Dr. Astha Chakravarty is a young, dynamic & experienced fertility specialist who has the capability to individualize treatment according to patient needs & affordability.
From the collection of healthy and fertile eggs to the fertilization of it with the sperm, each and every step required for your successful IVF is carefully done by specialists using hygienic equipment and the latest technology. During the various stages of IVF treatment, sapling IVF is closely connected to you, giving you both mental and clinical support.
https://saplingivf.com/ivf-in-vitro-fertilization/
Role of ovum donation, surrogacy & Adoption in Fertility treatment- Dr. Kaber...Kaberi Banerjee
This slide describes the various factors involved in egg donation and surrogacy program in India along with its success rates. It also explains the adoption process in India.
Ovarian age and reproduction. An appraisal of diagnostic methods.Mahmoud Abdel-Aleem
An understanding of the basics of ovarian cycle and its hormonal control. It provides the reader with the latest evidence about various tests used for assessment of ovarian reserve
What can you accomplish through IVF - Getting Pregnant NowAmr Azim
You want to get pregnant—and like, right now! These steps will help maximize your chances and give you tips on how to get pregnant. Lean how you can get pregnant through IVF.
From the collection of healthy and fertile eggs to the fertilization of it with the sperm, each and every step required for your successful IVF is carefully done by specialists using hygienic equipment and the latest technology. During the various stages of IVF treatment, sapling IVF is closely connected to you, giving you both mental and clinical support.
https://saplingivf.com/ivf-in-vitro-fertilization/
Role of ovum donation, surrogacy & Adoption in Fertility treatment- Dr. Kaber...Kaberi Banerjee
This slide describes the various factors involved in egg donation and surrogacy program in India along with its success rates. It also explains the adoption process in India.
Ovarian age and reproduction. An appraisal of diagnostic methods.Mahmoud Abdel-Aleem
An understanding of the basics of ovarian cycle and its hormonal control. It provides the reader with the latest evidence about various tests used for assessment of ovarian reserve
What can you accomplish through IVF - Getting Pregnant NowAmr Azim
You want to get pregnant—and like, right now! These steps will help maximize your chances and give you tips on how to get pregnant. Lean how you can get pregnant through IVF.
IVF Treatment in India: IVF is Like a Beam of Hope for Infertile PupilMedMonks
IVF Treatment: Infertility means the inability of couple (due to male or female partner or both) to be able to conceive after having regular unprotected intercourse.
Miracles IVF & Fertility Clinic is known for its ethical and international standard fertility treatment. With experienced fertility specialists, we have been able to maintain consistently high success rate and this made us the most preferred fertility clinic in Gurgaon for childless couples.
Tracing the evolution and relevance of iui in the era of icsiArunSharma10
Artificial insemination
Renewed interest in artificial insemination
History of artificial insemination
Controversy about ICSI remains
IVF revolution
Present value of artificial insemination
NICE guidelines: IUI
Clinical evidence
IUI insemination for male infertility
Moral and social implications of artificial insemination
In vitro fertilization is a multistage procedure for preventing fertility or genetic problems with the conception of a child. The in vitro fertilization is a complex process.IVF is the most effective form of assisted reproductive technology. There are certain steps involved in the process. The best center for in-vitro fertilization is the SCI IVF Centre.
Recognized as one of the best clinics in Gurgaon for Fertility treatment, Miracles Fertility & IVF Clinic is dedicated to providing the best-personalized health care tailored to individual patient needs.
IVF Treatment in India: IVF is Like a Beam of Hope for Infertile PupilMedMonks
IVF Treatment: Infertility means the inability of couple (due to male or female partner or both) to be able to conceive after having regular unprotected intercourse.
Miracles IVF & Fertility Clinic is known for its ethical and international standard fertility treatment. With experienced fertility specialists, we have been able to maintain consistently high success rate and this made us the most preferred fertility clinic in Gurgaon for childless couples.
Tracing the evolution and relevance of iui in the era of icsiArunSharma10
Artificial insemination
Renewed interest in artificial insemination
History of artificial insemination
Controversy about ICSI remains
IVF revolution
Present value of artificial insemination
NICE guidelines: IUI
Clinical evidence
IUI insemination for male infertility
Moral and social implications of artificial insemination
In vitro fertilization is a multistage procedure for preventing fertility or genetic problems with the conception of a child. The in vitro fertilization is a complex process.IVF is the most effective form of assisted reproductive technology. There are certain steps involved in the process. The best center for in-vitro fertilization is the SCI IVF Centre.
Recognized as one of the best clinics in Gurgaon for Fertility treatment, Miracles Fertility & IVF Clinic is dedicated to providing the best-personalized health care tailored to individual patient needs.
