistical study was conducted for patients with
osteoporosis using the SPSS program, and This study
presented the demographic results of dialysis patients,
which included age between 30- 60 years and BMI
between <25, 25-30, >30, as well as CHRONIC
DISEASES, which included Stroke, Diabetes,
Hypertension, and Cirrhosis, including economic level
and social status classification, which was divided into
single and married, where these collected data were
presented and shown in Table 1. As shown in Table 2,
where the study of this research paper relied on the
Outcomes of dyslipidemia in a dialysis patient to
present the data presented, which included LDL, HDL,
TRIGLYCERIDE as well as DESIRABLE, NON-
DESIRABLE, which were applied to both groups, one
of which is the DIALYSIS PATIENTS group and the
other group CONTROLS as is evident in Table 2. Table
3 it showed a comprehensive evaluation of CKD
patients Distribution of patients based on stages of
CKD, which was divided into five stages, which
included S1, S2, S3, S4, and S5, which depended on the
degree of eGFR, which was distributed to the
FREQUENCY OF PATIENTS GROUP for CKD As
shown in Table 3. In addition, the collected data were
evaluated statistically and analyzed logistically, which
included age, stroke, diabetes, hypertension, LDL,
HDL, TRIGLYCERIDE, S3, and BMI, which were
distributed to both groups, hemodialysis patients and
control patients, as shown in Table 4.
III. RESULTS
Table 1- The demographic results of dialysis patients.
ITEMS
DIALYSIS
PATIENTS(80)
CONTROLS(70) P-VALUE
AGE
30-39 25 (31.25%) 17 (24.29%) 0.044
40-49 34 (42.5%) 33 (47.14%) 0.0831
50-60 21 (26.25%) 20 (28.57%) 0.0475
BMI
< 25 17 (21.25%) 14 (20%) 0.0491
25-30 29 (36.25%) 25 (35.71%) 0.0493
>30 34 (42.5%) 31 (44.29%) 0.0485
CHRONIC DISEASES
Stroke 22 (27.5%) 16 (22.86%) 0.0433
Diabetes 17 (21.25%) 14 (20%) 0.0492
Hypertension 14 (17.5%) 18 (25.71%) 0.03853
Cirrhosis 27 (33.75%) 22 (31.43%) 0.0485
ECONOMIC LEVEL
LOW 35 (43.75%) 17 (24.29%) 0.0266
MIDDLE 25 (31.25%) 33 (47.14%) 0.0315
HIGH 21 (26.25%) 20 (28.57%) 0.0487
MARITAL STATUS
SINGLE 22 (27.5%) 18 (25.71%) 0.0481
MARRIED 58 (72.5%) 52 (74.29%) 0.0482
5. Alhelu et al./ Assessment Outcomes Dyslipidaemia in Dialysis Patient
Int. J. Med. Phar. Drug Re., 7(1), 2023
Online Available at: https://www.aipublications.com/ijmpd/ 23
IV. DISCUSSION
Changes in lipid metabolism are a consistent finding
in CKD, as dyslipidemia is an exacerbating factor in
CKD that increases the risk of atherosclerosis and its
complications [17]. Adequate control contributes to
reducing the high rates of cardiovascular disease and
mortality experienced by these patients [18]. As shown
in Table 1, where the collected data were presented for
both groups, which includes the Dialysis Patient group
and the control group, where the data included The
demographic results of dialysis patients, where the
ages presented were between 30-60, which showed 25
(31.25%) dialysis patients 17 (24.29%) ) for the control
group for ages between 30-39 years, while the ages
with the upper limit, which included the ages between
40-49 years, which contained 34 (42.5%) for the group
of dialysis patients33 (47.14%) while 0.0431 for the
group of control patients. However, the BMI results
showed a discrepancy in the evaluation of pathological
cases, where 17 (21.25%) were dialysis patients, while
14 (20%) were control patients, but in the case of >30, it
showed a sharp rise in dialysis
Patients were 34 (42.5%) were dialysis patients. and
31 (44.29%) for control patients with a 0.0485 P-
VALUE. Moreover, the demographic results showed
that the patients in Cirrhosis presented 27 (33.75%) for
dialysis patients and 22 (31.43%) for control patients
with P- VALUE 0.0485, as shown in Table 1. In chronic
kidney disease, early and aggressive intervention for
dyslipidemia appears to be a priority before a
significant decline in renal function occurs. Statin
therapy has been shown to be safe and effective in
lowering LDL-C and in reducing cardiovascular events
in individuals with chronic kidney disease or after
kidney transplantation; However, the evidence in
dialysis patients is lower, as shown in Table 2.
