ASAM - 複製
•
0 likes•142 views
This study developed doxorubicin-loaded microneedles that melt and release the drug upon exposure to near-infrared light, combining chemotherapy and photothermal therapy. The microneedles contain photothermal nanoparticles that generate heat from near-infrared light to quickly melt the microneedles and release doxorubicin into punctured tissue in an on-demand, controlled manner. In vivo tests in mice showed the combined treatment had a synergistic effect, completely destroying tumors without weight loss or tumor recurrence, demonstrating these light-triggerable microneedles are a promising system for superficial cancer treatment.
Report
Share
Report
Share
Download to read offline
![Near-Infrared Light-Triggerable Microneedles
for Chemo-Photothermal Synergistic Therapy
Zhi-Wei Lin, Hao-An Chan, Mei-Chin Chen*
Department of Chemical Engineering
National Cheng Kung University, Taiwan
This study reports doxorubicin (DOX)-loaded near-infrared (NIR) light-triggerable microneedles (MNs) to combine chemotherapy
and photothermal therapy in one system. The MNs are consisted of biodegradable polycaprolactone and photothermal nanoparticles
(NPs). Upon exposure to NIR, MNs can quickly melt at 50 °C due to the heating of the encapsulated NPs and then release DOX
into the punctured tissue. Drug release can be controlled in an on-demand fashion, when LASER ON produced a steep increasing
in drug release, and LASER OFF had no obvious release over a long time. In vivo antitumor activity tests demonstrated the DOX-
loaed MNs with external NIR photothermal therapy significantly enhanced the therapeutic effect of cancer treatment. Compared
with chemotherapy or photothermal therapy alone, the combined treatment possessed a better therapeutic effect. These results
showed that the NIR-triggerable MNs may serve as a useful system for superficial cancer treatment.
▲Drug-loaded NIR triggerable MNs
▲ (a) Infrared images of MNs under NIR exposure
(b) Temperature profile of MNs for different On and Off cycles
▲Cumulative release of DOX from MNs under different
cycles of NIR laser exposure
▲ Pig cadaver skin under
different irradiation cycles
Melting process
of MNs in cadaver
skin after different
irradiation cycles:
(a) 3D reconstruction
from histological
sections
(b) Bright- field and
(c) Fluorencence
micrographs
▲Tumors on mice after various treatments
Complete elimination
▲(a) Normalized tumor volume and (b) Body weight curves after various treatments
We succefully developed DOX-loaded NIR light-
triggerable MNs to combine chemotherapy and
photothermal therapy in one system. The NIR
light triggered release test showed that the drug
release from the microneedles can be controlled
by the adjustment ofthe parameters of NIR light.
Combined treatment demonstrated a synergistic
effect, resulting in complete destruction of
tumors without weight loss and recurrence of
tumors.
[1] Chen MC, Ling MH, Lai KH and Pramudityo E
(2012) Biomacromolecules, 13:4022-4031
[2] You J, Zhang GD and Li C (2010) ACS Nano 4:1033-
1041.](https://image.slidesharecdn.com/1ea37cd0-7acc-40e9-887b-f5125946bd10-150912024151-lva1-app6892/85/ASAM-1-320.jpg)
Recommended
Spatial Laser Induced Fluorescence Imaging (SLIFIMG) Analysis to Assess Tissu...
Fluorescence technique involves the optical detection and spectral analysis of light emitted by a substance undergoing a transition from an excited electronic state to a lower electronic state. The aim of this study is to assess the -amino levulinic acid (-ALA) uptake. Based on image processing technique, Matlab was used to analyze the fluorescence images resulted from activation of (-ALA) and follow its uptake along one week. Analyzing the RGB colours pixel profile from obtained results showed different profiles for malignant tissues, normal tissues, treated just after PDT and finally at one week post PDT. The treated tissues fluorescence profile showed changes from closer to malignant tissue profile till been closed to normal one.
Photodynamic therapy
This document provides an overview of photodynamic therapy (PDT), including its use in treating cancer. PDT involves applying a photosensitizing drug, incubating it, and then activating it with light, which causes cell damage and death. It is used to treat cancers of the esophagus, lung, and skin. Research is ongoing to develop more effective photosensitizers and expand PDT to additional cancer types and deeper tumors. Side effects are typically minor and temporary.
Treatment of residual pockets with photodynamic therapy,
Journal Club Presentation of comparative evaluation between PDT, LASER and SRP with detailed antimicrobial study
Optimization of Fibronectin Micro-contact Printing Protocol for Potential
This study optimized a micro-contact printing protocol to pattern fibronectin for potential nanoparticle uptake studies using endothelial cells. Different weights were tested during the micro-contact printing process and 20 grams was found to produce the most uniform fibronectin intensity across patterned areas and provided the most accurate coverage of the targeted 2500 μm2 area. This optimized 20 gram weight protocol will be adopted for future studies analyzing how cell cytoskeletal alignments influenced by patterned areas affect nanoparticle uptake in endothelial cells.
Knox Gelatine™ Effect On Radiation Absorption Poster
My senior project poster used to present to Cal Poly staff and Industrial Advisory Board members in Spring 2013.
Nanoparticles for drug delivery by shreya
This document discusses the advancement of nanotechnology and nanoparticles for cancer diagnosis and drug delivery. It outlines several challenges in developing effective nanoscale drug delivery systems, as well as properties of nanomaterials that make them suitable for drug delivery. Various nanodevices are described that could be used for targeted drug delivery, including liposomes, nanoshells, dendrimers, micelles, nanowires, nanotubes, quantum dots, and potential future nanorobots. Advantages of nanoparticle drug delivery systems include smaller size, higher bioavailability, and ability to target drugs directly to cells and nuclei. The only disadvantage mentioned is difficulty determining proper dosages.
Cancer Hyperthermia part2
This document discusses using magnetic nanoparticles (MNPs) for cancer hyperthermia therapy. It describes cancer and current cancer therapies like surgery, chemotherapy, and radiotherapy. It introduces nanomedicine and defines magnetic nanoparticles as nanoparticles that can be manipulated using magnetic fields. The document proposes using MNPs for magnetic hyperthermia cancer treatment, where applying an alternating magnetic field causes the MNPs to heat up. It outlines preparing and characterizing MNPs, then testing their cytotoxicity on cell cultures by exposing cell groups to MNPs, magnetic fields, or both to assess biocompatibility and toxicity.
Nanomaterial drug delivery updated 20202
The document discusses various types of nanoparticles that can be used for drug delivery, including spherical nanoparticles, nanotubes, nanocapsules, nanocrystalline drugs, nanogels, dendrimers, liposomes, polymeric micelles, and polymeric drug conjugates. It describes the properties and applications of each type of nanoparticle. Some key advantages of nanoparticles for drug delivery are their small size, ability to sequester drugs and provide controlled release, lower cytotoxicity, and potential for active targeting to sites in the body. Challenges to nanoparticle drug delivery include biological understanding, safety concerns, manufacturing difficulties, and targeting efficiency.
