15. 15
Definition of ARIDefinition of ARI (Acute Resp. Infection)(Acute Resp. Infection)
This term isThis term is usedused by HW to indicate ac. Inf. ofby HW to indicate ac. Inf. of
resp. system in U-5y childrenresp. system in U-5y children
In this age group such inf. are often not anatomicallyIn this age group such inf. are often not anatomically
localized, rather spreads rapidly to adjacent partslocalized, rather spreads rapidly to adjacent parts
An U-5 child getsAn U-5 child gets 3-6 ARIs/y3-6 ARIs/y regardless of livingregardless of living
standardstandard
HW: health worker. U-5: under 5 years of age. Inf.: infectionHW: health worker. U-5: under 5 years of age. Inf.: infection
21. 21
Normal Defence of RSNormal Defence of RS
These are unique!These are unique!
ā¢ Breathing, coughing, sneezingBreathing, coughing, sneezing
ā¢ Mucosal antibodiesMucosal antibodies
ā¢ Ciliary sweepingCiliary sweeping
ā¢ PhagocytesPhagocytes
ā¢ Physical filteringPhysical filtering
(Think how less often you catch cold and cough!)(Think how less often you catch cold and cough!)
24. 24
ARI in ChildrenARI in Children Spread Rapidly:Spread Rapidly:
ā¢ Shorter and narrower RTShorter and narrower RT
ā¢ Cough not strongCough not strong
ā¢ Less immuneLess immune
ā¢ Auditory tube is:Auditory tube is:
ā shortershorter
ā narrowernarrower
ā straighterstraighter
25. Sites of Infections (ARI)Sites of Infections (ARI)
ā¢ RhinitisRhinitis
ā¢ TonsillitisTonsillitis
ā¢ PharyngitisPharyngitis
ā¢ EpiglottitisEpiglottitis
ā¢ LaryngitisLaryngitis
ā¢ AOMAOM
ā¢ TracheitisTracheitis
ā¢ BronchitisBronchitis
ā¢ BronchiolitisBronchiolitis
ā¢ Pn./Br.PnPn./Br.Pn
Children usually have combinations:Children usually have combinations:
Ac. rhinopharyngotonsillitis +/- AOM, ac. LTBAc. rhinopharyngotonsillitis +/- AOM, ac. LTB
(croup) Br.Pn, etc.(croup) Br.Pn, etc.
26. 26
ARI is a syndrome:ARI is a syndrome:
ā cough,cough, breath ratebreath rate
ā chest indrawing,chest indrawing, stridorstridor
ā +/-+/- 4 general4 general danger signdanger signs (IMCI)s (IMCI)
NoNo Dr,Dr, nono stethoscope,stethoscope, nono lab.!lab.!
27. 27
Normal breathing rateNormal breathing rate
AgeAge RRRR Fast breathingFast breathing
<2mo<2mo <60/min<60/min ā„ā„6060
(preterm 70)(preterm 70)
2-12mo2-12mo <50/min<50/min ā„ 50ā„ 50
1-5y1-5y <40/min<40/min ā„ 40ā„ 40
Counting BreathingCounting Breathing
ā¢ The childThe child mustmust be calmbe calm
ā¢ Count full 1 minuteCount full 1 minute
ā¢ Count the abdominal swelling in inspirationCount the abdominal swelling in inspiration
33. 33
Depth of ARI as ProblemDepth of ARI as Problem
ā¢ Pneumonia is the biggest U-5 killer (0.9million/y);Pneumonia is the biggest U-5 killer (0.9million/y);
90% in L&MICs (70% in Africa & SEA)90% in L&MICs (70% in Africa & SEA)
ā¢ Commonest admission (Commonest admission (12-45%)12-45%)
ā¢ OPD: 20-60% ARIOPD: 20-60% ARI
ā¢ V. imp. precipitator of Mn, VADXV. imp. precipitator of Mn, VADX
ā¢ NationalNational Health IndexHealth Index of a countryof a country
((5.9 million U-5 death in 2015: 16,000/d.5.9 million U-5 death in 2015: 16,000/d. 70% from inf.)70% from inf.)
