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from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health
NATURAL
TESTOSTERONE
FORMULA
supports the production of testosterone
Natural Testosterone Formula | Call 480.454.2370 to order!
2
Introducing our all new Natural Testosterone
Formula
GONADROTROPHIC FUNCTION IN MEN In men, LH stimulates the Leydig cells in the testes to produce
testosterone. FSH stimulates Sertoli cells in the testes for production of spermatozoa in the seminiferous tubules of the
testes. Gonadotrophic hormone levels may be lower in men with chronic illness, as an undesirable affect of aging, in
men with hyperprolactinemia, and hypothalamic-pituitary disorders. Low levels have also been noted in obesity and
starvation.
GONADROTROPHIC FUNCTION IN WOMEN In women, LH stimulates the theta cells in the ovaries to produce
androgens and hormonal precursors for estradiol production. An LH surge triggers ovulation. FSH initiates follicular
growth specificullary stimulating granulosa cells to convert androgens (coming from thecal cells) to estratdiol by
aromatase during the follicular phase of the menstral cycle. Gonadotrophic hormone levels may be lower in women
with chronic illness, as an undesirable affect of aging, in women with hyperprolactinemia, and hypothalamicpituitary
disorders. Low levels have also been noted in obesity and starvation.
GENERALIZED PHYSICAL
• Decreased Lean Tissue
• Decreased Muscle Size
• Increased Body Fat
• Weight Gain
• Joint & Back Pain
• Skin has Decreased Firmness
or Fullness
• Headaches
• Anemia
SLEEP SYMPTOMS
• Insomnia
• Difficulty Falling to Sleep
• Difficulty Staying Asleep
• Night Sweats (in both men
and women)
ENERGY & STRENGTH
SYMPTOMS
• Tired & Fatigue
• Feel Weaker
• Decreased Endurance
GENERAL SYMPTOMS OF HYPOGONADISM
Natural Testosterone Formula | Call 480.454.2370 to order! 3
COGNITIVE SYMPTOMS
• Decreased Mental Skills
• Decreased Memory Function
• Can’t Solve Problems
• Can’t Focus Attention
• Can’t Remember Events
• Easily Confused
MOOD & BEHAVIORAL SYMPTOMS
• Depression
• Social Isolation
• Less Motivated
• Irritability
• Mood Changes
Neuro-Cognitive Symptoms of Low
Testosterone
SEXUAL SYMPTOMS
• Decreased Libido
• Diminished Orgasm
• Anorgasmia
• Pubic hair Thinning
ADDITIONAL MALE
SYMPTOMS & RISKS
• Risk for Insulin Resistance
• Erectile Dysfunction
• Risk for Heart Disease
• Sleep Apnea
ADDITIONAL FEMALE
SYMPTOMS & RISKS
• Vaginal Atrophy
• Pain with Intercourse
• Urinary Incontinence
• Vulvodynia
Sexual Symptoms of Low Testosterone
Low Testosterone Desired Therapeutic
Outcomes
• Increased
Testosterone
Production
• Increased action of
HPG Axis
• Increased
Testosterone Levels
• Increased Sexual
Function in men
• Increased Sexual
Function in women
• Increased Nitric Oxide
• Increased Anabolic
Activity
• Decreased Excessive
Cortisol activity
• Decreased Prolactin
levels
• Increased
Gonadotrophic
activity (FSH &/or LH)
• Increased Male
Reproductive ability
• Increased Female
Reproductive ability
Natural Testosterone Formula | Call 480.454.2370 to order!
4
How to Make your Own Testosterone
• By controlling negative/diminishing factors you can increase production of testosterone.
• While testosterone is anabolic, and builds muscle, cortisol is catabolic and breaks down muscle. In both male
and female athletes lower testosterone with a relatively higher cortisol results in an anabolic/catabolic hormone
imbalance adversely affect sports activity, and increase the risk of recurrent muscle injury.
• Long term stress results in increased production of cortisol and decreased production of testosterone—hormone
production shunts towards making cortisol and away from making testosterone.
ADAPTOGENS
• A number of herbs that can increase testosterone or have documented anabolic actions also help the body adapt
to stress and decrease the stress associated rise in cortisol. These plants are appropriately called “adaptogens”.
• A number of herbs actually have cortisol antagonist properties, which can counteract the negative consequences of
excessive cortisol. By controlling excessive cortisol, it can support a healthy production of testosterone – and allow
it to function optimally.
Call Cenegenics now to find out more about
our Natural Testosterone Formula.
480.454.2370
Natural Testosterone Formula | Call 480.454.2370 to order! 5
Ingredients THE HIGHEST QUALITY
MUIRA PUAMA (PTYCHOPETALUM
OLACOIDES) Muira puama is reputed to enhance erectile function
and orgasm in aging men suffering the effects of fatigue or age-related
complaints. Muira Puama has adaptogen properties (anti-stress, memory
enhancement, increased physical and/or sexual performance). Prevents
stress induced increase of corticosterone, indicating glucocorticoid
antagonist properties, which may contribute to a relative increase in
anabolic function. Traditionally used treating various age-related conditions,
Muira Puama is prized as a nerve tonic that facilitates memory retrieval and
improves cognitive function, due to both both antioxidant properties and
acetylcholinesterase inhibitory properties, which preserving acetylcholine
levels. The enhanced acetylcholine is another mechanism of improved
sexual function. Acetylcholine, as a parasympathetic neurotransmitter,
enhances sexual response in both genders by promoting relaxation of
penile cavernous smooth muscle or clitoral cavernous smooth muscle to
support penile erection or clitoral engorgement.
