Alzheimer's disease is a progressive neurologic disorder that causes the brain to shrink and brain cells to die, destroying neurons and their connections in the entorhinal cortex and hippocampus. It is characterized by memory loss, impaired thinking and reasoning, difficulty making judgments and decisions, and problems planning and performing familiar tasks. While the amyloid cascade hypothesis proposes that deposition of amyloid beta protein causes Alzheimer's pathology and symptoms, evidence also links tau tangles in neurons to neuronal loss and cognitive decline in Alzheimer's disease, which is fatal and not simply a normal part of aging.

1. Alzheimer
Submitted by – Chandan kumar

2. Alzheimer's disease
 Alzheimer's disease is a progressive
neurologic disorder that causes the brain
to shrink, loss function and brain cells to
die.
 Destroys neurons and there connections
In entorhinal cortex and hippocampus .
 Low level of certain neurotransmitters.
 It later affects the other area’s in the
cerebral cortex.
 The disease is fatal.

3. Symptoms
 Memory loss .
 Thinking and reasoning
 Making judgments and decisions
 Planning and performing familiar tasks

4. Etiology
 The amyloid cascade hypothesis says that deposition of
amyloid β protein (AβP) is the main component of the
plaques(amyloid plaques), is the causative agent of
Alzheimer’s pathology and that the neurofibrillary tangles,
cell loss, vascular damage, and dementia follow as a direct
result of this deposition.
 A common counter-argument to the amyloid hypothesis is
that plaques are found in the brains of many elderly
people with normal cognition. It has been consistently
shown that Aβ accumulation and deposition do not correlate
with neuronal loss and cognitive decline
 Tau tangles – Tau is a microtubule-associated tubule that
stabilizes neuronal microtubules but in AD it forms insoluble
filaments that accumulate as neurofibrillary tangles .

5. ALZHEIMER’SIS NOT A NORMAL PART OF
AGING.
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