Recommended
Spatial Laser Induced Fluorescence Imaging (SLIFIMG) Analysis to Assess Tissu...
Fluorescence technique involves the optical detection and spectral analysis of light emitted by a substance undergoing a transition from an excited electronic state to a lower electronic state. The aim of this study is to assess the -amino levulinic acid (-ALA) uptake. Based on image processing technique, Matlab was used to analyze the fluorescence images resulted from activation of (-ALA) and follow its uptake along one week. Analyzing the RGB colours pixel profile from obtained results showed different profiles for malignant tissues, normal tissues, treated just after PDT and finally at one week post PDT. The treated tissues fluorescence profile showed changes from closer to malignant tissue profile till been closed to normal one.
Photodynamic therapy
This document provides an overview of photodynamic therapy (PDT), including its use in treating cancer. PDT involves applying a photosensitizing drug, incubating it, and then activating it with light, which causes cell damage and death. It is used to treat cancers of the esophagus, lung, and skin. Research is ongoing to develop more effective photosensitizers and expand PDT to additional cancer types and deeper tumors. Side effects are typically minor and temporary.
Treatment of residual pockets with photodynamic therapy,
Journal Club Presentation of comparative evaluation between PDT, LASER and SRP with detailed antimicrobial study
Optimization of Fibronectin Micro-contact Printing Protocol for Potential
This study optimized a micro-contact printing protocol to pattern fibronectin for potential nanoparticle uptake studies using endothelial cells. Different weights were tested during the micro-contact printing process and 20 grams was found to produce the most uniform fibronectin intensity across patterned areas and provided the most accurate coverage of the targeted 2500 μm2 area. This optimized 20 gram weight protocol will be adopted for future studies analyzing how cell cytoskeletal alignments influenced by patterned areas affect nanoparticle uptake in endothelial cells.
Knox Gelatine™ Effect On Radiation Absorption Poster
My senior project poster used to present to Cal Poly staff and Industrial Advisory Board members in Spring 2013.
Nanoparticles for drug delivery by shreya
This document discusses the advancement of nanotechnology and nanoparticles for cancer diagnosis and drug delivery. It outlines several challenges in developing effective nanoscale drug delivery systems, as well as properties of nanomaterials that make them suitable for drug delivery. Various nanodevices are described that could be used for targeted drug delivery, including liposomes, nanoshells, dendrimers, micelles, nanowires, nanotubes, quantum dots, and potential future nanorobots. Advantages of nanoparticle drug delivery systems include smaller size, higher bioavailability, and ability to target drugs directly to cells and nuclei. The only disadvantage mentioned is difficulty determining proper dosages.
Cancer Hyperthermia part2
This document discusses using magnetic nanoparticles (MNPs) for cancer hyperthermia therapy. It describes cancer and current cancer therapies like surgery, chemotherapy, and radiotherapy. It introduces nanomedicine and defines magnetic nanoparticles as nanoparticles that can be manipulated using magnetic fields. The document proposes using MNPs for magnetic hyperthermia cancer treatment, where applying an alternating magnetic field causes the MNPs to heat up. It outlines preparing and characterizing MNPs, then testing their cytotoxicity on cell cultures by exposing cell groups to MNPs, magnetic fields, or both to assess biocompatibility and toxicity.
Nanomaterial drug delivery updated 20202
The document discusses various types of nanoparticles that can be used for drug delivery, including spherical nanoparticles, nanotubes, nanocapsules, nanocrystalline drugs, nanogels, dendrimers, liposomes, polymeric micelles, and polymeric drug conjugates. It describes the properties and applications of each type of nanoparticle. Some key advantages of nanoparticles for drug delivery are their small size, ability to sequester drugs and provide controlled release, lower cytotoxicity, and potential for active targeting to sites in the body. Challenges to nanoparticle drug delivery include biological understanding, safety concerns, manufacturing difficulties, and targeting efficiency.
Photodynamic therapy
Photodynamic therapy involves applying a photosensitizing drug that is activated by light to damage and destroy cancer cells. It involves three steps - application of the photosensitizing drug, an incubation period to allow the drug to accumulate in target tissues, and then exposing the target tissue to light which activates the drug. This causes oxidative damage to cells through singlet oxygen and free radical production, resulting in cell death via apoptosis or necrosis. It can directly kill tumor cells and also cut off their blood supply and trigger anti-tumor immune responses. Common photosensitizing drugs include porfimer sodium, ALA, and mTHPC. Lasers, LEDs, and filtered light are used as light sources to activate the drugs.
Photodynamic therapy
This document discusses the history and current state of photodynamic therapy (PDT) for cancer treatment. It covers the basics of PDT, including photosensitizers, light sources, the photodynamic reaction, and clinical applications for various cancer types. It also touches on dosimetry challenges, the potential for nanotechnology to advance PDT, and using PDT for theranostics and generating anti-cancer immune responses. In summary, PDT utilizes photosensitizing drugs activated by light to induce oxidative stress and kill cancer cells, with applications across dermatology, neuro-oncology, and other fields, though challenges remain in optimizing light doses and monitoring treatment responses.
photodynamic therapy
Photodynamic therapy (PDT) involves using a photosensitizing agent and light to treat cancer and other diseases. The first report of using a photosensitizing drug and light was in 1900. PDT works by activating a photosensitizing drug with visible light, which generates reactive oxygen species that kill tumor cells. The photosensitizing drug localizes preferentially in tumor tissue and is activated by light of a specific wavelength. This causes direct tumor cell death through apoptosis and necrosis, as well as indirect death through anti-vascular and anti-tumor immune responses. PDT has been used to treat various cancers including skin, brain, head and neck, lung, and GI cancers, with response rates often over
Photo dynamic therapy
Photodynamic therapy uses light-activated photosensitizing compounds and oxygen to kill targeted malignant and diseased cells. It has three key components: a light source, photosensitizer, and molecular oxygen. The photosensitizer is administered and absorbs light, generating reactive oxygen species that destroy nearby cells through apoptosis or necrosis. PDT has advantages of being minimally invasive, toxic, and allowing short recovery times compared to other treatments like surgery or chemotherapy. However, it is not suitable for all cancer types and can cause temporary skin sensitivity to light. Research continues to expand its applications and availability.
