The indigenous people of the Americas had complex societies prior to European contact, but their populations and cultures were devastated by diseases brought by colonizers and the disruption of their ways of life. Native leaders like Opechancanough tried to maintain their people's traditions and autonomy in the face of English colonization efforts. Similarly, Diego Vasicuio and other priests worked to preserve indigenous religious beliefs despite Spanish attempts to convert native Mexicans to Catholicism. Over time, some native groups were able to establish trading relationships with colonists, though many lost their lands and many were enslaved or killed as European colonial powers exploited the Americas.