Outcomes of dyslipidemia in a dialysis patient were
found to be 5.12 ± 3.4 for dialysis patients and 2.1 ± 3.3
for control patients with a P-value of 0.0474, while
TOTAL CHOLESTEROL was found to be very high.
Where it appeared that the pathological incidence of
DESIRABLE was 2.75 ± 1.7 for patients of the first
group, which was represented by dialysis patients, but
1.2 ± 0.32 for control patients. Results were also
presented for non-desirable patients, as it was
4.9 ± 1.34 for the group of dialysis patients and 3.6 ±
0.47 for control patients. In addition, the results
presented for the evaluation of HDL in patients were
2.43 ± 2.4 for hemodialysis patients and 1.4 ± 1.5 for
control patients, as shown in Table 2. A general
evaluation of the distribution of patients based on
stages of CKD was conducted, as it showed in five
stages, the second stage was more severe and
susceptible, as it was found according to the
evaluation of the EGFR score 70 ± 10 and the
FREQUENCY OF PATIENTS GROUP at a rate of 21
(26.25%), and the least affecting stages were the fourth
and five stages Where it showed in the fourth stage 22
± 7.4 for the EGFR score and the FREQUENCY OF
PATIENTS GROUP 8 (10%) and the S5 for EGFR 9 ±
6.6 and the FREQUENCY OF PATIENTS GROUP 19
(23.75%) as shown in Table 3. Also presented in Table
4, the logistic analysis of the collected data, which was
evaluated based on the pathological conditions,
showed Stroke 1.86 (1.65-2.5) for the group of dialysis
patients and 2.24 (1.9-6.4) for the group of control
patients, while Diabetes was found to be 1.5 (1.24-1.6)
for patients Hemodialysis and 1.42 (1.2-2.2) for control
patients, as well as Hypertension showed a rise, as 5.32
(2.3-6.67) for the dialysis patients group and 1.22 (0.5-
2.1) for control patients, in addition to HDL 1.4 (0.63-
1.5) for dialysis patients and 1.23 (1.23). 0.76-1.43) for
control patients. American studies showed that
dyslipidemia is a factor in the development of chronic
kidney disease, which increases the risk of
atherosclerosis and its complications [19,20].
Appropriate control contributes to reducing the high
cardiovascular morbidity and mortality presented by
these patients were. This effect may be related to a
diffuse inflammatory pattern that persists, although
some triggering factors can be corrected [21]
V. CONCLUSION
Changes in lipid metabolism are common in
hemodialysis patients. The classic pattern of
dyslipidemia on dialysis is determined by elevated
serum triglycerides, low HDL cholesterol, and in most
cases, normal or slightly elevated total cholesterol and
low-density lipoprotein cholesterol. Although serum
cholesterol levels were not particularly high, the
atherogenic index improved in a quarter of the
patients due to lower levels of HDL cholesterol, and
thus the risk of atherosclerosis was high in these
individuals. Although total cholesterol levels are
stable, this group may have alterations, particularly in
low-density lipoprotein (LDL), that confer a greater
propensity for atherosclerosis. Therefore, this study
concludes that the control patients were less at risk
6. Alhelu et al./ Assessment Outcomes Dyslipidaemia in Dialysis Patient
Int. J. Med. Phar. Drug Re., 7(1), 2023
Online Available at: https://www.aipublications.com/ijmpd/ 24
and better in terms of complications than the group of
dialysis patients.
REFERENCES
[1] Parmar JA, Joshi AG, Chakrabarti M.
Dyslipidemia and chronic kidney disease. ISRJ.
2014;3:396–397. [Google Scholar]
[2] Charles RH, Terry AJ. Managing dyslipidemia in
chronic kidney disease. J Am Coll Cardiol. 2008;51:2375–
2384. [PubMed] [Google Scholar]
[3] Ahmed MH, Khalil AA. Ezetimibe is a potential
treatment for dyslipidemia associated with chronic renal
failure and renal transplant. Saudi J Kidney Dis
Transplant. 2010;21:1021– 1029. [PubMed] [Google
Scholar]
[4] Balode AA, Khan ZH. Serum lipid profile in chronic
kidney disease patients on hemodialysis. IJAR.