HORNY GOAT WEED EXTRACT (EPIMEDIUM
SAGITTATU) Sagittatum promotes testosterone production
through the action of icariin, a flavonol that improves the condition of
reproductive organs and increased the circulating levels of testosterone
in animal studies. Icariin has phosphodiesterase-5 (PDE5) inhibitor action
affecting all three PDE5 isoforms. The long history of use for treating erectile
dysfunction in Traditional Chinese Medicine (TCM) may be attributed to the
PDE5 inhibitor actions. PDE5 inhibitors can potentiate the sexual response
in both men and women. The sexual potentiation effect and improved the
quality of life was even seen in patients with chronic disease. Researchers
have also described icariin as having “testosterone mimetic properties” with
therapeutic potential for the management of hypoandrogenism. Epimedium
also has glucocorticoid antagonist properties, which may contribute to a
relative increase in anabolic function.
VELVET BEAN EXTRACT (MUCANA
PRURIENS) Promotes testosterone production in humans by its
action on the hypothalamus-pituitary-gonadal axis, and raises serum levels
of both testosterone and LH. Semen quality and sperm concentrations
are improved in infertile men. Animal studies confirm that Mucuna causes
a significant improvement in sexual behavior, libido and potency, sperm
parameters, and testosterone and LH levels, as well as reproductive organs
in females. Mucuna also decreases prolactin levels, which is significant
because hyperprolactinemia is a major neuroendocrine-related cause of
reproductive disturbances in both men and women. Significant increase
of sexual behavior through enhanced libido has been attributed to
L-dopa, the constituent in Mucuna that suppresses excessive prolactin.
Mucuna pruriens also has a normalizing affect on blood sugar, with some
researchers concluding that it can be used in diabetesinduced erectile
dysfunction.
GOKHRU FRUIT EXTRACT (TRIBULUS
TERRESTRIS) The concentration of blood testosterone increased
statistically within 10 days in athletes consuming Tribulus. Tribulus
terrestris increases testosterone, dihydrotestosterone (DHT) and
dehydroepiandrosterone sulphate in primates. Chronic administration of
Tribulus terrestris produced a significant increase in serum testosterone
levels and sexual behavior with no significant effect on the sperm count, and
no overt body system dysfunctions were observed in 28-day oral toxicity
study in animal studies published January 2012. The ability of Tribulus
terrestris to increase the release of nitric oxide from the endothelium and
nitrergic nerve endings, may account for its claims as an aphrodisiac in both
genders. Tribulus terrestris appears to have a gonadotropin-like activity that
can increase the number of corpora lutea, primary and secondary follicles
while significantly decreasing the number of ovarian cysts.
Natural Testosterone Formula | Call 480.454.2370 to order!
6
Ingredients THE HIGHEST QUALITY
TONGKAT ALI (EURYCOMA LONGIFOLIA)
Promotes testosterone production with a significant increase of plasma
testosterone level noted in animal studies. Human studies showed similar
results, with increases in serum testosterone levels. The men in the study
also had less symptoms of hypogonadism. One group of researchers
proposed that the proandrogenic effects of Eurycoma longifolia have can
be used as an alternative treatment to prevent and treat male osteoporosis
without causing the side effects associated with testosterone replacement
therapy. A number of animal studies validate the usefulness of Eurycoma
longifolia for androgen-deficient osteoporosis, with some researchers
recommending that Eurycoma longifolia may be used in combination with
low-dose testosterone in androgen-deficient osteoporosis. Eurycoma
longifolia also has anti-estrogen properties and can reverse the effects of
estrogen, which allows testosterone to work more effectively.
PANS GINSENG ROOT EXTRACT (PANAX
GINSENG) Male patients treated with Panax ginseng showed an
increase in spermatozoa number/ml and progressive oscillating motility,
an increase in plasma total and free testosterone, DHT, FSH and LH levels,
and a decrease in PRL. However, following acute resistance exercise, Panax
does not cause a rise in hormones levels, and does not to promote an
anabolic hormonal status when taken immediately following resistance
exercise. Panax Ginseng can mimic actions of testosterone associated with
the increase in both sexual desire and sexual function. Various human
studies demonstrate that Panax ginseng is effective for treating male
erectile dysfunction. In addition, Panax ginseng improved sexual arousal in
menopausal women and caused significant improvement in the Kupperman
index and the Menopause Rating Scale, indicating that Panax ginseng might
be used in menopausal women to improve their sexual life. Panax ginseng
inhibited testosterone-induced cell proliferation in both animal studies and
human prostate cells, indicating that Panax may decrease risks of prostate
disorders in men receiving testosterone replacement therapy.
ELEUTHEROCOCCUS SENTICOSOSUS ROOT
EXTRACT (ELEUTHEROCOCCUS SENTICOSUS)
Best described as a functional mimetic of testosterone in that it mimics
a significant number of testosterone functions including enhanced
endurance capacity, elevated cardiovascular function, metabolism altered
for sparing glycogen, as well as improvement of sperm motility. It also has
an anti-fatigue action, enhances recovery of stress induced NK activity
and inhibits stress induced corticosterone elevation. Like testosterone,
it is protective against the glucocorticoids induced osteoporosis. It has
significant adaptogen properties, with the ability to increase a nonspecific
body resistance to stress, fatigue, and disease. Like testosterone, it can also
increase endothelial nitric oxide levels, which can contribute to improved
sexual function in both genders.