Understanding the Frozen Embryo Transfer Procedure: A Comprehensive GuideSCI IVF Hospital
The prospective mother’s ovaries are artificially stimulated in new IVF rounds to generate a larger number of mature eggs. The eggs are then extracted via a process known as a follicular puncture or ovum pick-up (OPU) and then fertilized in the lab using the husband’s or donor sperm. Here is a list of frozen embryo transfer tips to improve your success rate of embryo transfer.
IVF refers to a procedure where the woman's eggs are far away from her ovaries and fertilized with the man's spermatozoon during a laboratory. The embryos fashioned area unit then surrogate into the womb to realize a physiological condition.
IVF is the process of fertilization by extracting eggs, retrieving a sperm sample, and then manually combining an egg and sperm in a laboratory dish. The embryo(s) is then transferred to the uterus. Other forms of ART include gamete intrafallopian transfer (GIFT) and zygote intrafallopian transfer (ZIFT).
Hegde Fertility Centre offers the most advanced and efficient infertility treatments with the primary goal of being a centre par excellence that is focused on bringing avant-garde facilities, state-of-the-art labs, highly trained experts, and a dedicated caring staff for fulfilling a couple’s desire of having a baby. A team of embryologists, infertility consultants, and reproductive surgery specialists work together to provide a wide range of treatments from basic infertility care to the most advanced procedures to gift the joy of parenthood for couples. For more details visit https://hegdefertility.com
Infertility is typically defined as the inability to achieve pregnancy after
one year of unprotected intercourse. If you have been trying to conceive
for a year or more, you should consider an infertility evaluation.
Self-cycle surrogacy Surrogacy is an ART (Assisted Reproductive Procedure) where intended parents can opt for self-cycle surrogacy or donor cycle surrogacy depending upon the infertility condition of the couple.
In vitro Fertilization- IVF is a form of assisted reproductive technology (ART).In this special medical techniques are used to help a woman become pregnant. IVF, coupled with embryo transfer, in humans is aimed to enable couples suffering from certain types of sterility to have children.
Babies developed from this approach are known as "test-tube babies."
In gynecologic cancers, fertility preservation strategies include fertility-sparing surgical approaches and assisted reproductive technologies (ART). Fertility preservation can be considered in women with early stage I epithelial ovarian cancer and most borderline tumors, stages I–III
In vitro fertilization (IVF) is a type of assistive reproductive technology (ART). It involves retrieving eggs from a woman’s ovaries and fertilizing them with sperm. This fertilized egg is known as an embryo.
Best IVF Centre in Jalandhar | IVF Cost in Punjabseoservicesit
Janam Fertility Centre provides the best treatments for infertility at affordable cost. Our Best IVF Centre in Jalandhar also Offer Best IVF Cost in Punjab. Get started on your fertility journey. Your parenthood dream can come true. Consult with an IVF expert at Janam Fertility Centre.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.
Asha fertility clinic
1. Asha Fertility Clinic
Dr. Astha Chakravarty is a young, dynamic &
experienced fertility specialist who has the
capability to individualize treatment according to
patient needs & affordability.
3. Donor Sperm
Donor sperms are offered when a husband has azoospermia/ poor semen
parameters. It is also an option for single women and lesbian couples. The sample is
carefully selected, tested for infections and matched with husband profile.
4. Frozen Embryo Transfer
It is a procedure in which embryos frozen from the previous cycle are thawed and transferred.
Embryos are typically thawed the morning of the transfer and can be thawed fairly rapidly so
that if the desired number does not survive the thaw, additional embryos can be thawed in a
short period of time prior to the scheduled embryo transfer. Approximately 70% of good
quality day 3 embryos and 95% of Blastocyst embryos survive the thaw. Embryos with less
than complete cell survival can result in a normal pregnancy but the probability of a pregnancy
is lower.
5. Donor Egg
Use of donor egg is indicated in women with ovarian failure, diminished ovarian reserve or genetic
diseases or poor egg quality . Anonymous donors are provided by registered ART banks and tested for
communicable diseases.
A careful medical, psychological, genetic and family history is taken from the potential donor. They
undergo hormonal testing, blood, and cultures for sexually transmitted diseases and drug use. All donors
undergo mandatory screening by our staff psychologist. Egg donors have no continuing responsibility to
any child born following egg donation.
6. Laparoscopy Hysteroscopy
Laparoscopy is performed for treatment of fibroids, Ovarian Cysts (endometriotic cysts,
simple cysts), Tubal Blockage, Hydrosalpinx, Uterine Septum etc.
In the same sitting, Hydrosalpinx to check the inside of uterine cavity is performed and any
polyps, fibroids or spertum can be removed.