Photodyanamic therapy ppt
The document discusses photodynamic therapy (PDT), a treatment that uses photosensitizing drugs activated by light to treat cancer and other diseases. It describes several FDA-approved photosensitizing drugs including porfimer sodium, aminolevulinic acid, methyl ester of ALA, and verteporfin. The document also discusses the mechanism of PDT, advantages, potential side effects of the drugs, and future directions for improving PDT treatments.
Alberto Gavizón- Simposio Internacional 'Terapias oncológicas avanzadas'
This document summarizes a presentation given by Dr. Alberto Gabizon on the clinical efficacy and safety of cancer nanomedicines. Dr. Gabizon discussed how pegylated liposomal doxorubicin (Doxil/Caelyx) provides improved pharmacokinetics and tumor delivery over free doxorubicin, resulting in superior efficacy with reduced cardiotoxicity in several cancer types. He also reviewed other liposomal formulations in clinical use and development, including targeted liposomes. Dr. Gabizon explained how prolonged circulation time allows liposomes to accumulate in tumors via the enhanced permeability and retention effect. Combining drugs within liposomes was also discussed as a way to provide synergistic anti-tumor effects with non-
Photodynamic therapy is effective & promising method for
Photodynamic therapy uses photosensitizing drugs activated by light to kill cancer cells. It is an effective and promising method for cancer treatment. PDT involves injecting a photosensitizer which is absorbed by cancer cells and activated by light, producing reactive oxygen that destroys the cancer cells. It has advantages over other therapies like fewer side effects and the ability to precisely target tumors with minimal damage to healthy tissue. Limitations include light not penetrating deeply into the body and it being mostly used for superficial tumors.
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...CrimsonpublishersCancer
The kinetics and efficacy of anti-cancer via phototherapy are reviewed. Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers (PS), respectively, are analyzed. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. The singlet oxygen threshold dose for PDT and cell viability are governed by the product of PS concentration and light dose.Photo theraphy ,principle and mechanism
Phototherapy is a type of medical treatment that involves exposure to fluorescent light bulbs or other sources of light like halogen lights, sunlight, and light emitting diodes (LEDs) to treat certain medical conditions
Tecniche
The document discusses using magnetic nanoparticles for hyperthermia cancer therapy. It notes that resistance is a major challenge in cancer treatment. Mild hyperthermia between 42-45°C can induce apoptosis in cancer cells without damaging normal tissues. The document then describes a new type of nanoparticle called RA IN (resistance-free apoptosis-inducing nanoparticle) that aims to overcome resistance. The RA IN contains two subunits - one to inhibit heat shock proteins that protect cancer cells from heat-induced apoptosis, and another magnetic nanoparticle subunit to generate localized heat with an external magnetic field to kill cancer cells through apoptosis.
RECENT ADVANCES IN MICRO AND NANO DRUG DELIVERY SYSTEMS
This document discusses recent advances in micro and nano drug delivery systems. It describes how nanomedicine uses nanoparticles smaller than 100nm for diagnosis, treatment, and prevention of diseases. Various types of nanoparticles are discussed for drug delivery, including metal-based, lipid-based, polymer-based, and biological nanoparticles. Specific examples provided include gold nanoparticles that can self-assemble into plasmonic vesicles for stimuli-responsive drug release, silica-gold nanoshells for thermal ablation of cancer cells, and liposomes for encapsulation of both hydrophobic and hydrophilic drugs. The mechanisms of polymeric nanoparticles, lipid nanoparticles, and chitosan carriers for drug delivery are also summarized. The document concludes by discussing the potential of nanoparticles for
Nanotechnology and its Application in Cancer Treatment
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Photodynamic therapy technique
Photodynamic therapy (PDT) involves using a photosensitizing drug and a light source to damage cancer or abnormal tissues. The photosensitizing drug is administered and absorbed by tissues, then activated by exposure to a specific wavelength of light, which causes the drug to produce reactive oxygen species that destroy the targeted cells. PDT can be used to treat a variety of cancers and pre-cancerous conditions depending on the photosensitizing drug and light source used. It offers advantages such as precision targeting and minimal scarring or invasiveness compared to other treatments.
Particle beam – proton,neutron & heavy ion therapy
particle therapy is advanced external beam therapy used to treat cancer , which uses beams of protons or other charged particles such as helium, carbon or other ions instead of photons. charged particles have different depth-dose distributions compared to photons. They deposit most of their energy in the last final millimeters of their trajectory (when their speed slows). This results in a sharp and localized peak of dose, known as the Bragg peak.
Honors Research Poster - Darwin Kwok
This study investigated using ultrasound-stimulated microbubbles to increase permeability of the endothelial cell layer and enhance drug delivery. Researchers seeded human umbilical vein endothelial cells on transwell inserts and applied ultrasound at varying pressures in combination with microbubbles. They measured diffusion of FITC-dextran through the cell layer and found that permeability increased with higher ultrasound pressures. Cell density was maintained even at mild ultrasound pressures, suggesting tight junctions between cells were disrupted without damaging the overall monolayer. This non-invasive technique shows potential for targeted drug delivery across normally impermeable barriers.
Photon Vs proton beam therapy
Intensity modulated proton therapy (IMPT)
Photon Vs Proton beam therapy
Dosimetric comparison between Photon and Proton Beam
Dose Algorithm for Scanning Proton
This document discusses proton dose calculation algorithms. It covers several key points:
- Monte Carlo simulations can provide the most accurate dose modeling but are slow, so simplified analytical models are needed.
- Pencil beam algorithms calculate dose by modeling the fluence of individual beamlets and accounting for primary and secondary proton interactions and scattering.
- Lateral dose spread is modeled using double Gaussian functions to describe the primary Gaussian distribution and wider secondary "halo" distribution.
- Parameters of the Gaussian functions like sigma are tuned to match measured beam data like depth dose profiles and beam spot sizes.
- Benchmarking of proton treatment planning systems requires comparison of calculated and measured beam data for various energies and depths.
Presentation on Nanoparticles Smart Drug Delivery System For Cancer
Nano technology is a rapidly expanding field, encompassing the development of a man-made materials in 5-200 nanometer size range. This dimension vastly exceeds that of standard organic molecules.
Please contact us if you want our services.(We work on every kind of Thesis Presentations (Word, Power point, Excel, Adobe photoshop and Auto-cad).