ASHWAGANDHA ROOT EXTRACT (WITHANIA
SOMINFERA) Promotes testosterone production, and caused
significant increases in serum testosterone and luteinizing hormone in
men with a history of infertility. Those men also developed improved
sperm count and motility. Collectively, the research indicates that Withania
improves gonadal function in both genders. However, Withania suppresses
estrogen receptor-alpha function, promotes apoptosis, and inhibits growth
of MCF-7, and MDA-MB-231 human breast cancer cells. None-the-less,
Withania demonstrates anti-osteoporotic activity. Withania also mimics a
significant number of testosterone functions including adaptogenic with
increased stress tolerance, increased nitric oxide production, and increased
dopaminergic activity, and cardioprotection.
Natural Testosterone Formula | Call 480.454.2370 to order! 7
Ingredients THE HIGHEST QUALITY
MACA ROOT (LEPIDIUM MEYENII) Is a potent
testosterone mimetic that improves sexual function in both men and
women independent of testosterone or estrogen activity. Lepidium also
enhances female fertility in mice, spermatogenesis in male mice following
spermatogenic damage, and increases both the semen volume and sperm
motility in men. As a cruciferous vegetable, Lepidium meyenii may provides
benefits associated with consumption of cruciferous vegetables, such as a
reduced risk of prostate cancer. Maca reduced prostate size after 14 days
in animal studies, and prevented the prostate weight increase induced by
testosterone enanthate treatment, suggesting that Maca may decrease risks
of prostate disorders in men receiving testosterone replacement therapy.
DAMIANA LEAF (TERNERA DIFFUSA) Can
mimic functions of testosterone and act as a sexual stimulant, enhance
engorgement of erectile tissue due to its vasodilatory abilities, and
significantly reduce the post-ejaculatory interval. These effects were not
associated to an increase in locomotor activity or anxiety-like behaviors,
suggesting that the anxiolytic flavone apigenin may participate in its pro-
sexual effect. The testosterone mimetic effects are also considered as part
of a general adaptogen effect of Turnera diffusa.
Specific Actions
Herbal Ingredient
Adaptogenic
Androgenic
Testosterone
Production
Anabolic
Decrease
Excessive
Cortisol
Dopaminergic
–
lower
PRL
Nitric
Oxide
Enhancer
Antioxidant
Antiproliferative
Nootropic
Neuroprotect
Testosterone
Mimetic
Increased
Sexual
Desire
Improve
Sexula
Function
Ptychopetalum olacoides X X X X X X X X X X X
Epimedium sagittatum X X X X X X X X X
Mucuna pruriens X X X X X X X X X X X
Tribulus terrestris X X X X X X X X X
Eurycoma longifolia X X X X X X X X
Panax ginseng X X X X X X X X X X
Eleutherococcus senticosus X X X X X
Withania somnifera X X X X X X X X X
Lepidium meyenii X X X X X X X X X
Turnera diffus X X X X X
Natural Testosterone Formula | Call 480.454.2370 to order!
8
HERBAL FUNCTIONS
• Six of the herbs directly increase Testosterone production by the gonads
• Five of the herbs are documented to increase the actions of HPG Axis
• Six of the herbs are documented to increases Testosterone levels
• Three of the herbs Decreases Prolactin levels (remember, high prolactin suppresses FSH & LH)
• Five of the herbs increase Gonadotrophic levels (FSH &/or LH)
• Six of the herbs Increases Male Reproductive ability
• Three of the herbs Increases Female Reproductive ability
HERBAL SYNERGY
• Restoring the optimal function of testosterone is achieved by formulating the herbs so that the ultimate benefit is
derived from the combination.
• The herbs are formulated in such a way that they intensify and balance the action of the other herbs.
• The working together of the anabolic activities of some herbs with the abilities of other herbs to control excessive
cortisol. This control of excessive cortisol is important because high cortisol levels interfere with anabolic activity.
NATURAL TESTOSTERONE FUNCTION
Description - The primary functions of the Natural Testosterone Formula are to support the production of testosterone in
both men and women, and to support how tissues throughout the body respond to testosterone. This is accomplished by
supporting the function of testosterone producing glands in both genders, and by supporting the function of testosterone
tissues through the use of herbs that mimic the actions of testosterone.
NATURAL TESTOSTERONE FORMULA Suggested Usage: As a dietary supplement, adults may take 2 capsules
each day with food for 1 to 2 weeks or as directed by your healthcare professional. The dose may then be increased to
4 capsules each day with food for 2 to 4 months or as directed by your healthcare professional. After 2 to 4 months,
dosage may be lowered back down to 2 capsules each day with food and may continue on that dosage as needed or as
directed by your healthcare professional.
THE PRODUCT CONTAINS NO YEAST, WHEAT, GLUTEN, SOY PROTEIN, MILK/DAIRY, CORN, SO-
DIUM, SUGAR, STARCH, ARTIFICIAL COLORING, PRESERVATIVES OR FLAVORING.
Natural Testosterone Formula | Call 480.454.2370 to order! 9
Can men on testosterone replacement therapy
take NTF?
PROTECT THE PROSTATE
• Panax Ginseng decrease risks of prostate disorders in men receiving testosterone replacement therapy.
• Lepidium meyenii (Maca) prevented the prostate weight increase induced by testosterone enanthate treatment,
suggesting that Maca may decrease risks of prostate disorders in men receiving testosterone replacement therapy.
PROTECT THE BONES
• Eurycoma longifolia was suggested by researchers to be used with low-dose testosterone to treat male osteoporosis
without causing the side effects associated with full-dose testosterone replacement therapy.
Can men on testosterone replacement therapy
take NTF?
