Dr. Alok Gupta presents two interesting clinical cases. Case 1 involves a 59-year-old woman with relapsed ovarian clear cell carcinoma who had progressed through five lines of therapy. She was started on pazopanib, a targeted therapy, and showed an ongoing partial response for over a year. Case 2 involves a 58-year-old woman presenting with esophageal cancer who was also found to have synchronous colorectal cancer. She received neoadjuvant chemotherapy, followed by surgery to remove both cancers, and remains disease-free after two years of follow up and adjuvant chemotherapy. Both cases demonstrate successful treatment approaches for difficult cancer cases.