This document provides an overview and guidelines for Automatic Neighbor Relation (ANR) management in 3G and LTE networks. It describes ANR principles, parameters, feature dependencies, impact on network performance and capacity, as well as engineering guidelines for deploying intra-RAT ANR, inter-RAT ANR, ANR with shared cells, and X2 self-setup. The document contains 18 sections covering topics such as ANR concepts, architecture, event-triggered and fast ANR, manual neighbor relation management, and network monitoring and optimization procedures. It is intended to help network operators understand and implement ANR functionality.