MAINTAIN TESTES FUNCTION A common side effect to testosterone re& therapy in men is decreased testosterone
function and decreased sperm count and decreased function due to the suppression of gonadotrophic) hormones, LH
& FSH. The gonadotrophic hormones would normally become elevated if testosterone was low, but become suppressed
with testosterone replacement therapy. That is why decreased gonad size and infertility is common in men who use
testosterone.
• Mucuna pruriens improves semen quality and sperm concentrations, sperms in infertile men.
• Tribulus terrestris has a significant effect on the sperm count due to its gonadotrophic-like activity.
• Eurycoma longifolia use can result in higher sperm count and improved sperm motility.
• Withania somnifera has gonadotrophic and
spermatogenic activity.
• Lepidium meyenii increases spermatogenesis in
males.
Cenegenics Natural
Testosterone Formula
AVAILABLE ON CENEGENICSSTORE.COM
RETAIL PRICE: $65.00
WHO CAN TAKE NATURAL TESTOSTERONE
FORMULA?
• Non-Cenegenics Patients & Cenegenics Patients
• Both Men & Women
• Individuals over the age of 18
WHO CANNOT TAKE NATURAL
TESTOSTERONE FORMULA?
• Women who are nursing or pregnant
• Individuals under the age of 18
Natural Testosterone Formula | Call 480.454.2370 to order!
10
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serum testosterone levels in adult healthy men. Andrologia. 2002 Dec;34(6):367-72.
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Dec;22(12):1057-70. Review.
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Natural Testosterone Formula | Call 480.454.2370 to order! 11
• McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004 Mar;9(1):4-16.
• Mehta AK, Binkley P, Gandhi SS, Ticku MK. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res. 1991
Aug;94:312-5.
• Muruganandam AV, Kumar V, Bhattacharya SK. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian
J Exp Biol. 2002 Oct;40(10):1151-60.
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ginseng for chronic fatigue. Psychol Med. 2004 Jan;34(1):51-61.
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smooth muscle of the corpus cavernosum of guinea pig. Phytomedicine. 2003 Nov;10(8):669-74.
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reticuloendotherial system] Yakugaku Zasshi. 1990 Mar;110(3):179-85. Japanese.
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• Szolomicki J, Samochowiec L, Wojcicki J, Drozdzik M, Szolomicki S: The influence of active components of Eleutherococcus senticosus on cellular defence
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• Wang B, Quan J, Guo S: [Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat]. Zhonghua Fu
Chan Ke Za Zhi 2000;35:724-6.
• Wu T, Cui L, Zhang Z, et al: [Experimental study on antagonizing action of herba Epimedii on side effects induced by glucocorticoids]. Zhongguo Zhong Yao
Za Zhi 1996;21:748-51, 763.
• Nagashayana N, Sankarankutty P, Nampoothiri MR, Mohan PK, Mohanakumar KP. Association of L-DOPA with recovery following Ayurveda medication in
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• Oshima M, Gu Y, Tsukada S. Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone
and the rate of embryo implantation in mice. J Vet Med Sci. 2003 Oct;65(10):1145-6.
• Parihar MS, Hemnani T. Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus. J Neural
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• Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res. 1999 Jun;13(4):275-91.
Review.
Get back that zest. Call Cenegenics today!
480.454.2370
from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health
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SCOTTSDALE, AZ
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© 2012 Cenegenics. All rights reserved. Cenegenics® is a registered trademark of Cenegenics Medical Institute. No part
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Cenegenics Testosterone Brochure

  • 1. from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health NATURAL TESTOSTERONE FORMULA supports the production of testosterone
  • 2. Natural Testosterone Formula | Call 480.454.2370 to order! 2 Introducing our all new Natural Testosterone Formula GONADROTROPHIC FUNCTION IN MEN In men, LH stimulates the Leydig cells in the testes to produce testosterone. FSH stimulates Sertoli cells in the testes for production of spermatozoa in the seminiferous tubules of the testes. Gonadotrophic hormone levels may be lower in men with chronic illness, as an undesirable affect of aging, in men with hyperprolactinemia, and hypothalamic-pituitary disorders. Low levels have also been noted in obesity and starvation. GONADROTROPHIC FUNCTION IN WOMEN In women, LH stimulates the theta cells in the ovaries to produce androgens and hormonal precursors for estradiol production. An LH surge triggers ovulation. FSH initiates follicular growth specificullary stimulating granulosa cells to convert androgens (coming from thecal cells) to estratdiol by aromatase during the follicular phase of the menstral cycle. Gonadotrophic hormone levels may be lower in women with chronic illness, as an undesirable affect of aging, in women with hyperprolactinemia, and hypothalamicpituitary disorders. Low levels have also been noted in obesity and starvation. GENERALIZED PHYSICAL • Decreased Lean Tissue • Decreased Muscle Size • Increased Body Fat • Weight Gain • Joint & Back Pain • Skin has Decreased Firmness or Fullness • Headaches • Anemia SLEEP SYMPTOMS • Insomnia • Difficulty Falling to Sleep • Difficulty Staying Asleep • Night Sweats (in both men and women) ENERGY & STRENGTH SYMPTOMS • Tired & Fatigue • Feel Weaker • Decreased Endurance GENERAL SYMPTOMS OF HYPOGONADISM
