This document provides guidance on developing research questions. It explains that research questions guide systematic inquiry and discovery of new facts and theories. Effective research questions are clear, focused, novel and relevant. The process of developing research questions involves starting with a broad topic and progressively narrowing the focus through consideration of theories, time periods, locations and other limiting factors. Finally, the document advises researchers to avoid underestimating the time needed, asking questions beyond the scope of work, using unclear wording, and feeling stuck with an initial research question.