This document discusses andropause and sarcopenia, which are age-related declines in testosterone and muscle mass. It provides evidence that testosterone levels and muscle mass begin declining in the late 30s and accelerate after age 70. Intrinsic and extrinsic factors like lower hormone levels and muscle protein breakdown contribute to sarcopenia. The document recommends addressing these issues with a balanced diet, exercise, stress reduction, sleep, and potentially testosterone therapy. It summarizes several studies showing that natural supplements like tongkat ali can safely and effectively increase testosterone levels and muscle mass. The document promotes Andraiz T, a supplement containing these ingredients, to help treat andropause and sarcopenia symptoms.

1. Andropause & Sarcopenia
Stay Young … Strong and Lively
By Prabhakar Shetty, Body Satva Essentials
www.bodysatva.com

2. Andraiz T
Testosterone level begins to decline in the late thirties declines at 0.8 % to 1.6% per year
(Massachusetts Male Ageing Study, MMAS; Feldman et al., 2002).
In adults skeletal muscle mass is 60% of total body mass up to age 40 years and then
declines to 40% by the age of 70 years.
(Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol5:Art 217)
Additionally, loss of testicular mass, low androgen production, accelerated testosterone
metabolism or malfunctioning androgen receptors are extrinsic factors for Sarcopenia.
(Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol5:Art 217)
Aging is associated with lower levels of LH and therefore Testosterone. Simultaneously,
there is an increase in SHBG, leading to lower levels of free Testosterone available
to tissues like muscles and causing Sarcopenia.
Andropause & Sarcopenia are progressive
Andropause is characterized by insidious onset and slow progression

3. Andraiz T
 Erectile Dysfunction, Low libido
 Low sperm counts, Prostate problems
 Weakness, Fatigue
 Reduced muscle mass
 Disturbed sleep, Depression,
 Anxiety, Irritability
 Impairment of Memory & Cognitive function
 Osteoporosis, Frailty
 Low immunity, Slow wound healing
Andropause or Male Menopause Symptoms
Andropause is characterized by insidious onset and slow progression
Some of the common symptoms
Intervene early with D.E.A.R.
Diet, Exercise And Rest

4. Andraiz T
Sarcopenia is the age-related decline in skeletal muscle mass and strength generation,
the primary function of skeletal muscle mass
Synthesis and degradation of muscle proteins is regulated by various systemic hormones.
Levels of circulating testosterone, estrogens, IGF-1, vitamin D, and
thyroid hormones decrease with age
Men with low free testosterone levels were 57% more likely to develop mobility limitation
and 68% to experience increase in mobility limitation.
The synthesis of myosin heavy chain (MHC) protein is reduced. Myosin is 25-30% of
skeletal muscles. The muscle tissue undergoes a fiber- type shift from
fast to slow contracting muscle tissue, with increasing age
Sarcopenia is age-related and progressive
Sarcopenia has many intrinsic and extrinsic factors affecting the onset and steady progression of diseases
Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol 5: Art 217
Intervene early with D.E.A.R.
Diet, Exercise And Rest

5. Andraiz T
Intervene early and prevent Sarcopenia
 Balanced Diet
 Regular Exercise
 Stress Reduction
 Adequate Sleep &
 Testosterone Therapy
if needed
TE treatment increases expression of Androgen Receptor protein and Insulin-like Growth
Factor I (IGF-I) at 1 month and remained increased throughout TE administration.
We conclude that physiological and near-physiological increases of testosterone in
older men will increase muscle protein anabolism and muscle strength.
(Ferrando A A et al, Am J Physiol Endocrinol Metab 282: E601–E607, 2002.)
European Working Group on Sarcopenia in Older People 2 (EWGSOP2)
recommends increased awareness of Sarcopenia, early detection and treatment
( Alphonso J et al, Age and Ageing 2019; 48: 16–31 )

6. Andraiz T
Benefits & Safety of increasing Testosterone
in the physiological range
Testosterone Therapy (TTh) in the physiologic range for men with Testosterone Deficiency is a
safe and effective therapeutic modality and imparts great benefits on health and QOL.
Increases Lean Body Mass, Decreases Fat Mass, and Improves Body Composition
Ameliorates Components of MetS, Increases Insulin Sensitivity, and Lowers Risk of T2DM
Improves sexual function and ameliorates lower urinary tract symptoms
Improves Mood and Depressive Symptoms, Energy, and Quality of Life
Improves Bone Mineral Density and improves Anemia
In a meta analysis of 22 RCTs involving 2,351 men, those who received TTh were at
no greater risk of developing PCa (prostate cancer) than men who received placebo.
Of 52,579 men with PCa, those with exposure to TTh were at no greater risk
for having developed high-grade PCa than untreated men.
(Traish AM, Sex Med Rev 2018;6:86e105.)

