Today’s laboratories want more from their liquid chromatography system: Higher performance. Better reliability. More consistent and comprehensive analytical workflows. And most of all, more predictable and reproducible results. At the same time, you want
For labs with complex challenges, there’s Altus™ UPLC® – the chromatography platform with best-in-class technology that’s already at work in labs the world over, delivering superior performance (with up to nine times the throughput of traditional
With deep industry knowledge, OneSource addresses your lab requirements to help optimize your business outcomes, delivering everything from
everyday instrument repair to data integrity services. OneSource takes a one-of-kind managed approach, utilizing a powerful, interwoven suite of
solutions including analytics, compliance, laboratory computing, scientific lab support, asset management, lab relocation, and other services.
Extending the Depth of Coverage in SWATH® Acquisition with Deeper Ion Libraries SCIEX
When it comes to testing complex cellular samples, SWATH® Acquisition in combination with deeper ion libraries provides more reproducibly quantified proteins. Learn how to balance library generation with results required from SCIEX experts.
RGT-01 based on the differential pressure method and fluid level analysis technique, is the only instrument in the market so far that provides the quantitative analysis of seal performance and residual oxygen for various flexible vacuum packages.
For labs with complex challenges, there’s Altus™ UPLC® – the chromatography platform with best-in-class technology that’s already at work in labs the world over, delivering superior performance (with up to nine times the throughput of traditional
With deep industry knowledge, OneSource addresses your lab requirements to help optimize your business outcomes, delivering everything from
everyday instrument repair to data integrity services. OneSource takes a one-of-kind managed approach, utilizing a powerful, interwoven suite of
solutions including analytics, compliance, laboratory computing, scientific lab support, asset management, lab relocation, and other services.
Extending the Depth of Coverage in SWATH® Acquisition with Deeper Ion Libraries SCIEX
When it comes to testing complex cellular samples, SWATH® Acquisition in combination with deeper ion libraries provides more reproducibly quantified proteins. Learn how to balance library generation with results required from SCIEX experts.
RGT-01 based on the differential pressure method and fluid level analysis technique, is the only instrument in the market so far that provides the quantitative analysis of seal performance and residual oxygen for various flexible vacuum packages.
PERUSAAHN PENJUAL FTIR AGILENT : HANDAL | TERBUKTI | OK
AGILENT INSTRUMENT, Sudah terbukti keandalan dan supportnya di seluruh dunia. Bisa dipakai di dunia farmasi, pengujian, mikro, rumah sakit dan industri lainnya yang memerlukan alat berakurasi tinggi.
Kontak : 0852 3816 1622
Simplifying Intact Molecular Weight Determination for ADCsSCIEX
Heterogeneity and high molecular weight species pose challenges for analytical scientists and both of these problems converge with Antibody Drug Conjugates (ADCs). ADCs are one of the fastest growing segments of the biotherapeutic pipeline, with hundreds of therapeutics in development. Early in development, analysts are tasked with providing rapid feedback to their synthetic chemists on how well a conjugation strategy may have worked. Later in development as process development accelerates, analysts need means to rapidly confirm that the product has maintained its integrity, for example in formulation. Therefore there is always pressure to respond rapidly to the demands of multiple departments.
In this Technical Brief we illustrate how TripleTOF® technology coupled with SelexION™, Eksigent ekspert™ MicroLC, and BioPharmaView™ software or PeakView® software can provide answers where they are needed, fast. Assays that may have needed days to complete are now ready to report within less than an hour.
Routine Discovery Metabolomics Workflows on X500R QTOF SystemSCIEX
For Metabolomics researchers seeking to identify and quantify large numbers of metabolites on a routine basis, the X500R QTOF is the only accurate mass system which offers simplicity and robustness in a true benchtop instrument, with streamlined processing to deliver accurate and reproducible results — fast.
Designing, implementing and maintaining a truly universal approach to gas detection.
Protecting your people and your physical plant, while ensuring business continuity, are the most important functions of a xed gas detection solution. Engineering a reliable, high-performance sys- tem that makes it easier and more cost effective to meet this challenge is the driving force behind a truly universal approach to gas detection.