35. Key facts:Key facts: PneumoniaPneumonia
ā¢15% of all U-5 deaths:15% of all U-5 deaths: 900,000 in 2015900,000 in 2015
ā¢Kills by hypoxia due to pus and fluid in alveoliKills by hypoxia due to pus and fluid in alveoli
ā¢C/by viruses, bacteria or fungiC/by viruses, bacteria or fungi
ā¢Rx with low-cost, low-tech drugs and care (1/3Rx with low-cost, low-tech drugs and care (1/3rdrd
childrenchildren
with pneumonia get AB)with pneumonia get AB)
ā¢Preventable by immunization, nutrition & cleanPreventable by immunization, nutrition & clean
environmentenvironment
35
36. ARI mortality/morbidity highest in U-5yARI mortality/morbidity highest in U-5y
ā Lack of breast feedingLack of breast feeding
ā Bottle feeding, weaned earlyBottle feeding, weaned early
ā HIVHIV
ā <2y of age<2y of age
ā Lack of vaccinationLack of vaccination
ā Mn., VADXMn., VADX
ā Poor education, overcrowding, poor clothingPoor education, overcrowding, poor clothing
ā Difficult access to healthcare, medicationDifficult access to healthcare, medication
37. 37
Aetiology of ARIAetiology of ARI
ā¢ VirusesViruses
ā¢ BacteriaBacteria
ā¢ MycoplasmaMycoplasma
ā¢ FungusFungus
ā¢ Parasites, wormsParasites, worms
38. Aetiology ā¦Aetiology ā¦
ā¢ Varies: age, immune status, where contractedVaries: age, immune status, where contracted
ā¢ Community acquired (CAP)Community acquired (CAP)
ā Developing countriesDeveloping countries
ā¢ VirusesViruses 40%40%
ā¢ S. pneumoniae, Hib, S aureus, Moraxella,S. pneumoniae, Hib, S aureus, Moraxella,
Mycoplasma, Chlamydia inMycoplasma, Chlamydia in 60%60%
ā Developed countriesDeveloped countries
ā¢ Bacteria:Bacteria: 5-10%5-10%
39. Etiology Based on AgeEtiology Based on Age
AgeAge OrganismOrganism
NeonatesNeonates GBS, E coli, Klebsiella, SGBS, E coli, Klebsiella, S
aureusaureus
InfantsInfants Pneumococcus, Chlamydia,Pneumococcus, Chlamydia,
RSV, Hib, StaphRSV, Hib, Staph
1-5y1-5y Viruses, Pneumococcus, HibViruses, Pneumococcus, Hib
Chlamydia, Mycoplasma,Chlamydia, Mycoplasma,
Staph, GASStaph, GAS
5-18y5-18y Mycoplasma, Pneumococcus,Mycoplasma, Pneumococcus,
Chlamydia, HibChlamydia, Hib
40. 40
VirusesViruses
ā¢ RhinovirusesRhinoviruses
ā¢ RSVRSV
ā¢ AdenovirusesAdenoviruses
ā¢ Influenza, parainfluenza A B CInfluenza, parainfluenza A B C
ā¢ MyxovirusesMyxoviruses
ā¢ Corona viruses (SARS, MERS)Corona viruses (SARS, MERS)
ā¢ Boca virus, metapneumovirusBoca virus, metapneumovirus
41. 41
Common BacteriaCommon Bacteria
ā¢ **
S. pneumoniaeS. pneumoniae
ā¢ **
HibHib
ā¢ S. pyogenesS. pyogenes
ā¢ S. aureusS. aureus
ā¢ **
M. tuberculosisM. tuberculosis
ā¢ **
C diphtheriaeC diphtheriae
ā¢ Enteric bacilliEnteric bacilli
ā¢ PseudomonasPseudomonas
ā¢ KlebsiellaKlebsiella
ā¢ MoraxellaMoraxella
*Vaccine available
43. 43
How ARI HarmsHow ARI Harms
ā¢ Malnutrition andMalnutrition and VADX:VADX:
ā¢ HypoxiaHypoxia:: convulsion, deathconvulsion, death
ā¢ ChestChest: collapse, consolidation, effusion, L. abscess,: collapse, consolidation, effusion, L. abscess,
bronchiectasis, pneumothoraxbronchiectasis, pneumothorax
ā¢ Blood:Blood: sepsis, deranged ABB, dyselectrolytemia,sepsis, deranged ABB, dyselectrolytemia,
meningitis, IgA nephropathymeningitis, IgA nephropathy
VADX: Vitamin A defi. And xerophthalmiaVADX: Vitamin A defi. And xerophthalmia
44. 44
ARI Causes Mn. and VADXARI Causes Mn. and VADX
ā¢ Poor feedingPoor feeding
ā¢ Negative nitrogen balanceNegative nitrogen balance
ā¢ VD, F: dehydrationVD, F: dehydration