Contact : 03244708472
Photodynamic Therapy (PDT)
Photodynamic therapy is a cancer treatment that uses photosensitizing drugs and light to destroy cancer cells. The drugs are injected into the bloodstream and absorbed more by cancer cells than healthy cells. After 24-72 hours when the drug has left healthy cells but remains in cancer cells, the tumor is exposed to light which activates the photosensitizer. This causes the production of oxygen species that directly kill cancer cells by damaging their DNA or indirectly by destroying blood vessels that supply the tumor. PDT is currently used to treat several types of cancer affecting the skin, esophagus, lung, and other organs. It offers advantages over other treatments such as minimal invasiveness and ability to precisely target tumors, but it has limitations
Presentación del Filtro de Bosso 2
This paper proposes a new method for calculating dispersed amplitude in mammograms using the Bosso filter as a degradation model. The Bosso filter is presented as modeling the effect of radiation scattering in breast tissue on mammogram image quality. A theoretical framework is developed relating radiation intensity equations to the filter. An estimation method is outlined for calculating filter parameters from digital mammogram images to obtain an image with reduced effects of dispersed radiation, improving detail. The method is intended to improve clinical breast cancer diagnosis.
FIRHeat Plugin - Far Infrared Ray Heat Therapy Products
The Plug-in Heat Therapy Products can relieve all types of Chronic Pain. Heat Therapy can relieve neck pain, shoulder pain, upper and lower pain, elbow pain, wrist pain, knee pain and ankle pain. It also improves blood circulation.
About the LENS
The document discusses LENS (Low Energy Neurofeedback System) therapy, a form of neurofeedback. It provides details on what LENS is, how it works, how it differs from traditional neurofeedback, and potential clinical benefits. Some key points made:
- LENS is a passive form of neurofeedback that uses weak electromagnetic signals to help the brain reorganize inefficient pathways. It requires less sessions (often under 10) than traditional neurofeedback.
- Research has shown LENS can help reduce symptoms for various brain-related conditions like ADHD, depression, PTSD, chronic pain, and more. Case studies demonstrate improvements in symptoms like headaches, sleep, and focus after LENS sessions.
More Related Content
What's hot
Photodynamic therapy
Photodynamic therapy involves applying a photosensitizing drug that is activated by light to damage and destroy cancer cells. It involves three steps - application of the photosensitizing drug, an incubation period to allow the drug to accumulate in target tissues, and then exposing the target tissue to light which activates the drug. This causes oxidative damage to cells through singlet oxygen and free radical production, resulting in cell death via apoptosis or necrosis. It can directly kill tumor cells and also cut off their blood supply and trigger anti-tumor immune responses. Common photosensitizing drugs include porfimer sodium, ALA, and mTHPC. Lasers, LEDs, and filtered light are used as light sources to activate the drugs.
Photodynamic therapy
This document discusses the history and current state of photodynamic therapy (PDT) for cancer treatment. It covers the basics of PDT, including photosensitizers, light sources, the photodynamic reaction, and clinical applications for various cancer types. It also touches on dosimetry challenges, the potential for nanotechnology to advance PDT, and using PDT for theranostics and generating anti-cancer immune responses. In summary, PDT utilizes photosensitizing drugs activated by light to induce oxidative stress and kill cancer cells, with applications across dermatology, neuro-oncology, and other fields, though challenges remain in optimizing light doses and monitoring treatment responses.
photodynamic therapy
Photodynamic therapy (PDT) involves using a photosensitizing agent and light to treat cancer and other diseases. The first report of using a photosensitizing drug and light was in 1900. PDT works by activating a photosensitizing drug with visible light, which generates reactive oxygen species that kill tumor cells. The photosensitizing drug localizes preferentially in tumor tissue and is activated by light of a specific wavelength. This causes direct tumor cell death through apoptosis and necrosis, as well as indirect death through anti-vascular and anti-tumor immune responses. PDT has been used to treat various cancers including skin, brain, head and neck, lung, and GI cancers, with response rates often over
Photo dynamic therapy
Photodynamic therapy uses light-activated photosensitizing compounds and oxygen to kill targeted malignant and diseased cells. It has three key components: a light source, photosensitizer, and molecular oxygen. The photosensitizer is administered and absorbs light, generating reactive oxygen species that destroy nearby cells through apoptosis or necrosis. PDT has advantages of being minimally invasive, toxic, and allowing short recovery times compared to other treatments like surgery or chemotherapy. However, it is not suitable for all cancer types and can cause temporary skin sensitivity to light. Research continues to expand its applications and availability.
Photodyanamic therapy ppt
The document discusses photodynamic therapy (PDT), a treatment that uses photosensitizing drugs activated by light to treat cancer and other diseases. It describes several FDA-approved photosensitizing drugs including porfimer sodium, aminolevulinic acid, methyl ester of ALA, and verteporfin. The document also discusses the mechanism of PDT, advantages, potential side effects of the drugs, and future directions for improving PDT treatments.
Alberto Gavizón- Simposio Internacional 'Terapias oncológicas avanzadas'
This document summarizes a presentation given by Dr. Alberto Gabizon on the clinical efficacy and safety of cancer nanomedicines. Dr. Gabizon discussed how pegylated liposomal doxorubicin (Doxil/Caelyx) provides improved pharmacokinetics and tumor delivery over free doxorubicin, resulting in superior efficacy with reduced cardiotoxicity in several cancer types. He also reviewed other liposomal formulations in clinical use and development, including targeted liposomes. Dr. Gabizon explained how prolonged circulation time allows liposomes to accumulate in tumors via the enhanced permeability and retention effect. Combining drugs within liposomes was also discussed as a way to provide synergistic anti-tumor effects with non-
Photodynamic therapy is effective & promising method for
Photodynamic therapy uses photosensitizing drugs activated by light to kill cancer cells. It is an effective and promising method for cancer treatment. PDT involves injecting a photosensitizer which is absorbed by cancer cells and activated by light, producing reactive oxygen that destroys the cancer cells. It has advantages over other therapies like fewer side effects and the ability to precisely target tumors with minimal damage to healthy tissue. Limitations include light not penetrating deeply into the body and it being mostly used for superficial tumors.
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...CrimsonpublishersCancer
The kinetics and efficacy of anti-cancer via phototherapy are reviewed. Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers (PS), respectively, are analyzed. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. The singlet oxygen threshold dose for PDT and cell viability are governed by the product of PS concentration and light dose.Photo theraphy ,principle and mechanism
Phototherapy is a type of medical treatment that involves exposure to fluorescent light bulbs or other sources of light like halogen lights, sunlight, and light emitting diodes (LEDs) to treat certain medical conditions
Tecniche
The document discusses using magnetic nanoparticles for hyperthermia cancer therapy. It notes that resistance is a major challenge in cancer treatment. Mild hyperthermia between 42-45°C can induce apoptosis in cancer cells without damaging normal tissues. The document then describes a new type of nanoparticle called RA IN (resistance-free apoptosis-inducing nanoparticle) that aims to overcome resistance. The RA IN contains two subunits - one to inhibit heat shock proteins that protect cancer cells from heat-induced apoptosis, and another magnetic nanoparticle subunit to generate localized heat with an external magnetic field to kill cancer cells through apoptosis.