This white paper is about the evolution and bene ts of designing, implementing and maintaining a truly universal approach to gas detection. Our intention is to help you use this information, based on “universal truths,” to evaluate your current system and project the impact of next-generation gas detection on your organization’s safety and productivity in a global economy.
Testing for microbial excursions in pharmaceutical waters has meant lengthy delays due to plate counting or sample preparation requiring stains and reagents. With the application of advanced laser based technology, on-line 7000RMS (Real-time Microbial System) delivers continuous measurement of microbes and inert particles in real time.
This presentation describes a new food testing solution that allows mass detection to be accessible for many of the routine analyses found within a food testing lab. The ACQUITY UPLC, QDa detector in combination with the Empower software solution is fit for purpose and is easy to use. You simply power on and you are ready to go
With the ACQUITY QDa detector many of the normal processes that are required for mass spectrometers (such as mass calibration and optimisation and manual adjustments that need to be made) have all been fully automated.
Mediland is a group of Laboratories and Pathologists headed by Mediland Diagnostic & research Institute. Promoted with as primary objective of establishing super specialty diagnostic centre for various disease diagnosis and management.
A Hazard and Operability (HAZOP) study is a structured and systematic examination of a planned or existing process or operation in order to identify and evaluate problems that may represent risks to personnel or equipment, or prevent efficient operation.
Empower 3 Chromatography Data Software (CDS) helps your entire analytical laboratory operate better with advanced chromatography data acquisition, management, processing, and reporting that grows to meet your laboratory’s changing needs — easily scalable from a single workstation to an enterprise-wide network. In an Empower environment records are traceable so you always have full control of your data.
PERUSAAHN PENJUAL FTIR AGILENT : HANDAL | TERBUKTI | OK
AGILENT INSTRUMENT, Sudah terbukti keandalan dan supportnya di seluruh dunia. Bisa dipakai di dunia farmasi, pengujian, mikro, rumah sakit dan industri lainnya yang memerlukan alat berakurasi tinggi.
Kontak : 0852 3816 1622
Simplifying Intact Molecular Weight Determination for ADCsSCIEX
Heterogeneity and high molecular weight species pose challenges for analytical scientists and both of these problems converge with Antibody Drug Conjugates (ADCs). ADCs are one of the fastest growing segments of the biotherapeutic pipeline, with hundreds of therapeutics in development. Early in development, analysts are tasked with providing rapid feedback to their synthetic chemists on how well a conjugation strategy may have worked. Later in development as process development accelerates, analysts need means to rapidly confirm that the product has maintained its integrity, for example in formulation. Therefore there is always pressure to respond rapidly to the demands of multiple departments.
In this Technical Brief we illustrate how TripleTOF® technology coupled with SelexION™, Eksigent ekspert™ MicroLC, and BioPharmaView™ software or PeakView® software can provide answers where they are needed, fast. Assays that may have needed days to complete are now ready to report within less than an hour.
Routine Discovery Metabolomics Workflows on X500R QTOF SystemSCIEX
For Metabolomics researchers seeking to identify and quantify large numbers of metabolites on a routine basis, the X500R QTOF is the only accurate mass system which offers simplicity and robustness in a true benchtop instrument, with streamlined processing to deliver accurate and reproducible results — fast.
Designing, implementing and maintaining a truly universal approach to gas detection.
Protecting your people and your physical plant, while ensuring business continuity, are the most important functions of a xed gas detection solution. Engineering a reliable, high-performance sys- tem that makes it easier and more cost effective to meet this challenge is the driving force behind a truly universal approach to gas detection.
This white paper is about the evolution and bene ts of designing, implementing and maintaining a truly universal approach to gas detection. Our intention is to help you use this information, based on “universal truths,” to evaluate your current system and project the impact of next-generation gas detection on your organization’s safety and productivity in a global economy.
Testing for microbial excursions in pharmaceutical waters has meant lengthy delays due to plate counting or sample preparation requiring stains and reagents. With the application of advanced laser based technology, on-line 7000RMS (Real-time Microbial System) delivers continuous measurement of microbes and inert particles in real time.
