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ANTIDEPRESSANTS AND
THEIR ONSET OF ACTION
Iman Jabar Bahar Majid Poshkin Bestoon
7/15/2017
1
CONTENTS
• Depression definition and its cause .
• Introduce noradrenergic and serotonergic systems in
normal condition comparing that of depression.
• Antideppresants ,their actions and their classes .
• Side effects of antidepressants .
7/15/2017
2
WHAT IS DEPRESSION ?
• Depression is a mood disorder that causes a persistent
feeling of sadness,loss of interest as well as inability to
experience pleasure in usual activities ,loss of
energy,changes in sleep patterns and suicidal
thoughts.
7/15/2017 3
THE AMINE HYPOTHESIS OF MOOD
” the amine hypothesis of mood postulates that brain
amines ,particularly norepinephrine(NE) and serotonin(5-
HT),are neurotransmitters in pathways that function in
the expression of mood.According to the hypothesis, a
functional decrease in the activity of such amines is
thought to result in depression “
7/15/2017 4
Nor-Adrenergic and Serotonergic Systems
7/15/2017
5
Why Antidepressants Take so Long to Work?
MARK RASENICK, DISTINGUISHED PROFESSOR OF PHYSIOLOGY AND
BIOPHYSICS AND PSYCHIATRY ON UNIVERSITY OF UIC.
 “It’s likely that this effect on the movement
of G proteins out of the lipid rafts towards
regions of the cell membrane where they are
better able to function is the reason these
antidepressants take so long to work.”
“Determining the exact binding site could
contribute to the design of novel
antidepressants that speed the migration of
G proteins out of the lipid rafts, so that the
antidepressant effects might start to be felt
sooner. “
July 28,2016
7/15/2017
6
Antidepressants and their Classes 7/15/2017 7
7/15/2017
8
7/15/2017
9
7/15/2017
10
7/15/2017
11
SIDE EFFECTS OF ANTIDEPPRESANTS
• Nausea
• Drowsiness
• Weight gain
• Constipation
• Dry mouth
• Sedation
• Insomnia
• Sexual Dysfunction
7/15/2017
12
REFERENCE
• Whalen, K., Finkel, R., & Panavelil, T. A. (2015). Lippincott's illustrated reviews:
Pharmacology (6th ed., pp. 135,137,139,140). Philadelphia, PA: Wolters Kluwer.
• Trevor. (2015). Katzung & Trevor's Pharmacology: Examination & Board Review,
11e (11th ed., pp. 244,245,246). McGraw-Hill.
• Parmet, S. (2016, July 28). Why do antidepressants take so long to work? | UIC News
Center. Retrieved from https://news.uic.edu/why-do-antidepressants-take-so-long-
to-work
• Speed Pharmacology. (n.d.). Pharmacology - ANTIDEPRESSANTS - SSRIs, SNRIs,
TCAs, MAOIs, Lithium ( MADE EASY) [Video file]. Retrieved from
https://youtu.be/T25jvLC6X0w
7/15/2017
13
7/15/2017
14

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AntiDepressants & their onset of action

  • 1. ANTIDEPRESSANTS AND THEIR ONSET OF ACTION Iman Jabar Bahar Majid Poshkin Bestoon 7/15/2017 1
  • 2. CONTENTS • Depression definition and its cause . • Introduce noradrenergic and serotonergic systems in normal condition comparing that of depression. • Antideppresants ,their actions and their classes . • Side effects of antidepressants . 7/15/2017 2
  • 3. WHAT IS DEPRESSION ? • Depression is a mood disorder that causes a persistent feeling of sadness,loss of interest as well as inability to experience pleasure in usual activities ,loss of energy,changes in sleep patterns and suicidal thoughts. 7/15/2017 3
  • 4. THE AMINE HYPOTHESIS OF MOOD ” the amine hypothesis of mood postulates that brain amines ,particularly norepinephrine(NE) and serotonin(5- HT),are neurotransmitters in pathways that function in the expression of mood.According to the hypothesis, a functional decrease in the activity of such amines is thought to result in depression “ 7/15/2017 4
  • 5. Nor-Adrenergic and Serotonergic Systems 7/15/2017 5
  • 6. Why Antidepressants Take so Long to Work? MARK RASENICK, DISTINGUISHED PROFESSOR OF PHYSIOLOGY AND BIOPHYSICS AND PSYCHIATRY ON UNIVERSITY OF UIC.  “It’s likely that this effect on the movement of G proteins out of the lipid rafts towards regions of the cell membrane where they are better able to function is the reason these antidepressants take so long to work.” “Determining the exact binding site could contribute to the design of novel antidepressants that speed the migration of G proteins out of the lipid rafts, so that the antidepressant effects might start to be felt sooner. “ July 28,2016 7/15/2017 6
  • 7. Antidepressants and their Classes 7/15/2017 7
  • 12. SIDE EFFECTS OF ANTIDEPPRESANTS • Nausea • Drowsiness • Weight gain • Constipation • Dry mouth • Sedation • Insomnia • Sexual Dysfunction 7/15/2017 12
  • 13. REFERENCE • Whalen, K., Finkel, R., & Panavelil, T. A. (2015). Lippincott's illustrated reviews: Pharmacology (6th ed., pp. 135,137,139,140). Philadelphia, PA: Wolters Kluwer. • Trevor. (2015). Katzung & Trevor's Pharmacology: Examination & Board Review, 11e (11th ed., pp. 244,245,246). McGraw-Hill. • Parmet, S. (2016, July 28). Why do antidepressants take so long to work? | UIC News Center. Retrieved from https://news.uic.edu/why-do-antidepressants-take-so-long- to-work • Speed Pharmacology. (n.d.). Pharmacology - ANTIDEPRESSANTS - SSRIs, SNRIs, TCAs, MAOIs, Lithium ( MADE EASY) [Video file]. Retrieved from https://youtu.be/T25jvLC6X0w 7/15/2017 13