ā¢ Exhaustion of VAExhaustion of VA
ā¢ Faulty feeding, tabooFaulty feeding, taboo
Mn.: Malnutrition. VD: vomiting diarrhoea. F: fever. VA: vitamin AMn.: Malnutrition. VD: vomiting diarrhoea. F: fever. VA: vitamin A
45. 45
Dehydration in ARIDehydration in ARI::
ā¢ fast breathingfast breathing
ā¢ FF
ā¢ NVDNVD
ā¢ runny noserunny nose
ā¢ poor/faulty feedingpoor/faulty feeding
NVD: nausea vomiting diarrheaNVD: nausea vomiting diarrhea
47. 47
Hospital PictureHospital Picture
ā¢ Out of 1690 cases admitted in BMCH pediatricOut of 1690 cases admitted in BMCH pediatric
ward 400 (23.7%) had ARIward 400 (23.7%) had ARI
ā¢ Peak incidence during Oct-NovPeak incidence during Oct-Nov
48. 48
Death from ARI is DecliningDeath from ARI is Declining**
ā¢ Br. FeedingBr. Feeding
ā¢ No bottle feedingNo bottle feeding
ā¢ Socioeconomic &Socioeconomic &
environmental changeenvironmental change
ā¢ Falling Mn.Falling Mn.
ā¢ HPVAC distributionHPVAC distribution
ā¢ EPIEPI
ā¢ Family planningFamily planning
ā¢ Modern health careModern health care
ā¢ Better and cheap drugsBetter and cheap drugs
ā¢ Female literacyFemale literacy
ā¢ Health awarenessHealth awareness
*
Previously 4mn, now 0.9Previously 4mn, now 0.9
50. History TakingHistory Taking
1. General Danger Signs1. General Danger Signs
2. Main Symptoms2. Main Symptoms
a. Cougha. Cough
b. Diarrheab. Diarrhea
c. Feverc. Fever
d. Ear Problemsd. Ear Problems
3. Nutritional Status3. Nutritional Status
4. Immunization Status4. Immunization Status
5. Other Problems5. Other Problems
IMCI Record FormIMCI Record Form
51. 51
Assess whether the child hasAssess whether the child has
ā¢ No pneumonia (cold-cough; chr. cough)No pneumonia (cold-cough; chr. cough)
ā¢ Pneumonia orPneumonia or
ā¢ Severe Pn.Severe Pn.
In babies <2mo any pneumonia is severe pn.In babies <2mo any pneumonia is severe pn.
52. 52
Fast breathing +Fast breathing +
chest indrawing orchest indrawing or
Stridor in a calmStridor in a calm
child. (Any GD sign)child. (Any GD sign)
SevereSevere PneumoniaPneumonia
oror
(Very Severe Disease)(Very Severe Disease)
Fast breathingFast breathing PneumoniaPneumonia
No signs ofNo signs of
pneumonia or verypneumonia or very
severe diseasesevere disease
No pneumonia:No pneumonia:
cough or coldcough or cold
53. 53
Limitations ā¦Limitations ā¦
Pneumonia in IMCI may bePneumonia in IMCI may be
ā¢ BronchiolitisBronchiolitis
ā¢ Br. AsthmaBr. Asthma
ā¢ DiphtheriaDiphtheria
ā¢ PertussisPertussis
ā¢ HGF, CCFHGF, CCF
No pneumonia may be TBNo pneumonia may be TB
54. PneumoniaPneumonia
ā¢ Fast breathingFast breathing
ā¢ Inflam. of lung parenchyma + consolidationInflam. of lung parenchyma + consolidation
ā¢ Developed world:Developed world: viral:viral: Low morbidity mortalityLow morbidity mortality
ā¢ Developing world:Developing world:
ā Bacteria in 65%Bacteria in 65%
ā Cheap, oral ABT: Amoxicillin can causeCheap, oral ABT: Amoxicillin can cause 84%84%
reduction in deathreduction in death
55. 55
Severe PneumoniaSevere Pneumonia
ā¢ Very sick,Very sick, not able to feednot able to feed
ā¢ Tachypnoea,Tachypnoea, tachycardiatachycardia
ā¢ Chest indrawingChest indrawing
ā¢ Creps, wheezeCreps, wheeze
ā¢ Cyanosis, convulsionCyanosis, convulsion
ā¢ DrowsinessDrowsiness
+/- Fever+/- Fever
56. 56
Lab. Dx. of PneumoniaLab. Dx. of Pneumonia
(not for HW/IMCI)(not for HW/IMCI)
ā¢ CXRCXR
ā¢ CBC filmCBC film
ā¢ CS of blood, tracheal and lung aspirateCS of blood, tracheal and lung aspirate