This presentation describes a new food testing solution that allows mass detection to be accessible for many of the routine analyses found within a food testing lab. The ACQUITY UPLC, QDa detector in combination with the Empower software solution is fit for purpose and is easy to use. You simply power on and you are ready to go
With the ACQUITY QDa detector many of the normal processes that are required for mass spectrometers (such as mass calibration and optimisation and manual adjustments that need to be made) have all been fully automated.
Mediland is a group of Laboratories and Pathologists headed by Mediland Diagnostic & research Institute. Promoted with as primary objective of establishing super specialty diagnostic centre for various disease diagnosis and management.
A Hazard and Operability (HAZOP) study is a structured and systematic examination of a planned or existing process or operation in order to identify and evaluate problems that may represent risks to personnel or equipment, or prevent efficient operation.
Empower 3 Chromatography Data Software (CDS) helps your entire analytical laboratory operate better with advanced chromatography data acquisition, management, processing, and reporting that grows to meet your laboratory’s changing needs — easily scalable from a single workstation to an enterprise-wide network. In an Empower environment records are traceable so you always have full control of your data.
Learn about Waters technologies for analyzing oligonucleotides with LC-MS. We offer solutions for both oligo characterization and QC monitoring. Learn more: http://www.waters.com/oligos
Waters: Reviewing Audit Trail Information in Empower Chromatography Data Soft...Waters Corporation
This presentation provides an overview of how to review audit trail information within Waters Empower Chromatography Data Software. (From Inform 2016, our annual software users meeting)
KML is well equipped with sophisticated apparatus managed by our veteran professionals, Catering to your quality certification and assurance requirements.
A Flexible, Customized Platform to Give You Just What You Need. The Reveal platform gives you a customized solution along with flexibility on how to operate and integrate it. You have choice with Reveal. We can do the application modeling for you, or you can build your own.
Life Cycle Management of Chromatographic Methods for BiopharmaceuticalsWaters Corporation
The development and manufacture of biopharmaceuticals is a dynamic and rapidly growing industry. By the nature of their production, biopharmaceuticals are highly complex heterogeneous mixtures that require many analytical techniques for characterization and routine testing. As a result, many manufacturers incorporate life cycle management into their respective workflows to take advantage of newer technologies and methodologies to ensure efficacy and patient safety.
In this presentation, we will address the range of chromatographic categories – HPLC, UHPLC, and UPLC – and define the characteristics associated with each. The discussion will continue with several examples of methods transferred from legacy HPLC instrumentation to modern UHPLC and UPLC instruments. We will compare qualitative and quantitative data across each chromatographic class. Resolution, sensitivity, and overall run time will be used as metrics to assess the success of the method transfer to the respective LC platform, to ensure the transferred methods are in line with current acceptance criteria.
Learn:
- The importance of selecting the correct instrumentation to meet user needs.
- Which parameters influence method transfer from one LC platform to another.
- How workflows can benefit from features such as Multi-flow path technology and Gradient SmartStart when transitioning methods.
Interested in more detail? Watch the related on-demand webinar: http://view6.workcast.net/register?pak=3479247014905635
The 3500 8-capillary platform can run a wide variety of applications —including de novo sequencing and resequencing (mutational profiling)—as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array. The 3500 Series Data Collection Software integrates seamlessly with several downstream software packages to provide comprehensive analysis of genetic data. For more information visit https://products.appliedbiosystems.com/ab/en/US/adirect/ab?cmd=catNavigate2&catID=606262&tab=DetailInfo?CID=3500-SS-12312
Por que a triagem para SCID?
A Imunodeficiência combinada grave (SCID) é um grupo de distúrbios caracterizados por um defeito grave na produção e no funcionamento da célula. Normalmente, bebês com SCID falecerão por infecções antes de um ano de idade, a menos que o sistema imunológico do bebê seja restaurado através de tratamento [1].
Solução com marca CE para triagem SCID
A PerkinElmer tem orgulho em apresentar o primeiro ensaio comercial para triagem de TREC. O ensaio faz parte de um sistema completo, com marca CE para garantir o uso seguro e eficaz como um auxiliar na triagem de SCID.