  • 3. Natural Testosterone Formula | Call 480.454.2370 to order! 3 COGNITIVE SYMPTOMS • Decreased Mental Skills • Decreased Memory Function • Can’t Solve Problems • Can’t Focus Attention • Can’t Remember Events • Easily Confused MOOD & BEHAVIORAL SYMPTOMS • Depression • Social Isolation • Less Motivated • Irritability • Mood Changes Neuro-Cognitive Symptoms of Low Testosterone SEXUAL SYMPTOMS • Decreased Libido • Diminished Orgasm • Anorgasmia • Pubic hair Thinning ADDITIONAL MALE SYMPTOMS & RISKS • Risk for Insulin Resistance • Erectile Dysfunction • Risk for Heart Disease • Sleep Apnea ADDITIONAL FEMALE SYMPTOMS & RISKS • Vaginal Atrophy • Pain with Intercourse • Urinary Incontinence • Vulvodynia Sexual Symptoms of Low Testosterone Low Testosterone Desired Therapeutic Outcomes • Increased Testosterone Production • Increased action of HPG Axis • Increased Testosterone Levels • Increased Sexual Function in men • Increased Sexual Function in women • Increased Nitric Oxide • Increased Anabolic Activity • Decreased Excessive Cortisol activity • Decreased Prolactin levels • Increased Gonadotrophic activity (FSH &/or LH) • Increased Male Reproductive ability • Increased Female Reproductive ability
  • 4. Natural Testosterone Formula | Call 480.454.2370 to order! 4 How to Make your Own Testosterone • By controlling negative/diminishing factors you can increase production of testosterone. • While testosterone is anabolic, and builds muscle, cortisol is catabolic and breaks down muscle. In both male and female athletes lower testosterone with a relatively higher cortisol results in an anabolic/catabolic hormone imbalance adversely affect sports activity, and increase the risk of recurrent muscle injury. • Long term stress results in increased production of cortisol and decreased production of testosterone—hormone production shunts towards making cortisol and away from making testosterone. ADAPTOGENS • A number of herbs that can increase testosterone or have documented anabolic actions also help the body adapt to stress and decrease the stress associated rise in cortisol. These plants are appropriately called “adaptogens”. • A number of herbs actually have cortisol antagonist properties, which can counteract the negative consequences of excessive cortisol. By controlling excessive cortisol, it can support a healthy production of testosterone – and allow it to function optimally. Call Cenegenics now to find out more about our Natural Testosterone Formula. 480.454.2370
  • 5. Natural Testosterone Formula | Call 480.454.2370 to order! 5 Ingredients THE HIGHEST QUALITY MUIRA PUAMA (PTYCHOPETALUM OLACOIDES) Muira puama is reputed to enhance erectile function and orgasm in aging men suffering the effects of fatigue or age-related complaints. Muira Puama has adaptogen properties (anti-stress, memory enhancement, increased physical and/or sexual performance). Prevents stress induced increase of corticosterone, indicating glucocorticoid antagonist properties, which may contribute to a relative increase in anabolic function. Traditionally used treating various age-related conditions, Muira Puama is prized as a nerve tonic that facilitates memory retrieval and improves cognitive function, due to both both antioxidant properties and acetylcholinesterase inhibitory properties, which preserving acetylcholine levels. The enhanced acetylcholine is another mechanism of improved sexual function. Acetylcholine, as a parasympathetic neurotransmitter, enhances sexual response in both genders by promoting relaxation of penile cavernous smooth muscle or clitoral cavernous smooth muscle to support penile erection or clitoral engorgement. HORNY GOAT WEED EXTRACT (EPIMEDIUM SAGITTATU) Sagittatum promotes testosterone production through the action of icariin, a flavonol that improves the condition of reproductive organs and increased the circulating levels of testosterone in animal studies. Icariin has phosphodiesterase-5 (PDE5) inhibitor action affecting all three PDE5 isoforms. The long history of use for treating erectile dysfunction in Traditional Chinese Medicine (TCM) may be attributed to the PDE5 inhibitor actions. PDE5 inhibitors can potentiate the sexual response in both men and women. The sexual potentiation effect and improved the quality of life was even seen in patients with chronic disease. Researchers have also described icariin as having “testosterone mimetic properties” with therapeutic potential for the management of hypoandrogenism. Epimedium also has glucocorticoid antagonist properties, which may contribute to a relative increase in anabolic function. VELVET BEAN EXTRACT (MUCANA PRURIENS) Promotes testosterone production in humans by its action on the hypothalamus-pituitary-gonadal axis, and raises serum levels of both testosterone and LH. Semen quality and sperm concentrations are improved in infertile men. Animal studies confirm that Mucuna causes a significant improvement in sexual behavior, libido and potency, sperm parameters, and testosterone and LH levels, as well as reproductive organs in females. Mucuna also decreases prolactin levels, which is significant because hyperprolactinemia is a major neuroendocrine-related cause of reproductive disturbances in both men and women. Significant increase of sexual behavior through enhanced libido has been attributed to L-dopa, the constituent in Mucuna that suppresses excessive prolactin. Mucuna pruriens also has a normalizing affect on blood sugar, with some researchers concluding that it can be used in diabetesinduced erectile dysfunction. GOKHRU FRUIT EXTRACT (TRIBULUS TERRESTRIS) The concentration of blood testosterone increased statistically within 10 days in athletes consuming Tribulus. Tribulus terrestris increases testosterone, dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate in primates. Chronic administration of Tribulus terrestris produced a significant increase in serum testosterone levels and sexual behavior with no significant effect on the sperm count, and no overt body system dysfunctions were observed in 28-day oral toxicity study in animal studies published January 2012. The ability of Tribulus terrestris to increase the release of nitric oxide from the endothelium and nitrergic nerve endings, may account for its claims as an aphrodisiac in both genders. Tribulus terrestris appears to have a gonadotropin-like activity that can increase the number of corpora lutea, primary and secondary follicles while significantly decreasing the number of ovarian cysts.
