This document provides information about the anatomy and function of the inner ear. It describes the bony and membranous labyrinth that make up the inner ear's complex structure. Key components like the semicircular canals, cochlea, utricle, saccule and their roles in balance and hearing are explained. The basilar membrane, hair cells, and organ of Corti that are responsible for mechanotransduction and sound signal processing in the cochlea are discussed in detail. Common clinical conditions affecting the inner ear like BPPV, Meniere's disease, and labyrinthitis are also mentioned.
Anatomy 1-The anatomy and physiology of human earFatima Aftab
how human ear enables us to produce sound waves and how we actually interpret them.I got a grade hope students will be clarifying their basic concepts related to anatomy of the human ear.
Anatomy 1-The anatomy and physiology of human earFatima Aftab
how human ear enables us to produce sound waves and how we actually interpret them.I got a grade hope students will be clarifying their basic concepts related to anatomy of the human ear.
The outer ear
- pinna
- ear canal
- eardrum
2. The middle ear
- three ossicle bones;
(malleus, incus, stapes)
- two major muscles
(stapedial muscle, tensor
tympani)
- Eustachian tube
3. The inner ear
- cochlea (hearing)
- vestibular system (balance)
4. The central auditory system• PINNA: Important for sound
gathering and localization of
sound
• EAR CANAL or AUDITORY
MEATUS: important for
sound selection
• EARDRUM or TYMPANIC
MEMBRANE:
vibrates in response to
sound/pressure chan
The outer ear
- pinna
- ear canal
- eardrum
2. The middle ear
- three ossicle bones;
(malleus, incus, stapes)
- two major muscles
(stapedial muscle, tensor
tympani)
- Eustachian tube
3. The inner ear
- cochlea (hearing)
- vestibular system (balance)
4. The central auditory system• PINNA: Important for sound
gathering and localization of
sound
• EAR CANAL or AUDITORY
MEATUS: important for
sound selection
• EARDRUM or TYMPANIC
MEMBRANE:
vibrates in response to
sound/pressure chan
This presentation explains the working of the ear... It is best for medical students.. It includes all the key points necessary for an exam too... So this presentation can also be used as a notes for your exams...
Cochlear Fluid is the one of the most important fluid not only for hearing sensation but also for the balance of human body. It is very important to know the embryology, anatomy, and physiology of cochlear fluid mechanism to know the various pathological conditions of inner ear.
human's inner ear ,which is third part of ear, Having cochlea and vestibular system.in this slide we will discuss about the anatomy and physiology of inner ear.
Similar to Anatomy of ear(Part 3-Inner Ear) by Dr.K.AmrithaAnilkumar (20)
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
3. Kural 411
செல்வத்துட் செல்வஞ் செவிச்செல்வம் அச்செல்வம்
செல்வத்து செல்லாந் தலல.
TRANSLATION
Wealth of wealth is wealth acquired be ear attent;
Wealth mid all wealth supremely excellent.
EXPLANATION :
Wealth (gained) by the ear is wealth of
wealth; that wealth is
the chief of all wealth.
5. Inner ear
• It exits within the temporal bone (
petrous bone )
• It is a complex structure . It is located
in a bony cavity called bony labyrinth
• It is filled with a fluid called perilymh ,
which is similar to CSF
8. Membraneous labyrinth
• Has 2 parts
• semicircular canal – 3 lateral ,
posterior & superior ( crista ampularis )
angular secretion
• utricle & saccule – utricle 5 opening of
semicircular canal ( macula ) linear
acceleration
9. cochlea
• central axis modiolus
• cochlear canal – runs 2 ½ turns
• cochlear duct - Scala vestibule , Scala
tympani , Scala media & organ of corti
openings – fenestra vestibule
& fenestra cochlea
hair cells ( inner & outer )
transduction of mechanical
energy to electrical energy
10.