ā¢ Throat swabThroat swab
67. 67
Rx: General PrinciplesRx: General Principles
ā¢ O2, air way careO2, air way care
ā¢ Nebulized beta-agonist, anticholinergicNebulized beta-agonist, anticholinergic
ā¢ Antibiotics (parenteral)Antibiotics (parenteral)
ā¢ Feeding, warmth, FEBFeeding, warmth, FEB
ā¢ Vitamin A, ZnVitamin A, Zn
ā¢ Counseling, FUCounseling, FU
68. 68
Rx. Severe PneumoniaRx. Severe Pneumonia
ā¢ Admission,Admission, OO22
ā¢ Airway patency:Airway patency:
ā suction clearancesuction clearance
ā Nebulized bronchodilator, anti-secretoryNebulized bronchodilator, anti-secretory
ā¢ Parenteral ABParenteral AB
ā¢ Lowering HGFLowering HGF
ā¢ Feeding, FEB, warmthFeeding, FEB, warmth
ā¢ Vitamin A, zincVitamin A, zinc
69. 69
Antibiotics in PneumoniaAntibiotics in Pneumonia
Mostly viral but 2y infx. is commonMostly viral but 2y infx. is common
ā¢ Injectable: usuallyInjectable: usually >1 AB>1 AB
ā¢ Minimum 10dMinimum 10d
ā¢ Penicillin +genta/amikacin are goodPenicillin +genta/amikacin are good
ā¢ Staph coverage for babies <2yrStaph coverage for babies <2yr
70. 70
When You Defer ABWhen You Defer AB
ā¢ The child is stable, playful, no HGFThe child is stable, playful, no HGF
ā¢ EBF, no bottle feedingEBF, no bottle feeding
ā¢ Taking feeds normallyTaking feeds normally
ā¢ SupervisedSupervised
71. 71
Rx for Cough and Cold (no pn.)Rx for Cough and Cold (no pn.)
ā¢ Exclude AOMExclude AOM
ā¢ Ensure feedingEnsure feeding
ā¢ Treat feverTreat fever
ā¢ Clean noseClean nose
ā¢ Steam therapySteam therapy
ā¢ Honey+tulsiHoney+tulsi
Chr./rec. CoughChr./rec. Cough
ā¢ TB?TB?
ā¢ Congenital HD?Congenital HD?
ā¢ FB?FB?
ā¢ Reactive airway?Reactive airway?
ā¢ GERD?GERD?
73. 73
Follow up for PneumoniaFollow up for Pneumonia
ā¢ Count breath (most important single sign)Count breath (most important single sign)
ā¢ Watch activities: smiles, plays, feeds. Urine outputWatch activities: smiles, plays, feeds. Urine output
If the child stays at homeIf the child stays at home
ā¢ Teach mom how to observe SoB, count breathTeach mom how to observe SoB, count breath
ā¢ Nose cleaning, feeding, warmthNose cleaning, feeding, warmth
ā¢ Ask to return immediately:Ask to return immediately:
s/of deterioration (fast br., chest indrawing)s/of deterioration (fast br., chest indrawing)
poor feedingpoor feeding
78. ACUTE EPIGLOTTITISACUTE EPIGLOTTITIS
ā¢ Life-threatening inf. of epiglottis,Life-threatening inf. of epiglottis,
aryepiglottic folds & arytenoidaryepiglottic folds & arytenoid
(sudden suffocation)(sudden suffocation)
ā¢ mostly in wintersmostly in winters
ā¢ peak :-1ā6 y old. M:F 3:2peak :-1ā6 y old. M:F 3:2
ā¢ Commonly bacteria: Hib. Concomitant bacteremia, pn.,Commonly bacteria: Hib. Concomitant bacteremia, pn.,
AOM, arthritis, etc. by Hib may be presentAOM, arthritis, etc. by Hib may be present
80. ACUTE EPIGLOTTITISACUTE EPIGLOTTITIS
aka supraglottitisaka supraglottitis
CFCF
ā HGF, sore throat, SoB, rapidlyHGF, sore throat, SoB, rapidly
progressing res. obstructionprogressing res. obstruction
ā toxic, dysphagia, chest indrawing, drooling,toxic, dysphagia, chest indrawing, drooling,
hyper extended neck, tripod positionhyper extended neck, tripod position
ā stridor is a late finding; cyanosis, coma, deathstridor is a late finding; cyanosis, coma, death
ā mouth is open, jaw thrust forwardmouth is open, jaw thrust forward ((sniffingsniffing
positionposition).). Barking cough is rareBarking cough is rare
