The document discusses the key goals and benefits of anesthesia, with a focus on the volatile anesthetic SevoFlo (sevoflurane). The primary goals of anesthesia are to induce unconsciousness, analgesia, and muscle relaxation while minimizing negative effects like respiratory depression. SevoFlo provides rapid induction and recovery from anesthesia, with more precise control over depth compared to other volatile anesthetics. However, sevoflurane is a respiratory depressant and its use requires close monitoring of respiration and oxygen support when needed.

1. 1 Key Concepts of Anesthesia and Overview of the Benefits of SevoFlo® (sevoflurane) SEVO-262 January 2010 ©2010 Abbott Laboratories

2. 2 How Anesthesia Works SEVO-262 January 2010 ©2010 Abbott Laboratories

3. 3 Positive Effects of Anesthesia SEVO-262 January 2010 ©2010 Abbott Laboratories

4. 4 Primary Goals of Anesthesia Achieve Positive Effects Unconsciousness Analgesia Muscle relaxation While Minimizing Negatives Effects Cardiac depression Respiratory depression Decreased homeostasis SEVO-262 January 2010 ©2010 Abbott Laboratories

5. 5 Primary Goals of Anesthesia These are outcomes if the patient is maintained to the physiological norm: Facilitate better manipulation of patient SEVO-262 January 2010 ©2010 Abbott Laboratories

6. 6 Primary Goals of Anesthesia These are outcomes if the patient is maintained to the physiological norm: Facilitate better manipulation of patient Minimize post-surgical mortality and morbidity SEVO-262 January 2010 ©2010 Abbott Laboratories

7. 7 Primary Goals of Anesthesia These are outcomes if the patient is maintained to the physiological norm: Facilitate better manipulation of patient Minimize post-surgical mortality and morbidity Sustain immune function and improve speed and quality of healing SEVO-262 January 2010 ©2010 Abbott Laboratories

8. 8 Primary Goals of Anesthesia These are outcomes if the patient is maintained to the physiological norm: Facilitate better manipulation of patient Minimize post-surgical mortality and morbidity Sustain immune function and improve speed and quality of healing Maximize tissue perfusion SEVO-262 January 2010 ©2010 Abbott Laboratories

9. 9 Are You Hearing the Whole Story? SEVO-262 January 2010 ©2010 Abbott Laboratories

10. 10 Important SevoFlo® (sevoflurane) Risk Information How Supplied: SevoFlo (sevoflurane) is packaged in amber colored bottles containing 250 mL sevoflurane. Indications: SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. SEVO-262 January 2010 ©2010 Abbott Laboratories

11. 11 Important SevoFlo® (sevoflurane) Risk Information Warnings, Precautions, and Contraindications: Sevoflurane is a profound respiratory depressant. Respiration must be monitored closely in the dog and supported when necessary with supplemental oxygen and/or assisted ventilation. SEVO-262 January 2010 ©2010 Abbott Laboratories

12. 12 Important SevoFlo® (sevoflurane) Risk Information Warnings, Precautions, and Contraindications: Due to sevoflurane’s low solubility in blood, increasing the concentration may result in rapid hemodynamic changes compared to other volatile anesthetics. SevoFlo is contraindicated in dogs with a known sensitivity to sevoflurane or other halogenated agents. SEVO-262 January 2010 ©2010 Abbott Laboratories

13. 13 Important SevoFlo®(sevoflurane) Risk Information Adverse Reactions: The most frequently reported adverse reactions during maintenance anesthesia were hypotension, followed by tachypnea, muscle tenseness, excitation, apnea, muscle fasciculations and emesis. See package insert for full prescribing information. Package insert available at AbbottAnimalHealth.com. SEVO-262 January 2010 ©2010 Abbott Laboratories

14. 14 SevoFlo® (sevoflurane) Features & Benefits SevoFlo has been shown to be less of a respiratory depressant than isoflurane at the same anesthetic depth1 1 - DS Galloway et al “Anesthetic indices of sevoflurane and isoflurane in unpremedicated dogs” JAVMA 2004; 225: 700-704 See Important SevoFlo Risk Information on prior slides. SEVO-262 January 2010 ©2010 Abbott Laboratories

15. 15 SevoFlo® Features & Benefits SevoFlo’s low blood:gas solubility and greater range of vaporizer settings gives you rapid, precise control over the depth of anesthesia throughout the procedure See Important SevoFlo Risk Information on prior slides. SEVO-262 January 2010 ©2010 Abbott Laboratories

17. 17 SevoFlo® Features & Benefits SevoFlo has been approved for veterinary use for over 10 years, and is backed by expert support from Abbott Animal Health See Important SevoFlo Risk Information on prior slides. SEVO-262 January 2010 ©2010 Abbott Laboratories

18. 18 SevoFlo® Features & Benefits Only SevoFlo — available through all major U.S. distributors — provides four unique benefits: A minimum of 300 ppm water 2. Shatter-resistant PEN bottles Local Abbott representatives and expert advice Commitment to training and education SEVO-262 January 2010 ©2010 Abbott Laboratories

19. 19 To learn more about Abbott Animal Health, our dedication to animal health excellence and our quality products, contact your local Abbott sales representative or Customer Service at 888-299-7416 or visit www.AbbottAnimalHealth.com SEVO-262 January 2010 ©2010 Abbott Laboratories