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Alzheimer's Disease
Prediction (1)
Liudmyla Hirilishena, Aaron Pfennig, Riccardo Zanella
Dataset
ADNI (Alzheimer's Disease Neuroimaging Initiative)
- cognitive tests
- medical imaging (MRI and PET)
- socio-demographic features
Patients Labels
- CN (Cognitively Normal)
- MCI (Mild Cognitive Impaired)
- AD (Alzheimer's Disease)
- CN + MCI → AD (convert)
Goals
1. Estimation of the current stage of the disease
2. Prediction of the conversion (from CN and MCI stage) to AD
a. Prediction of the event
b. Prediction of the age of conversion (if stated)
Features
Other Features
Algorithms
Optimization by cross-validation over a parameter grid and multiple
algorithms:
→ Random Forest Classifier (Current Stage Classification)
→ Gradient Boost (Conversion Classification)
→ Bayesian Ridge (Conversion Age Regression)
Current Stage Estimation
AUC
CN: 88.8%
MCI: 81.2%
AD: 97%
Features:
₋ Cognitive tests
AD conversion (Classification)
AUC
87.8%
Features:
₋ Cognitive tests
₋ APOE-4
₋ Age
(first 3 obs.)
AD conversion (Regression)
Features:
₋ Cognitive tests
₋ APOE-4
₋ Age (at first
examination)
Outlook
● Use LSTM
● Evaluate other features
● Consider MRI data

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