This document discusses 16 different types of skin cancers that can occur in the oral cavity, including squamous cell carcinoma, basal cell carcinoma, and various forms of melanoma. Many of these skin cancers are rare in the oral cavity. The document provides details on clinical presentation, risk factors, location preference within the mouth, metastatic potential, and histopathological characteristics for each cancer type.

1.  Application of skin cancer in the oral cavity:
– Skin cancer such as BCC, SCC & melanoma can appear also in
the oral cavity
– Examples:i
1- Oral squamous cell carcinoma:ii
2- Spindle cell carcinoma:iii
 It is a variant of SCC
 Most commonly appear on the
lateral surface of the tongue, on
the alveolar mucosa & lower lip
 It metastasizes early & rapidly
grow
 The patient present with pain &
paresthesia
 It is one of the most common oral cancer
 The most important risk factors are alcohol
and smoking
 SCC of the tongue may also result from
chronic irritation
presented by: Toleen Mazloum

2. 3- Verrucous cell carcinoma:iv
4- Basaloid Squamous Cell Carcinomav,vi
5-Papillary SCC:vii
 It is a low-grade variant of SCC
 Associated mainly with chronic smokeless
tobacco use (chewing tobacco, snuff
dipping)
 Most commonly appear in the mandibular
vestibule, buccal mucosa & gingiva
(corresponding to the site of tobacco
placement)
 Locally destructive
 Rarely metastasize
 It is a rare, high grade variant of SCC
 Most commonly associated with the
base of the tongue, hypopharynx &
supra glottis larynx
 Most patient present with higher stage
with nodal metastases
 rarely occurring variant of SCC
 Within the oral cavity cases have been
reported on the alveolar ridge, oral
mucosa, floor of the mouth, ventral
tongue, and rarely other areas

3. 6-Adenosquamous carcinomaviii,ix
7-Acantholytic SCC:x
8- Carcinoma cuniculatiumxi
 It is a rare variant of SCC
 The oral cavity is the second most
common location after the larynx
 It is an aggressive tumor with frequent
local and loco-regional metastasis
 It is an uncommon but
well-recognized variant of SCC
 ASCC is commonly seen in the sun
exposed areas of adults
 Oral ASCC is extremely rare
 It is a rare, slow-growing variant of
SCC
 It affects mainly the sole of the
foot, but it can occur in the oral
cavity & genitals

4. 9-Basal cell carcinoma:xii
10-desmoplastic melanoma:xiii
11- amelanotic melanoma:xiv,xv
 It is an extremely rare condition of the oral
cavity
 Most of the well documented cases arise
from the gingiva
 It has the potential for local recurrence and
aggressive behavior
 It is a variant of melanoma
 Desmoplastic melanoma of the oral cavity is
an extremely rare condition
 Composed of superficial melanotic lesion
that often lacks pigmentation & a more
prominent dermal fibrous spindle-shaped
cell tumor
 It is a rare variant of melanoma (0.2% -
0.8% of all melanomas)
 characterized by the absence of melanin
pigment

5. 12-Malignant melanoma:xvi,xvii
13-Keratoacanthoma:xviii,xix
14-Epidermoid cyst:xx
 extremely rare lesions
 occur commonly in the maxillary gingiva
(more frequently on the palate)
 fewer incidences in the mandibular
gingiva
 they are clinically asymptomatic in the
early stages
 present as a hyperpigmented patch on
the gingival surface
 is an extremely rare, benign,
and self-limiting condition
 clinical and histopathological
characteristics similar to
squamous cell carcinoma
 benign subcutaneous
lesions
 They usually appear as a
solitary swelling yellowish
mass with a slow growth
rate not associated with
pain or trauma

6. 15- Melanocytic nevi:xxi,xxii
16- Blue nevus:xxiii,xxiv
17- Neurofibroma:xxv,xxvi
 Oral melanocytic nevi are
localized developmental
tissue malformations of
nevus cells in the oral mucosa
 Rare benign lesions
 typically found on the skin,
and they are uncommon in
the oral mucosa
 Asymptomatic benign
melanocytic lesion
 second most common type
of nevus of the oral cavity
 benign peripheral nerve sheath
tumor
 Neurofibromas of the oral cavity
are presented as a submucosal,
non-tender, discrete mass
 Most commonly affect the
tongue, buccal mucosa,&
vestibular area
 posterior mandible is the most
common intraosseous location

7. i
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ii
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iii
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iv
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v
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vi
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vii
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viii
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x
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xi
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xii
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xiii
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xv
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xvi
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8. xvii
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xviii
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xix
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xx
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xxi
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xxii
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https://emedicine.medscape.com/article/1079193-overview