A potência do Triplo Quad se combina com a versatilidade do Single Quad.
Limites de detecção incomparáveis, ao nível de ppq. Facilidade de uso inigualável. Finalmente, os analistas podem ter o melhor dos dois mundos com o revolucionário ICP-MS NexION 2000.
O cromatógrafo a gás/espectrômetro de massas (GC/MS) portátil Torion® T-9 da PerkinElmer traz novo significado à portabilidade. Pesando apenas 14,5 quilos, este GC/MS também é rápido, confiável e de fácil utilização.
A PerkinElmer, mantendo seu compromisso com a qualidade e se adaptando sempre às necessidades atuais e futuras, apresenta uma plataforma automatizada que traz imensos benefícios na transferência de líquidos.
Como a PerkinElmer contribui para diagnósticos mais rápidos?PerkinElmer, Inc.
Uma doença detectada precocemente, pode acelerar a inicialização de tratamentos eficazes, que mudarão a história de vida de crianças portadoras de doenças raras e, de seu núcleo familiar.
Como a PerkinElmer contribui para diagnósticos mais rápidos?PerkinElmer, Inc.
Uma doença detectada precocemente, pode acelerar a inicialização de tratamentos eficazes, que mudarão a história de vida de crianças portadoras de doenças raras e, de seu núcleo familiar.
Mais do que nunca, tornou uma premissa para os produtores de carnes, Frigoríficos e Laboratórios, garantirem a segurança e a qualidade dos alimentos que produzem.
Saiba como o DA 7250 pode te ajudar a garantir todos os certificados de segurança e qualidade.
O sequenciamento de nova geração (Next Generation
Sequencing - NGS) se tornou uma importante ferramenta
da biologia molecular, dentro das diversas áreas da
pesquisa e do ambiente clínico, devido à capacidade de
sequenciar, ou seja, identificar a ordem dos nucleotídeos que compõe o genoma humano, de forma rápida e em grande quantidade, além de ter reduzido significativamente o custo do sequenciamento por base.
Visando oferecer soluções que atendam aos padrões necessários de qualidade para as reações de NGS e também promover melhoria expressiva no importante processo de construção da biblioteca, a PerkinElmer adicionou ao seu portfólio de Applied Genomics os kits para o preparo de bibliotecas de NGS Bioo Scientific®.
Não importa o tamanho da rotina de seu laboratório. As plataformas LabChip®GX Touch vão se adequar à sua necessidade e proporcionar um fluxo de trabalho muito mais produtivo.
New Research Evaluating Cisplatin Uptake in Ovarian Cancer Cells by Single Ce...PerkinElmer, Inc.
Application Note
Authors:
Lauren Amable
National Institute on Minority Health and
Health Disparities, National Institutes of Health
Bethesda, MD
Stan Smith
Chady Stephan
PerkinElmer, Inc.
Shelton, CT
Cromatógrafo Gasoso PerkinElmer Clarus® All-In-One
Com exclusivo detector FID (Flame Ionization Detector) da família Clarus CG que não requer gás Nitrogênio (Make-Up), sendo necessário para o seu funcionamento apenas os gases Hidrogênio e Ar Sintético, a PerkinElmer mais uma vez inova no setor de Cromatografia Gasosa com sistema CG Clarus All-In-One.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
3. 3
Today’s laboratories want more from their liquid chromatography
system: Higher performance. Better reliability. More consistent
and comprehensive analytical workflows. And most of all, more
predictable and reproducible results. At the same time, you want
less complexity, hassle, and guesswork from those you count on for
service and support.
More of what you’re looking for in chromatography, and less of
everything else: That’s the Altus™
HPLC platform.
Based on proven technology at work in thousands of labs
worldwide, the Altus HPLC delivers integrated fluidics in a low-
dispersion design, with excellent reproducibility, peak capacity and
resolution, and exceptional results. Optimized detection choices
deliver extremely low detection limits for all the applications
you need most. And productivity-boosting automation features
– everything from simple system startup to automated sample
management to tool-free maintenance – ensure that everyone in
your lab can run analyses quickly and easily, taking full advantage of
the Altus HPLC system’s many strengths.