11. • cochlear canal - divided into Scala
vestibuli & Scala tympani by spiral
lamina & basilar membrane
cochlear duct is within
cochlear canal
receptor of organ hearing –
organ of corti
• organ of corti - specialized organ of
hearing
lies within cochlear duct
on the basilar membrane
contains hair cells –
impulses carried by VII nerve
12.
13. • receptors for balancing – macula (
thickening – in the walls of saccule &
utricle )
crest ( in the
ampulla of semicircular ducts )
14. Basilar membrane
• Forms the floor of scala media
• 35mm long
• Auditory nerve endings are located
in BM
• Organ of corti resides on the BM
15.
16. • Width
• Base ( 0.1 mm ) = narrow & stiff
• Apex (0.5 mm ) = boad / wide &
flaccid
• Opposite to cochlear ducts width
• Reacts more to vibrations of IE than
do most of the other structures.
17. Hair cells
• Hair cells lays down on the fibrous BM
• 3 – 5 rows of 12, 000 o 15, 000 parallel
outer hair cells (OHCs)
• One row of 3, 000 inner hair cells ( IHCs)
• On the top of each hair cells are hair –
like projection called “stereocilia”
• Stereo cilia on the top of OHCs are
embedded in the tectorial membrane
18.
19. The direction in which stereo cilia are
bent during stimulation
• If cilia bend in one direction – nerve
cells are stimulated
• If cilia bend in the other way – nerve
impulses are inhabited
• If cilia bend to the side - no
stimulation at all
20. cochlear microphone
• Resemblance between cochlea &
microphone in their function
• cochlea convers sound waves into an
energy form useful to the auditory nerve
• microphone converts the sound pressure
coming form a speakers mouth into an
alternating electrical current
• This action is called cochlear
microphone (CM )
21. • a result of changes in polarization caused
by the bending back & forth of hair cells
cilia
• for every up & down cycle of BM , there is
an one in & out cycle of stereo cilia of the
OHCs causing them to become
alternatively depolarized & hyper
polarized
• CM can be measured by placing needle
electrode over the RW or within the
cochlea
22.
23. Action potential
• A change in the electrical potential
occurring on the surface of each
neuron after they are being stimulated
by HCs
• Increases in the intensity of the
auditory input signal to the cochlea
result in increased electrical output
from HCs
• This stimulation causes increased
electrical activity in the neuron
24. Transformer action
• It is accomplished by
• Lever action of ossicles : handle of malleus is 13
times longer than long process of incus
25. Hydraulic action of
tympanic membrane
• the area of tympanic membrane is much
larger than the area of stapes footplate . the
average ration is 21:1 .
• the effective vibratory area of tympanic
membrane is only 2/3 rd. , so the effective
area ratio is reduced to 14: 1 .
• this is the mechanical advantage provided by
the tympanic membrane
27. CLINICAL ANATOMY OF INNER
EAR
1. Benign paroxysmal positional vertigo (BPPV)
- also known
as positional vertigo
- It is a dizzy or spinning
sensation in your head
- most common type
of vertigo.
28. 2. Meniere's disease
causes episodes of vertigo, ringing
in the ears (tinnitus), ear
pressure/fullness and hearing loss.
29. 3. Labyrinthitis and vestibular
neuritis
- occurs when the
Hearing & balance
nerves become inflamed
- resulting in sudden
1. hearing loss
2. balance problems
3. vertigo.
30. 4. Superior semicircular canal dehiscence (SSCD)
- patient has a loss or absence
of the bone that covers
your superior
semicircular canal
Symptoms
1. pressure/
sound-induced vertigo
2. hearing loss
3. ear pressure,
4. hearing your
own breathing and blinking
31. REFERENCES
• Diseases of Ear, Nose and Throat & Head
and Neck Surgery by P L Dhingra
• BD Chaurasia's Human Anatomy Regional
and Applied Dissection and Clinical: Vol. 3:
Head-Neck Brain