7. Andraiz T
Total of 11 RCTs (1,392 participants) showed no significant increase in PSA levels following TRT.
Subgroup analysis revealed that PSA levels did not increase following long-term TRT.
Short term TRT increased PSA levels significantly. Transdermal administration increased
PSA levels more than the injection or the oral administration
TRT did not increase IPSS (International Prostate Symptom Score) significantly in an analysis of
7 RCTs, involving 893 participants (short term or long term treatment with injection, transdermal or oral).
Prostate volume increased by an average of 1.58 following TRT, but no significant differences
in prostate volume with long term TRT in a total of 8 RCTs, involving 663 participants.
A total of 6 RCTs, involving 1,351 participants reveals that TRT did not increase
the number of serious adverse events (Cancer, Mortality, PE, DVT, MI, HF)
( ChangCheng Guo et al, EXPERIMENTAL AND THERAPEUTIC MEDICINE 11: 853-863, 2016 )
Benefits & Safety of increasing Testosterone
in the physiological range

8. Andraiz T
Androgenic Aid for Muscle Building, Sarcopenia and Erectile Dysfunction
Dietary
Supplement
Stay Young ……. Strong and Lively
Raises Testosterone, activates androgen receptors
and improves muscle synthesis
Aromatase Inhibition reduces conversion of Testosterone
to Estrogen and reduces body fat accumulation
Reduces Cortisol, stress and muscle catabolism
Manufactured in a WHO GMP approved
plant with ISO & HACCP certifications
Andraiz T Tablets
Increases Testosterone & Inhibits Aromatase

9. Andraiz T
Andraiz T is a blend of proven natural Testosterone enhancers, with Unique Tongkat
Ali along with Shilajit, Tribulus, Horny Goat Weed & Zinc
Natural Aromatase Inhibitors like Gingko Biloba and Grape Seed Extract, reduce
conversion of Testosterone to Estrogen & reduce body fat accumulation.
Andraiz T Tablets
Increases Testosterone
Inhibits Aromatase
Stay Young
Strong and Lively

10. Andraiz T
Significant improvements in the TA group for Tension (−11%), Anger (−12%), and
Confusion (−15%). Stress hormone profile significantly improved, with reduced
cortisol exposure (−16%) and increased testosterone (+37%)
In men with low testosterone levels, tongkat ali extract (200 mg/day) daily for 1 month
resulted in a significant improvement in serum testosterone levels and
quality-of-life parameters, suggesting a role for tongkat ali as
an “adaptogen” against aging-related stress
This “ancient” remedy may be an effective approach to shielding the body from
the detrimental effects of “modern” chronic stress, which may include
general day-to-day stress, as well as the stress of dieting,
sleep deprivation, and exercise training.
Stay Young ……. Strong and Lively
Effect of Tongkat Ali on stress hormones and psychological mood
state in moderately stressed subjects (63 patients, 32 men & 31 women)
Talbott SM et al, J Intl Society of Sports Nutrition 2013, 10:28

11. Andraiz T
Tongkat ali enhances muscle mass and strength gains, while accelerating fat loss, may be
considered a natural ergogenic aid for athletes and dieters alike.
Study of middle-aged women (aged 45–59 yrs) found that twice-weekly strength training plus
100 mg/day of E.longifolia for 12 wks enhanced fat free mass to a greater degree.
In a trial of endurance cyclists, cortisol levels were 32% lower and testosterone levels
were 16% higher in supplemented subjects, a more favorable biochemical
profile for promoting an “anabolic” hormone state.
Several weeks of dieting or overtraining raises Cortisol and drops Testosterone
levels. Tongkat ali helps faster and more complete recovery.
Effect of Tongkat Ali on stress hormones and psychological mood
state in moderately stressed subjects (63 patients, 32 men & 31 women)
Talbott SM et al, J Intl Society of Sports Nutrition 2013, 10:28
Stay Young ……. Strong and Lively

12. Andraiz T
LOH Patients (76) were treated with 200 mg/day of Tongkat ali for 1 month.
While the AMS score decreased from 38.05 (± 9.25) to 23.67 (± 5.11) after treatment, the
testosterone concentration increased from 5.66(±1.52) to 8.31(± 2.47) nm, which
represents an average increase of 46.8%. These changes are highly significant (P < 0.0001).
Tongkat ali, a suitable herbal supplement in overcoming symptoms of LOH and
managing hypogonadism. It may be used as an adjunct to testosterone
replacement therapy to enhance DHEA.
Standardized water-soluble extract of Eurycoma longifolia,
Tongkat ali, as testosterone booster for managing men with
late-onset hypogonadism? Tambi MI et al, Andrologia. 2012, 44(Suppl 1):226–30.
Stay Young ……. Strong and Lively
Tongkat Ali has anti-inflammatory action, antioxidant effect by activating Nrf2, increases
insulin sensitivity & glucose uptake. improves bone formation & reduces bone resorption
Rehman S U et al, Molecules 2016, 21, 331