81. EXAMINATIONEXAMINATION
ā¢ Do notDo not examine the throatexamine the throat
ā¢ Assess severityAssess severity
ā degree of stridor, resp. rate, HRdegree of stridor, resp. rate, HR
ā pulse oximetry, arousalpulse oximetry, arousal
ā¢ Dx:Dx:
ā āācherry redā epiglottischerry redā epiglottis
ā āāthumb signā on lateral neck XRthumb signā on lateral neck XR
ā blood cultures, electrolytesblood cultures, electrolytes
82. ā¢ Direct laryngoscopy:Direct laryngoscopy: cherry redcherry red epiglottisepiglottis
But not recommended!But not recommended!
ACUTE EPIGLOTTITIS ā¦ACUTE EPIGLOTTITIS ā¦
84. Rx (AC. EPIGLOTTITIS)Rx (AC. EPIGLOTTITIS)
A medical emergency!A medical emergency!
ā¢ ICUICU
ā¢ endotracheal intubation may be neededendotracheal intubation may be needed
ā¢ help from anesthetist & ENT surgeonhelp from anesthetist & ENT surgeon
ā¢ IV Amplicillin/Ceftriaxone (100 mg/kg/d) x10dIV Amplicillin/Ceftriaxone (100 mg/kg/d) x10d
ā¢ O2, ABB, IVF, nutritionO2, ABB, IVF, nutrition
ā¢ Rifampicin prophylaxis to close contactsRifampicin prophylaxis to close contacts
85. ALTB (croup)ALTB (croup)
ā¢ Mucositis of glottis-subglottisMucositis of glottis-subglottis;; usually viral:usually viral:
parainfluenza 1,2,3 (75%),parainfluenza 1,2,3 (75%), influenza A,B; RSV,influenza A,B; RSV,
epiglottitis, diphtheriaepiglottitis, diphtheria
ā¢ TracheitisTracheitis
ā¢ Age : 6moā6yAge : 6moā6y
ALTB: Ac. LaryngotracheobronchitisALTB: Ac. Laryngotracheobronchitis (CROUP)(CROUP)
86. ā¢ Inflam. swelling of throat: classical:Inflam. swelling of throat: classical: stridorstridor,,
"barking" cough"barking" cough,, hoarsenesshoarseness (within 1-2d)(within 1-2d)
ā¢ Features of URTI + croupFeatures of URTI + croup
ā¢ LGF, Prolonged inspirationLGF, Prolonged inspiration
ā¢ Severe at night, on lyingSevere at night, on lying
ā¢ Relieved by sitting upRelieved by sitting up
ā¢ Neck XR: subglotticNeck XR: subglottic
narrowingnarrowing (Steeple sign)(Steeple sign)
89. DD: Ac. LTB and Ac. EpiglottitisDD: Ac. LTB and Ac. Epiglottitis
CroupCroup EpiglottitisEpiglottitis
CourseCourse daysdays hourshours
ProdromeProdrome coryzacoryza nonenone
CoughCough barkingbarking slight if anyslight if any
FeedingFeeding ableable nono
MouthMouth closedclosed droolingdrooling
ToxicToxic nono yesyes
FeverFever <38.5<38.500
CC >38.5>38.5 00
CC
StridorStridor raspingrasping softsoft
VoiceVoice hoarsehoarse Weal/silentWeal/silent
90. ALTB: RxALTB: Rx
ā¢ humidified airhumidified air
ā¢ steroidssteroids
ā¢ reduce severity and duration/need forreduce severity and duration/need for
intubationintubation
ā¢Prednisolone p.o. 2mg/kg/d x3dPrednisolone p.o. 2mg/kg/d x3d
ā¢ nebulized budesonidenebulized budesonide
ā¢ nebulized adrenalinenebulized adrenaline
91. ā¢ Very common in childrenVery common in children
ā¢ Age: 2-6 mo. C/by:Age: 2-6 mo. C/by:
ā S. pneumoniaeS. pneumoniae, Hib, M. catarrhalis, Hib, M. catarrhalis
Symptoms:Symptoms:
ā¢ earache,earache, inconsolable cryinconsolable cry & sleep disturbances, fit,& sleep disturbances, fit,
sometimes DVsometimes DV
Signs:Signs:
ā¢ Otorrhea or bulged congested TM, PEDOtorrhea or bulged congested TM, PED
PED: perforated eardrumPED: perforated eardrum
95. TreatmentTreatment
ā¢Broad-spectrum ABTBroad-spectrum ABT
ā¢Analgesic, decongestant (local/systemic)Analgesic, decongestant (local/systemic)
ā¢ Saline nose washSaline nose wash
ā¢Myringotomy SOSMyringotomy SOS
ā¢Local AB drop for PEDLocal AB drop for PED