2013;3:20–22. [Google Scholar]
[5] Burmeister JE, Mosmann CB, Veridiana Borges Costa
VB, et al. Prevalence of cardiovascular risk factors in
hemodialysis patients – the CORDIAL study. Arq Bras
Cardiol. 2014;102:473–480. [PMC free article] [PubMed]
[Google Scholar]
[6] Kwan BCH, Kronenberg F, Beddhu S, Cheung AK.
Lipoprotein Metabolism and lipid management in
chronic kidney disease. J Am Soc Nephrol.
2007;18:1246– 1261. [PubMed] [Google Scholar]
[7] Chen S-C, Hung C-C, Kuo M-C, et al. Association of
dyslipidemia with renal outcomes in chronic kidney
disease. PLoS One. 2013;8:e55643. [PMC free article]
[PubMed] [Google Scholar]
[8] Wanner C, Ritz E. Reducing lipids for CV protection in
CKD patients—current evidence. Kidney Int. 2008;74:24–
28. [PubMed] [Google Scholar]
[9] Tsimihodimos V, Mitrogianni Z, Elisaf M. Dyslipidemia
associated with chronic kidney disease. Open
Cardiovasc Med J. 2011;5:41–48. [PMC free article]
[PubMed] [Google Scholar]
[10] Molitch ME. Management of dyslipidemias in patients
with diabetes and chronic kidney disease. Clin J Am Soc
Nephrol. 2006;1:1090–1099. [PubMed] [Google Scholar]
[11] Kimura H, Miyazaki R, Imura T, Masunaga S, Suzuki S,
Gejyo F, Yoshida H. Hepatic lipase mutation may
reduce vascular disease prevalence in hemodialysis
patients with high CETP levels. Kidney Int.
2003;64:1829–1837. [PubMed] [Google Scholar]
[12] Kronenberg F, Lingenhel A, Neyer U, et al. Prevalence of
dyslipidemic risk factors in hemodialysis and CAPD
patients. Kidney Int Suppl. 2003;84:113–116. [PubMed]
[Google Scholar]
[13] Iseki K, Yamazato M, Tozawa M, Takishita S.
Hypocholesterolemia is a significant predictor of death
in a cohort of chronic hemodialysis patients. Kidney Int.
2002;61:1887– 1893. [PubMed] [Google Scholar]
[14] Liu Y, Coresh J, Eustace JA, et al. Association between
cholesterol level and mortality in dialysis patients: role
of inflammation and malnutrition. JAMA. 2004;291:451–
459. [PubMed] [Google Scholar]
[15] Mikolašević I, Lukenda V, Sladoje-Martinović B, et al.
Metabolic complications after solid organ
transplantation. Medicina Fluminensis. 2014;50:61–66.
[Google Scholar]
[16] Kahwaji JM, Dudek RR. How can we manage
hyperlipidemia and avoid rhabdomyolysis in transplant
patients? Perm J. 2006;10:26–28. [PMC free article]
[PubMed] [Google Scholar]
[17] Mesquita J, Varela A, Medina JL. Dyslipidemia in renal
disease: causes, consequences, and treatment.
Endocrinol Nutr. 2010;57:440–448. [PubMed] [Google
Scholar]
[18] Thompson M, Ray U, Yu R. Kidney function as a
determinant of HDL and triglyceride concentrations in
the Australian population. J Clin Med. 2016;5:35.
[PMC free article] [PubMed] [Google Scholar]
[19] Omran J, Al-Dadah A, Dellsperger KC. Dyslipidemia in
patients with chronic and end-stage kidney disease.
Cardiorenal Med. 2013;3:165–177. [PMC free article]
[PubMed] [Google Scholar]
[20] Wanner C, Tonelli M, Kidney Disease: Improving Global
Outcomes Lipid Guideline Development Work Group
Members KDIGO clinical practice guideline for lipid
management in chronic kidney disease. Kidney Int
Suppl. 2013;3:259–305. [Google Scholar]
[21] Türk TR, Voropaeva E, Kohnle M, et al. Ezetimibe
treatment in hypercholesterolaemic kidney transplant
patients is safe and effective and reduces the decline of
renal allograft function: a pilot study. Nephrol Dial
Transplant. 2008;23:369–373. [PubMed] [Google Scholar]