Put that together with the leading chromatography data software
in the business and the industry’s best, most knowledgeable
service and support organization, and you can now run your
chromatography with the utmost confidence.
Altus HPLC
NOW EVERYONE IN
YOUR LAB IS A
CHROMATOGRAPHER
www.perkinelmer.com/altushplc
Food
The food, beverages, and nutraceuticals
we consume come to us from all over the
world. So ensuring that the global food
supply is genuine, unadulterated, and free of
contaminants is a critical undertaking. The
Altus HPLC, running Waters®
Empower®
3
software, enables your lab to better meet
stringent FDA, EFSA, and impending FSMA
requirements for food safety, without
additional investment.
Environmental
Safeguarding the environment is important
to all of us. The Altus HPLC solution delivers
powerful integration algorithms that
effectively detect and analyze low-level and
complex sample results. Peak detection using
a curvature approach is more sensitive than
traditional integration.
Industrial/Fine Chemicals
In many different ways, advanced materials
chemicals are playing a large – and growing –
part in our lives. And government regulations
are keeping pace. The Altus HPLC solution
can help lower your operating costs by
standardizing your workflows and platforms,
all while improving efficiency, data quality,
and lab productivity.
4. 4
Bigger sample capacity
The Altus HPLC system can handle up to 120 standard-size vials
in five separate sample carousels. So whether you’re running
a quick one-off sample or a series of methods from different
analysts, your sample queues are simple to set up and run. And
the sample environment can be temperature controlled and is
ideal for light-sensitive samples as well.
Easy to use
The Altus HPLC system's large built-in, easy-to-navigate user
interface enables your scientists to take full advantage of its fast
system setup procedures with SystemPREP™
, for quick, one-
touch walkup functionality. SystemPREP automatically readies
the system to run samples – ideal for daily startups, when
changing solvents, or after prolonged periods of
system inactivity.
The system’s solvent management feature also degasses and
accurately blends up to four chromatographic solvents for
pulse-free, effortless delivery. What’s more, PerformancePLUS™
check-valve technology maximizes system uptime.
.
Built-in, integrated fluidics
The Altus HPLC system’s integrated solvent and sample-
management functions deliver consistent performance from
system to system, for highly reproducible results. Automatic,
continuous solvent compressibility provides accurate and precise
solvent delivery and reproducible retention times, regardless of
solvent.
What’s more, the system’s fluidics design ensures that
accidental leakage and spills can be managed quickly and
safely. And you decide needle wash duration, with no wash or
rinse vials – making sample-carryover issues a thing of the past.
Thermal management
The column heating option uses integrated forced-air
recirculation, making for an exceptionally stable column
environment. With the passive column heating option, you
have the confidence that your sample will be at the same
temperature as the column.
The Altus HPLC platform is built to deliver robust, trouble-free operation – perfect for everyday
analysis and for meeting stringent and ever-changing industry regulations and requirements.
WITH CHROMATOGRAPHY
THIS GOOD, THE RESULTS
JUST FLOW
5. 5www.perkinelmer.com/altushplc
UV/Vis Detector
A sensitive, flexible dual-wavelength absorbance detector, with
the ability to identify and quantify low-level impurities in the
same run as the analyte of interest.
Photodiode Array (PDA) Detector
Advanced optical detection with exceptional chromatographic
and spectral sensitivity – perfect for performing peak-purity
analysis, even under extreme conditions.
Refractive Index Detector
An effective tool for isocratic quantification of components with
little or no UV absorption – just the thing for analyzing and
quantifying food sugars.
Multifluorescence Detector
A great solution for environmental monitoring applications
in which increased sensitivity and maximum selectivity are
required.
The Altus HPLC system delivers a full range of
sensitive detection options – everything you need
to analyze whatever compounds come your way.
Whether you use each singly or in combination
with other methods, you’ll be able to glean more
information per run than ever before.
KEEPING YOUR
DETECTION
OPTIONS OPEN
The full line of Altus A-10 detectors are fully
controlled via Empower® 3 software for all
chromatographic and spectral processing functions.
The Altus A-10 UV is the most sensitive and versatile
wavelength detector available for HPLC.