ā¢No bath in PEDNo bath in PED
96. Complications of OMComplications of OM
ā¢ MastoiditisMastoiditis
ā¢ MeningitisMeningitis
ā¢ Brain abscessBrain abscess
ā¢ PEDPED
ā¢ Deafness-dumbness, poor learningDeafness-dumbness, poor learning
ā¢ ConvulsionConvulsion
96
97. 97
MCQMCQ
ā¢ HPVAC is an important intervention to prevent ARIHPVAC is an important intervention to prevent ARI
ā¢ Feeding bottle is a baby killerFeeding bottle is a baby killer
ā¢ Cut-off mark of fast breathing at 9 mo is 40Cut-off mark of fast breathing at 9 mo is 40
ā¢ Any pneumonia in <6o-days of age is severe pn.Any pneumonia in <6o-days of age is severe pn.
ā¢ O2 is the most important Rx for severe pn.O2 is the most important Rx for severe pn.
98. MCQMCQ
ā¢ Parenteral ABT is recommended for severe pn.Parenteral ABT is recommended for severe pn.
ā¢ Zn has an imp. role in shortening of duration &Zn has an imp. role in shortening of duration &
prevention of recurrence of ARI in childrenprevention of recurrence of ARI in children
ā¢ Commonest c/of ac. epiglottitis is HibCommonest c/of ac. epiglottitis is Hib
ā¢ Ac. epiglottitis is usually Dx by direct laryngoscopy
ā¢ Croup means stridor, hoarseness, barking cough
98
Goblet cellĀ is a glandular, modified simple columnar epithĀ cell; secrete gel-forming mucins.
Mucin: hydratedĀ mucinogen,Ā containsĀ CHOĀ suchĀ asĀ thoseĀ fromĀ theĀ gobletĀ cellsĀ ofĀ gut, submaxillaryĀ g, etc.
ItĀ isĀ alsoĀ presentĀ in theĀ groundĀ substance ofĀ con. tissue, esp.Ā mucousĀ CT, isĀ solubleĀ inĀ alkalineĀ water, & isĀ precipitatedĀ byĀ aceticĀ a;Ā mucins lubricate & protectĀ body cavityĀ linings
SS: symptoms and signs
WHO pn. is the leading c/of death in children worldwide;
kills an estimated 1.1 million U-5 children/y āĀ moreĀ than AIDS, malaria and TB combined
can be prevented by immunization, adequateĀ nutritionĀ and by addressingĀ environmental factors
c/by bacteria can be Rx with ABs, but 30% of children with it receive the ABs
Death from diarrhoeal D has been dramatically lowered by successful ORT
Under-five mortality: situation: 5.9 millionĀ died in 2015, 16000/d
Highest in Ā AfricaĀ (90/1000 lb), x7 higher than that in Europe (12/1000lb). ManyĀ countriesĀ still have v high mortality ā particularly those in Africa,Ā homeĀ to 11 of 12 countries with a rate &gt;100/1000lb. In 2013, the U-5MR in low-income countries was 76/1000lb ā x13 theĀ average rateĀ in high-income countries (6/1000lb). Reducing these inequities across countries and savingĀ moreĀ childrenās lives by ending preventable child deaths are important priorities
Pneumocystis jirovecii: a yeast-likeĀ fungus; causes PneumocystisĀ pneumonia, an imp. pathogen, particularly amongĀ immunocompromised; akaĀ P. carinii
HW: health worker
G+ve capsulated diplococcus. Some have a halo: capsule. The capsule gives a survival advantage
Pneumatoceles are thin-walled, air-filled cysts within lung; can be single emphysematous but are more often multiple. Most often seen in ac. Pn., commonly byĀ S aureus; also withĀ S pneumoniae,Ā Hib,Ā E coli,Ā GAS, Serratia marcescens, K pneumoniae,Ā adenovirus, TB; generally seen soon after pn. but can be observed initially. Noninf. causes: hydrocarbon ingestion, trauma, and PP ventilation. In preemies with RDS, pneumatoceles result mostly from ventilator-induced lung injury. Mostly they are asymptomatic and do not require surgery.Ā Rx of pneumonia with ABT is the first-line therapy. Close observation in the early stages and periodic FU care is usually adequate. The natural course is slow with no further clinical sequelae. Invasive approaches should only be reserved for patients who develop complications
