Allergies occur through a process of sensitization and reaction. During sensitization, exposure to an allergen leads to the production of IgE antibodies that attach to mast cells. In the early phase reaction, re-exposure to the allergen causes it to attach to these IgE antibodies, activating mast cells and basophils to release inflammatory mediators causing sneezing, itching, and more. The late phase reaction occurs hours later through the actions of recruited cells. Chronic allergies can develop through priming and hyperreactivity. Common triggers include dust mites, animals, pollens, molds, foods, and irritants like smoke. Avoiding triggers and using medications or immunotherapy can help manage allergy
Overview of arthropod allergies
Routes of exposure for arthropod allergens and target organ of arthropod allergic diseases
Immune response to arthropod allergens
Pathogenesis of arthropod allergies
Arthropod species involved in allergic diseases
Immuno-diagnosis, skin prick tests. Allergen-specific immunotherapy, desensitization
Prevention and prophylaxis
Impacts of arthropod allergy on individual and community health
Allergic rhinitis is a very much prevalent condition in the community. This presentation hopes to spread a ray of hope in treating allergic and intrinsic rhinitis.
Overview of arthropod allergies
Routes of exposure for arthropod allergens and target organ of arthropod allergic diseases
Immune response to arthropod allergens
Pathogenesis of arthropod allergies
Arthropod species involved in allergic diseases
Immuno-diagnosis, skin prick tests. Allergen-specific immunotherapy, desensitization
Prevention and prophylaxis
Impacts of arthropod allergy on individual and community health
Allergic rhinitis is a very much prevalent condition in the community. This presentation hopes to spread a ray of hope in treating allergic and intrinsic rhinitis.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
4. EARLY PHASE REACTION
• Allergen attaches to IgE on mast cell
• Release of mediators
– Act on nerves, blood vessels
• Production of mediators
– Continue actions on blood vessels, nerves
– Recruit inflammatory cells
• Sneeze, itch, runny nose, stuffy nose
5. LATE PHASE REACTION
• 2-8 hours after initial reaction
• Same symptoms as early reaction
• Release of mediators from
recruited cells
• Related to severity of early
reaction
6. CHRONIC DISEASE
• Priming
– Need less allergen to trigger symptoms
• Hyperreactivity
– Symptoms from exposure to strong or
irritating fumes or odors
• Inflammation
– Ongoing symptoms
11. AVOIDANCE OF TRIGGERS
• No carpeting or upholstered furniture
• No furry or feathered pets
• Perform maintenance chores requiring
use of irritating chemicals/cleaners when
children not present
• Maintain heating/cooling systems
• No smoking
12. ALLERGY INJECTIONS
• When medications and avoidance don’t
work
• Usually prescribed by a specialist
• Effective for dust mites, cats, pollens
– When history confirms skin test results
• More properly called immunotherapy
13. Additional Resources
• Allergy & Asthma Network/Mothers of
Asthmatics, Inc. -- http://www.aanma.org
• American Academy of Allergy, Asthma, and
Immunology -- http://www.aaaai.org
• American Academy of Pediatrics --
http://www.aap.org
• American College of Allergy, Asthma, and
Immunology -- http://www.allergy.mcg.edu
14. Additional Resources
• Asthma & Allergy Foundation of America --
http://www.aafa.org/home
• US Environmental Protection Agency --
http://www.epa.gov/iaq
Editor's Notes
The allergic process begins with sensitization, which will be covered in a subsequent slide. Regardless of the organ involved, the allergy reaction consists of an acute reaction, which happens shortly after the exposure to the allergen, a late phase reaction that can occur 3-8 hours after the acute reaction, and chronic disease. Most patients have an acute reaction. Only about half the patients will have a late phase reaction, and it usually follows a more severe acute reaction. Chronic disease does not always occur, if the exposure to the allergen is limited. Continued exposure usually results in chronic disease.
Sensitization refers to the process where children with a genetic tendency to develop allergy begin to respond to exposure to an allergen by making a special antibody, called IgE. This IgE is specific for the allergen. Once the IgE is made by the immune system, it attaches to special cells in the tissues of various organs, called mast cells. Organs that contain mast cells include the eye, nose, respiratory tract, skin and GI tract.
This reaction occurs shortly after allergen exposure. Once there are enough IgE antibodies attached to the mast cell, then further exposure to that allergen can result in interaction between the allergen and the IgE antibody on the surface of the mast cell. This interaction results in the release of several different types of chemical from the mast cell, called mediators. These mediators act on nerves, blood vessels, and other cells. The mediators that act immediately on the blood vessels and nerves (and muscles in the airway) cause such symptoms as sneezing, itchy and runny nose, and stuffy nose.
Some of the mediators act to recruit other cells into the tissues, which are involved in late reactions.
In some patients, symptoms very similar to the early phase symptoms occur again 3-8 hours later. This doesn’t occur in every case, but tends to be more likely when the early reaction is severe. It is caused by the release of mediators from cells that are recruited into the tissues, by some of the mediators released by the mast cells.
The cells that are recruited into the tissues release mediators of their own, which causes damage to the tissues, or inflammation, and recruits even more cells into the tissues. This causes “priming” of the tissues, which means that they now react to even smaller doses of allergen. This is why patients with hay fever continue to have symptoms, even when the pollen count is low. The inflammation also causes the patient to react to non-allergens, such as strong odors or perfumes. If the exposure to the allergen continues, this causes a chronic inflammation in the tissues and the symptoms continue to occur.
There are many different allergens that can trigger reactions. This slide lists the more common allergens, and where the exposure occurs.
Dust mites are one of the most common allergens, worldwide. They are present indoors, and are very sensitive to humidity and heat. They grow best in warm, humid environments (indoors in warm or temperate climates) but do not grow well in very dry climates. For most children. Carpeting and the surface of mattresses and pillows are the major source of exposure.
Any furry or feathered pet can be an allergic trigger, but cats and dogs are the most common, because they are the most common household pets. Cats produce more allergen that dogs, and so are more “allergenic”. The allergen in the dog is present in the hair and skin, and it does not matter how long the hair is. In cats, the allergen is present in secretions from the skin and in the saliva. It is on the hair, because the cat is always grooming itself, but it is not the hair.
Pollens are encountered primarily outdoors. Tree pollens tend to be present in the early spring, grass in the late spring and early summer, and weed pollens in the late summer and early fall. In very warm climates, the pollen can be present for longer periods of time.
Cockroaches are common allergens in the inner city. They can be present wherever food or garbage is left out, however.
Molds are usually an outdoor allergen, and can be a particular problem in the midwest and southeast US during the summer, when the weather is hot and humid. Molds become an indoor problem only when there is a moisture problem as listed on the slide.
Foods can cause acute allergic reactions, but are uncommon causes of chronic allergy symptoms.
When a person has inflammation occurring in the nose or lungs from chronic allergen exposure, these substances can aggravate symptoms.
Therapy of allergy always involves avoidance of the allergen, whenever possible. This can result in improvement in symptoms and less need for medications.
Total avoidance is usually not possible, so medications play an important role in the management of allergic disease.
Allergy injections can be very effective treatment for some allergic conditions, and are usually used when avoidance and medications are not effective in relieving symptoms.
This slides lists some things that can be done in a school setting to reduce exposure to common allergens
Allergy injections are only useful when the symptoms correspond to an exposure to an allergen the patient has shown sensitivity to, usually by skin testing. Allergy injections should be prescribed by someone with training and experience in allergy.