  • 6. Natural Testosterone Formula | Call 480.454.2370 to order! 6 Ingredients THE HIGHEST QUALITY TONGKAT ALI (EURYCOMA LONGIFOLIA) Promotes testosterone production with a significant increase of plasma testosterone level noted in animal studies. Human studies showed similar results, with increases in serum testosterone levels. The men in the study also had less symptoms of hypogonadism. One group of researchers proposed that the proandrogenic effects of Eurycoma longifolia have can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with testosterone replacement therapy. A number of animal studies validate the usefulness of Eurycoma longifolia for androgen-deficient osteoporosis, with some researchers recommending that Eurycoma longifolia may be used in combination with low-dose testosterone in androgen-deficient osteoporosis. Eurycoma longifolia also has anti-estrogen properties and can reverse the effects of estrogen, which allows testosterone to work more effectively. PANS GINSENG ROOT EXTRACT (PANAX GINSENG) Male patients treated with Panax ginseng showed an increase in spermatozoa number/ml and progressive oscillating motility, an increase in plasma total and free testosterone, DHT, FSH and LH levels, and a decrease in PRL. However, following acute resistance exercise, Panax does not cause a rise in hormones levels, and does not to promote an anabolic hormonal status when taken immediately following resistance exercise. Panax Ginseng can mimic actions of testosterone associated with the increase in both sexual desire and sexual function. Various human studies demonstrate that Panax ginseng is effective for treating male erectile dysfunction. In addition, Panax ginseng improved sexual arousal in menopausal women and caused significant improvement in the Kupperman index and the Menopause Rating Scale, indicating that Panax ginseng might be used in menopausal women to improve their sexual life. Panax ginseng inhibited testosterone-induced cell proliferation in both animal studies and human prostate cells, indicating that Panax may decrease risks of prostate disorders in men receiving testosterone replacement therapy. ELEUTHEROCOCCUS SENTICOSOSUS ROOT EXTRACT (ELEUTHEROCOCCUS SENTICOSUS) Best described as a functional mimetic of testosterone in that it mimics a significant number of testosterone functions including enhanced endurance capacity, elevated cardiovascular function, metabolism altered for sparing glycogen, as well as improvement of sperm motility. It also has an anti-fatigue action, enhances recovery of stress induced NK activity and inhibits stress induced corticosterone elevation. Like testosterone, it is protective against the glucocorticoids induced osteoporosis. It has significant adaptogen properties, with the ability to increase a nonspecific body resistance to stress, fatigue, and disease. Like testosterone, it can also increase endothelial nitric oxide levels, which can contribute to improved sexual function in both genders. ASHWAGANDHA ROOT EXTRACT (WITHANIA SOMINFERA) Promotes testosterone production, and caused significant increases in serum testosterone and luteinizing hormone in men with a history of infertility. Those men also developed improved sperm count and motility. Collectively, the research indicates that Withania improves gonadal function in both genders. However, Withania suppresses estrogen receptor-alpha function, promotes apoptosis, and inhibits growth of MCF-7, and MDA-MB-231 human breast cancer cells. None-the-less, Withania demonstrates anti-osteoporotic activity. Withania also mimics a significant number of testosterone functions including adaptogenic with increased stress tolerance, increased nitric oxide production, and increased dopaminergic activity, and cardioprotection.
  • 7. Natural Testosterone Formula | Call 480.454.2370 to order! 7 Ingredients THE HIGHEST QUALITY MACA ROOT (LEPIDIUM MEYENII) Is a potent testosterone mimetic that improves sexual function in both men and women independent of testosterone or estrogen activity. Lepidium also enhances female fertility in mice, spermatogenesis in male mice following spermatogenic damage, and increases both the semen volume and sperm motility in men. As a cruciferous vegetable, Lepidium meyenii may provides benefits associated with consumption of cruciferous vegetables, such as a reduced risk of prostate cancer. Maca reduced prostate size after 14 days in animal studies, and prevented the prostate weight increase induced by testosterone enanthate treatment, suggesting that Maca may decrease risks of prostate disorders in men receiving testosterone replacement therapy. DAMIANA LEAF (TERNERA DIFFUSA) Can mimic functions of testosterone and act as a sexual stimulant, enhance engorgement of erectile tissue due to its vasodilatory abilities, and significantly reduce the post-ejaculatory interval. These effects were not associated to an increase in locomotor activity or anxiety-like behaviors, suggesting that the anxiolytic flavone apigenin may participate in its pro- sexual effect. The testosterone mimetic effects are also considered as part of a general adaptogen effect of Turnera diffusa. Specific Actions Herbal Ingredient Adaptogenic Androgenic Testosterone Production Anabolic Decrease Excessive Cortisol Dopaminergic – lower PRL Nitric Oxide Enhancer Antioxidant Antiproliferative Nootropic Neuroprotect Testosterone Mimetic Increased Sexual Desire Improve Sexula Function Ptychopetalum olacoides X X X X X X X X X X X Epimedium sagittatum X X X X X X X X X Mucuna pruriens X X X X X X X X X X X Tribulus terrestris X X X X X X X X X Eurycoma longifolia X X X X X X X X Panax ginseng X X X X X X X X X X Eleutherococcus senticosus X X X X X Withania somnifera X X X X X X X X X Lepidium meyenii X X X X X X X X X Turnera diffus X X X X X