RECENT ADVANCES IN MICRO AND NANO DRUG DELIVERY SYSTEMS
This document discusses recent advances in micro and nano drug delivery systems. It describes how nanomedicine uses nanoparticles smaller than 100nm for diagnosis, treatment, and prevention of diseases. Various types of nanoparticles are discussed for drug delivery, including metal-based, lipid-based, polymer-based, and biological nanoparticles. Specific examples provided include gold nanoparticles that can self-assemble into plasmonic vesicles for stimuli-responsive drug release, silica-gold nanoshells for thermal ablation of cancer cells, and liposomes for encapsulation of both hydrophobic and hydrophilic drugs. The mechanisms of polymeric nanoparticles, lipid nanoparticles, and chitosan carriers for drug delivery are also summarized. The document concludes by discussing the potential of nanoparticles for
Nanotechnology and its Application in Cancer Treatment
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Photodynamic therapy technique
Photodynamic therapy (PDT) involves using a photosensitizing drug and a light source to damage cancer or abnormal tissues. The photosensitizing drug is administered and absorbed by tissues, then activated by exposure to a specific wavelength of light, which causes the drug to produce reactive oxygen species that destroy the targeted cells. PDT can be used to treat a variety of cancers and pre-cancerous conditions depending on the photosensitizing drug and light source used. It offers advantages such as precision targeting and minimal scarring or invasiveness compared to other treatments.
Particle beam – proton,neutron & heavy ion therapy
particle therapy is advanced external beam therapy used to treat cancer , which uses beams of protons or other charged particles such as helium, carbon or other ions instead of photons. charged particles have different depth-dose distributions compared to photons. They deposit most of their energy in the last final millimeters of their trajectory (when their speed slows). This results in a sharp and localized peak of dose, known as the Bragg peak.
Honors Research Poster - Darwin Kwok
This study investigated using ultrasound-stimulated microbubbles to increase permeability of the endothelial cell layer and enhance drug delivery. Researchers seeded human umbilical vein endothelial cells on transwell inserts and applied ultrasound at varying pressures in combination with microbubbles. They measured diffusion of FITC-dextran through the cell layer and found that permeability increased with higher ultrasound pressures. Cell density was maintained even at mild ultrasound pressures, suggesting tight junctions between cells were disrupted without damaging the overall monolayer. This non-invasive technique shows potential for targeted drug delivery across normally impermeable barriers.
Photon Vs proton beam therapy
Intensity modulated proton therapy (IMPT)
Photon Vs Proton beam therapy
Dosimetric comparison between Photon and Proton Beam
Dose Algorithm for Scanning Proton
This document discusses proton dose calculation algorithms. It covers several key points:
- Monte Carlo simulations can provide the most accurate dose modeling but are slow, so simplified analytical models are needed.
- Pencil beam algorithms calculate dose by modeling the fluence of individual beamlets and accounting for primary and secondary proton interactions and scattering.
- Lateral dose spread is modeled using double Gaussian functions to describe the primary Gaussian distribution and wider secondary "halo" distribution.
- Parameters of the Gaussian functions like sigma are tuned to match measured beam data like depth dose profiles and beam spot sizes.
- Benchmarking of proton treatment planning systems requires comparison of calculated and measured beam data for various energies and depths.
Presentation on Nanoparticles Smart Drug Delivery System For Cancer
Nano technology is a rapidly expanding field, encompassing the development of a man-made materials in 5-200 nanometer size range. This dimension vastly exceeds that of standard organic molecules.
Please contact us if you want our services.(We work on every kind of Thesis Presentations (Word, Power point, Excel, Adobe photoshop and Auto-cad).
Contact : 03244708472
Photodynamic Therapy (PDT)
Photodynamic therapy is a cancer treatment that uses photosensitizing drugs and light to destroy cancer cells. The drugs are injected into the bloodstream and absorbed more by cancer cells than healthy cells. After 24-72 hours when the drug has left healthy cells but remains in cancer cells, the tumor is exposed to light which activates the photosensitizer. This causes the production of oxygen species that directly kill cancer cells by damaging their DNA or indirectly by destroying blood vessels that supply the tumor. PDT is currently used to treat several types of cancer affecting the skin, esophagus, lung, and other organs. It offers advantages over other treatments such as minimal invasiveness and ability to precisely target tumors, but it has limitations
Presentación del Filtro de Bosso 2
This paper proposes a new method for calculating dispersed amplitude in mammograms using the Bosso filter as a degradation model. The Bosso filter is presented as modeling the effect of radiation scattering in breast tissue on mammogram image quality. A theoretical framework is developed relating radiation intensity equations to the filter. An estimation method is outlined for calculating filter parameters from digital mammogram images to obtain an image with reduced effects of dispersed radiation, improving detail. The method is intended to improve clinical breast cancer diagnosis.
What's hot (20)
Alberto Gavizón- Simposio Internacional 'Terapias oncológicas avanzadas'
Alberto Gavizón- Simposio Internacional 'Terapias oncológicas avanzadas'
Photodynamic therapy is effective & promising method for
Photodynamic therapy is effective & promising method for
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...
Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy_Crimson Publ...
RECENT ADVANCES IN MICRO AND NANO DRUG DELIVERY SYSTEMS
RECENT ADVANCES IN MICRO AND NANO DRUG DELIVERY SYSTEMS
Nanotechnology and its Application in Cancer Treatment
Nanotechnology and its Application in Cancer Treatment
Particle beam – proton,neutron & heavy ion therapy
Particle beam – proton,neutron & heavy ion therapy
Presentation on Nanoparticles Smart Drug Delivery System For Cancer
Presentation on Nanoparticles Smart Drug Delivery System For Cancer
Viewers also liked
FIRHeat Plugin - Far Infrared Ray Heat Therapy Products
The Plug-in Heat Therapy Products can relieve all types of Chronic Pain. Heat Therapy can relieve neck pain, shoulder pain, upper and lower pain, elbow pain, wrist pain, knee pain and ankle pain. It also improves blood circulation.
About the LENS
The document discusses LENS (Low Energy Neurofeedback System) therapy, a form of neurofeedback. It provides details on what LENS is, how it works, how it differs from traditional neurofeedback, and potential clinical benefits. Some key points made:
- LENS is a passive form of neurofeedback that uses weak electromagnetic signals to help the brain reorganize inefficient pathways. It requires less sessions (often under 10) than traditional neurofeedback.
- Research has shown LENS can help reduce symptoms for various brain-related conditions like ADHD, depression, PTSD, chronic pain, and more. Case studies demonstrate improvements in symptoms like headaches, sleep, and focus after LENS sessions.
