Anti-viral drugs can be classified into categories based on the virus they target. This includes anti-herpes drugs like acyclovir and ganciclovir, anti-influenza drugs, and anti-hepatitis drugs that are effective against hepatitis B and C viruses. Drugs for hepatitis B include lamivudine, entecavir, and tenofovir which suppress viral replication and prevent disease progression. Interferons and ribavirin are used against hepatitis C by inhibiting viral RNA synthesis. Newer direct-acting antivirals like sofosbuvir and simeprevir target non-structural viral proteins essential for replication. Remdesivir, baricitinib,
Antiviral drugs are a class of medications used to treat viral infections by inhibiting the replication or growth of viruses in the body. These drugs work by targeting specific components of a virus, such as the viral enzymes, proteins, or nucleic acids, and disrupting their ability to infect or replicate inside host cells. This can help reduce the severity of symptoms, prevent complications, and speed up recovery.
There are many types of antiviral drugs available, including:
1. Nucleoside or nucleotide analogues: These drugs mimic the structure of the nucleosides or nucleotides needed for viral replication, thereby interfering with virus replication.
2. Protease inhibitors: These drugs block the activity of viral proteases, which are enzymes that are required for the replication and assembly of some viruses.
3. Interferons: These drugs are naturally occurring proteins that help the immune system fight viral infections by boosting the body's antiviral response.
4. Neuraminidase inhibitors: These drugs block the activity of viral neuraminidase, an enzyme that is required for the release of virus particles from infected cells.
5. Fusion inhibitors: These drugs block the fusion of viral and host cell membranes, which is an essential step in viral entry and replication.
Antiviral drugs can be used to treat a variety of viral infections, including influenza, HIV/AIDS, hepatitis B and C, herpes, and Ebola. However, the effectiveness of these drugs can vary depending on the specific virus and the stage of infection. Antiviral drugs may also have side effects, and it is important to consult with a healthcare provider before taking them.
Antiviral drugs are a class of medications used to treat viral infections by inhibiting the replication or growth of viruses in the body. These drugs work by targeting specific components of a virus, such as the viral enzymes, proteins, or nucleic acids, and disrupting their ability to infect or replicate inside host cells. This can help reduce the severity of symptoms, prevent complications, and speed up recovery.
There are many types of antiviral drugs available, including:
1. Nucleoside or nucleotide analogues: These drugs mimic the structure of the nucleosides or nucleotides needed for viral replication, thereby interfering with virus replication.
2. Protease inhibitors: These drugs block the activity of viral proteases, which are enzymes that are required for the replication and assembly of some viruses.
3. Interferons: These drugs are naturally occurring proteins that help the immune system fight viral infections by boosting the body's antiviral response.
4. Neuraminidase inhibitors: These drugs block the activity of viral neuraminidase, an enzyme that is required for the release of virus particles from infected cells.
5. Fusion inhibitors: These drugs block the fusion of viral and host cell membranes, which is an essential step in viral entry and replication.
Antiviral drugs can be used to treat a variety of viral infections, including influenza, HIV/AIDS, hepatitis B and C, herpes, and Ebola. However, the effectiveness of these drugs can vary depending on the specific virus and the stage of infection. Antiviral drugs may also have side effects, and it is important to consult with a healthcare provider before taking them.
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
Types of HIV Virus Anti-HIV drugs, classification, mechanism of action, pharmacological action, pharmacokinetics, adverse drug reactions, drug interactions, contraindications and therapeutic uses
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
Types of HIV Virus Anti-HIV drugs, classification, mechanism of action, pharmacological action, pharmacokinetics, adverse drug reactions, drug interactions, contraindications and therapeutic uses
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
6. DRUGS FOR HEPATITIS
Are drugs which are effective against
Hepatitis B Virus(HBV)-DNA virus
Hepatitus C Virus (HCV)-RNA virus
7. DRUGS FOR HEPATITIS B
Hepatitis B Virus is a DNA virus
It integrates into chromosomal DNA
Causes permanent infection
It is unable to eradicate the viral antigen from the body
GOAL OF TREATMENT
Suppress viral replication.
To reduce its inflammatory & hepatocyte damaging process.
Prevent progression of hepatic disease & complications like cirrhosis and
hepatic carcinoma
8. DRUGS FOR HEPATITIS B
LAMIVUDINE
ENTECAVIR
ADEFOVIR DIPIVOXIL
TENOFOVIR
TELBIVUDINE
INTERFERON
Not to be stopped suddenly as it can result in acute exacerbation of
hepatitis
To be continued till 6 months after seroconversion to minimize
reactivation
9.