1A: CXR: ill-defined R perihilar opacity obscuring R heart border & contains no air bronchograms. 1B: a corresponding triangular opacity with its base abutting the sternum and its apex directed toward hilum. Note anterior displacement of oblique fissure and elevation of R hemi-diaphragm.
Dx: : R Middle Lobe Atelectasis
ABT: usually ampi-genta, chloramphenicol
When the child is kept at home, teach the mother how to observe s/of breathlessness. Ask her to report to the HC immediately if there is deterioration
WHO classification and Rx of childhood pn. at health facilities
2 major changes: (A) now just 2 categories of pn. instead of 3 (āpn.ā which is treated at home with oral amoxicillin and āsevere pn.ā which requires Injectable AB and (B) oral amoxicillin replaces oral cotrimoxazole as DoC, preferably in 250mg dispersible tablet form, 2/d x5d which can be reduced to 3 in low HIV settings
For persistent cough (&gt;30d) full Ix are required to exclude TB, cong. HD, FB, atopy, etc.
Epiglottis: ceftriaxone is DoC. This is broad-spectrum against gram-negative, lower efficacy against gram-positive: 100mg/kg/d IV on first day; follow with 50 mg/kg on day 2 or 75 mg/kg qDay for 10-14 days
Croup is a commonĀ resp.Ā problem in young children. Common in the fall and winter. Main symptom is a harsh, barking cough. Causes edema in larynx, trachea, bronchi. This can make it hard for your child to breathe. It can be scary, but rarely serious; usually better in several days with rest and care at home
C/by the same viruses of common cold.
Laryngitis is one of the most common conditions in the larynx. It manifests in both acute and chronic forms.
Ac laryngitis is usually self-limited. If &gt;3w, it isĀ chronic. The etiology of AL: vocal misuse, exposure to noxious agents, URTI. Mostly viral but sometimes bacterial. Pix: larynx of a 62y F with an intermittent exudative AL treated conservatively. Rarely, laryngitis is autoimmune (RA,Ā relapsing polychondritis, Wegener granulomatosis, sarcoidosis). CL may be c/by cigarette smokeĀ or polluted air (chemicals), irritation fromĀ asthmaĀ inhalers, vocal misuse, or
GERD. Vocal misuse: increased adducting force of the vocal folds: increased contact and friction between folds. The area becomes swollen.Ā Vocal therapyĀ has the greatest benefit in the patient with CL
Although AL is usually not a result of vocal abuse, vocal abuse is often a result of AL. The underlying inf/inflam results in a hoarse voice. Typically, the pt exacerbates dysphonia by misuse of the voice in an attempt to maintain premorbid phonating ability
WHO
Zinc is imp for cellular growth, cellular differentiation and metabolism. Deficiency limits growth and decreases immunity. Although severe deficiency is rare, mild to moderate may be common worldwide. Zinc may reduce frequency and severity of ARI. Zinc deficient children are at increased risk of restricted growth and developing D, ARI. D and pn. are the 2 most common c/of U-5MR in LICs. Undernutrition is considered the underlying c/of 50% of pn.. Pn alone kills more than AIDS, malaria or measles combined. Zn may reduce the number of episodes and severity of bronchiolitis and pn. Zinc and ORS is the basis of management of D.