TDP Lamps-Longinghealth2016
This document describes the benefits of TDP mineral lamps for pain relief. It states that TDP lamps emit infrared light that penetrates the skin and warms muscles, increasing blood flow and relaxing muscles to relieve pain, stiffness, and inflammation. Several models of TDP lamps are presented with specifications like power output and range of motion. Directions are given for how to use the lamps, explaining they should be held 12-16 inches from the body for 5-40 minutes daily to treat pain, stiffness, and other issues. Contact information is provided to purchase a lamp.
Introducing Anodyne® Therapy
The word Anodyne comes from Latin and means without (ano) pain (dynus). Anodyne® Therapy is a patented form of Monochromatic InfraRed Photo-Thermal Energy (MIRE™). Anodyne® Therapy is a physical medicine modality used to temporarily improve circulation and reduce pain, stiffness and muscle spam anywhere the pads are placed on the body.
1362571372 anodyne paper
Distal polyneuropathy is the most common complication affecting the lower extremities of patients with diabetes mellitus. Up to 60% of patients with long-standing diabetes have diabetic peripheral neuropathy. Anodyne therapy using monochromatic infrared photoenergy was found to significantly improve vibration perception threshold scores and reduce symptoms of pain, numbness, and tingling in patients with diabetic peripheral neuropathy. Improved foot sensitivity with anodyne therapy may be associated with reduced incidence of diabetic foot wounds and amputations.
Case report burns secondary to infrared therapy in a six year old hbss patient
This article summarizes a case report of burns suffered by a 6-year-old sickle cell disease patient during infrared therapy. The patient developed foot drop after treatment for leg pain and was referred for physiotherapy. After several infrared heat therapy sessions, the patient developed burns on the plantar surfaces of the toes on one foot. The report discusses how infrared radiation is used in physiotherapy and can penetrate deep tissues, causing unnoticed burns. It recommends safety measures and medical supervision during physiotherapy, especially for vulnerable patients.
Establishing An Anodyne® Therapy Practice
The document provides information on establishing an Anodyne Therapy practice including recommended protocols, marketing support, benefits, and safety guidelines. It recommends 12 sessions over initial weeks for peripheral neuropathy patients, with ongoing sessions 2-3 times per week. Marketing support includes materials, referrals, and advertising to drive patients. Benefits include allowing home use and higher patient volumes while still requiring monitoring. Contraindications and less responsive conditions are also outlined.
Gano Vitals Photon Heating Pad
Gano Vital's revolutionary bVital Bio-Photon Heating Pad, using the latest in NASA Photon Technology and Far Infrared Rays.
Publish Clinical Studies
Three published clinical studies found that Anodyne Therapy using MIRE improved symptoms in patients with peripheral neuropathy:
1. A study of 49 diabetic patients found significant improvement in sensation after 12 treatments over 4 weeks.
2. A randomized controlled study of 27 diabetic patients found 106% improved sensation, 45% reduced pain, and 70% reported improved balance after 6 treatments over 2 weeks.
3. A study of 1047 peripheral neuropathy patients found 366% improved sensation to touch as measured by monofilaments after a mean of 18 treatments.
Lymphatic drainage using low level lasers
This document discusses using infrared diode laser therapy to induce lymphatic drainage for inflammation in the head and neck region. It begins with an overview of the lymphatic system and its role in inflammation, then describes the main lymph node networks in the head and neck area. It presents a case study demonstrating the successful use of laser therapy on specific lymph nodes to accelerate drainage and resolution of a labial herpes simplex infection over the course of just two treatment sessions. The document concludes that laser-mediated lymphatic drainage is an effective approach for managing infectious and contaminated areas without directly irradiating the infected tissues.
Viewers also liked (10)
FIRHeat Plugin - Far Infrared Ray Heat Therapy Products
FIRHeat Plugin - Far Infrared Ray Heat Therapy Products
Case report burns secondary to infrared therapy in a six year old hbss patient
Case report burns secondary to infrared therapy in a six year old hbss patient
Similar to ASAM - 複製
Presentation1 final
This document provides an overview of nanotechnology applications. It discusses the history of nanotechnology, types including dry, wet and computational nanotechnology, and structures such as nanoparticles, polymeric micelles, dendrimers, and magnetic nanoparticles. Applications of nanotechnology discussed include drug delivery, therapeutics such as cancer treatment and spinal fusion, diagnostics, sensors, and theranostics. Limitations regarding drug delivery such as toxicity and accumulation are also mentioned.
5cancer
This document discusses the use of nanotechnology for cancer treatment. It begins with background on cancer and challenges with chemotherapy. It then introduces various nanoparticles being explored for cancer applications, such as quantum dots, iron oxide, and gold nanoparticles. The document discusses the enhanced permeability and retention effect that allows nanoparticles to passively target tumors. It provides the example of Doxil, an FDA-approved liposomal drug delivery system. Other nanomedicine examples discussed include Abraxane protein-bound paclitaxel nanoparticles. The document covers topics like tumor tissue targeting, overcoming drug resistance, vascular and cellular targets, and using heat-generating nanoparticles for thermal ablation of cancer cells.
Biomedical applications of quantum dots
The document discusses the use of quantum dots (QDs) for biomedical applications such as bioimaging and therapy. It provides an overview of the photophysical properties of QDs that make them advantageous over organic dyes for imaging. Various biomedical applications of QDs are described, including in vitro and in vivo imaging, biosensing, photodynamic therapy, drug delivery, and gene delivery. Finally, the document outlines a research proposal to develop MoS2@polyaniline nanohybrids for dual-model imaging and synergistic photothermal/radiation therapy of tumors.
Acta Biomaterialia 49 (2017) 402–413Contents lists available.docx
Acta Biomaterialia 49 (2017) 402–413
Contents lists available at ScienceDirect
Acta Biomaterialia
journal homepage: www.elsevier.com/locate/actabiomat
Full length article
Programmed near-infrared light-responsive drug delivery system for
combined magnetic tumor-targeting magnetic resonance imaging and
chemo-phototherapy
http://dx.doi.org/10.1016/j.actbio.2016.11.035
1742-7061/� 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
⇑ Corresponding authors at: School of Pharmaceutical Sciences, Zhengzhou
University, 100 Kexue Avenue, Zhengzhou 450001, China.
E-mail addresses: [email protected] (L. Hou), [email protected]
(Z. Zhang).
