Presentation realised for an organised session on Application and challenges to the use of mixed methods in health systems research, held at HSR 2016, the Fourth Global Symposium on Health Systems Research, Vancouver, 14-18 november 2016. Authors: Valéry Ridde, Manuela De Allegri, Quan Nha Hong, Anne-Marie Turcotte-Tremblay, Nicolas Ortiz Ruis