10. LAMIVUDINE
A cytosine analogue
Effective for both HIV & Hep B
Mechanism OF ACTION
Inhibit HBV DNA Polymerase
Also get incorporated in the viral DNA and causes chain
termination
Inhibit HIV reverse transcriptase
13. TENOFOVIR
Mechanism of Action
Nucleotide analogue
Tenofovir undergoes diphosphorylation by cellular kinase
Tenofovir diphosphate inhibits HBV DNA polymerase
It also gets incorporated in the viral DNA to cause chain termination
Inhibits HIV Reverse Transcriptase enzyme
15. ENTECAVIR
Guanosine nucleoside analogue
Currently the first line drug for treatment of Chronic Hepatitis B
MOA :
Inhibits HBV DNA polymerase
Need to be taken in empty stomach ,food decreases oral
bioavailability
Long acting,half life is 128-148 hrs
Well tolerated,mild dyspepsia,disturbed sleep
Lactic acidosis in decompensated cirrhosis
16. Adefovir Dipivoxil
Prodrug of Adefovir
Adefovir adenosine analogue
MOA:Competitive inhibition of HBV DNA Polymerase
USES:Chronic Hepatitis B
Effective in Lamivudine resistant cases
Effective in patients with concomitant HIV infection
ADR:Nephrotoxicity
Flu syndrome,Sore throat
17. TELBIVUDINE
Newer anti-HBV drug
Thymidine analogue
MOA:Inhibits HBV DNA polymerase
Adavantages
Long acting
Orally effective
Faster & more complete suppression of HBV DNA titre
Disadvantages
Resistance
ADR: Well tolerated
Serum amylase may rise
19. INTERFERONS (IFN)
Interferons are cytokines produced by host cells in response to viral
infections
Three types of Interferons : IFN α, β, γ
Antiviral action IFN α
Only IFN α2A & INF α2B are produced by recombinant technology &
are used clinically
20. Interferons bind to receptors(JAK-STAT tyrosine
kinase receptors)
Induces expression of interferon induced
proteins
Inhibit viral replication at multiple steps
:penetration, synthesis of viral mRNA and
viral proteins, release of progeny virus
INTERFERONS-MECHANISM OF ACTION
21. Interferon Alfa
No oral BA- polypeptide
s/c or im
Pegylated Interferons:
Obtined by attachment of IFN to polyethylene glycol (PEG)
molecules – pegylation
Increase duration of action
Enable once-weekly dosing
Enhanced clinical effiacy
22. Interferon α - USES
1.Chronic Hepatitis B
2.Chronic Hepatitis C
3.AIDS related Kaposi sarcoma
4.Condyloma Acuminata:caused by papilloma virus
Treated with topical podophyllin
Intralesional interferon in resistant cases
5.Herpes infection:IFN my be added to acyclovir in
immunocompromised patients
6.Hematological Malignancy:CML,Follicular lymphoma,Cutaneous T cell
Lymphoma,Multiple Myeloma
24. RIBAVIRIN
A broad spectrum antiviral drug
Spectrum: HCV, Influenza A & B
Respiratory syncytial virus
MOA :Inhibits GTP synthesis& viral RNA synthesis
Long t1/2>10days,accumulates in body on daily dosing
25. RIBAVIRIN
USE: Chronic Hepatitis C , Influenza, Measles,
RSV-nebulised Ribavirin
NIPAH VIRUS
ADR: Dose dependent Hemolytic anemia,
Bone marrow supression
Cough,Dyspnoea,bronchospasm on nebulization
Teratogenicity
26. NEWER DRUGS FOR HEPATITIS C
NOVEL DIRECTLY ACTING AGENTS
They target NONSTRUCTURAL VIRAL PROTEINSreplication
Used in combination:Development of resistance
Advantages
-Better viral response
-Shorter duration of treatment
-Less toxic
-Delayed onset of resistance
Disadvantages
-More drug interactions
29. NS5B Polymerase Inhibitor:SOFOSBUVIR
It is a uridine analogue
Prodrug
Inhibits NS5B (HCV RNA polymerase )
PHARMACOKINETICS
Oral bioavailability is 80%improved with fatty meal
It is a substrate of Pgp efflux transporter should not be used with Pgp
inducers like Phenytoin, Rifampicin
ADR: Fatigue,pain abdomen,joint pain,anemia
Sever bradycardia if used with Amiodarone
30. NS3/4A PROTEASE Inhibitor:SIMEPRAVIR
Mechanism of Action
NS3/4A protein helps to form functional viral polypepetides
InhiBItion of this protein blocks viral replication
Pharmacokinetics
Orally effectiveabsorption increases when taken with meals
Metabolised by CYP3A4
Substrate for Pgp
USES:Chronic Hepatitis C
Given as Simepravir –Sofosbuvir combination for 12-24weeks
ADR:Photosensitivity,Rashes,dyspnea
DRUG INTERACTIONS
31. NS5A INHIBITORS
NS5A is a multifunctional protein essential for viral replication
I.DACLATASVIR
II.LEDIPASVIR
III.VALPATASVIR
Features
Used as combination therapy with SOFOSBUVIR
Metabolisd by CYP
Substrates of Pgp DRUG INTERACTIONS
Needs gastric acidity for
absorption