Qianhua Feng a,b,c, Yuanyuan Zhang a, Wanxia Zhang a, Yongwei Hao a,b,c, Yongchao Wang a,b,c,
Hongling Zhang a,b,c, Lin Hou a,b,c,⇑, Zhenzhong Zhang a,b,c,⇑
a School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China
b Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou 450001, China
c Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Henan Province, Zhengzhou 450001, China
a r t i c l e i n f o
Article history:
Received 15 July 2016
Received in revised form 3 November 2016
Accepted 15 November 2016
Available online 24 November 2016
Keywords:
Hollow mesoporous copper sulfide
Magnetic targeting
Controlled release
Theranostics
a b s t r a c t
In this study, an intelligent drug delivery system was developed by capping doxorubicin (DOX)-loaded
hollow mesoporous CuS nanoparticles (HMCuS NPs) with superparamagnetic iron oxide nanoparticles
(IONPs). Under near infrared (NIR) light irradiation, the versatile HMCuS NPs could exploit the merits
of both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Herein, the mul-
tifunctional IONPs as gatekeeper with the enhanced capping efficiency were supposed to realize ‘‘zero
premature release” and minimize the adverse side effects during the drug delivery in vivo. More impor-
tantly, the hybrid metal nanoplatform (HMCuS/[email protected]) allowed several emerging exceptional
characteristics. Our studies have substantiated the hybrid nanoparticles possessed an enhanced PTT
effect due to coupled plasmonic resonances with an elevated heat-generating capacity. Notably, an effec-
tive removal of IONP-caps occurred after NIR-induced photo-hyperthermia via weakening of the coordi-
nation interactions between HMCuS-NH2 and IONPs, which suggested the feasibility of sophisticated
controlled on-demand drug release upon exposing to NIR stimulus with spatial/temporal resolution.
Benefiting from the favorable magnetic tumor targeting efficacy, the in vitro and in vivo experiments indi-
cated a remarkable anti-tumor therapeutic efficacy under NIR irradiation, resulting from the synergistic
combination of chemo-phototherapy. In addition, T2-weighted magnetic resonance imaging (MRI) con-
trast performance of IONPs provided the identifica.
Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment...
Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment...CrimsonpublishersCancer
This summary provides the key information from the document in 3 sentences:
This review discusses combining photodynamic therapy (PDT) with radiotherapy (RT) for cancer treatment. PDT and RT both work to damage DNA in cancer cells, and combining the two approaches can have a synergistic effect that is more effective than either treatment alone. The document reviews various approaches that have been studied to combine PDT and RT, such as using photosensitizers conjugated to radioisotopes, and applying both near infrared light and X-rays during treatment, finding that the combined approach results in improved outcomes over single treatments.Nanoparticles in cancer diagnosis
This document discusses the use of nanotechnology for cancer diagnosis and therapy. It begins by defining cancer and tumors, and then introduces nanotechnology and its applications in medicine including drug delivery, imaging, and cancer treatment. Specific nanoparticles discussed for cancer diagnosis include gold nanoparticles, bismuth sulfide nanoparticles, and iron oxide nanoparticles which can be used for computed tomography, magnetic resonance imaging, and ultrasound imaging, respectively. The document also discusses various nanoparticle-based approaches for detecting different types of cancer like bladder and breast cancer. In general, the document outlines how nanotechnology enables more precise cancer diagnosis and targeted therapy.
HMSN Poster Final
1. Copper sulfide decorated hollow mesoporous silica nanoparticles (HMSN@CuS) are engineered for cancer theranostics applications like photothermal therapy and drug delivery.
2. HMSN@CuS accumulates in tumors through ligand targeting and exhibits enhanced photothermal effects under laser irradiation to generate heat and induce cancer cell death.
3. In mouse models, HMSN@CuS effectively targets and destroys tumors with both nanoparticle injection and laser treatment, showing potential for image-guided cancer therapy.
Novel rt in sarc2017
Radiotherapy techniques have advanced for treating sarcoma, including more precise tumor delineation using MRI fusion and CT atlases. Treatment planning has improved with IMRT, VMAT and IGRT allowing higher doses to the tumor while sparing normal tissues. Combining radiotherapy with chemotherapy in trials showed increased local control and survival. Alternative particle therapies like protons and carbon ions may further enhance local control rates for certain sarcomas. Ongoing research aims to enhance radiotherapy response through anti-angiogenesis agents and modulating DNA damage response pathways.
NCUR MLG
The document discusses the formulation and characterization of inhalable spray dried powders containing magnetic nanoparticles and anti-cancer agents for lung cancer treatment. Specifically, it formulates powders containing common anti-cancer drugs like cisplatin or erlotinib along with iron oxide magnetic nanoparticles and excipients through spray drying. It then characterizes the particles' properties, like their aerodynamic diameter and morphology, heating ability upon exposure to an alternating magnetic field, and aerosol performance through next generation impactor studies. The results demonstrate the successful production of spherical, uniformly sized spray dried particles that show improved aerosolization and heating capabilities, indicating potential for advancement of localized lung cancer treatments.
Breakthroughs_of_using_Photodynamic_Therapy_and_Gold_Nanoparticles_in_Cancer_...
Breakthroughs_of_using_Photodynamic_Therapy_and_Gold_Nanoparticles_in_Cancer_...National Institute of laser, Cairo university
The document summarizes research on using photodynamic therapy (PDT) and gold nanoparticles for cancer treatment, specifically breast cancer. PDT involves activating photosensitizers in tumor tissue with light in the presence of oxygen to damage cancer cells. Gold nanoparticles can be used for imaging, drug delivery, and generating heat when exposed to near-infrared light for photothermal ablation of tumors. Research has shown these techniques can effectively treat some superficial breast cancers alone or in combination with other therapies like hyperthermia and radiation therapy. Further research is still needed to improve targeting of tumor cells over healthy tissue and evaluate these approaches in clinical trials before widespread use.Luminescent materials for biomedical applications: the example of nanothermom...
Luminescent materials for biomedical applications: the example of nanothermom...Sociedade Brasileira de Pesquisa em Materiais
Plenary lecture of the XIII SBPMat (Brazilian MRS) meeting, given on September 29th 2014 by Prof. Luís Carlos Dias (Universidade de Aveiro, Portugal).Prezentare melanom ddfu ehb2021 216
Digital dermoscopy technology allows for precise early detection of melanoma and assessment of new treatment options. Melanoma is a form of skin cancer that develops from melanocytes and may begin in moles or other pigmented tissues. Treatment options include surgery, immunotherapy, chemotherapy, radiation therapy, and targeted therapies using drugs that inhibit genes like BRAF which are mutated in melanoma. Nanotechnology shows promise for more targeted treatment by using nanoparticles to deliver drugs or siRNA directly to melanoma cells to suppress tumor growth with fewer side effects than conventional therapies. The study examined 32 melanoma patients treated with various options like chemotherapy, immunotherapy, or a combination, and found an 80% overall improvement with 10% showing resistance due to genetic variations. Early diagnosis
PRESENTACIÓN BIOLOGÍA CELULAR
This document presents research by Verónica Gómez León on developing a "smart and dual-targeted BSA nanomedicine with controllable release by high autolysosome levels". The objectives are to study this nanomedicine approach and compare the effects of free doxorubicin (DOX) and DOX-loaded nanomedicine. Methods used include cell culturing, MTT assays to detect cell survival rates, fluorescence microscopy to visualize reactions, flow cytometry to classify activated cells, and immunohistochemistry staining. Results show the nanomedicine is endocytosed and traffics into lysosomes for acid-triggered drug release. This allows for reduced side effects compared to free DOX directly
Use of nanotechnology in medical science (pros and cons)
here in this presentation I had shared the basic information regarding use of nanotechnology in medical science and what wonders and improvements that nano technology did in the field of medical science.
nanobiotecnology in medical side
1. Nanobiotechnology involves engineering at the atomic or molecular scale to develop nanomaterials and devices typically less than 100nm in size for applications in medicine.
