Sevoflurane is a fast-acting volatile anesthetic agent that provides hemodynamic stability, rapid recovery, and airway tolerability. It is well-suited for all types of surgical procedures, including cardiovascular, neurological, ambulatory, and those involving obese patients. Sevoflurane has advantages over desflurane, isoflurane, and nitrous oxide in terms of hemodynamic stability, lack of airway irritation, rapid induction and emergence from anesthesia, and lack of genotoxic effects. Abbott's Quik-Fil delivery system for sevoflurane is designed for ease of use and minimal waste.
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1. Features
Reasons to Believe
Brand Positioning
Hemodynamic Stability RapidRecovery
AirwayTolerability
Procedures
DES+ve
SEVO +ve
ISO +ve
SEVOrane® Message Map
Titratability
2. SEVOrane is the original fast acting, cost-effective
anesthetic agent offering the clinical versatility and
predictability needed through speed, control and cardio-
protective effects ideally suited for all general
anesthetic procedures.
®
Brand Positioning
Back
3. “Sevoflurane: The best volatile anesthetic ever developed” Dr.LarsonUCLA /Stanford
University LINK83
A passion for anesthesia and a
commitment to excellence leading to 18
years of trust between Abbott and the
worldwide anesthesia community
The #1 worldwide inhalational anesthetic,
the gold standard for all procedure types
SEVOrane represents the
cornerstone of today’s anesthesia
around the world
(Continued)
Reasons toBelieve
5. HemodynamicStability
SEVOrane offers ideal cardiovascular stability and has demonstrated
exemplary cardio protective effects LINK 1
SEVOrane had a stable cardiovascular profile, particularly in aged
patients LINK 4
When managing elderly patients, SEVOrane provided a more stable
cardiovascular homeostasis compared to isoflurane LINK 4
Hypotension was observed in 16 patients receiving isoflurane and in 5
patients receiving SEVOrane (p<0.02) LINK 4
Back
6. Airway Tolerability
SEVOrane has a pleasant, non-irritating aroma, which allows for
inhalational induction in adults and children with minimum
excitement or signs of upper respiratory irritation LINK 1
SEVOrane is fast acting non irritating agent, and is associated with
a smooth, rapid loss of consciousness during inhalational
induction LINK 1
SEVOrane is an excellent option for use in patients breathing
through an LMA LINK 1
Back
7. Airway Tolerability
SEVOrane was associated with a lower incidence of coughing and
signs of airway irritation than isoflurane and desflurane. LINK 2
At 2 MAC concentration, SEVOrane is significantly less irritating
on the airways than isoflurane and desflurane. LINK 2
Smokers inhaling isoflurane had a 45% incidence of adverse
airway events compared to 10% in those inhaling SEVOrane.
LINK 3
Back
8. Rapid Recovery
Back
SEVOrane facilitates fast track eligibility LINK 104
SEVOrane allowed for a significantly faster emergence from anaesthesia
than isoflurane LINK 4
9. Titratability to Response
Blood:Gas: Determines the speed at which an agent will saturate the blood stream. The lower the number, the
faster the agent will be washed-in and eliminated.
Brain:Blood: Determines the speed at which the agent will enter and leave the cerebral tissues, important
for neuro-anesthesia post surgical assessment. The lower the number the faster the agent. Compare
with Isoflurane and Desflurane. SEVOrane is closest to N20
Agent
Blood:Gas Partition
Coefficient
Brain:Blood
Partition
Coefficient
Halothane 2.4 2.9
Enflurane 1.9 1.4
Isoflurane 1.42 2.6
Desflurane 0.42 1.3
Nitrous Oxide 0.47 1.1
SEVOrane 0.63 - 0.69 1.15
Key Coefficients of Volatile Agents *
Continue
10. Versatility & Predictability
The features of SEVOrane:
Hemodynamic stability
Airway tolerability
Rapid recovery
Titratability
All translate into the ideal inhalational anesthetic for all
procedures and patient types: pediatrics, adults and
elderly
That’s the SEVOrane Versatility and
Predictability !
Back
12. Cardiovascular Procedures v Desflurane
Anesthesiologist’s Goal: Stability & Speed
Hemodynamic Stability
• Sevoflurane maintains mean arterial pressure better than desflurane. LINK 98
• Sevoflurane shows a lower incidence of postoperative atrial fibrillation than propofol,
desflurane and midazolam. LINK 13
• Desflurane appears to cause a greater systemic and intrapulmonary pro-inflammatory
response than sevoflurane. LINK 60
Back
13. Neurologic Procedures vDesflurane
Anesthesiologist’s Goal: Speed & Stability
Stability
• Patients receiving desflurane demonstrated greater cerebral artery blood flow velocities,
heart rates and blood pressures than those receiving sevoflurane. LINK 74
• Desflurane causes more cerebral vasodilatation at hypocapnia therefore less suitable
for neuro Anesthesia (study done with Pigs) LINK 109
Back
14. Ambulatory Procedures v Desflurane
Anesthesiologist’s Goal: Rapid Recovery & Airway Tolerability
Rapid Recovery & Smooth Emergence
• Wake up times were faster with Desflurane but the hospital discharge times were faster with
sevoflurane. LINK 108
Airway Tolerability
• Desflurane enhances reactivity during the use of the LMA. LINK 22
• Sevoflurane is a better bronchodilator than desflurane. LINK 23
• Sevoflurane is non-pungent and produces minimal airway irritations. LINK 27
• Initiation of desflurane anesthesia resulted in significant changes which resulted in
hypertension, tachycardia, facial flushing, tearing and moderate upper airway obstruction.