The Altus A-10 FL detector is ideal for quantifying
low concentrations of naturally fluorescent or
derivatized compounds.
6. 6
WHAT BRINGS US
TOGETHER
SETS US APART
Chromatography data software with an edge
Chromatography data software (CDS) has one simple
purpose: to deliver the highest degree of confidence in your
results. And simply put, Empower®
3 software brings it all
together. The most versatile CDS in the business, it’s also the
easiest to use, delivering extraordinary results with minimal
training, workflow reengineering, or additional software
modules to support new instruments or techniques.
Empower®
3 software also provides customizable reports,
integrated custom fields and calculations, and online help,
too, while providing industry-leading security and
data integrity.
All the functionality you need – and more
Empower®
3 delivers all the functionality you need, with
unique interface options that are geared to each individual
user in your lab, novice and expert alike. Once your users
log in, they’re greeted with the interface that’s appropriate
to their tasks and skill levels.
7. Workflow-driven, user-centric
QuickStart™
interface
The single-window Empower®
3 QuickStart™
interface allows all
your users to perform tasks that match their skill level, with no
confusion. You can develop new methods, including PDA and
MS data extraction, customize reports, manage data, and receive
results and notifications by email.
The QuickStart™
interface streamlines the collection, processing,
reviewing, and reporting of chromatographic results. Capabilities
provided through the interface include:
• Instrument control and data acquisition
• Peak detection (including the ApexTrack™ peak detection
algorithm for consistent results)
• Quantitation
• GPC processing and calculations
• Data review
• Data searching
• Mass spectrometry
• Custom reporting
One software package for multiple
requirements
Empower®
3 software enables you to manage data generated by
all your instrumentation, plus run mission-specific applications,
including optional method development and validation,
integrated chemical structures, and polymer analysis.
www.perkinelmer.com/altushplc
The software features the ApexTrack™
peak detection algorithm,
enhancing peak integration capabilities, with excellent detection
of poorly resolved or low-level peaks on noisy or sloping
baselines, so you can process data efficiently with little or no
manual intervention required. Plus, it controls a wide range of
multivendor systems – HPLC, UHPLC, IC, GC, CE, and more –
allowing you to maximize your investment in CDS technology.
The right accessories, consumables methods
and application support
Whether you’re conducting routine raw materials confirmation
or performing the most demanding applications, our top
priority is to help improve efficiency, control costs, and optimize
your analysis. We have the consumables and accessories for
applications in atomic spectroscopy, materials characterization,
and chromatography and mass spectrometry, and our
comprehensive portfolio of solutions is designed to ensure you
receive accurate, repeatable results – on time, every time –
throughout the lifetime of your instrument.
Everything you need under one roof
When you engage with us, you’re benefiting from multivendor
service and support from the absolute best in the business.
Thousands of certified technicians in the field, who are familiar
with all the techniques you employ. More than 400,000
multivendor assets under our care. And operations in more than
120 countries across the globe.
Analytic method services, asset procurement and disposition,
business intelligence, qualification and validation, lab relocation,
and, of course, instrument service and repair – all these services
and more, plus a deep-seated knowledge of the business
requirements of our customers, uniquely qualify us to help
empower your science and drive your business.
Want more from your LC/GC solutions? You’re in good company.
Brownlee SPP Superficially Porous Particle Technology
With Brownlee SPP columns, you can achieve sharper peaks and faster separation results
without worrying about high backpressure or compromising column longevity. Unlike
other columns, Brownlee SPP columns use 2.7 µm particles comprised of a thin outer shell
of high-quality porous silica fused to a solid inner core. This advanced design allows for a
shorter diffusion path, keeps backpressure to a minimum, and improves column efficiency.
Certified LC Clean™
Vial, Cap, and Septa Kits
We have a variety of LC-certified vials, caps, and septa made from the finest materials to
ensure that you experience accurate and dependable measurements. Our vials are made
from Type 1 Borosilicate glass, which conforms to all USP, JP, and EP requirements. Each
product is manufactured using strict quality-control standards and is packed in a clean
environment to ensure that it arrives contaminant-free.
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