2. Nanoparticles show promise for targeted drug delivery, reducing side effects and improving bioavailability of drugs. They can be designed to target specific cells and tissues.
3. Nanoparticles are being used for imaging and detection purposes, such as quantum dots for cancer imaging and magnetic nanoparticles for MRI. They provide improved contrast and sensitivity.
LASER in Periodontics - Session 2
The document discusses the use of lasers in periodontics, including for treating dentinal hypersensitivity, non-surgical periodontal therapy, and surgical therapy. It summarizes the different types of lasers used, such as low-level lasers for biostimulation, Nd:YAG and diode lasers for bacterial reduction, and Er:YAG lasers for calculus detection and removal with minimal thermal damage to tooth surfaces. The document reviews studies on the effectiveness of lasers for calculus detection and removal, bacterial reduction, detoxification of root surfaces, and biostimulation effects with low-level laser therapy.
Pancreatic cancer
This document summarizes a human clinical trial that evaluated the safety and efficacy of using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. 10 patients received the standard gemcitabine chemotherapy protocol along with ultrasound-mediated microbubble delivery directly to their pancreatic tumors. Results showed no additional toxicity compared to gemcitabine alone. 5 patients experienced partial tumor shrinkage and 1 patient's tumor reduced enough to allow for potentially curative surgery. Patients also experienced less abdominal pain and weight loss. Overall survival was nearly twice as high compared to historical controls treated with gemcitabine only, suggesting ultrasound-mediated microbubble delivery improved gemcitabine treatment outcomes for inoperable pancreatic cancer.
U tokyo forum at usp 20131112
This document summarizes the work of Dr. Horacio Cabral in the area of nanomedicine for cancer diagnosis and treatment. It discusses (1) how polymeric nanodevices can be engineered to selectively target cancer cells and reduce toxicity compared to traditional chemotherapy, (2) research using in vivo imaging to observe the behavior and distribution of nanodevices in tumors over time, and (3) ongoing clinical trials evaluating nanomedicine formulations to treat various cancer types. The overall aim is to develop theranostic nanomedicines that can both diagnose and treat cancer with higher precision and lower side effects.
Role of nanotechnology in insect pest management
Nanotechnology is an emerging area in the field of agriculture. Nanopesticides and nanofungicides will give 100% better results when compared with the normal chemicals.
Medical applications of laser 3
The document summarizes the four main types of interactions that can occur between laser radiation and biological tissues: photochemical, photothermal, photoablative, and photomechanical. It provides details on the laser parameters and intensities required for each interaction and describes the resulting biological effects, such as chemical changes, heating, ablation of material, and cavitation. Photochemical interactions occur at low intensities and involve chemical reactions. Photothermal interactions produce heating effects. Photoablation removes layers of material at very high intensities. Photomechanical interactions generate shock waves and cavitation bubbles through plasma formation.
Similar to ASAM - 複製 (20)
Acta Biomaterialia 49 (2017) 402–413Contents lists available.docx
Acta Biomaterialia 49 (2017) 402–413Contents lists available.docx
Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment...
Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment...
Breakthroughs_of_using_Photodynamic_Therapy_and_Gold_Nanoparticles_in_Cancer_...
Breakthroughs_of_using_Photodynamic_Therapy_and_Gold_Nanoparticles_in_Cancer_...
Luminescent materials for biomedical applications: the example of nanothermom...
Luminescent materials for biomedical applications: the example of nanothermom...
Use of nanotechnology in medical science (pros and cons)
Use of nanotechnology in medical science (pros and cons)
ASAM - 複製
- 1. Near-Infrared Light-Triggerable Microneedles for Chemo-Photothermal Synergistic Therapy Zhi-Wei Lin, Hao-An Chan, Mei-Chin Chen* Department of Chemical Engineering National Cheng Kung University, Taiwan This study reports doxorubicin (DOX)-loaded near-infrared (NIR) light-triggerable microneedles (MNs) to combine chemotherapy and photothermal therapy in one system. The MNs are consisted of biodegradable polycaprolactone and photothermal nanoparticles (NPs). Upon exposure to NIR, MNs can quickly melt at 50 °C due to the heating of the encapsulated NPs and then release DOX into the punctured tissue. Drug release can be controlled in an on-demand fashion, when LASER ON produced a steep increasing in drug release, and LASER OFF had no obvious release over a long time. In vivo antitumor activity tests demonstrated the DOX- loaed MNs with external NIR photothermal therapy significantly enhanced the therapeutic effect of cancer treatment. Compared with chemotherapy or photothermal therapy alone, the combined treatment possessed a better therapeutic effect. These results showed that the NIR-triggerable MNs may serve as a useful system for superficial cancer treatment. ▲Drug-loaded NIR triggerable MNs ▲ (a) Infrared images of MNs under NIR exposure (b) Temperature profile of MNs for different On and Off cycles ▲Cumulative release of DOX from MNs under different cycles of NIR laser exposure ▲ Pig cadaver skin under different irradiation cycles Melting process of MNs in cadaver skin after different irradiation cycles: (a) 3D reconstruction from histological sections (b) Bright- field and (c) Fluorencence micrographs ▲Tumors on mice after various treatments Complete elimination ▲(a) Normalized tumor volume and (b) Body weight curves after various treatments We succefully developed DOX-loaded NIR light- triggerable MNs to combine chemotherapy and photothermal therapy in one system. The NIR light triggered release test showed that the drug release from the microneedles can be controlled by the adjustment ofthe parameters of NIR light. Combined treatment demonstrated a synergistic effect, resulting in complete destruction of tumors without weight loss and recurrence of tumors. [1] Chen MC, Ling MH, Lai KH and Pramudityo E (2012) Biomacromolecules, 13:4022-4031 [2] You J, Zhang GD and Li C (2010) ACS Nano 4:1033- 1041.