This study observes response to desflurane, it uses no sevoflurane. LINK 110
Back
15. 15
Obesity Articles
Vs. Desflurane
• No clinically relevant difference was found in recovery in the PACU between
morbidly obese patients anesthetized with desflurane or sevoflurane. LINK 35
• No difference in emergence and recovery profile in morbidly obese patients
receiving desflurane or sevoflurane. LINK 36
• Commentary: Obesity, Surgery, and Inhalational Anesthetics: Is there a Drug
of Choice? LINK 81
Back
16. Toxicity
Vs. Desflurane
• Desflurane produces a systemic and local oxidative stress. LINK 59
• Desflurane may be capable of producing genetic damage. LINK 56
Sevoflurane
• Short- term administration of sevoflurane did not induce sister
Chromatic exchanges. No indication for a possible genotoxic effect
has been observed. LINK 61
Back
17. Compound A Clinical Studies
Low flow Sevoflurane/Low flow Isoflurane:
• No statistically significant differences in measured parameters of renal
function after low flow sevoflurane anesthesia compared with
isoflurane. LINK 105
Low flow Sevoflurane:
• No evidence for nefrotoxicity was observed with sevoflurane. LINK 106
Low flow Sevoflurane:
• Prolonged low flow sevoflurane anesthesia had the same effect as high
flow sevoflurane and low flow isoflurane anesthesia. LINK 107 Back
18. ORPollution - Articles
Desflurane:
• Even if the trace concentrations of anesthetic agents were low in the
present investigation the NIOSH limit for desflurane could not be
ensured. LINK 68
Desflurane & Isoflurane:
• Routine use of scavenging devices during cardiopulmonary bypass is
recommended. LINK 69
Swedish OR Pollution guidelines:
• The guidelines are for your information. LINK 111 Back
19. Sevoflurane vs.Desflurane
Back
• Has a pleasant odour that does not irritate the airways
• SEVOrane does not increase heart rate at < 2MAC
• SEVOrane causes less air way irritability
• SEVOrane is indicated for mask induction
• SEVOrane is linked to a low incidence of PONV
• SEVOrane is an ideal bronchodilator
• Can be safely used in neurosurgery and coronary artery surgery
• Can be safely used in patients at risk for myocardial ischemia
• Can be used with standard vaporizer technology, desflurane requires and
expensive heated vaporizer
21. Cardiovascular Procedures v.Isoflurane
Anesthesiologist’s Goal: Stability & Speed
Hemodynamic Stability
• Sudden increases in Isoflurane concentrations led to larger hemodynamic changes
and sympathetic nerve activity than with sevoflurane. LINK 15
• Sevoflurane bolus is more effective during maintenance than remifentanil bolus for
control of hemodynamic responses. LINK 17
• Preconditioning with sevoflurane decreases PECAM-1 expression and improves 1 year
cardiovascular outcome in CABG surgery. LINK 19
Back
22. Neurologic Procedures vIsoflurane
Anesthesiologist’s Goal: Stability & Speed
Stability
• Autoregulation is better preserved with sevoflurane compared to isoflurane. LINK 78
• Autoregulation was better preserved during sevoflurane than isoflurane anesthesia at 1.5 MAC
concentration. LINK 79
• Sevoflurane has less intrinsic dose-dependent cerebral vasodilatory effect than isoflurane.
LINK 49
• Sevoflurane demonstrates less total cerebral vasodilatory effects than isoflurane at the same
depth of anesthesia. LINK 53
• Sevo shows sustained inhibition of neuronal damage. LINK 66
• Sevoflurane decreased middle cerebral artery flow velocity. LINK 73
• Editorial warning of the potential limitations of isoflurane neuroprotection. LINK 80
Rapid Recovery
• Sevoflurane provides faster recovery and postoperative Neurologic assessment than
Isoflurane. LINK 48
Back
23. Ambulatory Procedures v Isoflurane
Anesthesiologist’s Goal: Rapid Recovery & Airway Tolerability
Rapid Recovery & Smooth Emergence
• Sevoflurane anesthesia recovery time is faster. LINK 39
• Sevoflurane allows for faster discharge than Isoflurane. LINK 21
• Sevoflurane allows for smoother clinical course with more rapid recovery. LINK 42
• Sevoflurane provides significantly faster emergence than Isoflurane. LINK 85
• Significantly faster emergence, orientation, response to commands compared with Isoflurane.
LINK 85
Airway Tolerability
• Smokers inhaling isoflurane had a 45% incidence of adverse airway event vs. 10% in the
sevoflurane group. LINK 21
Back
24. ORPollution - Articles
Desflurane & Isoflurane:
• Routine use of scavenging devices during cardiopulmonary bypass is
recommended. LINK 69
Swedish OR Pollution guidelines:
• The guidelines are for your information. LINK 111
- Please consult your local regulatory department before using these clinical reprints -
Continue
25. Sevoflurane vs.Isoflurane
Back
• Has a pleasant odour that does not irritate the airways
• Is effective for induction, without the need for intravenous induction agents
• Produces a rapid and smooth loss of consciousness
• Maintains heart rate more effectively with less tachycardia
• Appears to have less of a depressant effect on blood pressure
• Provides shorter times to emergence, command response, and orientation
• Two times less soluble
• Rapid induction, emergence and recovery
• Rapid adjustment of anesthetic depth
29. ABBOTT SEVOrane
Back
Quik Fil System
Ready-to-use delivery
system that does not
require the mounting of a
separate adaptor by OR
staff. Designed to
minimize the release of
anesthetic into the room
air and the risk of leakage
and spillage
Water content > 300ppm
Protects against Lewis acid
degradation and provides a
stable formulation
Polyethylene Naphthalate
(PEN) bottle
Shatter resistant, lightweight,
transparent, easily recyclable,
cost effective disposal, no
risk of Lewis Acid formation
from the bottle
New Tamper Evident Shrink
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