  • 8. Natural Testosterone Formula | Call 480.454.2370 to order! 8 HERBAL FUNCTIONS • Six of the herbs directly increase Testosterone production by the gonads • Five of the herbs are documented to increase the actions of HPG Axis • Six of the herbs are documented to increases Testosterone levels • Three of the herbs Decreases Prolactin levels (remember, high prolactin suppresses FSH & LH) • Five of the herbs increase Gonadotrophic levels (FSH &/or LH) • Six of the herbs Increases Male Reproductive ability • Three of the herbs Increases Female Reproductive ability HERBAL SYNERGY • Restoring the optimal function of testosterone is achieved by formulating the herbs so that the ultimate benefit is derived from the combination. • The herbs are formulated in such a way that they intensify and balance the action of the other herbs. • The working together of the anabolic activities of some herbs with the abilities of other herbs to control excessive cortisol. This control of excessive cortisol is important because high cortisol levels interfere with anabolic activity. NATURAL TESTOSTERONE FUNCTION Description - The primary functions of the Natural Testosterone Formula are to support the production of testosterone in both men and women, and to support how tissues throughout the body respond to testosterone. This is accomplished by supporting the function of testosterone producing glands in both genders, and by supporting the function of testosterone tissues through the use of herbs that mimic the actions of testosterone. NATURAL TESTOSTERONE FORMULA Suggested Usage: As a dietary supplement, adults may take 2 capsules each day with food for 1 to 2 weeks or as directed by your healthcare professional. The dose may then be increased to 4 capsules each day with food for 2 to 4 months or as directed by your healthcare professional. After 2 to 4 months, dosage may be lowered back down to 2 capsules each day with food and may continue on that dosage as needed or as directed by your healthcare professional. THE PRODUCT CONTAINS NO YEAST, WHEAT, GLUTEN, SOY PROTEIN, MILK/DAIRY, CORN, SO- DIUM, SUGAR, STARCH, ARTIFICIAL COLORING, PRESERVATIVES OR FLAVORING.
  • 9. Natural Testosterone Formula | Call 480.454.2370 to order! 9 Can men on testosterone replacement therapy take NTF? PROTECT THE PROSTATE • Panax Ginseng decrease risks of prostate disorders in men receiving testosterone replacement therapy. • Lepidium meyenii (Maca) prevented the prostate weight increase induced by testosterone enanthate treatment, suggesting that Maca may decrease risks of prostate disorders in men receiving testosterone replacement therapy. PROTECT THE BONES • Eurycoma longifolia was suggested by researchers to be used with low-dose testosterone to treat male osteoporosis without causing the side effects associated with full-dose testosterone replacement therapy. Can men on testosterone replacement therapy take NTF? MAINTAIN TESTES FUNCTION A common side effect to testosterone re& therapy in men is decreased testosterone function and decreased sperm count and decreased function due to the suppression of gonadotrophic) hormones, LH & FSH. The gonadotrophic hormones would normally become elevated if testosterone was low, but become suppressed with testosterone replacement therapy. That is why decreased gonad size and infertility is common in men who use testosterone. • Mucuna pruriens improves semen quality and sperm concentrations, sperms in infertile men. • Tribulus terrestris has a significant effect on the sperm count due to its gonadotrophic-like activity. • Eurycoma longifolia use can result in higher sperm count and improved sperm motility. • Withania somnifera has gonadotrophic and spermatogenic activity. • Lepidium meyenii increases spermatogenesis in males. Cenegenics Natural Testosterone Formula AVAILABLE ON CENEGENICSSTORE.COM RETAIL PRICE: $65.00 WHO CAN TAKE NATURAL TESTOSTERONE FORMULA? • Non-Cenegenics Patients & Cenegenics Patients • Both Men & Women • Individuals over the age of 18 WHO CANNOT TAKE NATURAL TESTOSTERONE FORMULA? • Women who are nursing or pregnant • Individuals under the age of 18
  • 10. Natural Testosterone Formula | Call 480.454.2370 to order! 10 References • Andersen T, Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet. 2001 Jun;14(3):243-50. • Arcasoy HB, Erenmemisoglu A, Tekol Y, Kurucu S, Kartal M. Effect of Tribulus terrestris L. saponin mixture on some smooth muscle preparations: a preliminary study. Boll Chim Farm. 1998 Dec;137(11):473-5. • Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol. 1999 Jan;64(1):91-3. • Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A. Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats. Psychopharmacology (Berl). 1999 Mar;143(1):15-9. • Arushanian EB, Baida OA, Mastiagin SS, Popova AP, Shikina IB. [Effect of eleutherococcus on short-term memory and visual perception in healthy humans] Eksp Klin Farmakol. 2003 Sep-Oct;66(5):10-3. Russian. • Adaikan PG, Gauthaman K, Prasad RN, Ng SC. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. Ann Acad Med Singapore. 2000 Jan;29(1):22-6. • Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol. 2003 Apr;85(2-3):257-60. • Al-Qarawi AA, Abdel-Rahman HA, El-Badry AA, Harraz F, Razig NA, Abdel-Magied EM. The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats. Phytother Res. 2000 Jun;14(4):288-90. • Andallu, B. and Radhika, B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol. 2000 Jun; 38(6):607-9. • Dhuley JN. Nootropic-like effect of ashwagandha (Withania somnifera L.) in mice. Phytother Res. 2001 Sep;15(6):524-8. • Farnsworth, N. R. et al: Economic and Medicinal Plant Research Vol. 1, Academic Press, London (1985) • Fujii Y. Allelopathy in the natural and agricultural ecosystems and isolation of potent allelochemicals from Velvet bean (Mucuna pruriens) and Hairy vetch (Vicia villosa). Biol Sci Space. 