13. Andraiz T
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack
(Tongkat Ali): Rehman S U et al, Molecules 2016, 21, 331
E. longifolia extracts enhance male fertility (higher semen volumes, sperm count,
and motility) in rodents and in human trials.
The aphrodisiac effect of E.longifolia extract in men, was investigated in a 12wk study
(109 men, age 30-55 yrs) using 300mg/d. The E.longifolia treated group showed
improvement in sexual libido, sperm motility and semen-volume.
Henkel et al. investigating the ergogenic effect of E. longifolia (400 mg/day for 5 weeks), found
it a potential herbal supplement for physically active aged males and females (age 57–72 yrs).
Significant increases in total and free testosterone & muscular force in men & women.
Stay Young ……. Strong and Lively

14. Andraiz T
Andraiz T Tablets
Increases Testosterone
Inhibits Aromatase
Stay Young
Strong and Lively
Ingredients and Evidence
Tribulus terrestris improved the sexual drive in 60% of ED cases, and was accompanied
by significant improvement in DHEA levels. (Adimodelja A et al, Int. J. Impotence Res., v9, supp1,1997)
Tribulus Terrestris (TTE) improves testosterone production in healthy male. TTE enhances
production of luteinizing hormone (LH) and muscle growth. By increasing testosterone,
reducing inflammation and oxidative damage in muscle, TT appears to be a potent
performance enhancer. (Sellami et al. J.Int.Society of Sports Nutrition (2018) 15:14)
Tribulus terrestris (Saponins and Phytosterols) has beneficial effects on physical fitness,
libido, prostate function and urinary system. (Sellami et al. J.Int.Society of Sports Nutrition (2018) 15:14)
Horny Goat Weed Extract (Icariin) increases NO synthesis in the penis, inhibit PDE5
(like Sildenafil), have positive neurotrophic effect, enhance smooth muscle proliferation and
mimic endogenous androgens. Icariin has anti-inflammatory, anti-osteoporotic and
neuroprotective properties.(Corazza et al, BioMed Res. Intl, Vol 2014, Art. ID 841798)

15. Andraiz T
Andraiz T Tablets
Increases Testosterone
Inhibits Aromatase
Stay Young
Strong and Lively
Ingredients and Evidence
Shilajit (Fulvic acid) treatment for 90 days (250 mg twice daily), significantly increases total
testosterone, free testosterone and DHEA. which plays a role in Testosterone biosynthesis.
Gonadotropic hormones (LH and FSH) levels were well maintained in the RCT on healthy
volunteers (Pandit S et al, Andrologia 2016, 48, 570–575)
Shilajit 500 mg/d for 8 weeks promoted the retention of maximal muscular strength
following fatiguing and decreased baseline hydroxyproline (HYP), thus eliciting favorable
muscle and connective tissue adaptations. HYP is an indirect biomarker of collagen
degradation and the integrity of connective tissue following high-intensity exercise.
(Keller et al, J Intl Society of Sports Nutrition, 2019;16:3 )
Ginkgo biloba is a popular phytomedicine used for disorders of the CNS, CV and circulatory
diseases. The three major flavonoids (kaempferol, quercetin, and isorhamnetin)
synergistically inhibit estrogen biosynthesis through aromatase inhibition and induce
transcriptional suppression. (Y.J.Park et al, Asian Pacific Journal of Cancer Prevention, Vol 16, 2015).

16. Andraiz T
Andraiz T Tablets
Increases Testosterone
Inhibits Aromatase
Stay Young
Strong and Lively
Ingredients and Evidence
Ginkgo biloba extracts have been suggested to improve sexual function by improving
the blood flow to the brain and to the genital organs. They increase NO bioavailability, which
may have positive impact on sexual function. (Corazza et al, BioMed Res. Intl, Vol 2014, Art. ID 841798)
Grape Seed Extract Is an Aromatase Inhibitor and a Suppressor of Aromatase Expression
(I Kijima et al, Cancer Res 2006; 66: 5960-5967).
Zinc deficiency is associated with hypogonadism in men. One study found that zinc
supplementation for 6 months in marginally zinc-deficient elderly men resulted in an almost
two-fold increase in serum testosterone levels. (Gunnels et al, J Plant Biochem Physiol 2014, 2:2)
Piperine aids the absorption and increases the bio-availability of the other ingredients;
in addition to numerous health benefits.
Stay Young ……. Strong and Lively

17. Andraiz T
Andraiz T Tablets
Increases Testosterone
Inhibits Aromatase
Stay Young
Strong and Lively
Androgenic Aid for Muscle Building, Sarcopenia
and Erectile Dysfunction
Manufactured in a WHO GMP approved
plant with ISO & HACCP certifications
Disclaimer
Body Satva Essentials’ Team has taken maximum care to ensure authenticity of the information provided, by sourcing from reputed
Medical journals and books. Body Satva Essentials’ Team urges members to seek professional advice before commencing any
regimen of diet, exercise and medication. The products sold on this site are not for treating any disease or medical condition,
without medical supervision. We do not advice self-medication.
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