2003 Jun;17(1):6-13. • Fulder, S.: The Root of Being, Hutchinson & Co, London (1980) • Gauthaman K, Ganesan AP, Prasad RN. Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model. J Altern Complement Med 2003;9:257-265. • Godoi AF, Vilegas W, Godoi RH, Van Vaeck L, Van Grieken R. Application of low-pressure gas chromatography-ion-trap mass spectrometry to the analysis of the essential oil of Turnera diffusa (Ward.) Urb. J Chromatogr A. 2004 Feb 20;1027(1-2):127-30. • Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, Castillo S. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002 Dec;34(6):367-72. • Berger Ch, Mehrhoff FW, Beier KM, Meinck HM. [Sexual delinquency and Parkinson's disease] Nervenarzt. 2003 Apr;74(4):370-5. German. • Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec;7(6):463-9. • Cicero AF, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts. Andrologia. 2002 Jun;34(3):177-9. • Collins, JJ. 2002. Discover Your Menopause Type. Prima Publishing Rocklin, CA • Deyama T, Nishibe S, Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin. 2001 Dec;22(12):1057-70. Review. • Dhuley JN. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. J Ethnopharmacol. 2000 Apr;70(1):57-63. • la Cour B, Molgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol. 1995 May;46(2):125-9. • Liao HJ, Chen XM, Li WG: [Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;15:202-4. • Ma Z, Wang R, Qiu M: [Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats]. Zhonghua Fu Chan Ke Za Zhi 1999;34:82-5. • McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004 Mar;9(1):4-16. • Mehta AK, Binkley P, Gandhi SS, Ticku MK. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res. 1991 Aug;94:312-5. • Muruganandam AV, Kumar V, Bhattacharya SK. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian J Exp Biol. 2002 Oct;40(10):1151-60. • • • la Cour B, Molgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol. 1995 May;46(2):125-9. • Liao HJ, Chen XM, Li WG: [Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;15:202-4. • Ma Z, Wang R, Qiu M: [Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats]. Zhonghua Fu Chan Ke Za Zhi 1999;34:82-5.
  • 11. Natural Testosterone Formula | Call 480.454.2370 to order! 11 • McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004 Mar;9(1):4-16. • Mehta AK, Binkley P, Gandhi SS, Ticku MK. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res. 1991 Aug;94:312-5. • Muruganandam AV, Kumar V, Bhattacharya SK. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian J Exp Biol. 2002 Oct;40(10):1151-60. • Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, Butani Y, Wang W, Brake K, Ernst M, Kautzman H. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med. 2004 Jan;34(1):51-61. • Harvey NS. Serial cognitive profiles in levodopa-induced hypersexuality. Br J Psychiatry. 1988 Dec;153:833-6. • Hnatyszyn O, Moscatelli V, Garcia J, Rondina R, Costa M, Arranz C, Balaszczuk A, Ferraro G, Coussio JD. Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig. Phytomedicine. 2003 Nov;10(8):669-74. • Iinuma M, Tanaka T, Sakakibara N, Mizuno M, Matsuda H, Shiomoto H, Kubo M. [Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system] Yakugaku Zasshi. 1990 Mar;110(3):179-85. Japanese. • Jain S, Shukla SD, Sharma K, Bhatnagar M. Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat. Phytother Res. 2001 Sep;15(6):544-8. • Rogala E, Skopinska-Rozewska E, Sawicka T, Sommer E, Prosinska J, Drozd J. The influence of Eleuterococcus senticosus on cellular and humoral immunological response of mice. Pol J Vet Sci. 2003;6(3 Suppl):37-9. • Szolomicki J, Samochowiec L, Wojcicki J, Drozdzik M, Szolomicki S: The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother Res 2000;14:30-5. • Thakur RS, Puri HS Husain A. Major Medicinal Plants of India. 78-81. 89. Lucknow, Central Institute of Medicinal and Aromatic Plants. • Valentova K, Ulrichova J. Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):119-30. • Wang B, Quan J, Guo S: [Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat]. Zhonghua Fu Chan Ke Za Zhi 2000;35:724-6. • Wu T, Cui L, Zhang Z, et al: [Experimental study on antagonizing action of herba Epimedii on side effects induced by glucocorticoids]. Zhongguo Zhong Yao Za Zhi 1996;21:748-51, 763. • Nagashayana N, Sankarankutty P, Nampoothiri MR, Mohan PK, Mohanakumar KP. Association of L-DOPA with recovery following Ayurveda medication in Parkinson's disease. J Neurol Sci. 2000 Jun 15;176(2):124-7. • Oshima M, Gu Y, Tsukada S. Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone and the rate of embryo implantation in mice. J Vet Med Sci. 2003 Oct;65(10):1145-6. • Parihar MS, Hemnani T. Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus. J Neural Transm. 2004 Jan;111(1):1-12. Epub 2003 Dec 03. • Qian JQ. Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol Sin. 2002 Dec;23(12):1086-92. • Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res. 1999 Jun;13(4):275-91. Review. Get back that zest. Call Cenegenics today! 480.454.2370
  • 12. from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health LOCATED IN SCOTTSDALE, AZ visit us online at cenegenics-az.com © 2012 Cenegenics. All rights reserved. Cenegenics® is a registered trademark of Cenegenics Medical Institute. No part of this publication may be reproduced, stored in a retrievable system or transmitted by any means, electronic/digital, mechanical or photocopied or otherwise, without the prior written permission of Cenegenics Medical Institute.